Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHB6_LEIMA

TriTrypDb:

LmjF.10.0980 , LMJLV39_100016700 , LMJSD75_100016900

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.526
CLV_C14_Caspase3-7	384	388	PF00656	0.308
CLV_C14_Caspase3-7	631	635	PF00656	0.481
CLV_NRD_NRD_1	111	113	PF00675	0.414
CLV_NRD_NRD_1	484	486	PF00675	0.663
CLV_NRD_NRD_1	491	493	PF00675	0.402
CLV_NRD_NRD_1	537	539	PF00675	0.500
CLV_NRD_NRD_1	561	563	PF00675	0.486
CLV_PCSK_KEX2_1	111	113	PF00082	0.681
CLV_PCSK_KEX2_1	425	427	PF00082	0.520
CLV_PCSK_KEX2_1	491	493	PF00082	0.443
CLV_PCSK_KEX2_1	632	634	PF00082	0.478
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.520
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.478
CLV_PCSK_SKI1_1	383	387	PF00082	0.295
CLV_PCSK_SKI1_1	445	449	PF00082	0.346
CLV_PCSK_SKI1_1	605	609	PF00082	0.480
DEG_SPOP_SBC_1	142	146	PF00917	0.526
DOC_CKS1_1	581	586	PF01111	0.500
DOC_MAPK_MEF2A_6	193	200	PF00069	0.311
DOC_PP1_RVXF_1	195	201	PF00149	0.304
DOC_PP1_RVXF_1	443	450	PF00149	0.345
DOC_PP1_RVXF_1	603	609	PF00149	0.471
DOC_PP4_FxxP_1	505	508	PF00568	0.406
DOC_USP7_MATH_1	114	118	PF00917	0.546
DOC_USP7_MATH_1	236	240	PF00917	0.538
DOC_USP7_MATH_1	255	259	PF00917	0.479
DOC_USP7_MATH_1	27	31	PF00917	0.320
DOC_USP7_MATH_1	271	275	PF00917	0.486
DOC_USP7_MATH_1	430	434	PF00917	0.526
DOC_USP7_MATH_1	469	473	PF00917	0.459
DOC_USP7_MATH_1	476	480	PF00917	0.455
DOC_USP7_MATH_1	53	57	PF00917	0.503
DOC_USP7_MATH_1	595	599	PF00917	0.466
DOC_USP7_MATH_1	6	10	PF00917	0.522
DOC_USP7_MATH_1	609	613	PF00917	0.484
DOC_WW_Pin1_4	137	142	PF00397	0.622
DOC_WW_Pin1_4	182	187	PF00397	0.468
DOC_WW_Pin1_4	257	262	PF00397	0.532
DOC_WW_Pin1_4	294	299	PF00397	0.458
DOC_WW_Pin1_4	352	357	PF00397	0.504
DOC_WW_Pin1_4	547	552	PF00397	0.550
DOC_WW_Pin1_4	566	571	PF00397	0.462
DOC_WW_Pin1_4	580	585	PF00397	0.487
LIG_14-3-3_CanoR_1	133	141	PF00244	0.536
LIG_14-3-3_CanoR_1	243	249	PF00244	0.538
LIG_14-3-3_CanoR_1	445	450	PF00244	0.348
LIG_14-3-3_CanoR_1	622	626	PF00244	0.504
LIG_BIR_II_1	1	5	PF00653	0.492
LIG_eIF4E_1	370	376	PF01652	0.388
LIG_FHA_1	10	16	PF00498	0.471
LIG_FHA_1	105	111	PF00498	0.353
LIG_FHA_1	152	158	PF00498	0.386
LIG_FHA_1	178	184	PF00498	0.533
LIG_FHA_1	316	322	PF00498	0.326
LIG_FHA_1	475	481	PF00498	0.476
LIG_FHA_1	488	494	PF00498	0.378
