LeishMANIAdb
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LsmAD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
LsmAD domain-containing protein
Gene product:
PAB1-binding protein , putative
Species:
Leishmania major
UniProt:
Q4QHA3_LEIMA
TriTrypDb:
LmjF.10.1110 , LMJLV39_100018300 , LMJSD75_100018400
Length:
523

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 2
GO:0010494 cytoplasmic stress granule 5 2
GO:0035770 ribonucleoprotein granule 3 2
GO:0036464 cytoplasmic ribonucleoprotein granule 4 2
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0099080 supramolecular complex 2 2
GO:0110165 cellular anatomical entity 1 2
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Expansion

Sequence features

Q4QHA3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHA3

Function

Biological processes
TermNameLevelCount
GO:0006996 organelle organization 4 2
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 2
GO:0022607 cellular component assembly 4 2
GO:0034063 stress granule assembly 7 2
GO:0070925 organelle assembly 5 2
GO:0071840 cellular component organization or biogenesis 2 2
GO:0140694 non-membrane-bounded organelle assembly 6 2
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Molecular functions
TermNameLevelCount
GO:0003676 nucleic acid binding 3 10
GO:0003723 RNA binding 4 10
GO:0005488 binding 1 10
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 41 45 PF00656 0.327
CLV_C14_Caspase3-7 478 482 PF00656 0.815
CLV_C14_Caspase3-7 68 72 PF00656 0.376
CLV_NRD_NRD_1 229 231 PF00675 0.632
CLV_NRD_NRD_1 498 500 PF00675 0.795
CLV_PCSK_KEX2_1 223 225 PF00082 0.685
CLV_PCSK_KEX2_1 498 500 PF00082 0.779
CLV_PCSK_PC1ET2_1 223 225 PF00082 0.685
CLV_PCSK_SKI1_1 179 183 PF00082 0.436
CLV_PCSK_SKI1_1 310 314 PF00082 0.628
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I433 Leptomonas seymouri 68% 100%
A0A1X0NQC5 Trypanosomatidae 35% 95%
A0A3S5H6H2 Leishmania donovani 98% 100%
A0A422NGM0 Trypanosoma rangeli 38% 95%
A4H699 Leishmania braziliensis 87% 100%
A4HUM3 Leishmania infantum 97% 100%
E9ANC1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 99%
V5DKQ2 Trypanosoma cruzi 37% 95%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS