CASP-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

CASP-like protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHA5_LEIMA

TriTrypDb:

LmjF.10.1090 , LMJLV39_100018000 , LMJSD75_100018100

Length:

177

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0018995	host cellular component	2	1
GO:0033643	host cell part	3	1
GO:0033644	host cell membrane	4	1

Expansion

Sequence features

Q4QHA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHA5

Function

Biological processes
Term	Name	Level	Count
GO:0016032	viral process	1	1
GO:0019042	viral latency	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	45	47	PF00082	0.602
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.632
CLV_PCSK_SKI1_1	151	155	PF00082	0.337
CLV_PCSK_SKI1_1	158	162	PF00082	0.362
DEG_Nend_UBRbox_3	1	3	PF02207	0.616
DOC_MAPK_MEF2A_6	77	84	PF00069	0.557
DOC_MAPK_RevD_3	32	46	PF00069	0.420
DOC_PP1_RVXF_1	149	156	PF00149	0.534
DOC_USP7_UBL2_3	10	14	PF12436	0.584
DOC_USP7_UBL2_3	117	121	PF12436	0.452
LIG_14-3-3_CanoR_1	151	156	PF00244	0.551
LIG_14-3-3_CanoR_1	20	26	PF00244	0.558
LIG_FHA_1	22	28	PF00498	0.329
LIG_FHA_1	37	43	PF00498	0.277
LIG_FHA_1	66	72	PF00498	0.420
LIG_FHA_2	129	135	PF00498	0.348
LIG_FHA_2	152	158	PF00498	0.562
LIG_PCNA_yPIPBox_3	149	158	PF02747	0.540
LIG_SH2_STAP1	86	90	PF00017	0.346
LIG_SH2_STAT3	86	89	PF00017	0.464
LIG_SUMO_SIM_par_1	134	140	PF11976	0.427
LIG_SUMO_SIM_par_1	24	29	PF11976	0.346
LIG_SUMO_SIM_par_1	34	39	PF11976	0.289
LIG_SUMO_SIM_par_1	63	68	PF11976	0.380
LIG_UBA3_1	160	165	PF00899	0.467
LIG_WRC_WIRS_1	152	157	PF05994	0.440
MOD_CK1_1	99	105	PF00069	0.394
MOD_CK2_1	128	134	PF00069	0.437
MOD_GSK3_1	119	126	PF00069	0.503
MOD_GSK3_1	36	43	PF00069	0.302
MOD_GSK3_1	65	72	PF00069	0.380
MOD_GSK3_1	92	99	PF00069	0.391
MOD_N-GLC_1	21	26	PF02516	0.399
MOD_NEK2_1	145	150	PF00069	0.490
MOD_NEK2_1	16	21	PF00069	0.454
MOD_NEK2_1	36	41	PF00069	0.150
MOD_NEK2_1	65	70	PF00069	0.427
MOD_NEK2_1	96	101	PF00069	0.321
MOD_NEK2_2	40	45	PF00069	0.504
MOD_PIKK_1	119	125	PF00454	0.479
MOD_PIKK_1	145	151	PF00454	0.368
MOD_PIKK_1	171	177	PF00454	0.595
MOD_PKA_2	80	86	PF00069	0.427
MOD_Plk_1	21	27	PF00069	0.324
MOD_Plk_4	137	143	PF00069	0.459
MOD_Plk_4	151	157	PF00069	0.371
MOD_Plk_4	69	75	PF00069	0.293
MOD_Plk_4	80	86	PF00069	0.346
MOD_Plk_4	92	98	PF00069	0.387
MOD_SUMO_for_1	44	47	PF00179	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX82	Leptomonas seymouri	76%	100%
A0A0S4INN4	Bodo saltans	42%	99%
A0A1X0NQE8	Trypanosomatidae	60%	100%
A0A3R7KZM5	Trypanosoma rangeli	59%	100%
A0A3S7WRC6	Leishmania donovani	97%	100%
A4H697	Leishmania braziliensis	86%	100%
A4HUM1	Leishmania infantum	97%	100%
C9ZVP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ANB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%