DUF1861 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-1,2 mannoside phosphorylase, putative

Species:

Leishmania major

UniProt:

Q4QH86_LEIMA

TriTrypDb:

LmjF.10.1260 , LMJLV39_100020700 , LMJSD75_100020800

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH86

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.410
CLV_NRD_NRD_1	154	156	PF00675	0.241
CLV_PCSK_KEX2_1	12	14	PF00082	0.424
CLV_PCSK_KEX2_1	51	53	PF00082	0.409
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.465
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.401
CLV_PCSK_SKI1_1	2	6	PF00082	0.478
CLV_PCSK_SKI1_1	236	240	PF00082	0.452
DEG_COP1_1	69	77	PF00400	0.452
DEG_Nend_UBRbox_1	1	4	PF02207	0.485
DOC_CDC14_PxL_1	175	183	PF14671	0.442
DOC_CDC14_PxL_1	71	79	PF14671	0.282
DOC_CYCLIN_yCln2_LP_2	81	87	PF00134	0.379
DOC_MAPK_gen_1	12	20	PF00069	0.457
DOC_MAPK_gen_1	152	161	PF00069	0.425
DOC_MAPK_MEF2A_6	13	22	PF00069	0.474
DOC_PP4_FxxP_1	148	151	PF00568	0.385
DOC_USP7_MATH_1	310	314	PF00917	0.397
DOC_WW_Pin1_4	115	120	PF00397	0.360
LIG_APCC_ABBA_1	60	65	PF00400	0.369
LIG_BRCT_BRCA1_1	157	161	PF00533	0.328
LIG_BRCT_BRCA1_1	33	37	PF00533	0.385
LIG_FHA_2	116	122	PF00498	0.402
LIG_FHA_2	64	70	PF00498	0.385
LIG_LIR_Gen_1	158	167	PF02991	0.365
LIG_LIR_Gen_1	69	77	PF02991	0.402
LIG_LIR_Nem_3	109	114	PF02991	0.403
LIG_LIR_Nem_3	158	164	PF02991	0.368
LIG_LIR_Nem_3	186	192	PF02991	0.381
LIG_LIR_Nem_3	21	25	PF02991	0.412
LIG_LIR_Nem_3	222	227	PF02991	0.397
LIG_LIR_Nem_3	26	31	PF02991	0.397
LIG_LIR_Nem_3	278	283	PF02991	0.377
LIG_LIR_Nem_3	43	49	PF02991	0.400
LIG_LIR_Nem_3	69	74	PF02991	0.402
LIG_PDZ_Class_1	310	315	PF00595	0.548
LIG_PTB_Apo_2	223	230	PF02174	0.388
LIG_SH2_CRK	227	231	PF00017	0.396
LIG_SH2_CRK	280	284	PF00017	0.385
LIG_SH2_GRB2like	224	227	PF00017	0.385
LIG_SH2_STAP1	15	19	PF00017	0.394
LIG_SH2_STAP1	227	231	PF00017	0.373
LIG_SH2_STAT5	113	116	PF00017	0.393
LIG_SH2_STAT5	124	127	PF00017	0.376
LIG_SH2_STAT5	196	199	PF00017	0.395
LIG_SH2_STAT5	224	227	PF00017	0.385
LIG_SH2_STAT5	85	88	PF00017	0.362
LIG_SH3_3	227	233	PF00018	0.385
LIG_SH3_3	249	255	PF00018	0.369
LIG_SUMO_SIM_par_1	179	186	PF11976	0.238
LIG_TRFH_1	229	233	PF08558	0.385
LIG_TYR_ITIM	225	230	PF00017	0.385
LIG_WRC_WIRS_1	19	24	PF05994	0.399
MOD_CK2_1	115	121	PF00069	0.366
MOD_CK2_1	163	169	PF00069	0.423
MOD_Cter_Amidation	153	156	PF01082	0.241
MOD_GlcNHglycan	199	202	PF01048	0.377
MOD_GlcNHglycan	266	269	PF01048	0.385
MOD_GlcNHglycan	280	283	PF01048	0.385
MOD_GSK3_1	14	21	PF00069	0.367
