Putative ARP2/3 complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ARP2/3 complex subunit, putative

Species:

Leishmania major

UniProt:

Q4QHB4_LEIMA

TriTrypDb:

LmjF.10.1000 , LMJLV39_100016900 , LMJSD75_100017000

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005885	Arp2/3 protein complex	2	6
GO:0032991	protein-containing complex	1	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QHB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHB4

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	6
GO:0008064	regulation of actin polymerization or depolymerization	6	6
GO:0008154	actin polymerization or depolymerization	6	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0030041	actin filament polymerization	7	6
GO:0030832	regulation of actin filament length	5	6
GO:0030833	regulation of actin filament polymerization	7	6
GO:0032271	regulation of protein polymerization	6	6
GO:0032535	regulation of cellular component size	4	6
GO:0032956	regulation of actin cytoskeleton organization	5	6
GO:0032970	regulation of actin filament-based process	4	6
GO:0033043	regulation of organelle organization	5	6
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	6
GO:0043254	regulation of protein-containing complex assembly	5	6
GO:0043933	protein-containing complex organization	4	6
GO:0044087	regulation of cellular component biogenesis	4	6
GO:0045010	actin nucleation	6	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051128	regulation of cellular component organization	4	6
GO:0051258	protein polymerization	6	6
GO:0051493	regulation of cytoskeleton organization	6	6
GO:0065003	protein-containing complex assembly	5	6
GO:0065007	biological regulation	1	6
GO:0065008	regulation of biological quality	2	6
GO:0071840	cellular component organization or biogenesis	2	6
GO:0090066	regulation of anatomical structure size	3	6
GO:0097435	supramolecular fiber organization	4	6
GO:0110053	regulation of actin filament organization	6	6
GO:1902903	regulation of supramolecular fiber organization	5	6

