Putative eIF-2B GDP-GTP exchange factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor eIF-2B subunit beta, putative

Species:

Leishmania major

UniProt:

Q4QHB9_LEIMA

TriTrypDb:

LmjF.10.0950 , LMJLV39_100016400 , LMJSD75_100016600

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005851	eukaryotic translation initiation factor 2B complex	2	2
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

Q4QHB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHB9

Function

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Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2
GO:0050790	regulation of catalytic activity	3	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003743	translation initiation factor activity	4	10
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0016853	isomerase activity	2	1
GO:0016860	intramolecular oxidoreductase activity	3	1
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	4	1
GO:0045182	translation regulator activity	1	10
GO:0046523	S-methyl-5-thioribose-1-phosphate isomerase activity	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.563
CLV_C14_Caspase3-7	483	487	PF00656	0.560
CLV_NRD_NRD_1	119	121	PF00675	0.376
CLV_NRD_NRD_1	207	209	PF00675	0.656
CLV_NRD_NRD_1	316	318	PF00675	0.356
CLV_NRD_NRD_1	338	340	PF00675	0.356
CLV_NRD_NRD_1	489	491	PF00675	0.370
CLV_PCSK_KEX2_1	119	121	PF00082	0.376
CLV_PCSK_KEX2_1	196	198	PF00082	0.692
CLV_PCSK_KEX2_1	207	209	PF00082	0.588

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U6	Leptomonas seymouri	72%	100%
A0A0S4JL98	Bodo saltans	38%	89%
A0A1X0NQN7	Trypanosomatidae	48%	100%
A0A3S7WRA1	Leishmania donovani	98%	100%
A0A422NCU2	Trypanosoma rangeli	45%	100%
A4HUK8	Leishmania infantum	98%	100%
E9ANA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BTT5	Trypanosoma cruzi	46%	100%

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