Atx10homo_assoc domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spinocerebellar ataxia type 10 protein domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QH91_LEIMA

TriTrypDb:

LmjF.10.1220 , LMJLV39_100019700 , LMJSD75_100019700

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.438
CLV_NRD_NRD_1	266	268	PF00675	0.302
CLV_NRD_NRD_1	97	99	PF00675	0.472
CLV_PCSK_KEX2_1	164	166	PF00082	0.406
CLV_PCSK_KEX2_1	96	98	PF00082	0.463
CLV_PCSK_SKI1_1	169	173	PF00082	0.363
CLV_PCSK_SKI1_1	279	283	PF00082	0.280
CLV_Separin_Metazoa	121	125	PF03568	0.629
DOC_ANK_TNKS_1	96	103	PF00023	0.505
DOC_MAPK_MEF2A_6	169	176	PF00069	0.395
DOC_MAPK_MEF2A_6	23	32	PF00069	0.481
DOC_USP7_MATH_1	132	136	PF00917	0.572
DOC_USP7_MATH_1	2	6	PF00917	0.676
DOC_USP7_MATH_1	55	59	PF00917	0.508
DOC_USP7_UBL2_3	19	23	PF12436	0.502
DOC_WW_Pin1_4	103	108	PF00397	0.649
DOC_WW_Pin1_4	116	121	PF00397	0.644
LIG_14-3-3_CanoR_1	124	129	PF00244	0.517
LIG_14-3-3_CanoR_1	285	291	PF00244	0.530
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_BIR_III_3	1	5	PF00653	0.545
LIG_BRCT_BRCA1_1	286	290	PF00533	0.483
LIG_Clathr_ClatBox_1	147	151	PF01394	0.445
LIG_deltaCOP1_diTrp_1	246	250	PF00928	0.444
LIG_FHA_1	291	297	PF00498	0.388
LIG_FHA_2	116	122	PF00498	0.547
LIG_FHA_2	233	239	PF00498	0.434
LIG_FHA_2	59	65	PF00498	0.590
LIG_FHA_2	89	95	PF00498	0.458
LIG_LIR_Gen_1	226	237	PF02991	0.483
LIG_LIR_Gen_1	246	255	PF02991	0.345
LIG_LIR_Gen_1	34	43	PF02991	0.521
LIG_LIR_Nem_3	226	232	PF02991	0.483
LIG_LIR_Nem_3	246	250	PF02991	0.414
LIG_LIR_Nem_3	34	38	PF02991	0.526
LIG_Pex14_2	195	199	PF04695	0.435
LIG_SH2_NCK_1	47	51	PF00017	0.535
LIG_SH2_STAP1	47	51	PF00017	0.422
LIG_SH2_STAP1	88	92	PF00017	0.481
LIG_SH2_STAT5	162	165	PF00017	0.422
LIG_SH2_STAT5	179	182	PF00017	0.243
LIG_SH2_STAT5	194	197	PF00017	0.366
LIG_SUMO_SIM_anti_2	143	149	PF11976	0.377
LIG_SUMO_SIM_par_1	146	151	PF11976	0.366
LIG_SUMO_SIM_par_1	75	80	PF11976	0.463
LIG_WRC_WIRS_1	32	37	PF05994	0.511
MOD_CK1_1	106	112	PF00069	0.584
MOD_CK1_1	113	119	PF00069	0.538
MOD_CK1_1	143	149	PF00069	0.422
MOD_CK1_1	289	295	PF00069	0.584
MOD_CK1_1	34	40	PF00069	0.425
MOD_CK1_1	58	64	PF00069	0.642
MOD_CK2_1	115	121	PF00069	0.545
MOD_CK2_1	123	129	PF00069	0.496
MOD_CK2_1	88	94	PF00069	0.452
MOD_GlcNHglycan	232	235	PF01048	0.267
MOD_GlcNHglycan	257	261	PF01048	0.346
MOD_GlcNHglycan	57	60	PF01048	0.662
MOD_GSK3_1	106	113	PF00069	0.602
MOD_GSK3_1	284	291	PF00069	0.551
MOD_N-GLC_1	124	129	PF02516	0.555
MOD_N-GLC_1	208	213	PF02516	0.244
MOD_N-GLC_2	254	256	PF02516	0.244
MOD_NEK2_1	111	116	PF00069	0.631
MOD_NEK2_1	123	128	PF00069	0.491
MOD_NEK2_1	232	237	PF00069	0.446
MOD_NEK2_1	290	295	PF00069	0.524
MOD_PIKK_1	106	112	PF00454	0.681
MOD_PIKK_1	232	238	PF00454	0.483
MOD_PIKK_1	297	303	PF00454	0.675
MOD_PIKK_1	64	70	PF00454	0.451
MOD_PK_1	124	130	PF00069	0.488
MOD_PKA_2	123	129	PF00069	0.495
MOD_PKA_2	140	146	PF00069	0.405
MOD_PKA_2	223	229	PF00069	0.483
MOD_PKA_2	284	290	PF00069	0.483
MOD_Plk_1	124	130	PF00069	0.513
MOD_Plk_1	77	83	PF00069	0.484
MOD_Plk_1	88	94	PF00069	0.434
MOD_Plk_4	143	149	PF00069	0.445
MOD_Plk_4	152	158	PF00069	0.351
MOD_Plk_4	223	229	PF00069	0.496
MOD_Plk_4	88	94	PF00069	0.418
MOD_ProDKin_1	103	109	PF00069	0.656
MOD_ProDKin_1	116	122	PF00069	0.641
MOD_SUMO_for_1	199	202	PF00179	0.537
MOD_SUMO_rev_2	58	63	PF00179	0.542
TRG_DiLeu_BaEn_1	202	207	PF01217	0.444
TRG_DiLeu_BaEn_2	222	228	PF01217	0.504
TRG_DiLeu_BaEn_3	239	245	PF01217	0.458
TRG_DiLeu_LyEn_5	202	207	PF01217	0.501
TRG_ER_diArg_1	163	165	PF00400	0.382
TRG_ER_diArg_1	95	98	PF00400	0.450
TRG_NES_CRM1_1	166	178	PF08389	0.365
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX75	Leptomonas seymouri	76%	100%
A0A0S4KKL7	Bodo saltans	28%	87%
A0A1X0NS45	Trypanosomatidae	37%	100%
A0A3Q8IB48	Leishmania donovani	97%	100%
A0A422NBS9	Trypanosoma rangeli	41%	99%
A4H6B1	Leishmania braziliensis	92%	100%
A4HUN5	Leishmania infantum	97%	100%
C9ZVR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AND3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5B466	Trypanosoma cruzi	41%	88%