SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH93_LEIMA

TriTrypDb:

LmjF.10.1200 , LMJLV39_100019500 , LMJSD75_100019500

Length:

1062

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	11
GO:0140513	nuclear protein-containing complex	2	2
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9

Expansion

Sequence features

Q4QH93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH93

Function

Biological processes
Term	Name	Level	Count
GO:0006611	protein export from nucleus	5	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005049	nuclear export signal receptor activity	3	11
GO:0140104	molecular carrier activity	1	11
GO:0140142	nucleocytoplasmic carrier activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.374
CLV_MEL_PAP_1	497	503	PF00089	0.433
CLV_NRD_NRD_1	119	121	PF00675	0.507
CLV_NRD_NRD_1	238	240	PF00675	0.458
CLV_NRD_NRD_1	542	544	PF00675	0.607
CLV_NRD_NRD_1	714	716	PF00675	0.441
CLV_NRD_NRD_1	987	989	PF00675	0.381
CLV_PCSK_KEX2_1	119	121	PF00082	0.525
CLV_PCSK_KEX2_1	714	716	PF00082	0.415
CLV_PCSK_SKI1_1	1031	1035	PF00082	0.469
CLV_PCSK_SKI1_1	120	124	PF00082	0.615
CLV_PCSK_SKI1_1	148	152	PF00082	0.439
CLV_PCSK_SKI1_1	240	244	PF00082	0.472
CLV_PCSK_SKI1_1	57	61	PF00082	0.382
CLV_PCSK_SKI1_1	612	616	PF00082	0.446
CLV_PCSK_SKI1_1	644	648	PF00082	0.365
CLV_PCSK_SKI1_1	706	710	PF00082	0.312
CLV_PCSK_SKI1_1	763	767	PF00082	0.448
CLV_PCSK_SKI1_1	970	974	PF00082	0.436
CLV_PCSK_SKI1_1	988	992	PF00082	0.204
DEG_APCC_DBOX_1	987	995	PF00400	0.426
DOC_CYCLIN_RxL_1	237	247	PF00134	0.272
DOC_CYCLIN_RxL_1	261	274	PF00134	0.348
DOC_CYCLIN_yCln2_LP_2	635	641	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	670	676	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	911	917	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	990	996	PF00134	0.387
DOC_MAPK_FxFP_2	727	730	PF00069	0.386
DOC_MAPK_gen_1	132	142	PF00069	0.339
DOC_MAPK_gen_1	249	258	PF00069	0.308
DOC_MAPK_gen_1	786	795	PF00069	0.450
DOC_MAPK_gen_1	988	994	PF00069	0.396
DOC_MAPK_HePTP_8	783	795	PF00069	0.336
DOC_MAPK_MEF2A_6	61	68	PF00069	0.428
DOC_MAPK_MEF2A_6	786	795	PF00069	0.447
DOC_PP1_RVXF_1	208	214	PF00149	0.324
DOC_PP1_RVXF_1	761	767	PF00149	0.408
DOC_PP2B_LxvP_1	990	993	PF13499	0.385
DOC_PP4_FxxP_1	727	730	PF00568	0.386
DOC_USP7_MATH_1	322	326	PF00917	0.369
DOC_USP7_MATH_1	447	451	PF00917	0.564
DOC_USP7_MATH_1	479	483	PF00917	0.518
DOC_USP7_MATH_1	87	91	PF00917	0.403
DOC_USP7_MATH_1	923	927	PF00917	0.311
DOC_WW_Pin1_4	1012	1017	PF00397	0.460
DOC_WW_Pin1_4	299	304	PF00397	0.442
