Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH92_LEIMA

TriTrypDb:

LmjF.10.1210 , LMJLV39_100019600 , LMJSD75_100019600

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QH92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	260	266	PF00089	0.577
CLV_NRD_NRD_1	148	150	PF00675	0.530
CLV_NRD_NRD_1	286	288	PF00675	0.505
CLV_NRD_NRD_1	342	344	PF00675	0.558
CLV_NRD_NRD_1	427	429	PF00675	0.573
CLV_NRD_NRD_1	436	438	PF00675	0.505
CLV_NRD_NRD_1	52	54	PF00675	0.579
CLV_NRD_NRD_1	563	565	PF00675	0.635
CLV_PCSK_FUR_1	425	429	PF00082	0.623
CLV_PCSK_KEX2_1	25	27	PF00082	0.580
CLV_PCSK_KEX2_1	341	343	PF00082	0.622
CLV_PCSK_KEX2_1	381	383	PF00082	0.529
CLV_PCSK_KEX2_1	427	429	PF00082	0.544
CLV_PCSK_KEX2_1	436	438	PF00082	0.536
CLV_PCSK_KEX2_1	449	451	PF00082	0.593
CLV_PCSK_KEX2_1	52	54	PF00082	0.546
CLV_PCSK_KEX2_1	563	565	PF00082	0.635
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.545
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.532
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.663
CLV_PCSK_PC7_1	432	438	PF00082	0.589
CLV_PCSK_SKI1_1	102	106	PF00082	0.497
CLV_PCSK_SKI1_1	26	30	PF00082	0.562
CLV_PCSK_SKI1_1	484	488	PF00082	0.698
CLV_PCSK_SKI1_1	61	65	PF00082	0.608
DEG_COP1_1	219	226	PF00400	0.450
DEG_Nend_UBRbox_1	1	4	PF02207	0.675
DEG_SPOP_SBC_1	124	128	PF00917	0.551
DEG_SPOP_SBC_1	488	492	PF00917	0.634
DOC_CKS1_1	158	163	PF01111	0.709
DOC_CYCLIN_RxL_1	99	106	PF00134	0.522
DOC_MAPK_gen_1	447	457	PF00069	0.588
DOC_MAPK_MEF2A_6	235	243	PF00069	0.504
DOC_MAPK_RevD_3	274	288	PF00069	0.573
DOC_PP1_RVXF_1	198	204	PF00149	0.498
DOC_PP1_RVXF_1	380	387	PF00149	0.562
DOC_USP7_MATH_1	124	128	PF00917	0.617
DOC_USP7_MATH_1	159	163	PF00917	0.714
DOC_USP7_MATH_1	206	210	PF00917	0.538
DOC_USP7_MATH_1	295	299	PF00917	0.573
DOC_USP7_MATH_1	318	322	PF00917	0.599
DOC_USP7_MATH_1	33	37	PF00917	0.503
DOC_USP7_MATH_1	488	492	PF00917	0.621
DOC_USP7_MATH_1	553	557	PF00917	0.716
DOC_USP7_UBL2_3	25	29	PF12436	0.596
DOC_WW_Pin1_4	157	162	PF00397	0.679
DOC_WW_Pin1_4	226	231	PF00397	0.630
DOC_WW_Pin1_4	534	539	PF00397	0.499
LIG_14-3-3_CanoR_1	116	124	PF00244	0.679
LIG_14-3-3_CanoR_1	2	10	PF00244	0.630
LIG_14-3-3_CanoR_1	200	204	PF00244	0.536
LIG_14-3-3_CanoR_1	263	271	PF00244	0.539
LIG_14-3-3_CanoR_1	290	297	PF00244	0.488
