Putative pteridine transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter, putative

Species:

Leishmania major

UniProt:

Q4QH81_LEIMA

TriTrypDb:

LmjF.10.1310 , LMJLV39_240005100 , LMJSD75_100021300

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

Q4QH81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH81

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	651	655	PF00656	0.630
CLV_NRD_NRD_1	260	262	PF00675	0.329
CLV_PCSK_KEX2_1	134	136	PF00082	0.300
CLV_PCSK_KEX2_1	192	194	PF00082	0.257
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.300
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.210
CLV_PCSK_SKI1_1	117	121	PF00082	0.360
CLV_PCSK_SKI1_1	189	193	PF00082	0.210
CLV_PCSK_SKI1_1	588	592	PF00082	0.491
CLV_PCSK_SKI1_1	81	85	PF00082	0.353
DEG_SCF_FBW7_2	17	24	PF00400	0.591
DEG_SCF_TRCP1_1	225	230	PF00400	0.204
DEG_SPOP_SBC_1	559	563	PF00917	0.467
DEG_SPOP_SBC_1	575	579	PF00917	0.253
DOC_ANK_TNKS_1	104	111	PF00023	0.509
DOC_CKS1_1	596	601	PF01111	0.441
DOC_CYCLIN_RxL_1	77	87	PF00134	0.604
DOC_CYCLIN_yClb1_LxF_4	523	529	PF00134	0.193
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.450
DOC_MAPK_gen_1	134	140	PF00069	0.507
DOC_MAPK_gen_1	261	268	PF00069	0.560
DOC_MAPK_MEF2A_6	228	235	PF00069	0.336
DOC_MAPK_MEF2A_6	499	506	PF00069	0.363
DOC_MAPK_MEF2A_6	64	71	PF00069	0.542
DOC_MAPK_NFAT4_5	64	72	PF00069	0.609
DOC_PP2B_LxvP_1	398	401	PF13499	0.450
DOC_PP2B_PxIxI_1	228	234	PF00149	0.288
DOC_PP4_FxxP_1	596	599	PF00568	0.261
DOC_USP7_MATH_1	310	314	PF00917	0.511
DOC_USP7_MATH_1	559	563	PF00917	0.447
DOC_USP7_MATH_1	575	579	PF00917	0.278
DOC_USP7_MATH_1	639	643	PF00917	0.719
DOC_USP7_UBL2_3	296	300	PF12436	0.409
DOC_USP7_UBL2_3	632	636	PF12436	0.558
DOC_USP7_UBL2_3	646	650	PF12436	0.833
DOC_USP7_UBL2_3	77	81	PF12436	0.389
DOC_WW_Pin1_4	17	22	PF00397	0.776
DOC_WW_Pin1_4	306	311	PF00397	0.536
DOC_WW_Pin1_4	42	47	PF00397	0.477
DOC_WW_Pin1_4	576	581	PF00397	0.355
DOC_WW_Pin1_4	595	600	PF00397	0.424
LIG_14-3-3_CanoR_1	351	356	PF00244	0.481
LIG_14-3-3_CanoR_1	476	480	PF00244	0.498
LIG_APCC_ABBAyCdc20_2	31	37	PF00400	0.532
LIG_BIR_III_2	43	47	PF00653	0.618
LIG_BRCT_BRCA1_1	110	114	PF00533	0.488
LIG_BRCT_BRCA1_1	123	127	PF00533	0.400
LIG_BRCT_BRCA1_1	442	446	PF00533	0.325
LIG_BRCT_BRCA1_1	544	548	PF00533	0.500
LIG_BRCT_BRCA1_1	592	596	PF00533	0.436
LIG_EH1_1	519	527	PF00400	0.379
LIG_EVH1_2	580	584	PF00568	0.366
LIG_FHA_1	118	124	PF00498	0.575
LIG_FHA_1	228	234	PF00498	0.357
LIG_FHA_1	36	42	PF00498	0.582
LIG_FHA_1	361	367	PF00498	0.388
LIG_FHA_1	376	382	PF00498	0.261
LIG_FHA_1	393	399	PF00498	0.338
LIG_FHA_1	480	486	PF00498	0.330
LIG_FHA_1	5	11	PF00498	0.705
LIG_FHA_1	54	60	PF00498	0.539
LIG_FHA_1	596	602	PF00498	0.427
LIG_FHA_1	97	103	PF00498	0.414
LIG_FHA_2	276	282	PF00498	0.547
LIG_FHA_2	326	332	PF00498	0.597
LIG_GBD_Chelix_1	71	79	PF00786	0.233
