Putative carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carrier protein, putative

Species:

Leishmania major

UniProt:

Q4QHB2_LEIMA

TriTrypDb:

LmjF.10.1020 , LMJLV39_100017100 , LMJSD75_100017200

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	32
GO:0110165	cellular anatomical entity	1	32
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4QHB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHB2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0006862	nucleotide transport	6	5
GO:0009987	cellular process	1	5
GO:0015748	organophosphate ester transport	5	5
GO:0015931	nucleobase-containing compound transport	5	5
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055085	transmembrane transport	2	5
GO:0071702	organic substance transport	4	5
GO:0071705	nitrogen compound transport	4	5
GO:0035352	NAD transmembrane transport	4	1
GO:0043132	NAD transport	7	1
GO:1901679	nucleotide transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0051724	NAD transmembrane transporter activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.476
CLV_NRD_NRD_1	109	111	PF00675	0.319
CLV_NRD_NRD_1	209	211	PF00675	0.196
CLV_NRD_NRD_1	345	347	PF00675	0.257
CLV_PCSK_KEX2_1	209	211	PF00082	0.196
CLV_PCSK_KEX2_1	345	347	PF00082	0.289
CLV_PCSK_PC7_1	341	347	PF00082	0.321
CLV_PCSK_SKI1_1	137	141	PF00082	0.308
CLV_PCSK_SKI1_1	201	205	PF00082	0.248
CLV_PCSK_SKI1_1	227	231	PF00082	0.221
CLV_PCSK_SKI1_1	255	259	PF00082	0.499
CLV_PCSK_SKI1_1	97	101	PF00082	0.310
DEG_APCC_DBOX_1	136	144	PF00400	0.592
DEG_Nend_Nbox_1	1	3	PF02207	0.723
DEG_SCF_FBW7_1	328	335	PF00400	0.487
DOC_CKS1_1	329	334	PF01111	0.451
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	317	323	PF00134	0.338
DOC_MAPK_MEF2A_6	189	197	PF00069	0.445
DOC_USP7_MATH_1	169	173	PF00917	0.537
DOC_USP7_MATH_1	20	24	PF00917	0.765
DOC_USP7_MATH_1	205	209	PF00917	0.488
DOC_USP7_MATH_1	370	374	PF00917	0.306
DOC_WW_Pin1_4	203	208	PF00397	0.522
DOC_WW_Pin1_4	328	333	PF00397	0.454
DOC_WW_Pin1_4	49	54	PF00397	0.765
LIG_14-3-3_CanoR_1	110	120	PF00244	0.538
LIG_14-3-3_CanoR_1	209	215	PF00244	0.469
LIG_14-3-3_CanoR_1	224	230	PF00244	0.495
LIG_Actin_WH2_2	213	229	PF00022	0.537
LIG_BRCT_BRCA1_1	126	130	PF00533	0.454
LIG_CtBP_PxDLS_1	103	107	PF00389	0.496
LIG_deltaCOP1_diTrp_1	284	292	PF00928	0.443
LIG_FHA_1	120	126	PF00498	0.535
LIG_FHA_1	233	239	PF00498	0.307
LIG_FHA_1	312	318	PF00498	0.301
LIG_FHA_1	338	344	PF00498	0.449
LIG_FHA_1	56	62	PF00498	0.668
LIG_FHA_1	69	75	PF00498	0.578
LIG_FHA_2	292	298	PF00498	0.364
LIG_FHA_2	370	376	PF00498	0.277
LIG_IBAR_NPY_1	319	321	PF08397	0.456
LIG_LIR_Apic_2	284	290	PF02991	0.482
LIG_LIR_Gen_1	154	164	PF02991	0.464
LIG_LIR_Gen_1	373	381	PF02991	0.284
LIG_LIR_Gen_1	77	86	PF02991	0.517
LIG_LIR_LC3C_4	235	239	PF02991	0.446
LIG_LIR_Nem_3	121	126	PF02991	0.544
LIG_LIR_Nem_3	133	139	PF02991	0.614
LIG_LIR_Nem_3	154	160	PF02991	0.479
LIG_LIR_Nem_3	213	217	PF02991	0.473
LIG_LIR_Nem_3	228	233	PF02991	0.320
LIG_LIR_Nem_3	373	379	PF02991	0.250
LIG_LIR_Nem_3	77	81	PF02991	0.512
LIG_LYPXL_SIV_4	320	328	PF13949	0.480
LIG_Pex14_1	247	251	PF04695	0.252
LIG_PTB_Apo_2	253	260	PF02174	0.150
LIG_PTB_Phospho_1	253	259	PF10480	0.150
LIG_SH2_CRK	251	255	PF00017	0.352
LIG_SH2_CRK	353	357	PF00017	0.351
LIG_SH2_SRC	15	18	PF00017	0.616
LIG_SH2_SRC	374	377	PF00017	0.235
LIG_SH2_STAP1	376	380	PF00017	0.245
LIG_SH2_STAT5	157	160	PF00017	0.480
LIG_SH2_STAT5	182	185	PF00017	0.398
LIG_SH2_STAT5	321	324	PF00017	0.458
LIG_SH3_3	188	194	PF00018	0.499
LIG_SH3_3	23	29	PF00018	0.782
LIG_TYR_ITIM	155	160	PF00017	0.518
