DUF4216 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania major

UniProt:

Q4QH89_LEIMA

TriTrypDb:

LmjF.10.1230 , LMJLV39_100020400 , LMJSD75_100020400

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH89

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.362
CLV_NRD_NRD_1	21	23	PF00675	0.379
CLV_NRD_NRD_1	68	70	PF00675	0.352
CLV_NRD_NRD_1	80	82	PF00675	0.397
CLV_PCSK_KEX2_1	21	23	PF00082	0.475
CLV_PCSK_KEX2_1	68	70	PF00082	0.375
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.504
CLV_PCSK_SKI1_1	275	279	PF00082	0.269
DEG_MDM2_SWIB_1	204	211	PF02201	0.352
DOC_CYCLIN_RxL_1	272	281	PF00134	0.198
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.346
DOC_USP7_MATH_1	283	287	PF00917	0.347
DOC_USP7_UBL2_3	120	124	PF12436	0.320
LIG_AP2alpha_2	101	103	PF02296	0.371
LIG_BIR_III_4	206	210	PF00653	0.344
LIG_BIR_III_4	234	238	PF00653	0.389
LIG_CAP-Gly_1	324	328	PF01302	0.337
LIG_FHA_1	217	223	PF00498	0.229
LIG_FHA_1	244	250	PF00498	0.356
LIG_FHA_1	26	32	PF00498	0.324
LIG_FHA_1	42	48	PF00498	0.418
LIG_FHA_1	57	63	PF00498	0.352
LIG_FHA_2	178	184	PF00498	0.391
LIG_FHA_2	319	325	PF00498	0.368
LIG_FHA_2	81	87	PF00498	0.352
LIG_LIR_Gen_1	177	185	PF02991	0.332
LIG_LIR_Gen_1	33	42	PF02991	0.320
LIG_LIR_Gen_1	57	66	PF02991	0.428
LIG_LIR_Gen_1	86	95	PF02991	0.369
LIG_LIR_LC3C_4	152	157	PF02991	0.198
LIG_LIR_Nem_3	110	116	PF02991	0.363
LIG_LIR_Nem_3	177	182	PF02991	0.335
LIG_LIR_Nem_3	206	211	PF02991	0.346
LIG_LIR_Nem_3	259	263	PF02991	0.333
LIG_LIR_Nem_3	297	302	PF02991	0.343
LIG_LIR_Nem_3	33	39	PF02991	0.370
LIG_LIR_Nem_3	57	63	PF02991	0.345
LIG_LIR_Nem_3	86	91	PF02991	0.369
LIG_PDZ_Class_2	323	328	PF00595	0.431
LIG_Pex14_2	204	208	PF04695	0.352
LIG_SH2_CRK	260	264	PF00017	0.411
LIG_SH2_CRK	299	303	PF00017	0.352
LIG_SH2_NCK_1	88	92	PF00017	0.402
LIG_SH2_SRC	250	253	PF00017	0.293
LIG_SH2_STAP1	258	262	PF00017	0.311
LIG_SH2_STAT5	128	131	PF00017	0.358
LIG_SH2_STAT5	142	145	PF00017	0.342
LIG_SH2_STAT5	215	218	PF00017	0.362
LIG_SH2_STAT5	230	233	PF00017	0.321
LIG_SH2_STAT5	243	246	PF00017	0.352
LIG_SH2_STAT5	88	91	PF00017	0.366
LIG_SH3_2	270	275	PF14604	0.314
LIG_SH3_3	208	214	PF00018	0.280
LIG_SH3_3	246	252	PF00018	0.352
LIG_SH3_3	267	273	PF00018	0.335
LIG_SH3_3	7	13	PF00018	0.484
LIG_SUMO_SIM_par_1	154	160	PF11976	0.301
LIG_WRC_WIRS_1	245	250	PF05994	0.352
LIG_WRC_WIRS_1	36	41	PF05994	0.366
MOD_CK1_1	3	9	PF00069	0.500
MOD_CK2_1	3	9	PF00069	0.507
MOD_CK2_1	86	92	PF00069	0.352
MOD_GlcNHglycan	125	128	PF01048	0.423
MOD_GlcNHglycan	144	147	PF01048	0.281
MOD_GlcNHglycan	194	197	PF01048	0.333
