RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4QHA0_LEIMA

TriTrypDb:

LmjF.10.1140 , LMJLV39_100018600 , LMJSD75_100018700

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHA0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0061630	ubiquitin protein ligase activity	5	12
GO:0061659	ubiquitin-like protein ligase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.586
CLV_NRD_NRD_1	76	78	PF00675	0.566
CLV_PCSK_KEX2_1	76	78	PF00082	0.590
CLV_PCSK_SKI1_1	274	278	PF00082	0.398
CLV_PCSK_SKI1_1	356	360	PF00082	0.413
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.624
DOC_MAPK_gen_1	125	132	PF00069	0.622
DOC_MAPK_gen_1	271	279	PF00069	0.493
DOC_MAPK_gen_1	76	82	PF00069	0.512
DOC_PP2B_LxvP_1	162	165	PF13499	0.551
DOC_PP2B_LxvP_1	243	246	PF13499	0.463
DOC_PP4_FxxP_1	31	34	PF00568	0.670
DOC_USP7_MATH_1	118	122	PF00917	0.508
DOC_USP7_MATH_1	139	143	PF00917	0.617
DOC_USP7_MATH_1	253	257	PF00917	0.667
DOC_USP7_MATH_1	262	266	PF00917	0.443
DOC_WW_Pin1_4	220	225	PF00397	0.710
DOC_WW_Pin1_4	86	91	PF00397	0.647
LIG_14-3-3_CanoR_1	131	138	PF00244	0.640
LIG_14-3-3_CanoR_1	187	191	PF00244	0.511
LIG_14-3-3_CanoR_1	252	258	PF00244	0.583
LIG_14-3-3_CanoR_1	341	349	PF00244	0.398
LIG_14-3-3_CanoR_1	4	10	PF00244	0.704
LIG_14-3-3_CterR_2	356	360	PF00244	0.413
LIG_BRCT_BRCA1_1	264	268	PF00533	0.386
LIG_BRCT_BRCA1_1	34	38	PF00533	0.635
LIG_FHA_1	132	138	PF00498	0.599
LIG_FHA_1	149	155	PF00498	0.557
LIG_FHA_1	157	163	PF00498	0.548
LIG_FHA_1	267	273	PF00498	0.585
LIG_FHA_1	320	326	PF00498	0.337
LIG_FHA_1	65	71	PF00498	0.495
LIG_FHA_2	14	20	PF00498	0.685
LIG_FHA_2	147	153	PF00498	0.551
LIG_FHA_2	239	245	PF00498	0.441
LIG_FHA_2	3	9	PF00498	0.770
LIG_FHA_2	64	70	PF00498	0.629
LIG_LIR_Nem_3	189	193	PF02991	0.445
LIG_Pex14_2	27	31	PF04695	0.611
LIG_PTB_Apo_2	278	285	PF02174	0.557
LIG_PTB_Phospho_1	278	284	PF10480	0.552
LIG_SH2_CRK	190	194	PF00017	0.423
LIG_SH2_NCK_1	173	177	PF00017	0.719
LIG_SH2_SRC	173	176	PF00017	0.703
LIG_SH2_STAP1	173	177	PF00017	0.719
LIG_SH2_STAP1	49	53	PF00017	0.636
LIG_SH2_STAT5	240	243	PF00017	0.396
LIG_SH2_STAT5	28	31	PF00017	0.475
LIG_SH2_STAT5	353	356	PF00017	0.398
LIG_SH3_3	155	161	PF00018	0.524
LIG_SH3_3	295	301	PF00018	0.685
LIG_SH3_3	40	46	PF00018	0.629
LIG_SH3_4	33	40	PF00018	0.563
LIG_SUMO_SIM_par_1	191	196	PF11976	0.406
LIG_SUMO_SIM_par_1	66	71	PF11976	0.545
LIG_TRAF2_1	245	248	PF00917	0.581
LIG_TRAF2_1	303	306	PF00917	0.601
LIG_TYR_ITIM	188	193	PF00017	0.436
LIG_TYR_ITIM	238	243	PF00017	0.430
LIG_UBA3_1	167	172	PF00899	0.624
LIG_WW_3	223	227	PF00397	0.657
MOD_CDK_SPxK_1	220	226	PF00069	0.698
MOD_CK1_1	178	184	PF00069	0.621
MOD_CK1_1	84	90	PF00069	0.533
MOD_CK2_1	13	19	PF00069	0.657
MOD_CK2_1	2	8	PF00069	0.800
MOD_CK2_1	238	244	PF00069	0.473
MOD_GlcNHglycan	134	137	PF01048	0.643
MOD_GlcNHglycan	83	86	PF01048	0.551
MOD_GSK3_1	148	155	PF00069	0.601
MOD_GSK3_1	176	183	PF00069	0.669
MOD_GSK3_1	220	227	PF00069	0.684
MOD_GSK3_1	253	260	PF00069	0.688
MOD_GSK3_1	262	269	PF00069	0.551
MOD_GSK3_1	64	71	PF00069	0.634
MOD_N-GLC_1	181	186	PF02516	0.456
MOD_N-GLC_1	2	7	PF02516	0.802
MOD_N-GLC_1	206	211	PF02516	0.750
MOD_N-GLC_2	334	336	PF02516	0.402
MOD_N-GLC_2	345	347	PF02516	0.252
MOD_NEK2_1	132	137	PF00069	0.637
MOD_NEK2_1	180	185	PF00069	0.640
MOD_NEK2_1	68	73	PF00069	0.519
MOD_NMyristoyl	1	7	PF02799	0.674
MOD_PIKK_1	105	111	PF00454	0.568
MOD_PIKK_1	206	212	PF00454	0.740
MOD_PIKK_1	224	230	PF00454	0.749
MOD_PKA_2	186	192	PF00069	0.520
MOD_PKA_2	262	268	PF00069	0.508
MOD_PKA_2	3	9	PF00069	0.708
MOD_PKA_2	340	346	PF00069	0.449
MOD_Plk_1	181	187	PF00069	0.624
MOD_Plk_1	247	253	PF00069	0.557
MOD_Plk_1	320	326	PF00069	0.363
MOD_Plk_4	153	159	PF00069	0.573
MOD_Plk_4	238	244	PF00069	0.419
MOD_Plk_4	320	326	PF00069	0.330
MOD_ProDKin_1	220	226	PF00069	0.711
MOD_ProDKin_1	86	92	PF00069	0.643
MOD_SUMO_for_1	171	174	PF00179	0.684
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.493
TRG_ENDOCYTIC_2	190	193	PF00928	0.411
TRG_ENDOCYTIC_2	240	243	PF00928	0.396
TRG_ENDOCYTIC_2	28	31	PF00928	0.554
TRG_ER_diArg_1	113	116	PF00400	0.505
TRG_ER_diArg_1	75	77	PF00400	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A9	Leptomonas seymouri	48%	93%
A0A0S4ITU9	Bodo saltans	30%	79%
A0A1X0NRX0	Trypanosomatidae	35%	98%
A0A3R7KAZ9	Trypanosoma rangeli	35%	100%
A0A3S7WRB2	Leishmania donovani	95%	100%
A4H6A2	Leishmania braziliensis	79%	100%
A4HUM6	Leishmania infantum	95%	100%
C9ZVQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ANC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BTV5	Trypanosoma cruzi	37%	99%