Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHA4_LEIMA

TriTrypDb:

LmjF.10.1100 , LMJLV39_100018100 , LMJSD75_100018200

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	227	229	PF00675	0.361
CLV_NRD_NRD_1	29	31	PF00675	0.385
CLV_NRD_NRD_1	313	315	PF00675	0.488
CLV_NRD_NRD_1	392	394	PF00675	0.544
CLV_NRD_NRD_1	48	50	PF00675	0.500
CLV_NRD_NRD_1	5	7	PF00675	0.615
CLV_NRD_NRD_1	52	54	PF00675	0.497
CLV_NRD_NRD_1	83	85	PF00675	0.475
CLV_PCSK_FUR_1	98	102	PF00082	0.446
CLV_PCSK_KEX2_1	100	102	PF00082	0.609
CLV_PCSK_KEX2_1	192	194	PF00082	0.480
CLV_PCSK_KEX2_1	227	229	PF00082	0.361
CLV_PCSK_KEX2_1	29	31	PF00082	0.394
CLV_PCSK_KEX2_1	392	394	PF00082	0.544
CLV_PCSK_KEX2_1	48	50	PF00082	0.500
CLV_PCSK_KEX2_1	5	7	PF00082	0.615
CLV_PCSK_KEX2_1	52	54	PF00082	0.497
CLV_PCSK_KEX2_1	83	85	PF00082	0.440
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.649
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.480
CLV_PCSK_PC7_1	188	194	PF00082	0.472
CLV_PCSK_PC7_1	48	54	PF00082	0.418
CLV_PCSK_SKI1_1	193	197	PF00082	0.482
CLV_PCSK_SKI1_1	245	249	PF00082	0.426
CLV_PCSK_SKI1_1	332	336	PF00082	0.489
CLV_PCSK_SKI1_1	349	353	PF00082	0.438
CLV_PCSK_SKI1_1	380	384	PF00082	0.467
CLV_PCSK_SKI1_1	6	10	PF00082	0.595
CLV_PCSK_SKI1_1	84	88	PF00082	0.481
DEG_APCC_DBOX_1	165	173	PF00400	0.465
DEG_APCC_DBOX_1	227	235	PF00400	0.379
DEG_APCC_DBOX_1	4	12	PF00400	0.595
DOC_CDC14_PxL_1	277	285	PF14671	0.382
DOC_CYCLIN_yCln2_LP_2	172	178	PF00134	0.501
DOC_MAPK_DCC_7	112	120	PF00069	0.574
DOC_MAPK_gen_1	12	20	PF00069	0.503
DOC_MAPK_gen_1	227	233	PF00069	0.380
DOC_MAPK_gen_1	59	69	PF00069	0.484
DOC_MAPK_gen_1	83	93	PF00069	0.485
DOC_MAPK_MEF2A_6	112	120	PF00069	0.574
DOC_MAPK_MEF2A_6	14	22	PF00069	0.529
DOC_MAPK_MEF2A_6	343	352	PF00069	0.488
DOC_PP2B_LxvP_1	172	175	PF13499	0.463
DOC_PP2B_LxvP_1	195	198	PF13499	0.471
DOC_PP2B_LxvP_1	406	409	PF13499	0.669
DOC_USP7_MATH_1	250	254	PF00917	0.554
DOC_USP7_MATH_1	417	421	PF00917	0.575
DOC_USP7_MATH_2	230	236	PF00917	0.457
DOC_WW_Pin1_4	246	251	PF00397	0.473
DOC_WW_Pin1_4	341	346	PF00397	0.588
DOC_WW_Pin1_4	404	409	PF00397	0.646
LIG_14-3-3_CanoR_1	133	142	PF00244	0.503
LIG_14-3-3_CanoR_1	179	187	PF00244	0.499
LIG_14-3-3_CanoR_1	255	261	PF00244	0.539
LIG_14-3-3_CanoR_1	98	104	PF00244	0.474
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_eIF4E_1	333	339	PF01652	0.544
LIG_FHA_1	129	135	PF00498	0.573
LIG_FHA_1	17	23	PF00498	0.525
LIG_FHA_1	333	339	PF00498	0.587
LIG_FHA_1	58	64	PF00498	0.471
LIG_FHA_1	77	83	PF00498	0.632
LIG_FHA_2	342	348	PF00498	0.501
LIG_FHA_2	373	379	PF00498	0.461
LIG_LIR_Gen_1	373	383	PF02991	0.466
LIG_LIR_Nem_3	287	292	PF02991	0.466
LIG_LYPXL_yS_3	274	277	PF13949	0.409
LIG_LYPXL_yS_3	292	295	PF13949	0.433
LIG_NRBOX	261	267	PF00104	0.388
LIG_Pex14_1	225	229	PF04695	0.368
LIG_PROFILIN_1	408	414	PF00235	0.556
LIG_PTB_Apo_2	55	62	PF02174	0.528