LIG_IRF3_LxIS_1	587	593	PF10401	0.403
LIG_LIR_Apic_2	30	36	PF02991	0.643
LIG_LIR_Apic_2	593	599	PF02991	0.352
LIG_LIR_Gen_1	100	109	PF02991	0.514
LIG_LIR_Gen_1	124	132	PF02991	0.524
LIG_LIR_Gen_1	184	195	PF02991	0.526
LIG_LIR_Gen_1	203	214	PF02991	0.502
LIG_LIR_Gen_1	263	273	PF02991	0.554
LIG_LIR_Gen_1	328	338	PF02991	0.556
LIG_LIR_Gen_1	377	386	PF02991	0.293
LIG_LIR_Gen_1	395	405	PF02991	0.298
LIG_LIR_Gen_1	445	454	PF02991	0.331
LIG_LIR_Gen_1	490	497	PF02991	0.330
LIG_LIR_Gen_1	545	554	PF02991	0.516
LIG_LIR_Gen_1	583	592	PF02991	0.266
LIG_LIR_Gen_1	86	96	PF02991	0.546
LIG_LIR_Nem_3	100	106	PF02991	0.453
LIG_LIR_Nem_3	124	130	PF02991	0.498
LIG_LIR_Nem_3	184	190	PF02991	0.532
LIG_LIR_Nem_3	203	209	PF02991	0.302
LIG_LIR_Nem_3	263	268	PF02991	0.540
LIG_LIR_Nem_3	328	333	PF02991	0.566
LIG_LIR_Nem_3	377	382	PF02991	0.289
LIG_LIR_Nem_3	395	400	PF02991	0.378
LIG_LIR_Nem_3	445	450	PF02991	0.307
LIG_LIR_Nem_3	45	50	PF02991	0.596
LIG_LIR_Nem_3	490	495	PF02991	0.328
LIG_LIR_Nem_3	498	503	PF02991	0.287
LIG_LIR_Nem_3	545	551	PF02991	0.477
LIG_LIR_Nem_3	583	587	PF02991	0.261
LIG_LIR_Nem_3	86	92	PF02991	0.444
LIG_NRBOX	586	592	PF00104	0.226
LIG_Pex14_1	633	637	PF04695	0.471
LIG_Pex14_2	170	174	PF04695	0.376
LIG_Pex14_2	242	246	PF04695	0.310
LIG_Pex14_2	247	251	PF04695	0.295
LIG_Pex14_2	442	446	PF04695	0.313
LIG_Pex14_2	466	470	PF04695	0.375
LIG_SH2_CRK	103	107	PF00017	0.520
LIG_SH2_CRK	137	141	PF00017	0.378
LIG_SH2_CRK	152	156	PF00017	0.332
LIG_SH2_CRK	187	191	PF00017	0.522
LIG_SH2_CRK	330	334	PF00017	0.623
LIG_SH2_CRK	358	362	PF00017	0.355
LIG_SH2_CRK	379	383	PF00017	0.314
LIG_SH2_CRK	447	451	PF00017	0.306
LIG_SH2_NCK_1	447	451	PF00017	0.308
LIG_SH2_PTP2	265	268	PF00017	0.398
LIG_SH2_PTP2	33	36	PF00017	0.636
LIG_SH2_PTP2	418	421	PF00017	0.360
LIG_SH2_PTP2	50	53	PF00017	0.649
LIG_SH2_PTP2	503	506	PF00017	0.402
LIG_SH2_SRC	33	36	PF00017	0.642
LIG_SH2_SRC	50	53	PF00017	0.574
LIG_SH2_STAP1	132	136	PF00017	0.508
LIG_SH2_STAP1	187	191	PF00017	0.494
LIG_SH2_STAP1	330	334	PF00017	0.600
LIG_SH2_STAP1	89	93	PF00017	0.544
LIG_SH2_STAT5	132	135	PF00017	0.506
LIG_SH2_STAT5	265	268	PF00017	0.475
LIG_SH2_STAT5	33	36	PF00017	0.631
LIG_SH2_STAT5	418	421	PF00017	0.351
LIG_SH2_STAT5	464	467	PF00017	0.316
LIG_SH2_STAT5	50	53	PF00017	0.610
LIG_SH2_STAT5	503	506	PF00017	0.313
LIG_SH2_STAT5	512	515	PF00017	0.297
LIG_SH2_STAT5	73	76	PF00017	0.525
LIG_SH3_3	434	440	PF00018	0.287
LIG_SH3_3	57	63	PF00018	0.528
LIG_SH3_3	605	611	PF00018	0.392
LIG_SH3_3	615	621	PF00018	0.469
LIG_SH3_4	646	653	PF00018	0.835
LIG_SUMO_SIM_anti_2	387	392	PF11976	0.443
LIG_SUMO_SIM_anti_2	493	498	PF11976	0.326
LIG_SUMO_SIM_par_1	365	370	PF11976	0.292
LIG_SUMO_SIM_par_1	493	498	PF11976	0.352
LIG_TYR_ITIM	150	155	PF00017	0.388
LIG_TYR_ITIM	381	386	PF00017	0.385
LIG_TYR_ITIM	416	421	PF00017	0.344
LIG_TYR_ITSM	326	333	PF00017	0.193
LIG_TYR_ITSM	443	450	PF00017	0.414