DOC_WW_Pin1_4	803	808	PF00397	0.550
LIG_14-3-3_CanoR_1	1012	1016	PF00244	0.514
LIG_14-3-3_CanoR_1	119	125	PF00244	0.503
LIG_14-3-3_CanoR_1	18	27	PF00244	0.493
LIG_14-3-3_CanoR_1	239	243	PF00244	0.461
LIG_14-3-3_CanoR_1	306	312	PF00244	0.406
LIG_14-3-3_CanoR_1	436	442	PF00244	0.465
LIG_14-3-3_CanoR_1	446	454	PF00244	0.449
LIG_14-3-3_CanoR_1	500	508	PF00244	0.494
LIG_14-3-3_CanoR_1	543	552	PF00244	0.534
LIG_14-3-3_CanoR_1	618	623	PF00244	0.526
LIG_14-3-3_CanoR_1	677	683	PF00244	0.496
LIG_14-3-3_CanoR_1	697	701	PF00244	0.190
LIG_14-3-3_CanoR_1	706	716	PF00244	0.401
LIG_Actin_WH2_2	1044	1061	PF00022	0.501
LIG_Actin_WH2_2	224	241	PF00022	0.378
LIG_APCC_ABBA_1	624	629	PF00400	0.476
LIG_APCC_ABBA_1	840	845	PF00400	0.365
LIG_APCC_ABBAyCdc20_2	239	245	PF00400	0.376
LIG_BIR_II_1	1	5	PF00653	0.373
LIG_BRCT_BRCA1_1	11	15	PF00533	0.382
LIG_BRCT_BRCA1_1	909	913	PF00533	0.374
LIG_CaM_NSCaTE_8	465	472	PF13499	0.432
LIG_Clathr_ClatBox_1	994	998	PF01394	0.339
LIG_deltaCOP1_diTrp_1	813	816	PF00928	0.451
LIG_EH1_1	984	992	PF00400	0.474
LIG_EVH1_2	898	902	PF00568	0.334
LIG_FHA_1	178	184	PF00498	0.502
LIG_FHA_1	231	237	PF00498	0.328
LIG_FHA_1	24	30	PF00498	0.462
LIG_FHA_1	258	264	PF00498	0.290
LIG_FHA_1	322	328	PF00498	0.337
LIG_FHA_1	36	42	PF00498	0.324
LIG_FHA_1	371	377	PF00498	0.470
LIG_FHA_1	501	507	PF00498	0.500
LIG_FHA_1	521	527	PF00498	0.493
LIG_FHA_1	532	538	PF00498	0.454
LIG_FHA_1	605	611	PF00498	0.373
LIG_FHA_1	661	667	PF00498	0.501
LIG_FHA_1	693	699	PF00498	0.410
LIG_FHA_1	745	751	PF00498	0.455
LIG_FHA_1	847	853	PF00498	0.387
LIG_FHA_1	873	879	PF00498	0.411
LIG_FHA_1	971	977	PF00498	0.335
LIG_FHA_2	1041	1047	PF00498	0.551
LIG_FHA_2	1055	1061	PF00498	0.457
LIG_FHA_2	113	119	PF00498	0.475
LIG_FHA_2	191	197	PF00498	0.457
LIG_FHA_2	225	231	PF00498	0.451
LIG_FHA_2	242	248	PF00498	0.388
LIG_FHA_2	667	673	PF00498	0.494
LIG_GBD_Chelix_1	1047	1055	PF00786	0.439
LIG_GBD_Chelix_1	224	232	PF00786	0.361
LIG_LIR_Apic_2	725	730	PF02991	0.398
LIG_LIR_Gen_1	241	250	PF02991	0.558
LIG_LIR_Gen_1	265	274	PF02991	0.441
LIG_LIR_Gen_1	277	286	PF02991	0.258
LIG_LIR_Gen_1	331	339	PF02991	0.227
LIG_LIR_Gen_1	40	50	PF02991	0.380
LIG_LIR_Gen_1	617	626	PF02991	0.430
LIG_LIR_Gen_1	8	19	PF02991	0.358
LIG_LIR_Gen_1	900	908	PF02991	0.459
LIG_LIR_Nem_3	209	215	PF02991	0.317
LIG_LIR_Nem_3	241	246	PF02991	0.565
LIG_LIR_Nem_3	265	270	PF02991	0.437
LIG_LIR_Nem_3	277	282	PF02991	0.253
LIG_LIR_Nem_3	331	336	PF02991	0.301
LIG_LIR_Nem_3	40	45	PF02991	0.334
LIG_LIR_Nem_3	424	430	PF02991	0.434