MOD_GSK3_1	207	214	PF00069	0.254
MOD_GSK3_1	232	239	PF00069	0.429
MOD_GSK3_1	31	38	PF00069	0.395
MOD_N-GLC_1	31	36	PF02516	0.389
MOD_NEK2_1	197	202	PF00069	0.418
MOD_NEK2_1	63	68	PF00069	0.390
MOD_NEK2_1	95	100	PF00069	0.383
MOD_NEK2_2	245	250	PF00069	0.348
MOD_PK_1	155	161	PF00069	0.241
MOD_PKA_1	155	161	PF00069	0.241
MOD_PKA_2	289	295	PF00069	0.395
MOD_Plk_1	120	126	PF00069	0.363
MOD_Plk_1	31	37	PF00069	0.359
MOD_Plk_1	69	75	PF00069	0.402
MOD_Plk_4	106	112	PF00069	0.408
MOD_Plk_4	120	126	PF00069	0.393
MOD_Plk_4	14	20	PF00069	0.423
MOD_Plk_4	219	225	PF00069	0.394
MOD_Plk_4	299	305	PF00069	0.473
MOD_ProDKin_1	115	121	PF00069	0.360
MOD_SUMO_rev_2	248	258	PF00179	0.337
MOD_SUMO_rev_2	273	277	PF00179	0.232
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.271
TRG_ENDOCYTIC_2	111	114	PF00928	0.427
TRG_ENDOCYTIC_2	15	18	PF00928	0.427
TRG_ENDOCYTIC_2	227	230	PF00928	0.426
TRG_ENDOCYTIC_2	280	283	PF00928	0.385
TRG_ENDOCYTIC_2	46	49	PF00928	0.413
TRG_ER_diArg_1	150	153	PF00400	0.278
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	61%	100%
A0A0N1HYU8	Leptomonas seymouri	62%	99%
A0A0N1I429	Leptomonas seymouri	50%	96%
A0A0N1I5D6	Leptomonas seymouri	76%	100%
A0A0N1I720	Leptomonas seymouri	55%	100%
A0A0N1IL04	Leptomonas seymouri	66%	100%
A0A0N1PCE9	Leptomonas seymouri	51%	98%
A0A0R6XPC0	Leishmania donovani	59%	99%
A0A3Q8IHB3	Leishmania donovani	50%	98%
A0A3S5H6H4	Leishmania donovani	51%	96%
A0A3S5H6H5	Leishmania donovani	53%	100%
A0A3S7WRC9	Leishmania donovani	64%	100%
A0A3S7WRD5	Leishmania donovani	92%	100%
A0A3S7WRE8	Leishmania donovani	72%	100%
A4H6B5	Leishmania braziliensis	49%	96%
A4H6B6	Leishmania braziliensis	48%	98%
A4H6B7	Leishmania braziliensis	60%	99%
A4H6B8	Leishmania braziliensis	85%	100%
A4H6B9	Leishmania braziliensis	56%	100%
A4H6C0	Leishmania braziliensis	61%	100%
A4H6C1	Leishmania braziliensis	69%	100%
A4HUN8	Leishmania infantum	51%	96%
A4HUN9	Leishmania infantum	50%	98%
A4HUP0	Leishmania infantum	59%	99%
A4HUP1	Leishmania infantum	92%	100%
A4HUP2	Leishmania infantum	54%	100%
A4HUP3	Leishmania infantum	64%	100%
A4HUP4	Leishmania infantum	72%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	96%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	98%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	99%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QH83	Leishmania major	75%	100%
Q4QH84	Leishmania major	64%	100%
Q4QH85	Leishmania major	53%	100%
Q4QH87	Leishmania major	60%	99%
Q4QH88	Leishmania major	50%	98%
Q4QH89	Leishmania major	52%	96%