Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHA7_LEIMA

TriTrypDb:

LmjF.10.1070 , LMJLV39_100017600 , LMJSD75_100017700

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.761
CLV_C14_Caspase3-7	263	267	PF00656	0.603
CLV_C14_Caspase3-7	374	378	PF00656	0.454
CLV_C14_Caspase3-7	582	586	PF00656	0.531
CLV_NRD_NRD_1	124	126	PF00675	0.705
CLV_NRD_NRD_1	160	162	PF00675	0.679
CLV_NRD_NRD_1	270	272	PF00675	0.583
CLV_NRD_NRD_1	290	292	PF00675	0.346
CLV_NRD_NRD_1	299	301	PF00675	0.539
CLV_NRD_NRD_1	330	332	PF00675	0.663
CLV_NRD_NRD_1	425	427	PF00675	0.616
CLV_NRD_NRD_1	469	471	PF00675	0.662
CLV_NRD_NRD_1	472	474	PF00675	0.687
CLV_NRD_NRD_1	52	54	PF00675	0.636
CLV_NRD_NRD_1	555	557	PF00675	0.613
CLV_PCSK_FUR_1	470	474	PF00082	0.508
CLV_PCSK_FUR_1	518	522	PF00082	0.434
CLV_PCSK_KEX2_1	126	128	PF00082	0.699
CLV_PCSK_KEX2_1	270	272	PF00082	0.583
CLV_PCSK_KEX2_1	290	292	PF00082	0.346
CLV_PCSK_KEX2_1	299	301	PF00082	0.539
CLV_PCSK_KEX2_1	329	331	PF00082	0.668
CLV_PCSK_KEX2_1	423	425	PF00082	0.602
CLV_PCSK_KEX2_1	471	473	PF00082	0.706
CLV_PCSK_KEX2_1	52	54	PF00082	0.636
CLV_PCSK_KEX2_1	520	522	PF00082	0.430
CLV_PCSK_KEX2_1	555	557	PF00082	0.613
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.699
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.672
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.706
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.430
CLV_PCSK_PC7_1	286	292	PF00082	0.592
CLV_PCSK_PC7_1	420	426	PF00082	0.559
CLV_PCSK_SKI1_1	145	149	PF00082	0.652
CLV_PCSK_SKI1_1	198	202	PF00082	0.633
CLV_PCSK_SKI1_1	273	277	PF00082	0.570
CLV_PCSK_SKI1_1	291	295	PF00082	0.391
CLV_PCSK_SKI1_1	360	364	PF00082	0.646
CLV_PCSK_SKI1_1	42	46	PF00082	0.591
CLV_PCSK_SKI1_1	508	512	PF00082	0.457
CLV_PCSK_SKI1_1	548	552	PF00082	0.588
CLV_Separin_Metazoa	515	519	PF03568	0.664
DEG_APCC_DBOX_1	124	132	PF00400	0.595
DEG_APCC_DBOX_1	144	152	PF00400	0.343
DEG_APCC_DBOX_1	197	205	PF00400	0.568
DEG_APCC_DBOX_1	328	336	PF00400	0.621
DEG_APCC_DBOX_1	547	555	PF00400	0.624
DEG_MDM2_SWIB_1	142	149	PF02201	0.678
DEG_Nend_Nbox_1	1	3	PF02207	0.701
DEG_SPOP_SBC_1	19	23	PF00917	0.786
DEG_SPOP_SBC_1	54	58	PF00917	0.661
DEG_SPOP_SBC_1	73	77	PF00917	0.662
DOC_CKS1_1	81	86	PF01111	0.812
DOC_CYCLIN_RxL_1	270	278	PF00134	0.584
DOC_MAPK_gen_1	172	181	PF00069	0.615
DOC_MAPK_gen_1	270	276	PF00069	0.663
