J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QHA9_LEIMA

TriTrypDb:

LmjF.10.1050 , LMJLV39_100017400 , LMJSD75_100017500

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	229	231	PF00675	0.584
CLV_NRD_NRD_1	234	236	PF00675	0.570
CLV_NRD_NRD_1	252	254	PF00675	0.550
CLV_NRD_NRD_1	57	59	PF00675	0.436
CLV_PCSK_KEX2_1	229	231	PF00082	0.584
CLV_PCSK_KEX2_1	234	236	PF00082	0.542
CLV_PCSK_KEX2_1	252	254	PF00082	0.567
CLV_PCSK_KEX2_1	59	61	PF00082	0.349
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.374
CLV_PCSK_PC7_1	230	236	PF00082	0.677
CLV_PCSK_SKI1_1	151	155	PF00082	0.656
CLV_PCSK_SKI1_1	270	274	PF00082	0.581
CLV_PCSK_SKI1_1	78	82	PF00082	0.419
CLV_PCSK_SKI1_1	95	99	PF00082	0.324
DEG_APCC_KENBOX_2	196	200	PF00400	0.566
DOC_ANK_TNKS_1	33	40	PF00023	0.486
DOC_CKS1_1	47	52	PF01111	0.246
DOC_CYCLIN_RxL_1	40	49	PF00134	0.246
DOC_CYCLIN_RxL_1	92	99	PF00134	0.402
DOC_MAPK_gen_1	58	64	PF00069	0.368
DOC_MIT_MIM_1	56	64	PF04212	0.434
DOC_PP1_RVXF_1	41	48	PF00149	0.430
DOC_PP4_FxxP_1	141	144	PF00568	0.582
DOC_PP4_FxxP_1	153	156	PF00568	0.553
DOC_PP4_FxxP_1	47	50	PF00568	0.335
DOC_USP7_MATH_1	112	116	PF00917	0.782
DOC_USP7_MATH_1	117	121	PF00917	0.746
DOC_USP7_MATH_1	144	148	PF00917	0.674
DOC_USP7_MATH_1	176	180	PF00917	0.535
DOC_WW_Pin1_4	258	263	PF00397	0.388
DOC_WW_Pin1_4	46	51	PF00397	0.246
LIG_14-3-3_CanoR_1	151	156	PF00244	0.632
LIG_14-3-3_CanoR_1	159	166	PF00244	0.554
LIG_BRCT_BRCA1_1	215	219	PF00533	0.452
LIG_deltaCOP1_diTrp_1	131	141	PF00928	0.651
LIG_LIR_Apic_2	140	144	PF02991	0.582
LIG_LIR_Gen_1	131	141	PF02991	0.684
LIG_LIR_Gen_1	179	187	PF02991	0.459
LIG_LIR_Gen_1	216	227	PF02991	0.599
LIG_LIR_Gen_1	88	98	PF02991	0.447
LIG_LIR_Nem_3	131	137	PF02991	0.653
LIG_LIR_Nem_3	179	183	PF02991	0.410
LIG_LIR_Nem_3	216	222	PF02991	0.528
LIG_LIR_Nem_3	264	269	PF02991	0.486
LIG_LIR_Nem_3	88	94	PF02991	0.335
LIG_MAD2	43	51	PF02301	0.363
LIG_MLH1_MIPbox_1	215	219	PF16413	0.522
LIG_NRBOX	93	99	PF00104	0.408
LIG_Pex14_2	153	157	PF04695	0.604
LIG_SH2_CRK	91	95	PF00017	0.335
LIG_SH2_NCK_1	12	16	PF00017	0.421
LIG_SH2_PTP2	271	274	PF00017	0.497
LIG_SH2_STAP1	186	190	PF00017	0.579
LIG_SH2_STAT5	218	221	PF00017	0.558
LIG_SH2_STAT5	271	274	PF00017	0.454
LIG_SH2_STAT5	91	94	PF00017	0.480
LIG_TYR_ITIM	10	15	PF00017	0.415
LIG_TYR_ITIM	269	274	PF00017	0.498
MOD_CDK_SPK_2	258	263	PF00069	0.388
MOD_CK1_1	115	121	PF00069	0.698
MOD_CK1_1	146	152	PF00069	0.638
MOD_CK1_1	164	170	PF00069	0.378
MOD_CK1_1	221	227	PF00069	0.481
MOD_CK2_1	164	170	PF00069	0.576
MOD_Cter_Amidation	250	253	PF01082	0.500
MOD_GlcNHglycan	115	118	PF01048	0.690
MOD_GlcNHglycan	119	122	PF01048	0.695
MOD_GlcNHglycan	123	126	PF01048	0.661
MOD_GlcNHglycan	225	228	PF01048	0.538
MOD_GSK3_1	113	120	PF00069	0.655
MOD_GSK3_1	157	164	PF00069	0.612
MOD_GSK3_1	208	215	PF00069	0.526
MOD_GSK3_1	237	244	PF00069	0.637
MOD_GSK3_1	261	268	PF00069	0.586
MOD_GSK3_1	46	53	PF00069	0.372
MOD_GSK3_1	85	92	PF00069	0.471
MOD_N-GLC_1	176	181	PF02516	0.525
MOD_NEK2_2	265	270	PF00069	0.600
MOD_NMyristoyl	1	7	PF02799	0.417
MOD_PKA_1	229	235	PF00069	0.699
MOD_PKA_2	112	118	PF00069	0.744
MOD_PKA_2	158	164	PF00069	0.620
MOD_PKA_2	193	199	PF00069	0.587
MOD_PKA_2	229	235	PF00069	0.699
MOD_PKB_1	111	119	PF00069	0.633
MOD_Plk_1	176	182	PF00069	0.448
MOD_Plk_4	161	167	PF00069	0.637
MOD_ProDKin_1	258	264	PF00069	0.390
MOD_ProDKin_1	46	52	PF00069	0.246
MOD_SUMO_rev_2	164	174	PF00179	0.584
MOD_SUMO_rev_2	71	80	PF00179	0.363
TRG_ENDOCYTIC_2	12	15	PF00928	0.669
TRG_ENDOCYTIC_2	271	274	PF00928	0.438
TRG_ENDOCYTIC_2	91	94	PF00928	0.335
TRG_ER_diArg_1	110	113	PF00400	0.593
TRG_ER_diArg_1	228	230	PF00400	0.588
TRG_ER_diArg_1	252	255	PF00400	0.523
TRG_ER_diArg_1	57	60	PF00400	0.439
TRG_Pf-PMV_PEXEL_1	188	193	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	43	48	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRV7	Leptomonas seymouri	57%	100%
A0A0S4JQU3	Bodo saltans	31%	100%
A0A1X0NRW0	Trypanosomatidae	34%	100%
A0A3Q8IB40	Leishmania donovani	88%	100%
A0A3R7ND09	Trypanosoma rangeli	34%	100%
A4H693	Leishmania braziliensis	76%	100%
A4HUL6	Leishmania infantum	89%	100%
C9ZVP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ANB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%