Cilia- and flagella-associated protein 45

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tumour suppressor, Mitostatin, putative

Species:

Leishmania major

UniProt:

Q4QH99_LEIMA

TriTrypDb:

LmjF.10.1150 , LMJLV39_100018700 , LMJSD75_100018800

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	4
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QH99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.210
CLV_NRD_NRD_1	16	18	PF00675	0.482
CLV_NRD_NRD_1	192	194	PF00675	0.212
CLV_NRD_NRD_1	211	213	PF00675	0.159
CLV_NRD_NRD_1	24	26	PF00675	0.447
CLV_NRD_NRD_1	240	242	PF00675	0.219
CLV_NRD_NRD_1	246	248	PF00675	0.211
CLV_NRD_NRD_1	274	276	PF00675	0.255
CLV_NRD_NRD_1	299	301	PF00675	0.284
CLV_NRD_NRD_1	329	331	PF00675	0.219
CLV_NRD_NRD_1	340	342	PF00675	0.176
CLV_NRD_NRD_1	405	407	PF00675	0.228
CLV_NRD_NRD_1	427	429	PF00675	0.201
CLV_NRD_NRD_1	440	442	PF00675	0.202
CLV_NRD_NRD_1	456	458	PF00675	0.141
CLV_NRD_NRD_1	472	474	PF00675	0.385
CLV_NRD_NRD_1	82	84	PF00675	0.515
CLV_PCSK_FUR_1	209	213	PF00082	0.304
CLV_PCSK_FUR_1	297	301	PF00082	0.291
CLV_PCSK_FUR_1	327	331	PF00082	0.211
CLV_PCSK_FUR_1	403	407	PF00082	0.304
CLV_PCSK_FUR_1	425	429	PF00082	0.213
CLV_PCSK_KEX2_1	148	150	PF00082	0.225
CLV_PCSK_KEX2_1	15	17	PF00082	0.545
CLV_PCSK_KEX2_1	153	155	PF00082	0.224
CLV_PCSK_KEX2_1	192	194	PF00082	0.262
CLV_PCSK_KEX2_1	211	213	PF00082	0.227
CLV_PCSK_KEX2_1	240	242	PF00082	0.210
CLV_PCSK_KEX2_1	246	248	PF00082	0.197
CLV_PCSK_KEX2_1	299	301	PF00082	0.284
CLV_PCSK_KEX2_1	329	331	PF00082	0.206
CLV_PCSK_KEX2_1	340	342	PF00082	0.190
CLV_PCSK_KEX2_1	405	407	PF00082	0.304
CLV_PCSK_KEX2_1	425	427	PF00082	0.114
CLV_PCSK_KEX2_1	472	474	PF00082	0.497
CLV_PCSK_KEX2_1	81	83	PF00082	0.519
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.229
CLV_PCSK_PC7_1	144	150	PF00082	0.153
CLV_PCSK_SKI1_1	118	122	PF00082	0.482
CLV_PCSK_SKI1_1	133	137	PF00082	0.211
CLV_PCSK_SKI1_1	472	476	PF00082	0.445
DEG_APCC_DBOX_1	471	479	PF00400	0.464
DOC_MAPK_gen_1	192	200	PF00069	0.396
DOC_MAPK_gen_1	263	271	PF00069	0.425
DOC_MAPK_gen_1	297	306	PF00069	0.504
DOC_MAPK_gen_1	472	478	PF00069	0.575
DOC_MAPK_MEF2A_6	193	202	PF00069	0.400
DOC_PP2B_LxvP_1	465	468	PF13499	0.411
DOC_USP7_MATH_1	34	38	PF00917	0.474
DOC_USP7_UBL2_3	372	376	PF12436	0.447
DOC_WW_Pin1_4	94	99	PF00397	0.508
LIG_14-3-3_CanoR_1	133	141	PF00244	0.529
LIG_14-3-3_CanoR_1	16	24	PF00244	0.533
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_CaM_IQ_9	197	213	PF13499	0.482
LIG_CaM_IQ_9	227	243	PF13499	0.447
LIG_CaM_IQ_9	386	402	PF13499	0.504
LIG_FHA_1	402	408	PF00498	0.447
LIG_FHA_1	6	12	PF00498	0.496
LIG_FHA_2	39	45	PF00498	0.421