LIG_Rb_LxCxE_1	72	92	PF01857	0.478
LIG_RPA_C_Fungi	25	37	PF08784	0.373
LIG_RPA_C_Fungi	309	321	PF08784	0.564
LIG_SH2_SRC	241	244	PF00017	0.408
LIG_SH2_STAT5	333	336	PF00017	0.499
LIG_SH2_STAT5	7	10	PF00017	0.548
LIG_SH3_3	113	119	PF00018	0.595
LIG_SH3_3	290	296	PF00018	0.439
LIG_SH3_3	342	348	PF00018	0.586
LIG_SH3_3	405	411	PF00018	0.648
LIG_SUMO_SIM_par_1	18	24	PF11976	0.477
LIG_SUMO_SIM_par_1	229	235	PF11976	0.448
LIG_TRAF2_1	203	206	PF00917	0.515
LIG_TRAF2_1	43	46	PF00917	0.411
LIG_TRAF2_1	72	75	PF00917	0.459
LIG_TYR_ITIM	272	277	PF00017	0.484
LIG_WRC_WIRS_1	237	242	PF05994	0.455
LIG_WRC_WIRS_1	352	357	PF05994	0.534
MOD_CK1_1	155	161	PF00069	0.565
MOD_CK1_1	249	255	PF00069	0.703
MOD_CK1_1	99	105	PF00069	0.533
MOD_CK2_1	261	267	PF00069	0.453
MOD_CK2_1	372	378	PF00069	0.430
MOD_CK2_1	40	46	PF00069	0.482
MOD_CK2_1	69	75	PF00069	0.512
MOD_GlcNHglycan	154	157	PF01048	0.606
MOD_GlcNHglycan	198	201	PF01048	0.533
MOD_GlcNHglycan	234	237	PF01048	0.443
MOD_GlcNHglycan	256	259	PF01048	0.462
MOD_GSK3_1	128	135	PF00069	0.580
MOD_GSK3_1	232	239	PF00069	0.477
MOD_GSK3_1	246	253	PF00069	0.511
MOD_GSK3_1	322	329	PF00069	0.536
MOD_GSK3_1	366	373	PF00069	0.543
MOD_GSK3_1	417	424	PF00069	0.598
MOD_N-GLC_1	57	62	PF02516	0.523
MOD_NEK2_1	142	147	PF00069	0.560
MOD_NEK2_1	303	308	PF00069	0.356
MOD_NEK2_1	339	344	PF00069	0.606
MOD_NEK2_1	351	356	PF00069	0.415
MOD_NEK2_1	96	101	PF00069	0.487
MOD_NEK2_2	236	241	PF00069	0.453
MOD_PIKK_1	370	376	PF00454	0.521
MOD_PKA_2	132	138	PF00069	0.544
MOD_PKA_2	211	217	PF00069	0.413
MOD_PKA_2	254	260	PF00069	0.490
MOD_PKA_2	321	327	PF00069	0.678
MOD_PKA_2	339	345	PF00069	0.446
MOD_Plk_1	57	63	PF00069	0.451
MOD_Plk_4	155	161	PF00069	0.537
MOD_Plk_4	236	242	PF00069	0.418
MOD_Plk_4	261	267	PF00069	0.492
MOD_ProDKin_1	246	252	PF00069	0.480
MOD_ProDKin_1	341	347	PF00069	0.585
MOD_ProDKin_1	404	410	PF00069	0.643
MOD_SUMO_rev_2	239	247	PF00179	0.420
MOD_SUMO_rev_2	324	334	PF00179	0.510
MOD_SUMO_rev_2	88	96	PF00179	0.436
TRG_DiLeu_BaEn_1	299	304	PF01217	0.415
TRG_DiLeu_BaEn_4	267	273	PF01217	0.474
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.464
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.492
TRG_ENDOCYTIC_2	274	277	PF00928	0.409
TRG_ENDOCYTIC_2	292	295	PF00928	0.433
TRG_ENDOCYTIC_2	376	379	PF00928	0.456
TRG_ER_diArg_1	227	229	PF00400	0.361
TRG_ER_diArg_1	391	393	PF00400	0.562
TRG_ER_diArg_1	47	49	PF00400	0.497
TRG_ER_diArg_1	5	7	PF00400	0.615
TRG_ER_diArg_1	51	53	PF00400	0.488
TRG_ER_diArg_1	61	64	PF00400	0.368
TRG_ER_diArg_1	82	84	PF00400	0.467
TRG_NES_CRM1_1	213	226	PF08389	0.407
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA4	Leptomonas seymouri	46%	100%
A0A3Q8IHA3	Leishmania donovani	89%	100%
A4H698	Leishmania braziliensis	67%	80%
A4HUM2	Leishmania infantum	90%	100%
E9ANC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%