RNA-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein-like protein

Species:

Leishmania major

UniProt:

Q4QHB1_LEIMA

TriTrypDb:

LmjF.10.1030 , LMJLV39_100017200 , LMJSD75_100017300

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHB1

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000470	maturation of LSU-rRNA	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.586
CLV_NRD_NRD_1	250	252	PF00675	0.484
CLV_NRD_NRD_1	261	263	PF00675	0.385
CLV_NRD_NRD_1	281	283	PF00675	0.333
CLV_NRD_NRD_1	370	372	PF00675	0.729
CLV_NRD_NRD_1	58	60	PF00675	0.730
CLV_PCSK_FUR_1	203	207	PF00082	0.254
CLV_PCSK_KEX2_1	18	20	PF00082	0.608
CLV_PCSK_KEX2_1	205	207	PF00082	0.254
CLV_PCSK_KEX2_1	249	251	PF00082	0.532
CLV_PCSK_KEX2_1	260	262	PF00082	0.386
CLV_PCSK_KEX2_1	281	283	PF00082	0.538
CLV_PCSK_KEX2_1	330	332	PF00082	0.582
CLV_PCSK_KEX2_1	367	369	PF00082	0.719
CLV_PCSK_KEX2_1	85	87	PF00082	0.591
CLV_PCSK_KEX2_1	93	95	PF00082	0.636
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.608
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.321
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.582
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.622
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.603
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.605
CLV_PCSK_SKI1_1	244	248	PF00082	0.505
CLV_PCSK_SKI1_1	261	265	PF00082	0.519
CLV_PCSK_SKI1_1	367	371	PF00082	0.632
CLV_PCSK_SKI1_1	79	83	PF00082	0.671
DEG_SPOP_SBC_1	70	74	PF00917	0.638
DOC_CYCLIN_RxL_1	17	28	PF00134	0.607
DOC_MAPK_gen_1	18	24	PF00069	0.622
DOC_MAPK_gen_1	209	218	PF00069	0.521
DOC_MAPK_gen_1	281	290	PF00069	0.516
DOC_MAPK_MEF2A_6	220	228	PF00069	0.521
DOC_MAPK_MEF2A_6	281	290	PF00069	0.516
DOC_PP1_RVXF_1	170	176	PF00149	0.327
DOC_PP1_RVXF_1	18	25	PF00149	0.617
DOC_PP4_FxxP_1	175	178	PF00568	0.451
DOC_PP4_FxxP_1	180	183	PF00568	0.459
DOC_USP7_MATH_1	103	107	PF00917	0.709
DOC_USP7_MATH_1	124	128	PF00917	0.724
DOC_USP7_MATH_1	151	155	PF00917	0.637
DOC_USP7_MATH_1	361	365	PF00917	0.792
DOC_USP7_MATH_1	70	74	PF00917	0.667
DOC_USP7_UBL2_3	335	339	PF12436	0.633
DOC_USP7_UBL2_3	349	353	PF12436	0.600
DOC_USP7_UBL2_3	363	367	PF12436	0.731
DOC_USP7_UBL2_3	4	8	PF12436	0.695
DOC_WW_Pin1_4	136	141	PF00397	0.518
DOC_WW_Pin1_4	362	367	PF00397	0.627
LIG_14-3-3_CanoR_1	172	176	PF00244	0.333
LIG_14-3-3_CanoR_1	19	25	PF00244	0.611
LIG_14-3-3_CanoR_1	203	213	PF00244	0.466
LIG_14-3-3_CanoR_1	244	249	PF00244	0.515
LIG_14-3-3_CanoR_1	333	342	PF00244	0.618
LIG_FHA_1	127	133	PF00498	0.479
LIG_FHA_1	352	358	PF00498	0.750
LIG_FHA_1	36	42	PF00498	0.570
LIG_FHA_2	137	143	PF00498	0.540
LIG_LIR_Apic_2	174	178	PF02991	0.484
LIG_LIR_Apic_2	179	183	PF02991	0.473
LIG_LIR_Nem_3	166	171	PF02991	0.409
LIG_Pex14_2	188	192	PF04695	0.454
LIG_Pex14_2	310	314	PF04695	0.424
LIG_SH2_CRK	168	172	PF00017	0.414
