Putative eukaryotic translation initation factor 4 gamma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4 gamma 5

Species:

Leishmania major

UniProt:

Q4QHA6_LEIMA

TriTrypDb:

LmjF.10.1080 , LMJLV39_100017700 , LMJSD75_100017800

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHA6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006412	translation	4	2
GO:0006518	peptide metabolic process	4	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043043	peptide biosynthetic process	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043603	amide metabolic process	3	2
GO:0043604	amide biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003729	mRNA binding	5	2
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.549
CLV_NRD_NRD_1	112	114	PF00675	0.640
CLV_NRD_NRD_1	165	167	PF00675	0.470
CLV_NRD_NRD_1	328	330	PF00675	0.227
CLV_NRD_NRD_1	403	405	PF00675	0.561
CLV_NRD_NRD_1	706	708	PF00675	0.417
CLV_NRD_NRD_1	740	742	PF00675	0.433
CLV_NRD_NRD_1	780	782	PF00675	0.603
CLV_PCSK_KEX2_1	272	274	PF00082	0.315
CLV_PCSK_KEX2_1	328	330	PF00082	0.221
CLV_PCSK_KEX2_1	377	379	PF00082	0.220
CLV_PCSK_KEX2_1	403	405	PF00082	0.679
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.251
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.261
CLV_PCSK_SKI1_1	161	165	PF00082	0.579
CLV_PCSK_SKI1_1	189	193	PF00082	0.256
CLV_PCSK_SKI1_1	209	213	PF00082	0.145
CLV_PCSK_SKI1_1	273	277	PF00082	0.285
CLV_PCSK_SKI1_1	519	523	PF00082	0.416
CLV_PCSK_SKI1_1	604	608	PF00082	0.575
CLV_PCSK_SKI1_1	703	707	PF00082	0.404
CLV_PCSK_SKI1_1	708	712	PF00082	0.408
CLV_PCSK_SKI1_1	734	738	PF00082	0.441
CLV_PCSK_SKI1_1	741	745	PF00082	0.383
CLV_Separin_Metazoa	251	255	PF03568	0.524
CLV_Separin_Metazoa	704	708	PF03568	0.457
DEG_APCC_DBOX_1	505	513	PF00400	0.349
DEG_APCC_DBOX_1	740	748	PF00400	0.444
DEG_Nend_UBRbox_3	1	3	PF02207	0.612
DOC_CKS1_1	67	72	PF01111	0.539
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.592
DOC_MAPK_gen_1	186	196	PF00069	0.464
DOC_MAPK_gen_1	292	299	PF00069	0.420
DOC_MAPK_MEF2A_6	713	722	PF00069	0.439
DOC_PP1_RVXF_1	207	213	PF00149	0.485
DOC_PP1_RVXF_1	284	290	PF00149	0.444
DOC_PP1_RVXF_1	375	382	PF00149	0.460
DOC_SPAK_OSR1_1	611	615	PF12202	0.307
DOC_USP7_MATH_1	118	122	PF00917	0.605
DOC_USP7_MATH_1	218	222	PF00917	0.429
DOC_USP7_MATH_1	416	420	PF00917	0.531
DOC_USP7_MATH_1	46	50	PF00917	0.696
DOC_WW_Pin1_4	275	280	PF00397	0.524
DOC_WW_Pin1_4	619	624	PF00397	0.384
DOC_WW_Pin1_4	66	71	PF00397	0.607
DOC_WW_Pin1_4	666	671	PF00397	0.482