LIG_LIR_Nem_3	567	571	PF02991	0.404
LIG_LIR_Nem_3	617	623	PF02991	0.479
LIG_LIR_Nem_3	8	14	PF02991	0.362
LIG_LIR_Nem_3	853	859	PF02991	0.420
LIG_LIR_Nem_3	900	905	PF02991	0.452
LIG_MAD2	718	726	PF02301	0.364
LIG_MYND_1	218	222	PF01753	0.425
LIG_MYND_1	726	730	PF01753	0.451
LIG_NRBOX	325	331	PF00104	0.418
LIG_NRBOX	487	493	PF00104	0.450
LIG_NRBOX	847	853	PF00104	0.380
LIG_PCNA_yPIPBox_3	285	296	PF02747	0.474
LIG_PCNA_yPIPBox_3	978	991	PF02747	0.492
LIG_PDZ_Class_3	1057	1062	PF00595	0.452
LIG_Pex14_2	568	572	PF04695	0.453
LIG_Pex14_2	888	892	PF04695	0.449
LIG_Rb_LxCxE_1	704	725	PF01857	0.446
LIG_SH2_CRK	11	15	PF00017	0.366
LIG_SH2_CRK	253	257	PF00017	0.363
LIG_SH2_CRK	620	624	PF00017	0.481
LIG_SH2_CRK	717	721	PF00017	0.366
LIG_SH2_CRK	827	831	PF00017	0.346
LIG_SH2_NCK_1	11	15	PF00017	0.366
LIG_SH2_SRC	253	256	PF00017	0.293
LIG_SH2_SRC	996	999	PF00017	0.468
LIG_SH2_STAP1	11	15	PF00017	0.356
LIG_SH2_STAP1	253	257	PF00017	0.363
LIG_SH2_STAP1	620	624	PF00017	0.426
LIG_SH2_STAP1	74	78	PF00017	0.430
LIG_SH2_STAP1	843	847	PF00017	0.417
LIG_SH2_STAT3	342	345	PF00017	0.515
LIG_SH2_STAT5	1008	1011	PF00017	0.482
LIG_SH2_STAT5	361	364	PF00017	0.412
LIG_SH2_STAT5	538	541	PF00017	0.559
LIG_SH2_STAT5	571	574	PF00017	0.425
LIG_SH2_STAT5	620	623	PF00017	0.426
LIG_SH2_STAT5	645	648	PF00017	0.414
LIG_SH2_STAT5	779	782	PF00017	0.347
LIG_SH2_STAT5	996	999	PF00017	0.468
LIG_SH3_3	508	514	PF00018	0.271
LIG_SH3_3	804	810	PF00018	0.447
LIG_SUMO_SIM_anti_2	227	234	PF11976	0.414
LIG_SUMO_SIM_anti_2	323	331	PF11976	0.432
LIG_SUMO_SIM_anti_2	455	462	PF11976	0.507
LIG_SUMO_SIM_anti_2	494	499	PF11976	0.427
LIG_SUMO_SIM_par_1	111	118	PF11976	0.388
LIG_SUMO_SIM_par_1	227	234	PF11976	0.375
LIG_SUMO_SIM_par_1	254	260	PF11976	0.353
LIG_SUMO_SIM_par_1	323	331	PF11976	0.438
LIG_SUMO_SIM_par_1	37	43	PF11976	0.340
LIG_SUMO_SIM_par_1	698	704	PF11976	0.373
LIG_UBA3_1	1054	1059	PF00899	0.484
LIG_UBA3_1	282	287	PF00899	0.293
LIG_UBA3_1	371	378	PF00899	0.276
LIG_WRC_WIRS_1	121	126	PF05994	0.557
LIG_WRC_WIRS_1	308	313	PF05994	0.319
MOD_CDK_SPxxK_3	299	306	PF00069	0.340
MOD_CK1_1	1011	1017	PF00069	0.462
MOD_CK1_1	156	162	PF00069	0.494
MOD_CK1_1	234	240	PF00069	0.396
MOD_CK1_1	241	247	PF00069	0.432
MOD_CK1_1	307	313	PF00069	0.466
MOD_CK1_1	325	331	PF00069	0.213
MOD_CK1_1	341	347	PF00069	0.364
MOD_CK1_1	381	387	PF00069	0.573
MOD_CK1_1	450	456	PF00069	0.510
MOD_CK1_1	606	612	PF00069	0.360
MOD_CK1_1	660	666	PF00069	0.514
MOD_CK1_1	691	697	PF00069	0.550
MOD_CK1_1	803	809	PF00069	0.578
MOD_CK1_1	88	94	PF00069	0.456
