Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHB8_LEIMA

TriTrypDb:

LmjF.10.0960 , LMJLV39_100016500 , LMJSD75_100016700

Length:

805

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005930	axoneme	2	2
GO:0035253	ciliary rootlet	2	2
GO:0036064	ciliary basal body	3	2
GO:0097542	ciliary tip	2	2
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

Q4QHB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHB8

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036158	outer dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	373	377	PF00656	0.462
CLV_C14_Caspase3-7	723	727	PF00656	0.689
CLV_NRD_NRD_1	130	132	PF00675	0.464
CLV_NRD_NRD_1	14	16	PF00675	0.672
CLV_NRD_NRD_1	21	23	PF00675	0.671
CLV_NRD_NRD_1	279	281	PF00675	0.478
CLV_NRD_NRD_1	294	296	PF00675	0.443
CLV_NRD_NRD_1	589	591	PF00675	0.774
CLV_NRD_NRD_1	59	61	PF00675	0.502
CLV_NRD_NRD_1	610	612	PF00675	0.803
CLV_NRD_NRD_1	654	656	PF00675	0.756
CLV_NRD_NRD_1	740	742	PF00675	0.755
CLV_NRD_NRD_1	779	781	PF00675	0.663
CLV_NRD_NRD_1	803	805	PF00675	0.664
CLV_NRD_NRD_1	82	84	PF00675	0.617
CLV_PCSK_FUR_1	128	132	PF00082	0.564
CLV_PCSK_FUR_1	652	656	PF00082	0.755
CLV_PCSK_FUR_1	738	742	PF00082	0.761
CLV_PCSK_FUR_1	80	84	PF00082	0.654
CLV_PCSK_KEX2_1	130	132	PF00082	0.461
CLV_PCSK_KEX2_1	14	16	PF00082	0.605
CLV_PCSK_KEX2_1	278	280	PF00082	0.483
CLV_PCSK_KEX2_1	294	296	PF00082	0.429
CLV_PCSK_KEX2_1	58	60	PF00082	0.495
CLV_PCSK_KEX2_1	589	591	PF00082	0.774
CLV_PCSK_KEX2_1	610	612	PF00082	0.803
CLV_PCSK_KEX2_1	652	654	PF00082	0.767
CLV_PCSK_KEX2_1	740	742	PF00082	0.755
CLV_PCSK_KEX2_1	779	781	PF00082	0.614
CLV_PCSK_KEX2_1	784	786	PF00082	0.542
CLV_PCSK_KEX2_1	80	82	PF00082	0.622
CLV_PCSK_KEX2_1	803	805	PF00082	0.670
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.578
CLV_PCSK_PC1ET2_1	784	786	PF00082	0.536
CLV_PCSK_PC7_1	10	16	PF00082	0.556
CLV_PCSK_PC7_1	780	786	PF00082	0.545
CLV_PCSK_SKI1_1	268	272	PF00082	0.486
CLV_PCSK_SKI1_1	328	332	PF00082	0.579
CLV_PCSK_SKI1_1	368	372	PF00082	0.617
CLV_PCSK_SKI1_1	429	433	PF00082	0.676
CLV_PCSK_SKI1_1	627	631	PF00082	0.760
DEG_APCC_DBOX_1	204	212	PF00400	0.529
DEG_APCC_DBOX_1	233	241	PF00400	0.560
DEG_APCC_DBOX_1	327	335	PF00400	0.633
DEG_APCC_DBOX_1	57	65	PF00400	0.622
DEG_SPOP_SBC_1	514	518	PF00917	0.460
DOC_ANK_TNKS_1	716	723	PF00023	0.696
DOC_CYCLIN_RxL_1	232	245	PF00134	0.593
DOC_CYCLIN_RxL_1	527	537	PF00134	0.615
DOC_MAPK_gen_1	193	201	PF00069	0.548
DOC_MAPK_gen_1	232	239	PF00069	0.469
DOC_MAPK_gen_1	461	471	PF00069	0.519
DOC_MAPK_JIP1_4	174	180	PF00069	0.542
DOC_MAPK_MEF2A_6	515	524	PF00069	0.673
DOC_PP1_RVXF_1	686	693	PF00149	0.758
DOC_PP2B_LxvP_1	682	685	PF13499	0.712
DOC_PP2B_LxvP_1	93	96	PF13499	0.594
DOC_USP7_MATH_1	370	374	PF00917	0.449
DOC_USP7_MATH_1	431	435	PF00917	0.608
DOC_USP7_MATH_1	514	518	PF00917	0.693