DOC_WW_Pin1_4	676	681	PF00397	0.362
LIG_14-3-3_CanoR_1	19	24	PF00244	0.607
LIG_14-3-3_CanoR_1	197	204	PF00244	0.429
LIG_14-3-3_CanoR_1	257	261	PF00244	0.556
LIG_14-3-3_CanoR_1	273	278	PF00244	0.361
LIG_14-3-3_CanoR_1	495	501	PF00244	0.346
LIG_14-3-3_CanoR_1	762	766	PF00244	0.483
LIG_14-3-3_CanoR_1	8	13	PF00244	0.643
LIG_Actin_WH2_2	691	709	PF00022	0.458
LIG_Actin_WH2_2	747	764	PF00022	0.457
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.606
LIG_BRCT_BRCA1_1	684	688	PF00533	0.281
LIG_BRCT_BRCA1_1	731	735	PF00533	0.363
LIG_CaM_IQ_9	284	300	PF13499	0.451
LIG_FHA_1	263	269	PF00498	0.445
LIG_FHA_1	303	309	PF00498	0.465
LIG_FHA_1	434	440	PF00498	0.603
LIG_FHA_1	488	494	PF00498	0.323
LIG_FHA_1	569	575	PF00498	0.303
LIG_FHA_1	715	721	PF00498	0.393
LIG_FHA_2	198	204	PF00498	0.442
LIG_FHA_2	214	220	PF00498	0.442
LIG_FHA_2	364	370	PF00498	0.485
LIG_FHA_2	596	602	PF00498	0.619
LIG_FHA_2	637	643	PF00498	0.552
LIG_FHA_2	657	663	PF00498	0.532
LIG_FHA_2	762	768	PF00498	0.433
LIG_HCF-1_HBM_1	101	104	PF13415	0.587
LIG_Integrin_isoDGR_2	428	430	PF01839	0.602
LIG_LIR_Apic_2	353	359	PF02991	0.455
LIG_LIR_Gen_1	107	117	PF02991	0.585
LIG_LIR_Gen_1	220	231	PF02991	0.463
LIG_LIR_Gen_1	333	343	PF02991	0.425
LIG_LIR_Gen_1	453	461	PF02991	0.377
LIG_LIR_Gen_1	511	521	PF02991	0.363
LIG_LIR_Gen_1	541	552	PF02991	0.391
LIG_LIR_Gen_1	652	661	PF02991	0.370
LIG_LIR_Gen_1	685	695	PF02991	0.304
LIG_LIR_Nem_3	107	112	PF02991	0.484
LIG_LIR_Nem_3	220	226	PF02991	0.433
LIG_LIR_Nem_3	333	338	PF02991	0.466
LIG_LIR_Nem_3	391	397	PF02991	0.578
LIG_LIR_Nem_3	453	457	PF02991	0.558
LIG_LIR_Nem_3	511	516	PF02991	0.344
LIG_LIR_Nem_3	541	547	PF02991	0.405
LIG_LIR_Nem_3	610	615	PF02991	0.346
LIG_LIR_Nem_3	652	657	PF02991	0.386
LIG_LIR_Nem_3	685	691	PF02991	0.287
LIG_LIR_Nem_3	700	705	PF02991	0.351
LIG_MLH1_MIPbox_1	684	688	PF16413	0.358
LIG_NRBOX	317	323	PF00104	0.429
LIG_NRBOX	614	620	PF00104	0.361
LIG_PCNA_PIPBox_1	380	389	PF02747	0.451
LIG_PCNA_yPIPBox_3	307	318	PF02747	0.581
LIG_PCNA_yPIPBox_3	377	387	PF02747	0.524
LIG_Pex14_1	492	496	PF04695	0.441
LIG_Pex14_2	735	739	PF04695	0.318
LIG_REV1ctd_RIR_1	209	217	PF16727	0.485
LIG_RPA_C_Fungi	745	757	PF08784	0.469
LIG_SH2_CRK	335	339	PF00017	0.427
LIG_SH2_CRK	621	625	PF00017	0.412
LIG_SH2_GRB2like	496	499	PF00017	0.362
LIG_SH2_GRB2like	653	656	PF00017	0.345
LIG_SH2_PTP2	227	230	PF00017	0.249
LIG_SH2_SRC	356	359	PF00017	0.294
LIG_SH2_STAP1	126	130	PF00017	0.571
LIG_SH2_STAP1	223	227	PF00017	0.396
LIG_SH2_STAP1	693	697	PF00017	0.455