MOD_CK1_1	9	15	PF00069	0.413
MOD_CK2_1	1040	1046	PF00069	0.452
MOD_CK2_1	1054	1060	PF00069	0.520
MOD_CK2_1	112	118	PF00069	0.452
MOD_CK2_1	224	230	PF00069	0.453
MOD_CK2_1	241	247	PF00069	0.397
MOD_CK2_1	37	43	PF00069	0.499
MOD_CK2_1	666	672	PF00069	0.459
MOD_CK2_1	687	693	PF00069	0.559
MOD_CK2_1	707	713	PF00069	0.325
MOD_CK2_1	737	743	PF00069	0.478
MOD_DYRK1A_RPxSP_1	1012	1016	PF00069	0.459
MOD_GlcNHglycan	276	279	PF01048	0.499
MOD_GlcNHglycan	449	452	PF01048	0.584
MOD_GlcNHglycan	470	473	PF01048	0.457
MOD_GlcNHglycan	481	484	PF01048	0.456
MOD_GlcNHglycan	545	548	PF01048	0.535
MOD_GlcNHglycan	584	587	PF01048	0.464
MOD_GlcNHglycan	658	662	PF01048	0.410
MOD_GlcNHglycan	690	693	PF01048	0.502
MOD_GlcNHglycan	769	772	PF01048	0.436
MOD_GlcNHglycan	786	789	PF01048	0.243
MOD_GlcNHglycan	797	800	PF01048	0.479
MOD_GlcNHglycan	8	11	PF01048	0.391
MOD_GlcNHglycan	802	805	PF01048	0.449
MOD_GlcNHglycan	998	1002	PF01048	0.509
MOD_GSK3_1	1008	1015	PF00069	0.495
MOD_GSK3_1	1050	1057	PF00069	0.364
MOD_GSK3_1	126	133	PF00069	0.476
MOD_GSK3_1	14	21	PF00069	0.360
MOD_GSK3_1	190	197	PF00069	0.572
MOD_GSK3_1	230	237	PF00069	0.288
MOD_GSK3_1	321	328	PF00069	0.377
MOD_GSK3_1	431	438	PF00069	0.492
MOD_GSK3_1	5	12	PF00069	0.462
MOD_GSK3_1	529	536	PF00069	0.516
MOD_GSK3_1	538	545	PF00069	0.492
MOD_GSK3_1	602	609	PF00069	0.473
MOD_GSK3_1	614	621	PF00069	0.430
MOD_GSK3_1	662	669	PF00069	0.434
MOD_GSK3_1	684	691	PF00069	0.620
MOD_GSK3_1	692	699	PF00069	0.553
MOD_GSK3_1	81	88	PF00069	0.447
MOD_GSK3_1	846	853	PF00069	0.375
MOD_GSK3_1	868	875	PF00069	0.408
MOD_N-GLC_1	447	452	PF02516	0.508
MOD_N-GLC_1	627	632	PF02516	0.457
MOD_N-GLC_2	937	939	PF02516	0.448
MOD_NEK2_1	1054	1059	PF00069	0.454
MOD_NEK2_1	112	117	PF00069	0.364
MOD_NEK2_1	238	243	PF00069	0.390
MOD_NEK2_1	257	262	PF00069	0.183
MOD_NEK2_1	37	42	PF00069	0.352
MOD_NEK2_1	4	9	PF00069	0.371
MOD_NEK2_1	491	496	PF00069	0.407
MOD_NEK2_1	507	512	PF00069	0.398
MOD_NEK2_1	531	536	PF00069	0.436
MOD_NEK2_1	584	589	PF00069	0.521
MOD_NEK2_1	614	619	PF00069	0.440
MOD_NEK2_1	657	662	PF00069	0.455
MOD_NEK2_1	736	741	PF00069	0.452
MOD_NEK2_1	795	800	PF00069	0.613
MOD_NEK2_1	851	856	PF00069	0.383
MOD_NEK2_1	868	873	PF00069	0.302
MOD_NEK2_1	907	912	PF00069	0.293
MOD_NEK2_1	956	961	PF00069	0.393
MOD_NEK2_1	976	981	PF00069	0.227
MOD_NEK2_2	23	28	PF00069	0.487
MOD_NEK2_2	463	468	PF00069	0.392
MOD_PIKK_1	32	38	PF00454	0.440
MOD_PIKK_1	341	347	PF00454	0.375
MOD_PIKK_1	435	441	PF00454	0.410
MOD_PIKK_1	551	557	PF00454	0.448
MOD_PIKK_1	676	682	PF00454	0.491
MOD_PIKK_1	744	750	PF00454	0.413