DOC_USP7_MATH_1	575	579	PF00917	0.750
DOC_USP7_MATH_1	605	609	PF00917	0.728
DOC_USP7_UBL2_3	189	193	PF12436	0.515
DOC_WW_Pin1_4	446	451	PF00397	0.648
DOC_WW_Pin1_4	549	554	PF00397	0.787
DOC_WW_Pin1_4	664	669	PF00397	0.542
LIG_14-3-3_CanoR_1	14	21	PF00244	0.672
LIG_14-3-3_CanoR_1	22	32	PF00244	0.538
LIG_14-3-3_CanoR_1	247	257	PF00244	0.537
LIG_14-3-3_CanoR_1	266	275	PF00244	0.419
LIG_14-3-3_CanoR_1	328	334	PF00244	0.598
LIG_14-3-3_CanoR_1	429	437	PF00244	0.740
LIG_14-3-3_CanoR_1	59	65	PF00244	0.544
LIG_14-3-3_CanoR_1	610	618	PF00244	0.768
LIG_Actin_WH2_2	57	74	PF00022	0.497
LIG_BIR_III_4	537	541	PF00653	0.632
LIG_BIR_III_4	711	715	PF00653	0.801
LIG_BRCT_BRCA1_1	433	437	PF00533	0.609
LIG_BRCT_BRCA1_1	703	707	PF00533	0.563
LIG_CaM_IQ_9	254	270	PF13499	0.564
LIG_CaM_IQ_9	286	302	PF13499	0.589
LIG_FHA_1	305	311	PF00498	0.631
LIG_FHA_1	508	514	PF00498	0.690
LIG_FHA_1	697	703	PF00498	0.748
LIG_FHA_2	109	115	PF00498	0.564
LIG_FHA_2	221	227	PF00498	0.573
LIG_FHA_2	23	29	PF00498	0.643
LIG_FHA_2	250	256	PF00498	0.558
LIG_FHA_2	267	273	PF00498	0.554
LIG_FHA_2	348	354	PF00498	0.648
LIG_FHA_2	61	67	PF00498	0.537
LIG_FHA_2	612	618	PF00498	0.798
LIG_FHA_2	721	727	PF00498	0.591
LIG_LYPXL_SIV_4	249	257	PF13949	0.584
LIG_Rb_pABgroove_1	237	245	PF01858	0.547
LIG_RPA_C_Fungi	648	660	PF08784	0.758
LIG_SH2_NCK_1	359	363	PF00017	0.580
LIG_SH2_STAP1	250	254	PF00017	0.511
LIG_SH2_STAP1	359	363	PF00017	0.524
LIG_SH2_STAT3	218	221	PF00017	0.555
LIG_SH2_STAT3	390	393	PF00017	0.590
LIG_SH2_STAT5	125	128	PF00017	0.573
LIG_SH2_STAT5	177	180	PF00017	0.553
LIG_SH2_STAT5	398	401	PF00017	0.627
LIG_SH2_STAT5	422	425	PF00017	0.665
LIG_SH2_STAT5	470	473	PF00017	0.576
LIG_SH3_1	741	747	PF00018	0.547
LIG_SH3_3	103	109	PF00018	0.691
LIG_SH3_3	499	505	PF00018	0.531
LIG_SH3_3	599	605	PF00018	0.573
LIG_SH3_3	741	747	PF00018	0.547
LIG_Vh1_VBS_1	520	538	PF01044	0.617
LIG_WRC_WIRS_1	456	461	PF05994	0.531
MOD_CDC14_SPxK_1	552	555	PF00782	0.712
MOD_CDK_SPxK_1	549	555	PF00069	0.716
MOD_CK1_1	151	157	PF00069	0.412
MOD_CK1_1	17	23	PF00069	0.689
MOD_CK1_1	349	355	PF00069	0.705
MOD_CK1_1	516	522	PF00069	0.561
MOD_CK1_1	548	554	PF00069	0.788
MOD_CK1_1	696	702	PF00069	0.652
MOD_CK2_1	108	114	PF00069	0.580
MOD_CK2_1	151	157	PF00069	0.607
MOD_CK2_1	22	28	PF00069	0.583
MOD_CK2_1	220	226	PF00069	0.585
MOD_CK2_1	249	255	PF00069	0.522
MOD_CK2_1	266	272	PF00069	0.553
MOD_CK2_1	41	47	PF00069	0.462
MOD_Cter_Amidation	608	611	PF01082	0.805
MOD_Cter_Amidation	738	741	PF01082	0.754
MOD_GlcNHglycan	16	19	PF01048	0.577
MOD_GlcNHglycan	262	265	PF01048	0.543
MOD_GlcNHglycan	337	340	PF01048	0.697
MOD_GlcNHglycan	433	436	PF01048	0.664
MOD_GlcNHglycan	440	443	PF01048	0.658
MOD_GlcNHglycan	571	574	PF01048	0.747
MOD_GlcNHglycan	607	610	PF01048	0.735
MOD_GlcNHglycan	623	626	PF01048	0.734
MOD_GlcNHglycan	647	650	PF01048	0.720