LIG_SH2_STAT5	223	226	PF00017	0.326
LIG_SH2_STAT5	227	230	PF00017	0.301
LIG_SH2_STAT5	488	491	PF00017	0.312
LIG_SH2_STAT5	496	499	PF00017	0.318
LIG_SH2_STAT5	502	505	PF00017	0.368
LIG_SH2_STAT5	550	553	PF00017	0.329
LIG_SH2_STAT5	621	624	PF00017	0.407
LIG_SH2_STAT5	653	656	PF00017	0.380
LIG_SH2_STAT5	723	726	PF00017	0.308
LIG_SH3_3	22	28	PF00018	0.635
LIG_SH3_3	343	349	PF00018	0.396
LIG_SH3_3	432	438	PF00018	0.565
LIG_SH3_3	446	452	PF00018	0.456
LIG_SH3_3	53	59	PF00018	0.656
LIG_SH3_3	69	75	PF00018	0.669
LIG_SH3_3	93	99	PF00018	0.578
LIG_SH3_4	62	69	PF00018	0.539
LIG_SUMO_SIM_anti_2	471	479	PF11976	0.372
LIG_SUMO_SIM_anti_2	483	488	PF11976	0.351
LIG_SUMO_SIM_anti_2	639	646	PF11976	0.386
LIG_SUMO_SIM_anti_2	767	776	PF11976	0.508
LIG_SUMO_SIM_par_1	471	479	PF11976	0.514
LIG_SUMO_SIM_par_1	716	721	PF11976	0.427
LIG_SUMO_SIM_par_1	767	776	PF11976	0.359
LIG_TRAF2_1	200	203	PF00917	0.396
LIG_TRAF2_1	443	446	PF00917	0.566
LIG_TRAF2_1	538	541	PF00917	0.501
LIG_TRAF2_1	77	80	PF00917	0.721
LIG_TRAF2_1	81	84	PF00917	0.733
LIG_TRAF2_2	600	605	PF00917	0.619
LIG_TYR_ITSM	331	338	PF00017	0.396
LIG_UBA3_1	512	519	PF00899	0.386
LIG_UBA3_1	543	549	PF00899	0.418
LIG_WRC_WIRS_1	687	692	PF05994	0.288
LIG_WW_2	74	77	PF00397	0.496
MOD_CK1_1	157	163	PF00069	0.511
MOD_CK1_1	221	227	PF00069	0.415
MOD_CK1_1	475	481	PF00069	0.393
MOD_CK1_1	568	574	PF00069	0.314
MOD_CK1_1	94	100	PF00069	0.594
MOD_CK2_1	179	185	PF00069	0.365
MOD_CK2_1	196	202	PF00069	0.175
MOD_CK2_1	213	219	PF00069	0.249
MOD_CK2_1	234	240	PF00069	0.396
MOD_CK2_1	260	266	PF00069	0.438
MOD_CK2_1	363	369	PF00069	0.396
MOD_CK2_1	466	472	PF00069	0.380
MOD_CK2_1	535	541	PF00069	0.488
MOD_CK2_1	595	601	PF00069	0.529
MOD_CK2_1	761	767	PF00069	0.422
MOD_CK2_1	769	775	PF00069	0.393
MOD_CK2_1	94	100	PF00069	0.651
MOD_GlcNHglycan	10	13	PF01048	0.555
MOD_GlcNHglycan	262	265	PF01048	0.404
MOD_GlcNHglycan	289	292	PF01048	0.399
MOD_GlcNHglycan	418	421	PF01048	0.741
MOD_GlcNHglycan	537	540	PF01048	0.499
MOD_GlcNHglycan	684	687	PF01048	0.300
MOD_GlcNHglycan	82	88	PF01048	0.686
MOD_GSK3_1	157	164	PF00069	0.529
MOD_GSK3_1	256	263	PF00069	0.341
MOD_GSK3_1	416	423	PF00069	0.504
MOD_GSK3_1	472	479	PF00069	0.467
MOD_GSK3_1	496	503	PF00069	0.423
MOD_GSK3_1	62	69	PF00069	0.611
MOD_GSK3_1	666	673	PF00069	0.449
MOD_GSK3_1	682	689	PF00069	0.213
MOD_N-GLC_1	142	147	PF02516	0.636
MOD_N-GLC_1	154	159	PF02516	0.621
MOD_N-GLC_1	212	217	PF02516	0.281
MOD_N-GLC_1	416	421	PF02516	0.680
MOD_NEK2_1	212	217	PF00069	0.263