MOD_CDC14_SPxK_1	206	209	PF00782	0.396
MOD_CDK_SPxK_1	203	209	PF00069	0.396
MOD_CDK_SPxxK_3	203	210	PF00069	0.405
MOD_CK1_1	172	178	PF00069	0.492
MOD_CK1_1	213	219	PF00069	0.502
MOD_CK1_1	270	276	PF00069	0.419
MOD_CK1_1	291	297	PF00069	0.308
MOD_CK1_1	311	317	PF00069	0.312
MOD_CK1_1	44	50	PF00069	0.766
MOD_CK2_1	3	9	PF00069	0.743
MOD_CK2_1	369	375	PF00069	0.256
MOD_GlcNHglycan	113	116	PF01048	0.400
MOD_GlcNHglycan	179	182	PF01048	0.238
MOD_GlcNHglycan	260	264	PF01048	0.590
MOD_GlcNHglycan	310	313	PF01048	0.250
MOD_GlcNHglycan	353	356	PF01048	0.340
MOD_GlcNHglycan	44	47	PF01048	0.574
MOD_GSK3_1	201	208	PF00069	0.496
MOD_GSK3_1	288	295	PF00069	0.367
MOD_GSK3_1	304	311	PF00069	0.280
MOD_GSK3_1	328	335	PF00069	0.491
MOD_GSK3_1	44	51	PF00069	0.734
MOD_GSK3_1	70	77	PF00069	0.574
MOD_N-GLC_1	74	79	PF02516	0.344
MOD_N-GLC_2	361	363	PF02516	0.422
MOD_NEK2_1	187	192	PF00069	0.545
MOD_NEK2_1	2	7	PF00069	0.715
MOD_NEK2_1	233	238	PF00069	0.339
MOD_NEK2_1	258	263	PF00069	0.309
MOD_NEK2_1	356	361	PF00069	0.325
MOD_NEK2_1	369	374	PF00069	0.240
MOD_NEK2_2	22	27	PF00069	0.611
MOD_NEK2_2	225	230	PF00069	0.430
MOD_PIKK_1	273	279	PF00454	0.491
MOD_PKA_1	110	116	PF00069	0.579
MOD_PKA_2	267	273	PF00069	0.476
MOD_Plk_1	3	9	PF00069	0.716
MOD_Plk_1	74	80	PF00069	0.499
MOD_Plk_4	193	199	PF00069	0.419
MOD_Plk_4	233	239	PF00069	0.305
MOD_Plk_4	3	9	PF00069	0.728
MOD_Plk_4	332	338	PF00069	0.521
MOD_ProDKin_1	203	209	PF00069	0.522
MOD_ProDKin_1	328	334	PF00069	0.454
MOD_ProDKin_1	49	55	PF00069	0.759
TRG_DiLeu_BaEn_4	62	68	PF01217	0.729
TRG_ENDOCYTIC_2	157	160	PF00928	0.476
TRG_ENDOCYTIC_2	200	203	PF00928	0.520
TRG_ENDOCYTIC_2	251	254	PF00928	0.259
TRG_ENDOCYTIC_2	321	324	PF00928	0.460
TRG_ENDOCYTIC_2	353	356	PF00928	0.292
TRG_ENDOCYTIC_2	376	379	PF00928	0.245
TRG_ENDOCYTIC_2	78	81	PF00928	0.490
TRG_ER_diArg_1	209	211	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V4	Leptomonas seymouri	24%	100%
A0A0N1I8S5	Leptomonas seymouri	30%	100%
A0A0N1IBB8	Leptomonas seymouri	23%	81%
A0A0N1IHK9	Leptomonas seymouri	65%	100%
A0A0S4JF45	Bodo saltans	29%	95%
A0A0S4JH99	Bodo saltans	43%	77%
A0A0S4JIT1	Bodo saltans	31%	100%
A0A1X0NN16	Trypanosomatidae	30%	100%
A0A1X0NQB5	Trypanosomatidae	53%	100%
A0A1X0P6Z0	Trypanosomatidae	26%	97%
A0A3Q8IC78	Leishmania donovani	90%	99%
A0A3Q8IS12	Leishmania donovani	30%	100%
A0A3R7L1P3	Trypanosoma rangeli	29%	100%
A0A3S7WUZ5	Leishmania donovani	25%	87%
A0A422NGL1	Trypanosoma rangeli	53%	100%
A0A422P0Q3	Trypanosoma rangeli	29%	99%
A1CWA4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	100%
A4H690	Leishmania braziliensis	81%	96%
A4H9K7	Leishmania braziliensis	25%	85%
A4HQI4	Leishmania braziliensis	29%	100%
A4HUL3	Leishmania infantum	90%	99%
A4HXX3	Leishmania infantum	26%	87%
A4RPU0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	100%
B0Y4J4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	25%	100%
C9ZVP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZZS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	97%
E9AHZ3	Leishmania infantum	30%	100%
E9ANB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
E9ARN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	87%
E9AU97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q3TZX3	Mus musculus	24%	100%
Q4Q094	Leishmania major	30%	100%
Q4QDU2	Leishmania major	27%	100%
Q4WQC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54VX4	Dictyostelium discoideum	21%	100%
Q9BSK2	Homo sapiens	24%	100%
V5BTU3	Trypanosoma cruzi	52%	100%
V5DDT9	Trypanosoma cruzi	29%	100%
V5DN72	Trypanosoma cruzi	29%	99%