DOC_MAPK_gen_1	546	553	PF00069	0.534
DOC_MAPK_MEF2A_6	174	183	PF00069	0.649
DOC_PP1_RVXF_1	34	41	PF00149	0.613
DOC_USP7_MATH_1	19	23	PF00917	0.684
DOC_USP7_MATH_1	222	226	PF00917	0.724
DOC_USP7_MATH_1	253	257	PF00917	0.798
DOC_USP7_MATH_1	439	443	PF00917	0.651
DOC_USP7_MATH_1	6	10	PF00917	0.680
DOC_USP7_MATH_1	73	77	PF00917	0.667
DOC_WW_Pin1_4	167	172	PF00397	0.776
DOC_WW_Pin1_4	65	70	PF00397	0.768
DOC_WW_Pin1_4	80	85	PF00397	0.811
LIG_14-3-3_CanoR_1	112	116	PF00244	0.699
LIG_14-3-3_CanoR_1	178	182	PF00244	0.713
LIG_14-3-3_CanoR_1	508	513	PF00244	0.572
LIG_14-3-3_CanoR_1	555	565	PF00244	0.635
LIG_Actin_WH2_2	526	543	PF00022	0.648
LIG_CaM_IQ_9	433	448	PF13499	0.426
LIG_FHA_1	171	177	PF00498	0.732
LIG_FHA_1	178	184	PF00498	0.550
LIG_FHA_1	230	236	PF00498	0.612
LIG_FHA_1	270	276	PF00498	0.663
LIG_FHA_1	292	298	PF00498	0.554
LIG_FHA_1	80	86	PF00498	0.591
LIG_FHA_2	216	222	PF00498	0.618
LIG_FHA_2	320	326	PF00498	0.663
LIG_FHA_2	372	378	PF00498	0.469
LIG_FHA_2	534	540	PF00498	0.575
LIG_FHA_2	557	563	PF00498	0.642
LIG_LIR_Apic_2	93	97	PF02991	0.592
LIG_LIR_Gen_1	143	151	PF02991	0.675
LIG_LIR_Gen_1	507	517	PF02991	0.583
LIG_LIR_Nem_3	143	149	PF02991	0.577
LIG_LIR_Nem_3	507	512	PF02991	0.593
LIG_PCNA_yPIPBox_3	518	531	PF02747	0.577
LIG_Pex14_2	142	146	PF04695	0.577
LIG_RPA_C_Fungi	325	337	PF08784	0.579
LIG_SH2_CRK	509	513	PF00017	0.685
LIG_SH2_STAP1	398	402	PF00017	0.649
LIG_SH2_STAT5	119	122	PF00017	0.645
LIG_SH3_3	112	118	PF00018	0.578
LIG_SH3_3	78	84	PF00018	0.673
LIG_SUMO_SIM_anti_2	549	555	PF11976	0.572
LIG_SUMO_SIM_par_1	528	534	PF11976	0.570
LIG_TRAF2_1	321	324	PF00917	0.657
LIG_TRAF2_1	380	383	PF00917	0.557
LIG_TRAF2_1	407	410	PF00917	0.647
LIG_TRAF2_1	526	529	PF00917	0.569
LIG_UBA3_1	156	162	PF00899	0.653
MOD_CDK_SPK_2	167	172	PF00069	0.660
MOD_CDK_SPK_2	65	70	PF00069	0.768
MOD_CDK_SPxxK_3	167	174	PF00069	0.762
MOD_CK1_1	104	110	PF00069	0.688
MOD_CK1_1	111	117	PF00069	0.647
MOD_CK1_1	13	19	PF00069	0.716
MOD_CK1_1	170	176	PF00069	0.750
MOD_CK1_1	260	266	PF00069	0.533
MOD_CK1_1	28	34	PF00069	0.584
MOD_CK1_1	55	61	PF00069	0.794
MOD_CK1_1	567	573	PF00069	0.556
MOD_CK2_1	189	195	PF00069	0.599
MOD_CK2_1	224	230	PF00069	0.735
MOD_CK2_1	275	281	PF00069	0.579
MOD_CK2_1	319	325	PF00069	0.565
MOD_CK2_1	428	434	PF00069	0.431
MOD_CK2_1	523	529	PF00069	0.631
MOD_CK2_1	533	539	PF00069	0.507
