RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH94_LEIMA

TriTrypDb:

LmjF.10.1195 , LMJLV39_100019400 , LMJSD75_100019400

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QH94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH94

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.500
CLV_NRD_NRD_1	14	16	PF00675	0.617
CLV_NRD_NRD_1	169	171	PF00675	0.375
CLV_NRD_NRD_1	60	62	PF00675	0.491
CLV_NRD_NRD_1	67	69	PF00675	0.570
CLV_PCSK_KEX2_1	109	111	PF00082	0.488
CLV_PCSK_KEX2_1	14	16	PF00082	0.617
CLV_PCSK_KEX2_1	60	62	PF00082	0.491
CLV_PCSK_KEX2_1	67	69	PF00082	0.556
CLV_PCSK_KEX2_1	91	93	PF00082	0.300
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.300
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DEG_SPOP_SBC_1	37	41	PF00917	0.501
DOC_USP7_MATH_1	27	31	PF00917	0.694
DOC_USP7_MATH_1	37	41	PF00917	0.453
DOC_USP7_UBL2_3	171	175	PF12436	0.355
DOC_WW_Pin1_4	177	182	PF00397	0.382
DOC_WW_Pin1_4	51	56	PF00397	0.462
LIG_14-3-3_CanoR_1	48	58	PF00244	0.612
LIG_FHA_2	30	36	PF00498	0.520
LIG_FHA_2	73	79	PF00498	0.451
LIG_Integrin_RGDW_4	76	79	PF00362	0.331
LIG_LIR_Apic_2	120	124	PF02991	0.417
LIG_LIR_Apic_2	154	160	PF02991	0.402
LIG_MYND_1	102	106	PF01753	0.496
LIG_SH2_STAT5	46	49	PF00017	0.520
LIG_SH3_2	147	152	PF14604	0.535
LIG_SH3_3	105	111	PF00018	0.534
LIG_SH3_3	141	147	PF00018	0.471
LIG_SH3_3	21	27	PF00018	0.526
LIG_SH3_3	97	103	PF00018	0.300
LIG_Sin3_3	21	28	PF02671	0.506
LIG_WRC_WIRS_1	47	52	PF05994	0.603
LIG_WW_2	102	105	PF00397	0.452
LIG_WW_2	147	150	PF00397	0.558
MOD_CK1_1	177	183	PF00069	0.392
MOD_CK1_1	49	55	PF00069	0.656
MOD_CK2_1	29	35	PF00069	0.538
MOD_CK2_1	87	93	PF00069	0.325
MOD_GlcNHglycan	176	179	PF01048	0.386
MOD_GlcNHglycan	29	32	PF01048	0.542
MOD_GSK3_1	151	158	PF00069	0.613
MOD_GSK3_1	38	45	PF00069	0.654
MOD_GSK3_1	68	75	PF00069	0.631
MOD_LATS_1	66	72	PF00433	0.527
MOD_N-GLC_2	42	44	PF02516	0.474
MOD_NEK2_1	174	179	PF00069	0.379
MOD_NEK2_1	36	41	PF00069	0.675
MOD_PKA_1	109	115	PF00069	0.488
MOD_PKA_2	109	115	PF00069	0.488
MOD_PKB_1	70	78	PF00069	0.636
MOD_Plk_1	152	158	PF00069	0.467
MOD_Plk_4	152	158	PF00069	0.467
MOD_Plk_4	42	48	PF00069	0.593
MOD_ProDKin_1	177	183	PF00069	0.385
MOD_ProDKin_1	51	57	PF00069	0.461
MOD_SUMO_rev_2	180	187	PF00179	0.568
TRG_ER_diArg_1	108	110	PF00400	0.508
TRG_ER_diArg_1	13	15	PF00400	0.634
TRG_ER_diArg_1	60	62	PF00400	0.493
TRG_ER_diArg_1	67	70	PF00400	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKB7	Leptomonas seymouri	27%	68%
A0A0N1PC91	Leptomonas seymouri	64%	100%
A0A1X0NQG6	Trypanosomatidae	81%	92%
A0A3R7KWS8	Trypanosoma rangeli	66%	72%
A0A3S7WRC4	Leishmania donovani	95%	100%
A4H6A8	Leishmania braziliensis	81%	99%
A4HUN2	Leishmania infantum	95%	100%
C9ZJT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	66%
C9ZVR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AND0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%