DUF1861 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania major

UniProt:

Q4QH85_LEIMA

TriTrypDb:

LmjF.10.1270 , LMJLV39_100020800 , LMJSD75_100020900

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH85

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	53	55	PF00675	0.352
CLV_PCSK_KEX2_1	238	240	PF00082	0.198
CLV_PCSK_KEX2_1	53	55	PF00082	0.375
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.198
CLV_PCSK_SKI1_1	7	11	PF00082	0.414
DEG_MDM2_SWIB_1	189	196	PF02201	0.352
DOC_CDC14_PxL_1	184	192	PF14671	0.425
DOC_PP1_RVXF_1	5	11	PF00149	0.404
DOC_USP7_MATH_1	268	272	PF00917	0.347
DOC_USP7_MATH_1	87	91	PF00917	0.385

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	56%	99%
A0A0N1HYU8	Leptomonas seymouri	55%	98%
A0A0N1I429	Leptomonas seymouri	57%	96%
A0A0N1I5D6	Leptomonas seymouri	54%	99%
A0A0N1I720	Leptomonas seymouri	68%	100%
A0A0N1IL04	Leptomonas seymouri	56%	100%
A0A0N1PCE9	Leptomonas seymouri	54%	98%
A0A0R6XPC0	Leishmania donovani	53%	98%
A0A3Q8IHB3	Leishmania donovani	53%	98%
A0A3S5H6H4	Leishmania donovani	57%	95%

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