LIG_FHA_1	499	505	PF00498	0.355
LIG_FHA_1	528	534	PF00498	0.717
LIG_FHA_1	613	619	PF00498	0.474
LIG_FHA_2	143	149	PF00498	0.534
LIG_FHA_2	161	167	PF00498	0.279
LIG_FHA_2	209	215	PF00498	0.356
LIG_FHA_2	258	264	PF00498	0.534
LIG_FHA_2	402	408	PF00498	0.504
LIG_FHA_2	460	466	PF00498	0.452
LIG_FHA_2	548	554	PF00498	0.522
LIG_FHA_2	584	590	PF00498	0.520
LIG_FHA_2	62	68	PF00498	0.513
LIG_GBD_Chelix_1	443	451	PF00786	0.344
LIG_HCF-1_HBM_1	16	19	PF13415	0.427
LIG_LIR_Apic_2	502	508	PF02991	0.390
LIG_LIR_Gen_1	16	27	PF02991	0.394
LIG_LIR_Gen_1	448	457	PF02991	0.384
LIG_LIR_Nem_3	16	22	PF02991	0.420
LIG_LIR_Nem_3	217	221	PF02991	0.534
LIG_LIR_Nem_3	387	393	PF02991	0.324
LIG_LIR_Nem_3	450	456	PF02991	0.389
LIG_PDZ_Class_2	634	639	PF00595	0.481
LIG_Pex14_2	330	334	PF04695	0.308
LIG_Pex14_2	449	453	PF04695	0.345
LIG_SH2_SRC	19	22	PF00017	0.400
LIG_SH2_SRC	46	49	PF00017	0.402
LIG_SH2_STAT5	370	373	PF00017	0.396
LIG_SH2_STAT5	461	464	PF00017	0.457
LIG_SH3_3	265	271	PF00018	0.557
LIG_SH3_3	318	324	PF00018	0.332
LIG_SH3_3	332	338	PF00018	0.463
LIG_SH3_3	564	570	PF00018	0.575
LIG_SH3_3	603	609	PF00018	0.471
LIG_SUMO_SIM_anti_2	247	252	PF11976	0.517
LIG_SUMO_SIM_anti_2	572	578	PF11976	0.513
LIG_TYR_ITIM	371	376	PF00017	0.381
LIG_WRC_WIRS_1	382	387	PF05994	0.306
LIG_WRC_WIRS_1	446	451	PF05994	0.328
LIG_WRC_WIRS_1	558	563	PF05994	0.463
MOD_CDK_SPxxK_3	580	587	PF00069	0.502
MOD_CK1_1	230	236	PF00069	0.498
MOD_CK1_1	294	300	PF00069	0.458
MOD_CK1_1	30	36	PF00069	0.317
MOD_CK1_1	355	361	PF00069	0.511
MOD_CK1_1	401	407	PF00069	0.500
MOD_CK1_1	569	575	PF00069	0.511
MOD_CK1_1	612	618	PF00069	0.475
MOD_CK1_1	9	15	PF00069	0.476
MOD_CK2_1	160	166	PF00069	0.373
MOD_CK2_1	208	214	PF00069	0.347
MOD_CK2_1	257	263	PF00069	0.541
MOD_CK2_1	30	36	PF00069	0.317
MOD_CK2_1	371	377	PF00069	0.374
MOD_CK2_1	401	407	PF00069	0.500
MOD_CK2_1	459	465	PF00069	0.454
MOD_DYRK1A_RPxSP_1	566	570	PF00069	0.502
MOD_GlcNHglycan	1	4	PF01048	0.517
MOD_GlcNHglycan	116	119	PF01048	0.504
MOD_GlcNHglycan	123	126	PF01048	0.514
MOD_GlcNHglycan	231	235	PF01048	0.502
MOD_GlcNHglycan	238	241	PF01048	0.503
MOD_GlcNHglycan	252	256	PF01048	0.522
MOD_GlcNHglycan	286	289	PF01048	0.535
MOD_GlcNHglycan	293	296	PF01048	0.403
MOD_GlcNHglycan	359	362	PF01048	0.512
MOD_GlcNHglycan	394	398	PF01048	0.404
MOD_GlcNHglycan	414	417	PF01048	0.526
