Putative ARP2/3 complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ARP2/3 complex subunit, putative

Species:

Leishmania major

UniProt:

Q4QHB4_LEIMA

TriTrypDb:

LmjF.10.1000 , LMJLV39_100016900 , LMJSD75_100017000

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005885	Arp2/3 protein complex	2	6
GO:0032991	protein-containing complex	1	6
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

Q4QHB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHB4

Function

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Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	6
GO:0008064	regulation of actin polymerization or depolymerization	6	6
GO:0008154	actin polymerization or depolymerization	6	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0030041	actin filament polymerization	7	6
GO:0030832	regulation of actin filament length	5	6
GO:0030833	regulation of actin filament polymerization	7	6
GO:0032271	regulation of protein polymerization	6	6

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Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	298	300	PF00675	0.621
CLV_NRD_NRD_1	8	10	PF00675	0.570
CLV_PCSK_KEX2_1	298	300	PF00082	0.621
CLV_PCSK_KEX2_1	308	310	PF00082	0.524
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.612
CLV_PCSK_SKI1_1	199	203	PF00082	0.564
DEG_APCC_DBOX_1	198	206	PF00400	0.548
DEG_SCF_FBW7_1	250	257	PF00400	0.433
DEG_SIAH_1	255	263	PF03145	0.577
DEG_SPOP_SBC_1	105	109	PF00917	0.630

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P323	Leptomonas seymouri	32%	95%
A0A3Q8I8S8	Leishmania donovani	87%	100%
A4H688	Leishmania braziliensis	64%	95%
E9AGA0	Leishmania infantum	88%	100%
E9ANB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%

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