DUF1861 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania major

UniProt:

Q4QH87_LEIMA

TriTrypDb:

LmjF.10.1250 , LMJLV39_100020600 , LMJSD75_100020700

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH87

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.340
CLV_C14_Caspase3-7	311	315	PF00656	0.484
CLV_C14_Caspase3-7	96	100	PF00656	0.220
CLV_NRD_NRD_1	109	111	PF00675	0.377
CLV_PCSK_KEX2_1	59	61	PF00082	0.375
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.368
CLV_PCSK_SKI1_1	115	119	PF00082	0.349
CLV_PCSK_SKI1_1	145	149	PF00082	0.335
CLV_PCSK_SKI1_1	25	29	PF00082	0.399
DOC_CDC14_PxL_1	184	192	PF14671	0.408
DOC_CYCLIN_RxL_1	21	29	PF00134	0.380
DOC_PP1_RVXF_1	57	64	PF00149	0.198
DOC_PP1_RVXF_1	9	15	PF00149	0.430
DOC_PP4_FxxP_1	157	160	PF00568	0.352
DOC_USP7_MATH_1	273	277	PF00917	0.347
DOC_USP7_MATH_1	93	97	PF00917	0.385
DOC_USP7_UBL2_3	261	265	PF12436	0.352
DOC_WW_Pin1_4	177	182	PF00397	0.501
DOC_WW_Pin1_4	260	265	PF00397	0.309
LIG_14-3-3_CanoR_1	115	120	PF00244	0.354
LIG_14-3-3_CanoR_1	159	168	PF00244	0.348
LIG_AP2alpha_2	92	94	PF02296	0.371
LIG_APCC_ABBA_1	68	73	PF00400	0.336
LIG_BIR_II_1	1	5	PF00653	0.503
LIG_BRCT_BRCA1_1	41	45	PF00533	0.352
LIG_FHA_1	178	184	PF00498	0.344
LIG_FHA_2	134	140	PF00498	0.364
LIG_FHA_2	180	186	PF00498	0.331
LIG_FHA_2	309	315	PF00498	0.376
LIG_FHA_2	4	10	PF00498	0.437
LIG_FHA_2	72	78	PF00498	0.352
LIG_IBAR_NPY_1	241	243	PF08397	0.229
LIG_LIR_Gen_1	118	128	PF02991	0.354
LIG_LIR_Gen_1	2	12	PF02991	0.390
LIG_LIR_Gen_1	216	225	PF02991	0.359
LIG_LIR_Gen_1	234	244	PF02991	0.463
LIG_LIR_Gen_1	66	72	PF02991	0.330
LIG_LIR_Gen_1	77	87	PF02991	0.369
LIG_LIR_Nem_3	118	123	PF02991	0.370
LIG_LIR_Nem_3	195	201	PF02991	0.348
LIG_LIR_Nem_3	2	7	PF02991	0.395
LIG_LIR_Nem_3	216	221	PF02991	0.365
LIG_LIR_Nem_3	231	236	PF02991	0.363
LIG_LIR_Nem_3	287	292	PF02991	0.343
LIG_LIR_Nem_3	29	33	PF02991	0.378
LIG_LIR_Nem_3	51	57	PF02991	0.367
LIG_LIR_Nem_3	66	70	PF02991	0.306
LIG_LIR_Nem_3	77	82	PF02991	0.369
LIG_PCNA_yPIPBox_3	110	120	PF02747	0.352
LIG_PDZ_Class_2	313	318	PF00595	0.436
LIG_Pex14_1	63	67	PF04695	0.278
LIG_PTB_Apo_2	232	239	PF02174	0.354
LIG_PTB_Apo_2	97	104	PF02174	0.205
LIG_REV1ctd_RIR_1	121	129	PF16727	0.309
LIG_SH2_CRK	236	240	PF00017	0.363
LIG_SH2_CRK	289	293	PF00017	0.352
LIG_SH2_GRB2like	233	236	PF00017	0.352
LIG_SH2_PTP2	67	70	PF00017	0.333
LIG_SH2_STAP1	23	27	PF00017	0.361
LIG_SH2_STAP1	236	240	PF00017	0.340
LIG_SH2_STAT5	120	123	PF00017	0.358
LIG_SH2_STAT5	133	136	PF00017	0.342
LIG_SH2_STAT5	205	208	PF00017	0.362
LIG_SH2_STAT5	220	223	PF00017	0.321
LIG_SH2_STAT5	233	236	PF00017	0.352
LIG_SH2_STAT5	243	246	PF00017	0.355
LIG_SH2_STAT5	67	70	PF00017	0.382
LIG_SH3_3	236	242	PF00018	0.352
LIG_TRFH_1	238	242	PF08558	0.352
LIG_TRFH_1	79	83	PF08558	0.294
LIG_TYR_ITSM	232	239	PF00017	0.374
LIG_WRC_WIRS_1	1	6	PF05994	0.485