MOD_GlcNHglycan	252	255	PF01048	0.469
MOD_GlcNHglycan	285	288	PF01048	0.352
MOD_GlcNHglycan	299	302	PF01048	0.352
MOD_GlcNHglycan	56	59	PF01048	0.224
MOD_GSK3_1	164	171	PF00069	0.359
MOD_GSK3_1	177	184	PF00069	0.335
MOD_N-GLC_1	3	8	PF02516	0.502
MOD_N-GLC_2	173	175	PF02516	0.207
MOD_N-GLC_2	255	257	PF02516	0.348
MOD_N-GLC_2	49	51	PF02516	0.314
MOD_NEK2_1	216	221	PF00069	0.385
MOD_NEK2_1	25	30	PF00069	0.418
MOD_NEK2_1	54	59	PF00069	0.419
MOD_NEK2_1	80	85	PF00069	0.357
MOD_NMyristoyl	1	7	PF02799	0.713
MOD_PIKK_1	187	193	PF00454	0.413
MOD_PKA_2	116	122	PF00069	0.307
MOD_PKA_2	67	73	PF00069	0.436
MOD_PKA_2	80	86	PF00069	0.301
MOD_Plk_1	14	20	PF00069	0.433
MOD_Plk_1	199	205	PF00069	0.358
MOD_Plk_1	32	38	PF00069	0.359
MOD_Plk_1	86	92	PF00069	0.369
MOD_Plk_2-3	86	92	PF00069	0.352
MOD_Plk_4	14	20	PF00069	0.490
MOD_Plk_4	199	205	PF00069	0.403
MOD_Plk_4	244	250	PF00069	0.347
MOD_Plk_4	32	38	PF00069	0.390
MOD_Plk_4	86	92	PF00069	0.365
MOD_SUMO_rev_2	253	263	PF00179	0.313
TRG_DiLeu_BaEn_1	100	105	PF01217	0.220
TRG_ENDOCYTIC_2	260	263	PF00928	0.417
TRG_ENDOCYTIC_2	299	302	PF00928	0.352
TRG_ENDOCYTIC_2	60	63	PF00928	0.384
TRG_ENDOCYTIC_2	88	91	PF00928	0.398
TRG_NES_CRM1_1	148	160	PF08389	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	57%	100%
A0A0N1HYU8	Leptomonas seymouri	55%	100%
A0A0N1I429	Leptomonas seymouri	79%	100%
A0A0N1I5D6	Leptomonas seymouri	51%	100%
A0A0N1I720	Leptomonas seymouri	60%	100%
A0A0N1IL04	Leptomonas seymouri	50%	100%
A0A0N1PCE9	Leptomonas seymouri	55%	100%
A0A0R6XPC0	Leishmania donovani	56%	100%
A0A3Q8IHB3	Leishmania donovani	53%	100%
A0A3S5H6H4	Leishmania donovani	95%	100%
A0A3S5H6H5	Leishmania donovani	57%	100%
A0A3S7WRC9	Leishmania donovani	55%	100%
A0A3S7WRD5	Leishmania donovani	53%	100%
A0A3S7WRE8	Leishmania donovani	50%	100%
A4H6B5	Leishmania braziliensis	81%	100%
A4H6B6	Leishmania braziliensis	51%	100%
A4H6B7	Leishmania braziliensis	57%	100%
A4H6B8	Leishmania braziliensis	50%	100%
A4H6B9	Leishmania braziliensis	58%	100%
A4H6C0	Leishmania braziliensis	53%	100%
A4H6C1	Leishmania braziliensis	51%	100%
A4HUN8	Leishmania infantum	95%	100%
A4HUN9	Leishmania infantum	53%	100%
A4HUP0	Leishmania infantum	56%	100%
A4HUP1	Leishmania infantum	53%	100%
A4HUP2	Leishmania infantum	57%	100%
A4HUP3	Leishmania infantum	54%	100%
A4HUP4	Leishmania infantum	50%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
Q4QH83	Leishmania major	52%	100%
Q4QH84	Leishmania major	54%	98%
Q4QH85	Leishmania major	57%	100%
Q4QH86	Leishmania major	52%	100%
Q4QH87	Leishmania major	54%	100%
Q4QH88	Leishmania major	53%	100%