MOD_CK2_1	556	562	PF00069	0.643
MOD_GlcNHglycan	22	25	PF01048	0.622
MOD_GlcNHglycan	223	227	PF01048	0.702
MOD_GlcNHglycan	255	258	PF01048	0.773
MOD_GlcNHglycan	27	30	PF01048	0.555
MOD_GlcNHglycan	351	354	PF01048	0.650
MOD_GlcNHglycan	479	482	PF01048	0.784
MOD_GlcNHglycan	487	490	PF01048	0.698
MOD_GlcNHglycan	499	502	PF01048	0.475
MOD_GlcNHglycan	547	551	PF01048	0.583
MOD_GlcNHglycan	569	572	PF01048	0.512
MOD_GlcNHglycan	76	79	PF01048	0.809
MOD_GlcNHglycan	8	11	PF01048	0.691
MOD_GSK3_1	101	108	PF00069	0.643
MOD_GSK3_1	14	21	PF00069	0.682
MOD_GSK3_1	253	260	PF00069	0.748
MOD_GSK3_1	275	282	PF00069	0.539
MOD_GSK3_1	6	13	PF00069	0.756
MOD_GSK3_1	86	93	PF00069	0.786
MOD_N-GLC_1	349	354	PF02516	0.654
MOD_NEK2_1	101	106	PF00069	0.698
MOD_NEK2_1	18	23	PF00069	0.730
MOD_NEK2_1	235	240	PF00069	0.809
MOD_NEK2_1	275	280	PF00069	0.578
MOD_NEK2_2	189	194	PF00069	0.590
MOD_PIKK_1	279	285	PF00454	0.541
MOD_PIKK_1	583	589	PF00454	0.618
MOD_PKA_1	52	58	PF00069	0.769
MOD_PKA_2	111	117	PF00069	0.693
MOD_PKA_2	177	183	PF00069	0.685
MOD_PKA_2	269	275	PF00069	0.662
MOD_PKA_2	419	425	PF00069	0.659
MOD_PKA_2	52	58	PF00069	0.685
MOD_PKA_2	540	546	PF00069	0.650
MOD_Plk_1	189	195	PF00069	0.677
MOD_Plk_1	349	355	PF00069	0.657
MOD_Plk_1	546	552	PF00069	0.581
MOD_Plk_2-3	428	434	PF00069	0.431
MOD_ProDKin_1	167	173	PF00069	0.764
MOD_ProDKin_1	65	71	PF00069	0.766
MOD_ProDKin_1	80	86	PF00069	0.809
TRG_DiLeu_BaEn_4	528	534	PF01217	0.570
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.686
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.587
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.623
TRG_ENDOCYTIC_2	509	512	PF00928	0.686
TRG_ER_diArg_1	125	128	PF00400	0.606
TRG_ER_diArg_1	171	174	PF00400	0.635
TRG_ER_diArg_1	269	271	PF00400	0.582
TRG_ER_diArg_1	329	331	PF00400	0.668
TRG_ER_diArg_1	424	426	PF00400	0.679
TRG_ER_diArg_1	469	472	PF00400	0.594
TRG_ER_diArg_1	554	556	PF00400	0.618
TRG_NLS_MonoCore_2	469	474	PF00514	0.505
TRG_NLS_MonoExtC_3	124	130	PF00514	0.465
TRG_NLS_MonoExtC_3	470	475	PF00514	0.707
TRG_NLS_MonoExtN_4	470	475	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL10	Leptomonas seymouri	33%	100%
A0A3S7WRC5	Leishmania donovani	88%	100%
A4H695	Leishmania braziliensis	69%	100%
A4HUL8	Leishmania infantum	88%	100%
E9ANB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%