LIG_14-3-3_CanoR_1	302	308	PF00244	0.368
LIG_14-3-3_CanoR_1	343	353	PF00244	0.494
LIG_14-3-3_CanoR_1	358	364	PF00244	0.569
LIG_14-3-3_CanoR_1	467	473	PF00244	0.547
LIG_14-3-3_CanoR_1	497	502	PF00244	0.704
LIG_Actin_WH2_2	102	118	PF00022	0.378
LIG_Actin_WH2_2	273	289	PF00022	0.507
LIG_BRCT_BRCA1_1	161	165	PF00533	0.637
LIG_FHA_1	234	240	PF00498	0.450
LIG_FHA_1	303	309	PF00498	0.409
LIG_FHA_2	227	233	PF00498	0.578
LIG_LIR_Gen_1	185	193	PF02991	0.480
LIG_LIR_Gen_1	495	506	PF02991	0.600
LIG_LIR_Nem_3	185	189	PF02991	0.420
LIG_LIR_Nem_3	495	501	PF02991	0.585
LIG_LYPXL_S_1	267	271	PF13949	0.566
LIG_LYPXL_yS_3	268	271	PF13949	0.565
LIG_NRBOX	100	106	PF00104	0.519
LIG_PCNA_PIPBox_1	462	471	PF02747	0.544
LIG_PCNA_yPIPBox_3	458	469	PF02747	0.546
LIG_RPA_C_Fungi	285	297	PF08784	0.534
LIG_SH2_CRK	498	502	PF00017	0.719
LIG_SH2_CRK	526	530	PF00017	0.575
LIG_SH2_STAP1	353	357	PF00017	0.603
LIG_SH2_STAP1	498	502	PF00017	0.686
LIG_SH2_STAT3	396	399	PF00017	0.472
LIG_SH2_STAT3	435	438	PF00017	0.674
LIG_SH2_STAT5	498	501	PF00017	0.652
LIG_SH3_3	266	272	PF00018	0.557
LIG_TRAF2_1	154	157	PF00917	0.581
LIG_TRAF2_1	209	212	PF00917	0.570
LIG_TRAF2_1	279	282	PF00917	0.524
LIG_TRAF2_1	362	365	PF00917	0.468
LIG_TRAF2_1	417	420	PF00917	0.543
MOD_CDK_SPxxK_3	534	541	PF00069	0.496
MOD_CK1_1	11	17	PF00069	0.566
MOD_CK1_1	253	259	PF00069	0.463
MOD_CK1_1	306	312	PF00069	0.538
MOD_CK1_1	492	498	PF00069	0.617
MOD_CK2_1	151	157	PF00069	0.511
MOD_CK2_1	206	212	PF00069	0.447
MOD_CK2_1	306	312	PF00069	0.528
MOD_CK2_1	33	39	PF00069	0.564
MOD_CK2_1	359	365	PF00069	0.557
MOD_CK2_1	43	49	PF00069	0.493
MOD_Cter_Amidation	50	53	PF01082	0.566
MOD_GlcNHglycan	128	131	PF01048	0.684
MOD_GlcNHglycan	132	135	PF01048	0.607
MOD_GlcNHglycan	16	19	PF01048	0.630
MOD_GlcNHglycan	161	164	PF01048	0.712
MOD_GlcNHglycan	208	211	PF01048	0.573
MOD_GlcNHglycan	245	248	PF01048	0.567
MOD_GlcNHglycan	251	255	PF01048	0.511
MOD_GlcNHglycan	26	29	PF01048	0.466
MOD_GlcNHglycan	264	267	PF01048	0.411
MOD_GlcNHglycan	272	275	PF01048	0.544
MOD_GlcNHglycan	312	315	PF01048	0.533
MOD_GlcNHglycan	491	494	PF01048	0.700
MOD_GlcNHglycan	5	8	PF01048	0.673
MOD_GlcNHglycan	550	553	PF01048	0.622
MOD_GlcNHglycan	97	101	PF01048	0.602
MOD_GSK3_1	103	110	PF00069	0.533
MOD_GSK3_1	126	133	PF00069	0.646