LIG_FHA_2	70	76	PF00498	0.669
LIG_FHA_2	98	104	PF00498	0.539
LIG_PCNA_yPIPBox_3	376	387	PF02747	0.498
LIG_REV1ctd_RIR_1	1	11	PF16727	0.627
LIG_SH2_STAT3	161	164	PF00017	0.467
LIG_SH2_STAT3	280	283	PF00017	0.467
LIG_SH2_STAT5	180	183	PF00017	0.504
LIG_SH2_STAT5	206	209	PF00017	0.415
LIG_SH2_STAT5	280	283	PF00017	0.411
LIG_SH2_STAT5	335	338	PF00017	0.504
LIG_SH3_3	8	14	PF00018	0.525
LIG_SUMO_SIM_anti_2	412	417	PF11976	0.411
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.414
LIG_TRAF2_1	100	103	PF00917	0.581
LIG_TRAF2_1	76	79	PF00917	0.590
LIG_WW_3	12	16	PF00397	0.455
MOD_CDK_SPK_2	94	99	PF00069	0.410
MOD_CK1_1	59	65	PF00069	0.691
MOD_CK2_1	38	44	PF00069	0.429
MOD_CK2_1	69	75	PF00069	0.624
MOD_CK2_1	97	103	PF00069	0.598
MOD_GlcNHglycan	350	353	PF01048	0.215
MOD_GlcNHglycan	36	39	PF01048	0.597
MOD_GSK3_1	34	41	PF00069	0.489
MOD_GSK3_1	56	63	PF00069	0.586
MOD_NEK2_1	3	8	PF00069	0.477
MOD_NEK2_1	60	65	PF00069	0.582
MOD_PKA_2	34	40	PF00069	0.497
MOD_PKA_2	348	354	PF00069	0.484
MOD_PKB_1	15	23	PF00069	0.498
MOD_Plk_1	409	415	PF00069	0.401
MOD_ProDKin_1	94	100	PF00069	0.503
MOD_SUMO_rev_2	122	131	PF00179	0.425
MOD_SUMO_rev_2	228	236	PF00179	0.447
MOD_SUMO_rev_2	268	278	PF00179	0.425
MOD_SUMO_rev_2	452	459	PF00179	0.511
TRG_DiLeu_BaEn_1	115	120	PF01217	0.395
TRG_DiLeu_BaEn_3	381	387	PF01217	0.411
TRG_DiLeu_BaEn_4	435	441	PF01217	0.491
TRG_ER_diArg_1	14	17	PF00400	0.547
TRG_ER_diArg_1	185	188	PF00400	0.504
TRG_ER_diArg_1	209	212	PF00400	0.504
TRG_ER_diArg_1	239	241	PF00400	0.420
TRG_ER_diArg_1	246	248	PF00400	0.400
TRG_ER_diArg_1	297	300	PF00400	0.495
TRG_ER_diArg_1	326	329	PF00400	0.429
TRG_ER_diArg_1	403	406	PF00400	0.504
TRG_ER_diArg_1	425	428	PF00400	0.401
TRG_ER_diArg_1	471	473	PF00400	0.467
TRG_ER_diArg_1	81	83	PF00400	0.564
TRG_NES_CRM1_1	221	234	PF08389	0.546
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.211
TRG_Pf-PMV_PEXEL_1	385	390	PF00026	0.282
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.114
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.200

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W7	Leptomonas seymouri	78%	100%
A0A0S4INS9	Bodo saltans	47%	98%
A0A1X0NS36	Trypanosomatidae	57%	100%
A0A3S7WRD8	Leishmania donovani	97%	100%
A0A422NGP1	Trypanosoma rangeli	55%	100%
A0A480NP79	Sus scrofa	31%	87%
A4H6A3	Leishmania braziliensis	91%	100%
A4HUM7	Leishmania infantum	97%	100%
A8I9E8	Chlamydomonas reinhardtii	44%	96%
C9ZVQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ANC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q32LN4	Bos taurus	32%	87%
Q9D9U9	Mus musculus	32%	87%
Q9UL16	Homo sapiens	31%	87%
V5BJP2	Trypanosoma cruzi	58%	99%