LIG_WRC_WIRS_1	27	32	PF05994	0.366
MOD_CDK_SPK_2	260	265	PF00069	0.361
MOD_CK1_1	132	138	PF00069	0.328
MOD_CK1_1	216	222	PF00069	0.405
MOD_CK2_1	179	185	PF00069	0.387
MOD_CK2_1	3	9	PF00069	0.503
MOD_GlcNHglycan	275	278	PF01048	0.352
MOD_GlcNHglycan	289	292	PF01048	0.352
MOD_GlcNHglycan	41	44	PF01048	0.422
MOD_GSK3_1	129	136	PF00069	0.311
MOD_GSK3_1	155	162	PF00069	0.359
MOD_N-GLC_1	129	134	PF02516	0.228
MOD_N-GLC_1	234	239	PF02516	0.365
MOD_N-GLC_1	39	44	PF02516	0.356
MOD_NEK2_1	104	109	PF00069	0.349
MOD_NEK2_1	71	76	PF00069	0.357
MOD_NEK2_2	26	31	PF00069	0.249
MOD_PKA_2	109	115	PF00069	0.307
MOD_PKA_2	124	130	PF00069	0.311
MOD_PKA_2	298	304	PF00069	0.362
MOD_Plk_1	129	135	PF00069	0.330
MOD_Plk_1	228	234	PF00069	0.348
MOD_Plk_1	77	83	PF00069	0.369
MOD_Plk_4	129	135	PF00069	0.360
MOD_Plk_4	179	185	PF00069	0.326
MOD_Plk_4	216	222	PF00069	0.378
MOD_Plk_4	234	240	PF00069	0.347
MOD_Plk_4	308	314	PF00069	0.429
MOD_Plk_4	63	69	PF00069	0.300
MOD_ProDKin_1	177	183	PF00069	0.501
MOD_ProDKin_1	260	266	PF00069	0.309
MOD_SUMO_for_1	45	48	PF00179	0.214
MOD_SUMO_for_1	7	10	PF00179	0.397
MOD_SUMO_rev_2	5	12	PF00179	0.451
TRG_DiLeu_BaEn_4	185	191	PF01217	0.352
TRG_ENDOCYTIC_2	120	123	PF00928	0.393
TRG_ENDOCYTIC_2	218	221	PF00928	0.369
TRG_ENDOCYTIC_2	236	239	PF00928	0.392
TRG_ENDOCYTIC_2	289	292	PF00928	0.352
TRG_ENDOCYTIC_2	67	70	PF00928	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	64%	100%
A0A0N1HYU8	Leptomonas seymouri	86%	100%
A0A0N1I429	Leptomonas seymouri	55%	97%
A0A0N1I5D6	Leptomonas seymouri	57%	100%
A0A0N1I720	Leptomonas seymouri	57%	100%
A0A0N1IL04	Leptomonas seymouri	56%	100%
A0A0N1PCE9	Leptomonas seymouri	52%	99%
A0A0R6XPC0	Leishmania donovani	97%	100%
A0A3Q8IHB3	Leishmania donovani	49%	99%
A0A3S5H6H4	Leishmania donovani	54%	97%
A0A3S5H6H5	Leishmania donovani	54%	100%
A0A3S7WRC9	Leishmania donovani	64%	100%
A0A3S7WRD5	Leishmania donovani	61%	100%
A0A3S7WRE8	Leishmania donovani	56%	100%
A4H6B5	Leishmania braziliensis	50%	97%
A4H6B6	Leishmania braziliensis	49%	99%
A4H6B7	Leishmania braziliensis	91%	100%
A4H6B8	Leishmania braziliensis	59%	100%
A4H6B9	Leishmania braziliensis	54%	100%
A4H6C0	Leishmania braziliensis	63%	100%
A4H6C1	Leishmania braziliensis	56%	100%
A4HUN8	Leishmania infantum	54%	97%
A4HUN9	Leishmania infantum	49%	99%
A4HUP0	Leishmania infantum	97%	100%
A4HUP1	Leishmania infantum	61%	100%
A4HUP2	Leishmania infantum	54%	100%
A4HUP3	Leishmania infantum	64%	100%
A4HUP4	Leishmania infantum	56%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	97%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	99%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
Q4QH83	Leishmania major	56%	100%
Q4QH84	Leishmania major	64%	99%
Q4QH85	Leishmania major	54%	100%
Q4QH86	Leishmania major	60%	100%
Q4QH88	Leishmania major	50%	99%
Q4QH89	Leishmania major	54%	97%