Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHA8_LEIMA

TriTrypDb:

LmjF.10.1060 , LMJLV39_100017500 , LMJSD75_100017600

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.611
CLV_NRD_NRD_1	146	148	PF00675	0.477
CLV_PCSK_KEX2_1	146	148	PF00082	0.477
CLV_PCSK_KEX2_1	228	230	PF00082	0.545
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.545
CLV_PCSK_SKI1_1	214	218	PF00082	0.550
DEG_Nend_UBRbox_1	1	4	PF02207	0.518
DOC_MAPK_gen_1	195	204	PF00069	0.490
DOC_MAPK_RevD_3	215	229	PF00069	0.441
DOC_PP4_FxxP_1	21	24	PF00568	0.619
DOC_USP7_MATH_1	141	145	PF00917	0.444
DOC_USP7_MATH_1	86	90	PF00917	0.572
DOC_WW_Pin1_4	126	131	PF00397	0.474
DOC_WW_Pin1_4	20	25	PF00397	0.661
DOC_WW_Pin1_4	57	62	PF00397	0.553
LIG_14-3-3_CanoR_1	229	235	PF00244	0.530
LIG_Actin_WH2_2	215	230	PF00022	0.502
LIG_Clathr_ClatBox_1	311	315	PF01394	0.433
LIG_EH1_1	311	319	PF00400	0.543
LIG_EVH1_1	21	25	PF00568	0.518
LIG_EVH1_2	160	164	PF00568	0.507
LIG_FHA_1	197	203	PF00498	0.592
LIG_FHA_1	231	237	PF00498	0.548
LIG_FHA_1	58	64	PF00498	0.616
LIG_FHA_1	92	98	PF00498	0.560
LIG_FHA_2	24	30	PF00498	0.558
LIG_FHA_2	249	255	PF00498	0.670
LIG_LIR_Apic_2	18	24	PF02991	0.519
LIG_LIR_Gen_1	129	138	PF02991	0.605
LIG_LIR_Gen_1	174	182	PF02991	0.376
LIG_LIR_Nem_3	129	134	PF02991	0.589
LIG_LIR_Nem_3	174	178	PF02991	0.373
LIG_Pex14_2	134	138	PF04695	0.387
LIG_Pex14_2	308	312	PF04695	0.567
LIG_PTB_Apo_2	132	139	PF02174	0.472
LIG_SH2_GRB2like	133	136	PF00017	0.486
LIG_SH2_STAT3	181	184	PF00017	0.506
LIG_SH2_STAT5	133	136	PF00017	0.493
LIG_SH2_STAT5	163	166	PF00017	0.408
LIG_SH2_STAT5	177	180	PF00017	0.407
LIG_SH3_3	19	25	PF00018	0.515
LIG_SUMO_SIM_par_1	50	56	PF11976	0.533
LIG_TRAF2_1	241	244	PF00917	0.584
LIG_WRC_WIRS_1	172	177	PF05994	0.371
LIG_WW_1	160	163	PF00397	0.516
MOD_CK1_1	136	142	PF00069	0.484
MOD_CK1_1	23	29	PF00069	0.629
MOD_CK1_1	230	236	PF00069	0.534
MOD_CK1_1	277	283	PF00069	0.721
MOD_CK1_1	293	299	PF00069	0.431
MOD_CK1_1	56	62	PF00069	0.437
MOD_CK1_1	91	97	PF00069	0.492
MOD_CK2_1	134	140	PF00069	0.469
MOD_CK2_1	23	29	PF00069	0.596
MOD_CK2_1	86	92	PF00069	0.601
MOD_GlcNHglycan	154	157	PF01048	0.579
MOD_GlcNHglycan	229	232	PF01048	0.508
MOD_GlcNHglycan	276	279	PF01048	0.679
MOD_GlcNHglycan	290	293	PF01048	0.643
MOD_GlcNHglycan	55	58	PF01048	0.371
MOD_GlcNHglycan	78	81	PF01048	0.676
MOD_GlcNHglycan	9	13	PF01048	0.642
MOD_GSK3_1	167	174	PF00069	0.486
MOD_GSK3_1	53	60	PF00069	0.381
MOD_N-GLC_1	134	139	PF02516	0.469
MOD_NEK2_1	134	139	PF00069	0.482
MOD_NEK2_1	152	157	PF00069	0.439
MOD_NEK2_1	227	232	PF00069	0.552
MOD_NEK2_1	53	58	PF00069	0.392
MOD_NEK2_1	76	81	PF00069	0.583
MOD_NEK2_2	141	146	PF00069	0.483
MOD_NEK2_2	40	45	PF00069	0.378
MOD_PIKK_1	28	34	PF00454	0.531
MOD_PIKK_1	91	97	PF00454	0.553
MOD_PKA_2	196	202	PF00069	0.621
MOD_Plk_1	134	140	PF00069	0.475
MOD_Plk_1	141	147	PF00069	0.400
MOD_Plk_1	86	92	PF00069	0.668
MOD_Plk_2-3	171	177	PF00069	0.414
MOD_Plk_4	293	299	PF00069	0.623
MOD_ProDKin_1	126	132	PF00069	0.476
MOD_ProDKin_1	20	26	PF00069	0.653
MOD_ProDKin_1	57	63	PF00069	0.566
TRG_ENDOCYTIC_2	118	121	PF00928	0.538
TRG_ENDOCYTIC_2	131	134	PF00928	0.367
TRG_ENDOCYTIC_2	163	166	PF00928	0.369
TRG_ER_diArg_1	145	147	PF00400	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X0	Leptomonas seymouri	49%	95%
A0A1X0NS26	Trypanosomatidae	31%	100%
A0A3S7WRA2	Leishmania donovani	91%	100%
A0A422NGN0	Trypanosoma rangeli	32%	100%
A4H694	Leishmania braziliensis	85%	100%
A4HUL7	Leishmania infantum	91%	100%
C9ZVP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ANB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DKP6	Trypanosoma cruzi	35%	100%