MOD_PK_1	533	539	PF00069	0.519
MOD_PKA_1	543	549	PF00069	0.548
MOD_PKA_2	1011	1017	PF00069	0.462
MOD_PKA_2	238	244	PF00069	0.465
MOD_PKA_2	435	441	PF00069	0.554
MOD_PKA_2	499	505	PF00069	0.460
MOD_PKA_2	542	548	PF00069	0.542
MOD_PKA_2	676	682	PF00069	0.469
MOD_PKA_2	696	702	PF00069	0.246
MOD_Plk_1	126	132	PF00069	0.456
MOD_Plk_1	272	278	PF00069	0.364
MOD_Plk_1	32	38	PF00069	0.476
MOD_Plk_1	447	453	PF00069	0.525
MOD_Plk_1	627	633	PF00069	0.515
MOD_Plk_1	657	663	PF00069	0.461
MOD_Plk_1	742	748	PF00069	0.400
MOD_Plk_1	843	849	PF00069	0.403
MOD_Plk_1	976	982	PF00069	0.493
MOD_Plk_4	1050	1056	PF00069	0.408
MOD_Plk_4	138	144	PF00069	0.434
MOD_Plk_4	224	230	PF00069	0.329
MOD_Plk_4	23	29	PF00069	0.383
MOD_Plk_4	231	237	PF00069	0.281
MOD_Plk_4	238	244	PF00069	0.282
MOD_Plk_4	322	328	PF00069	0.339
MOD_Plk_4	37	43	PF00069	0.272
MOD_Plk_4	437	443	PF00069	0.403
MOD_Plk_4	491	497	PF00069	0.389
MOD_Plk_4	533	539	PF00069	0.503
MOD_Plk_4	606	612	PF00069	0.488
MOD_Plk_4	618	624	PF00069	0.483
MOD_Plk_4	662	668	PF00069	0.522
MOD_Plk_4	851	857	PF00069	0.318
MOD_Plk_4	9	15	PF00069	0.375
MOD_Plk_4	956	962	PF00069	0.368
MOD_ProDKin_1	1012	1018	PF00069	0.454
MOD_ProDKin_1	299	305	PF00069	0.437
MOD_ProDKin_1	803	809	PF00069	0.546
TRG_DiLeu_BaEn_1	411	416	PF01217	0.373
TRG_DiLeu_BaEn_2	374	380	PF01217	0.393
TRG_DiLeu_BaEn_3	424	430	PF01217	0.365
TRG_DiLeu_BaEn_4	405	411	PF01217	0.417
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.429
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.415
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.442
TRG_ENDOCYTIC_2	11	14	PF00928	0.351
TRG_ENDOCYTIC_2	253	256	PF00928	0.478
TRG_ENDOCYTIC_2	42	45	PF00928	0.444
TRG_ENDOCYTIC_2	620	623	PF00928	0.481
TRG_ENDOCYTIC_2	645	648	PF00928	0.373
TRG_ENDOCYTIC_2	717	720	PF00928	0.350
TRG_ENDOCYTIC_2	827	830	PF00928	0.334
TRG_ER_diArg_1	101	104	PF00400	0.452
TRG_ER_diArg_1	119	121	PF00400	0.301
TRG_ER_diArg_1	248	251	PF00400	0.333
TRG_ER_diArg_1	714	716	PF00400	0.439
TRG_NES_CRM1_1	137	152	PF08389	0.376
TRG_NES_CRM1_1	363	375	PF08389	0.351
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKL7	Leptomonas seymouri	64%	96%
A0A1X0NQX8	Trypanosomatidae	27%	100%
A0A3R7NI03	Trypanosoma rangeli	28%	100%
A0A3S7WRC3	Leishmania donovani	97%	100%
A4H6A9	Leishmania braziliensis	89%	100%
A4HUN3	Leishmania infantum	97%	100%
C9ZVR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AND1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q9H2T7	Homo sapiens	21%	98%
V5BTW0	Trypanosoma cruzi	28%	100%