MOD_GlcNHglycan	656	659	PF01048	0.727
MOD_GlcNHglycan	703	706	PF01048	0.720
MOD_GlcNHglycan	756	759	PF01048	0.598
MOD_GSK3_1	24	31	PF00069	0.616
MOD_GSK3_1	262	269	PF00069	0.522
MOD_GSK3_1	342	349	PF00069	0.708
MOD_GSK3_1	425	432	PF00069	0.717
MOD_GSK3_1	503	510	PF00069	0.571
MOD_GSK3_1	544	551	PF00069	0.719
MOD_GSK3_1	693	700	PF00069	0.663
MOD_GSK3_1	749	756	PF00069	0.767
MOD_N-GLC_1	23	28	PF02516	0.598
MOD_N-GLC_1	67	72	PF02516	0.584
MOD_N-GLC_1	707	712	PF02516	0.756
MOD_N-GLC_1	726	731	PF02516	0.489
MOD_NEK2_1	242	247	PF00069	0.510
MOD_NEK2_1	286	291	PF00069	0.454
MOD_NEK2_1	334	339	PF00069	0.722
MOD_NEK2_1	513	518	PF00069	0.604
MOD_NEK2_1	6	11	PF00069	0.814
MOD_NEK2_1	645	650	PF00069	0.734
MOD_NEK2_1	789	794	PF00069	0.553
MOD_PIKK_1	118	124	PF00454	0.531
MOD_PIKK_1	148	154	PF00454	0.398
MOD_PIKK_1	286	292	PF00454	0.488
MOD_PIKK_1	304	310	PF00454	0.476
MOD_PK_1	503	509	PF00069	0.445
MOD_PKA_1	14	20	PF00069	0.541
MOD_PKA_1	22	28	PF00069	0.486
MOD_PKA_1	653	659	PF00069	0.756
MOD_PKA_1	784	790	PF00069	0.575
MOD_PKA_2	14	20	PF00069	0.649
MOD_PKA_2	334	340	PF00069	0.645
MOD_PKA_2	645	651	PF00069	0.739
MOD_PKA_2	653	659	PF00069	0.734
MOD_PKA_2	784	790	PF00069	0.617
MOD_PKB_1	58	66	PF00069	0.387
MOD_PKB_1	652	660	PF00069	0.755
MOD_Plk_1	304	310	PF00069	0.528
MOD_Plk_1	394	400	PF00069	0.493
MOD_Plk_1	67	73	PF00069	0.498
MOD_Plk_2-3	108	114	PF00069	0.656
MOD_Plk_4	151	157	PF00069	0.639
MOD_Plk_4	220	226	PF00069	0.566
MOD_Plk_4	329	335	PF00069	0.645
MOD_Plk_4	394	400	PF00069	0.532
MOD_Plk_4	455	461	PF00069	0.548
MOD_ProDKin_1	446	452	PF00069	0.646
MOD_ProDKin_1	549	555	PF00069	0.787
MOD_ProDKin_1	664	670	PF00069	0.541
MOD_SUMO_rev_2	142	151	PF00179	0.591
MOD_SUMO_rev_2	561	570	PF00179	0.703
MOD_SUMO_rev_2	776	786	PF00179	0.675
TRG_DiLeu_BaEn_2	454	460	PF01217	0.628
TRG_DiLeu_BaEn_3	304	310	PF01217	0.644
TRG_DiLeu_BaEn_4	305	311	PF01217	0.595
TRG_DiLeu_BaEn_4	462	468	PF01217	0.584
TRG_ENDOCYTIC_2	177	180	PF00928	0.553
TRG_ER_diArg_1	128	131	PF00400	0.454
TRG_ER_diArg_1	13	15	PF00400	0.707
TRG_ER_diArg_1	294	296	PF00400	0.463
TRG_ER_diArg_1	57	60	PF00400	0.575
TRG_ER_diArg_1	589	591	PF00400	0.741
TRG_ER_diArg_1	610	613	PF00400	0.813
TRG_ER_diArg_1	652	655	PF00400	0.763
TRG_ER_diArg_1	738	741	PF00400	0.770
TRG_ER_diArg_1	778	780	PF00400	0.670
TRG_ER_diArg_1	790	793	PF00400	0.456
TRG_ER_diArg_1	80	83	PF00400	0.616
TRG_ER_diArg_1	803	805	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P488	Leptomonas seymouri	51%	89%
A0A1X0NQB6	Trypanosomatidae	27%	100%
A0A3Q8I8W1	Leishmania donovani	92%	100%
A0A422NCY5	Trypanosoma rangeli	27%	100%
A4H684	Leishmania braziliensis	71%	100%
A4HUK9	Leishmania infantum	91%	100%
C9ZVN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9ANA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BJM8	Trypanosoma cruzi	27%	100%