MOD_GlcNHglycan	432	435	PF01048	0.473
MOD_GlcNHglycan	438	441	PF01048	0.386
MOD_GlcNHglycan	505	508	PF01048	0.430
MOD_GlcNHglycan	512	515	PF01048	0.490
MOD_GlcNHglycan	520	523	PF01048	0.476
MOD_GlcNHglycan	8	11	PF01048	0.508
MOD_GSK3_1	137	144	PF00069	0.628
MOD_GSK3_1	160	167	PF00069	0.292
MOD_GSK3_1	251	258	PF00069	0.572
MOD_GSK3_1	355	362	PF00069	0.645
MOD_GSK3_1	432	439	PF00069	0.447
MOD_GSK3_1	470	477	PF00069	0.544
MOD_GSK3_1	499	506	PF00069	0.386
MOD_GSK3_1	508	515	PF00069	0.479
MOD_GSK3_1	545	552	PF00069	0.560
MOD_GSK3_1	575	582	PF00069	0.500
MOD_N-GLC_1	127	132	PF02516	0.510
MOD_N-GLC_1	401	406	PF02516	0.498
MOD_N-GLC_1	6	11	PF02516	0.496
MOD_NEK2_1	160	165	PF00069	0.302
MOD_NEK2_1	315	320	PF00069	0.316
MOD_NEK2_1	328	333	PF00069	0.303
MOD_NEK2_1	346	351	PF00069	0.469
MOD_NEK2_1	393	398	PF00069	0.396
MOD_NEK2_1	452	457	PF00069	0.500
MOD_NEK2_1	470	475	PF00069	0.742
MOD_NEK2_1	498	503	PF00069	0.655
MOD_NEK2_1	620	625	PF00069	0.502
MOD_PIKK_1	27	33	PF00454	0.336
MOD_PKA_2	132	138	PF00069	0.534
MOD_PKA_2	398	404	PF00069	0.503
MOD_PKA_2	53	59	PF00069	0.529
MOD_PKA_2	621	627	PF00069	0.507
MOD_Plk_1	151	157	PF00069	0.376
MOD_Plk_1	255	261	PF00069	0.496
MOD_Plk_1	470	476	PF00069	0.543
MOD_Plk_1	6	12	PF00069	0.494
MOD_Plk_4	246	252	PF00069	0.516
MOD_Plk_4	30	36	PF00069	0.317
MOD_Plk_4	306	312	PF00069	0.351
MOD_Plk_4	360	366	PF00069	0.491
MOD_Plk_4	371	377	PF00069	0.370
MOD_Plk_4	381	387	PF00069	0.289
MOD_Plk_4	452	458	PF00069	0.469
MOD_Plk_4	88	94	PF00069	0.340
MOD_ProDKin_1	137	143	PF00069	0.621
MOD_ProDKin_1	182	188	PF00069	0.463
MOD_ProDKin_1	257	263	PF00069	0.537
MOD_ProDKin_1	294	300	PF00069	0.466
MOD_ProDKin_1	352	358	PF00069	0.507
MOD_ProDKin_1	547	553	PF00069	0.551
MOD_ProDKin_1	566	572	PF00069	0.462
MOD_ProDKin_1	580	586	PF00069	0.491
MOD_SUMO_rev_2	56	60	PF00179	0.534
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.363
TRG_ENDOCYTIC_2	19	22	PF00928	0.393
TRG_ENDOCYTIC_2	373	376	PF00928	0.373
TRG_ER_diArg_1	110	112	PF00400	0.373
TRG_ER_diArg_1	171	174	PF00400	0.581
TRG_ER_diArg_1	491	493	PF00400	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSV0	Leptomonas seymouri	35%	100%
A0A3S7WRB9	Leishmania donovani	89%	100%
A4HUL1	Leishmania infantum	88%	100%
E9ANA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%