MOD_NEK2_1	234	239	PF00069	0.299
MOD_NEK2_1	260	265	PF00069	0.411
MOD_NEK2_1	302	307	PF00069	0.280
MOD_NEK2_1	370	375	PF00069	0.288
MOD_NEK2_1	386	391	PF00069	0.281
MOD_NEK2_1	464	469	PF00069	0.385
MOD_NEK2_1	512	517	PF00069	0.420
MOD_NEK2_1	682	687	PF00069	0.354
MOD_NEK2_1	697	702	PF00069	0.334
MOD_NEK2_1	729	734	PF00069	0.466
MOD_NEK2_1	761	766	PF00069	0.503
MOD_NEK2_2	218	223	PF00069	0.263
MOD_PIKK_1	62	68	PF00454	0.734
MOD_PIKK_1	697	703	PF00454	0.461
MOD_PKA_2	196	202	PF00069	0.262
MOD_PKA_2	256	262	PF00069	0.407
MOD_PKA_2	363	369	PF00069	0.294
MOD_PKA_2	402	408	PF00069	0.668
MOD_PKA_2	7	13	PF00069	0.645
MOD_PKA_2	761	767	PF00069	0.470
MOD_Plk_1	142	148	PF00069	0.636
MOD_Plk_1	154	160	PF00069	0.625
MOD_Plk_1	218	224	PF00069	0.279
MOD_Plk_1	333	339	PF00069	0.294
MOD_Plk_1	504	510	PF00069	0.490
MOD_Plk_1	649	655	PF00069	0.444
MOD_Plk_1	766	772	PF00069	0.502
MOD_Plk_1	94	100	PF00069	0.666
MOD_Plk_2-3	142	148	PF00069	0.636
MOD_Plk_4	256	262	PF00069	0.374
MOD_Plk_4	27	33	PF00069	0.602
MOD_Plk_4	317	323	PF00069	0.396
MOD_Plk_4	333	339	PF00069	0.294
MOD_Plk_4	420	426	PF00069	0.575
MOD_Plk_4	472	478	PF00069	0.472
MOD_Plk_4	512	518	PF00069	0.497
MOD_Plk_4	553	559	PF00069	0.482
MOD_Plk_4	560	566	PF00069	0.526
MOD_Plk_4	636	642	PF00069	0.628
MOD_Plk_4	649	655	PF00069	0.405
MOD_Plk_4	714	720	PF00069	0.377
MOD_Plk_4	766	772	PF00069	0.474
MOD_ProDKin_1	275	281	PF00069	0.396
MOD_ProDKin_1	619	625	PF00069	0.402
MOD_ProDKin_1	66	72	PF00069	0.603
MOD_ProDKin_1	666	672	PF00069	0.471
MOD_ProDKin_1	676	682	PF00069	0.358
MOD_SUMO_for_1	187	190	PF00179	0.249
MOD_SUMO_for_1	77	80	PF00179	0.617
MOD_SUMO_rev_2	160	168	PF00179	0.479
MOD_SUMO_rev_2	593	600	PF00179	0.521
MOD_SUMO_rev_2	601	608	PF00179	0.489
TRG_DiLeu_BaEn_3	242	248	PF01217	0.294
TRG_ENDOCYTIC_2	223	226	PF00928	0.322
TRG_ENDOCYTIC_2	227	230	PF00928	0.304
TRG_ENDOCYTIC_2	335	338	PF00928	0.316
TRG_ENDOCYTIC_2	454	457	PF00928	0.512
TRG_ENDOCYTIC_2	702	705	PF00928	0.430
TRG_ER_diArg_1	506	509	PF00400	0.353
TRG_NES_CRM1_1	185	198	PF08389	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC9	Leptomonas seymouri	71%	100%
A0A0S4J374	Bodo saltans	30%	90%
A0A1X0NQC6	Trypanosomatidae	44%	100%
A0A3R7KDY4	Trypanosoma rangeli	40%	100%
A0A3S7WRD0	Leishmania donovani	97%	100%
A4H696	Leishmania braziliensis	90%	100%
A4HUL9	Leishmania infantum	97%	100%
C9ZVP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ANB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BTU8	Trypanosoma cruzi	39%	100%