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	298	300	PF00675	0.621
CLV_NRD_NRD_1	8	10	PF00675	0.570
CLV_PCSK_KEX2_1	298	300	PF00082	0.621
CLV_PCSK_KEX2_1	308	310	PF00082	0.524
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.612
CLV_PCSK_SKI1_1	199	203	PF00082	0.564
DEG_APCC_DBOX_1	198	206	PF00400	0.548
DEG_SCF_FBW7_1	250	257	PF00400	0.433
DEG_SIAH_1	255	263	PF03145	0.577
DEG_SPOP_SBC_1	105	109	PF00917	0.630
DEG_SPOP_SBC_1	14	18	PF00917	0.578
DEG_SPOP_SBC_1	262	266	PF00917	0.626
DOC_CKS1_1	177	182	PF01111	0.401
DOC_CYCLIN_yClb5_NLxxxL_5	128	136	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	151	157	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	172	178	PF00134	0.524
DOC_MAPK_gen_1	308	316	PF00069	0.649
DOC_MAPK_gen_1	367	375	PF00069	0.497
DOC_MAPK_gen_1	85	95	PF00069	0.616
DOC_MAPK_MEF2A_6	308	316	PF00069	0.644
DOC_MAPK_MEF2A_6	367	375	PF00069	0.497
DOC_PP2B_LxvP_1	172	175	PF13499	0.538
DOC_PP2B_LxvP_1	219	222	PF13499	0.669
DOC_PP2B_PxIxI_1	110	116	PF00149	0.648
DOC_PP4_FxxP_1	117	120	PF00568	0.717
DOC_USP7_MATH_1	106	110	PF00917	0.775
DOC_USP7_MATH_1	163	167	PF00917	0.688
DOC_USP7_MATH_1	262	266	PF00917	0.691
DOC_USP7_MATH_1	69	73	PF00917	0.599
DOC_USP7_MATH_2	156	162	PF00917	0.678
DOC_WW_Pin1_4	15	20	PF00397	0.790
DOC_WW_Pin1_4	150	155	PF00397	0.707
DOC_WW_Pin1_4	176	181	PF00397	0.647
DOC_WW_Pin1_4	250	255	PF00397	0.643
DOC_WW_Pin1_4	258	263	PF00397	0.692
LIG_14-3-3_CanoR_1	103	113	PF00244	0.656
LIG_14-3-3_CanoR_1	389	399	PF00244	0.511
LIG_Actin_WH2_2	186	201	PF00022	0.527
LIG_Actin_WH2_2	355	372	PF00022	0.502
LIG_APCC_ABBA_1	220	225	PF00400	0.481
LIG_APCC_ABBA_1	25	30	PF00400	0.515
LIG_APCC_ABBA_1	375	380	PF00400	0.487
LIG_APCC_ABBAyCdc20_2	24	30	PF00400	0.517
LIG_BIR_II_1	1	5	PF00653	0.804
LIG_FHA_1	146	152	PF00498	0.688
LIG_FHA_1	255	261	PF00498	0.635
LIG_FHA_1	277	283	PF00498	0.494
LIG_FHA_1	343	349	PF00498	0.447
LIG_FHA_2	177	183	PF00498	0.637
LIG_FHA_2	224	230	PF00498	0.573
LIG_HCF-1_HBM_1	337	340	PF13415	0.637
LIG_LIR_Apic_2	148	152	PF02991	0.705
LIG_LIR_Gen_1	302	312	PF02991	0.566
LIG_LIR_Nem_3	107	113	PF02991	0.719
LIG_LIR_Nem_3	302	307	PF02991	0.547
LIG_LYPXL_yS_3	110	113	PF13949	0.702
LIG_NRBOX	201	207	PF00104	0.510
LIG_Pex14_1	342	346	PF04695	0.557
LIG_PTAP_UEV_1	255	260	PF05743	0.522
LIG_Rb_LxCxE_1	90	112	PF01857	0.599
LIG_SH2_CRK	149	153	PF00017	0.644
LIG_SH2_PTP2	177	180	PF00017	0.401
LIG_SH2_SRC	300	303	PF00017	0.476
LIG_SH2_STAP1	395	399	PF00017	0.522
LIG_SH2_STAT5	177	180	PF00017	0.507
LIG_SH2_STAT5	26	29	PF00017	0.622
LIG_SH2_STAT5	300	303	PF00017	0.498
LIG_SH3_2	19	24	PF14604	0.694
LIG_SH3_3	16	22	PF00018	0.673
LIG_SH3_3	253	259	PF00018	0.602
LIG_SH3_3	344	350	PF00018	0.539
LIG_SH3_3	48	54	PF00018	0.712
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.656
LIG_SUMO_SIM_par_1	277	283	PF11976	0.493
LIG_SUMO_SIM_par_1	312	319	PF11976	0.634
LIG_TRFH_1	346	350	PF08558	0.584
LIG_TYR_ITSM	106	113	PF00017	0.723
MOD_CDK_SPK_2	176	181	PF00069	0.413
MOD_CDK_SPxxK_3	176	183	PF00069	0.642
MOD_CK1_1	109	115	PF00069	0.636
MOD_CK1_1	166	172	PF00069	0.641
MOD_CK1_1	209	215	PF00069	0.597
MOD_CK1_1	241	247	PF00069	0.555
MOD_CK1_1	261	267	PF00069	0.796
MOD_CK1_1	355	361	PF00069	0.538
MOD_CK1_1	41	47	PF00069	0.693
MOD_CK2_1	176	182	PF00069	0.640
MOD_CK2_1	93	99	PF00069	0.708
MOD_GlcNHglycan	160	163	PF01048	0.645
MOD_GlcNHglycan	209	212	PF01048	0.570
MOD_GlcNHglycan	238	241	PF01048	0.591
MOD_GlcNHglycan	243	246	PF01048	0.571
MOD_GlcNHglycan	266	269	PF01048	0.646
MOD_GlcNHglycan	276	279	PF01048	0.460
MOD_GlcNHglycan	318	321	PF01048	0.574
MOD_GlcNHglycan	354	357	PF01048	0.608
MOD_GlcNHglycan	58	61	PF01048	0.773
MOD_GlcNHglycan	71	74	PF01048	0.722
MOD_GSK3_1	10	17	PF00069	0.655
MOD_GSK3_1	105	112	PF00069	0.700
MOD_GSK3_1	221	228	PF00069	0.688
MOD_GSK3_1	248	255	PF00069	0.569
MOD_GSK3_1	258	265	PF00069	0.639
MOD_GSK3_1	274	281	PF00069	0.464
MOD_GSK3_1	34	41	PF00069	0.706
MOD_NEK2_1	206	211	PF00069	0.583
MOD_NEK2_1	227	232	PF00069	0.737
MOD_NEK2_1	248	253	PF00069	0.499
MOD_NEK2_2	191	196	PF00069	0.547
MOD_PIKK_1	230	236	PF00454	0.705
MOD_PKA_2	316	322	PF00069	0.656
MOD_PKA_2	369	375	PF00069	0.502
MOD_Plk_1	191	197	PF00069	0.528
MOD_Plk_1	33	39	PF00069	0.692
MOD_Plk_4	109	115	PF00069	0.654
MOD_Plk_4	238	244	PF00069	0.658
MOD_Plk_4	342	348	PF00069	0.448
MOD_Plk_4	369	375	PF00069	0.493
MOD_ProDKin_1	15	21	PF00069	0.781
MOD_ProDKin_1	150	156	PF00069	0.711
MOD_ProDKin_1	176	182	PF00069	0.640
MOD_ProDKin_1	250	256	PF00069	0.653
MOD_ProDKin_1	258	264	PF00069	0.694
MOD_SUMO_rev_2	302	310	PF00179	0.551
TRG_DiLeu_BaEn_1	216	221	PF01217	0.649
TRG_ENDOCYTIC_2	110	113	PF00928	0.715
TRG_ENDOCYTIC_2	129	132	PF00928	0.411
TRG_ER_diArg_1	297	299	PF00400	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P323	Leptomonas seymouri	32%	95%
A0A3Q8I8S8	Leishmania donovani	87%	100%
A4H688	Leishmania braziliensis	64%	95%
E9AGA0	Leishmania infantum	88%	100%
E9ANB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%