LIG_SH2_CRK	186	190	PF00017	0.479
LIG_SH2_STAT5	215	218	PF00017	0.454
LIG_SH2_STAT5	302	305	PF00017	0.485
LIG_SH3_3	38	44	PF00018	0.684
LIG_SH3_3	96	102	PF00018	0.745
LIG_SUMO_SIM_par_1	224	230	PF11976	0.479
LIG_TRAF2_1	106	109	PF00917	0.670
LIG_TRAF2_1	95	98	PF00917	0.633
MOD_CDC14_SPxK_1	365	368	PF00782	0.612
MOD_CDK_SPK_2	362	367	PF00069	0.710
MOD_CDK_SPxK_1	362	368	PF00069	0.729
MOD_CK1_1	153	159	PF00069	0.668
MOD_CK1_1	161	167	PF00069	0.604
MOD_CK1_1	204	210	PF00069	0.456
MOD_CK1_1	334	340	PF00069	0.779
MOD_CK1_1	362	368	PF00069	0.589
MOD_CK2_1	103	109	PF00069	0.734
MOD_CK2_1	138	144	PF00069	0.622
MOD_CK2_1	20	26	PF00069	0.533
MOD_Cter_Amidation	16	19	PF01082	0.651
MOD_GlcNHglycan	11	14	PF01048	0.573
MOD_GlcNHglycan	153	156	PF01048	0.647
MOD_GlcNHglycan	221	224	PF01048	0.335
MOD_GlcNHglycan	4	7	PF01048	0.687
MOD_GlcNHglycan	73	76	PF01048	0.699
MOD_GlcNHglycan	86	89	PF01048	0.582
MOD_GSK3_1	126	133	PF00069	0.630
MOD_GSK3_1	149	156	PF00069	0.678
MOD_GSK3_1	20	27	PF00069	0.549
MOD_GSK3_1	314	321	PF00069	0.475
MOD_GSK3_1	334	341	PF00069	0.675
MOD_GSK3_1	352	359	PF00069	0.675
MOD_GSK3_1	65	72	PF00069	0.749
MOD_GSK3_1	9	16	PF00069	0.667
MOD_N-GLC_1	161	166	PF02516	0.610
MOD_NEK2_1	192	197	PF00069	0.521
MOD_NEK2_1	24	29	PF00069	0.598
MOD_NEK2_1	314	319	PF00069	0.464
MOD_NEK2_1	84	89	PF00069	0.589
MOD_NEK2_2	25	30	PF00069	0.545
MOD_PIKK_1	314	320	PF00454	0.470
MOD_PKA_1	20	26	PF00069	0.601
MOD_PKA_1	329	335	PF00069	0.694
MOD_PKA_1	367	373	PF00069	0.693
MOD_PKA_1	66	72	PF00069	0.650
MOD_PKA_2	158	164	PF00069	0.643
MOD_PKA_2	171	177	PF00069	0.162
MOD_PKA_2	367	373	PF00069	0.709
MOD_PKB_1	242	250	PF00069	0.507
MOD_PKB_1	77	85	PF00069	0.504
MOD_Plk_1	25	31	PF00069	0.580
MOD_Plk_2-3	126	132	PF00069	0.527
MOD_Plk_4	171	177	PF00069	0.369
MOD_Plk_4	192	198	PF00069	0.509
MOD_ProDKin_1	136	142	PF00069	0.524
MOD_ProDKin_1	362	368	PF00069	0.632
TRG_DiLeu_BaEn_3	229	235	PF01217	0.405
TRG_ENDOCYTIC_2	168	171	PF00928	0.380
TRG_ENDOCYTIC_2	186	189	PF00928	0.454
TRG_ENDOCYTIC_2	215	218	PF00928	0.454
TRG_ER_diArg_1	241	244	PF00400	0.472
TRG_ER_diArg_1	248	251	PF00400	0.495
TRG_ER_diArg_1	260	262	PF00400	0.339
TRG_ER_diArg_1	280	282	PF00400	0.357
TRG_NLS_Bipartite_1	8	23	PF00514	0.667
TRG_NLS_MonoCore_2	17	22	PF00514	0.637
TRG_NLS_MonoCore_2	327	332	PF00514	0.622
TRG_NLS_MonoExtC_3	328	333	PF00514	0.637
TRG_NLS_MonoExtN_4	18	23	PF00514	0.623
TRG_NLS_MonoExtN_4	328	334	PF00514	0.644
TRG_NLS_MonoExtN_4	58	63	PF00514	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9B0	Leptomonas seymouri	58%	91%
A0A3Q8I7S8	Leishmania donovani	90%	99%
A0A3R7KMG8	Trypanosoma rangeli	48%	90%
A4H691	Leishmania braziliensis	73%	97%
A4HUL4	Leishmania infantum	90%	99%
C9ZVP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	89%
E9ANB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%