MOD_GSK3_1	222	229	PF00069	0.535
MOD_GSK3_1	302	309	PF00069	0.542
MOD_GSK3_1	488	495	PF00069	0.614
MOD_GSK3_1	497	504	PF00069	0.597
MOD_N-GLC_1	303	308	PF02516	0.530
MOD_NEK2_1	1	6	PF00069	0.708
MOD_NEK2_1	115	120	PF00069	0.628
MOD_NEK2_1	243	248	PF00069	0.612
MOD_NEK2_1	250	255	PF00069	0.581
MOD_NEK2_1	300	305	PF00069	0.487
MOD_NEK2_1	486	491	PF00069	0.640
MOD_NEK2_1	501	506	PF00069	0.612
MOD_NEK2_1	96	101	PF00069	0.568
MOD_NEK2_2	33	38	PF00069	0.623
MOD_PIKK_1	103	109	PF00454	0.589
MOD_PIKK_1	290	296	PF00454	0.597
MOD_PIKK_1	364	370	PF00454	0.555
MOD_PKA_1	24	30	PF00069	0.601
MOD_PKA_2	1	7	PF00069	0.650
MOD_PKA_2	115	121	PF00069	0.638
MOD_PKA_2	199	205	PF00069	0.575
MOD_PKA_2	262	268	PF00069	0.582
MOD_PKA_2	359	365	PF00069	0.603
MOD_PKA_2	442	448	PF00069	0.597
MOD_PKA_2	496	502	PF00069	0.684
MOD_PKA_2	548	554	PF00069	0.578
MOD_Plk_1	11	17	PF00069	0.495
MOD_Plk_1	151	157	PF00069	0.570
MOD_Plk_1	211	217	PF00069	0.548
MOD_Plk_1	280	286	PF00069	0.528
MOD_Plk_1	303	309	PF00069	0.532
MOD_Plk_1	78	84	PF00069	0.601
MOD_Plk_1	96	102	PF00069	0.384
MOD_Plk_4	303	309	PF00069	0.515
MOD_Plk_4	501	507	PF00069	0.636
MOD_ProDKin_1	157	163	PF00069	0.686
MOD_ProDKin_1	226	232	PF00069	0.628
MOD_ProDKin_1	534	540	PF00069	0.491
MOD_SUMO_rev_2	419	424	PF00179	0.608
TRG_DiLeu_BaEn_1	312	317	PF01217	0.562
TRG_DiLeu_BaEn_4	281	287	PF01217	0.535
TRG_ENDOCYTIC_2	268	271	PF00928	0.481
TRG_ENDOCYTIC_2	353	356	PF00928	0.608
TRG_ENDOCYTIC_2	498	501	PF00928	0.649
TRG_ENDOCYTIC_2	526	529	PF00928	0.576
TRG_ER_diArg_1	333	336	PF00400	0.617
TRG_ER_diArg_1	341	343	PF00400	0.575
TRG_ER_diArg_1	357	360	PF00400	0.478
TRG_ER_diArg_1	389	392	PF00400	0.468
TRG_ER_diArg_1	425	428	PF00400	0.625
TRG_ER_diArg_1	435	437	PF00400	0.570
TRG_ER_diArg_1	521	524	PF00400	0.596
TRG_ER_diArg_1	562	564	PF00400	0.631
TRG_NES_CRM1_1	232	245	PF08389	0.583
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W6	Leptomonas seymouri	55%	100%
A0A1X0NRY0	Trypanosomatidae	30%	97%
A0A3Q8I7T8	Leishmania donovani	93%	100%
A0A3R7MBP9	Trypanosoma rangeli	27%	97%
A4H6B0	Leishmania braziliensis	78%	100%
A4HUN4	Leishmania infantum	93%	100%
C9ZVR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	98%
E9AND2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BJP6	Trypanosoma cruzi	30%	92%