LIG_UBA3_1	266	270	PF00899	0.522
LIG_UBA3_1	534	541	PF00899	0.225
LIG_Vh1_VBS_1	367	385	PF01044	0.254
LIG_WRC_WIRS_1	551	556	PF05994	0.228
MOD_CDK_SPxxK_3	42	49	PF00069	0.309
MOD_CK1_1	422	428	PF00069	0.390
MOD_CK1_1	431	437	PF00069	0.416
MOD_CK1_1	471	477	PF00069	0.363
MOD_CK1_1	560	566	PF00069	0.368
MOD_CK2_1	275	281	PF00069	0.400
MOD_CK2_1	310	316	PF00069	0.285
MOD_GlcNHglycan	106	109	PF01048	0.329
MOD_GlcNHglycan	160	163	PF01048	0.360
MOD_GlcNHglycan	225	228	PF01048	0.385
MOD_GlcNHglycan	235	238	PF01048	0.382
MOD_GlcNHglycan	421	424	PF01048	0.442
MOD_GlcNHglycan	592	595	PF01048	0.327
MOD_GlcNHglycan	641	644	PF01048	0.582
MOD_GSK3_1	104	111	PF00069	0.417
MOD_GSK3_1	117	124	PF00069	0.358
MOD_GSK3_1	223	230	PF00069	0.403
MOD_GSK3_1	290	297	PF00069	0.388
MOD_GSK3_1	306	313	PF00069	0.352
MOD_GSK3_1	347	354	PF00069	0.426
MOD_GSK3_1	442	449	PF00069	0.380
MOD_GSK3_1	471	478	PF00069	0.366
MOD_GSK3_1	557	564	PF00069	0.385
MOD_GSK3_1	648	655	PF00069	0.697
MOD_GSK3_1	79	86	PF00069	0.390
MOD_N-GLC_1	351	356	PF02516	0.225
MOD_N-GLC_1	84	89	PF02516	0.388
MOD_NEK2_1	112	117	PF00069	0.387
MOD_NEK2_1	123	128	PF00069	0.353
MOD_NEK2_1	130	135	PF00069	0.292
MOD_NEK2_1	138	143	PF00069	0.349
MOD_NEK2_1	157	162	PF00069	0.331
MOD_NEK2_1	223	228	PF00069	0.363
MOD_NEK2_1	332	337	PF00069	0.520
MOD_NEK2_1	375	380	PF00069	0.385
MOD_NEK2_1	392	397	PF00069	0.299
MOD_NEK2_1	442	447	PF00069	0.360
MOD_NEK2_1	479	484	PF00069	0.384
MOD_NEK2_1	533	538	PF00069	0.313
MOD_NEK2_1	557	562	PF00069	0.361
MOD_NEK2_1	569	574	PF00069	0.344
MOD_NEK2_1	590	595	PF00069	0.464
MOD_NEK2_1	637	642	PF00069	0.537
MOD_NEK2_1	79	84	PF00069	0.368
MOD_NEK2_2	543	548	PF00069	0.225
MOD_PIKK_1	440	446	PF00454	0.225
MOD_PK_1	351	357	PF00069	0.225
MOD_PKA_2	104	110	PF00069	0.387
MOD_PKA_2	227	233	PF00069	0.227
MOD_PKA_2	475	481	PF00069	0.352
MOD_Plk_1	351	357	PF00069	0.470
MOD_Plk_1	431	437	PF00069	0.400
MOD_Plk_1	543	549	PF00069	0.306
MOD_Plk_1	84	90	PF00069	0.411
MOD_Plk_2-3	325	331	PF00069	0.498
MOD_Plk_4	299	305	PF00069	0.387
MOD_Plk_4	367	373	PF00069	0.287
MOD_Plk_4	400	406	PF00069	0.425
MOD_Plk_4	442	448	PF00069	0.445
MOD_Plk_4	475	481	PF00069	0.353
MOD_Plk_4	487	493	PF00069	0.325
MOD_Plk_4	543	549	PF00069	0.383
MOD_Plk_4	569	575	PF00069	0.344
MOD_Plk_4	625	631	PF00069	0.560
MOD_Plk_4	79	85	PF00069	0.322
MOD_ProDKin_1	17	23	PF00069	0.738
MOD_ProDKin_1	306	312	PF00069	0.399
MOD_ProDKin_1	42	48	PF00069	0.316
MOD_ProDKin_1	576	582	PF00069	0.427
MOD_ProDKin_1	595	601	PF00069	0.424
MOD_SUMO_for_1	269	272	PF00179	0.428
MOD_SUMO_rev_2	617	624	PF00179	0.418
TRG_DiLeu_BaEn_1	254	259	PF01217	0.460
TRG_DiLeu_BaEn_2	262	268	PF01217	0.315
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.285
TRG_DiLeu_BaLyEn_6	596	601	PF01217	0.331
TRG_ENDOCYTIC_2	103	106	PF00928	0.332
TRG_ENDOCYTIC_2	137	140	PF00928	0.357
TRG_ENDOCYTIC_2	152	155	PF00928	0.347
TRG_ENDOCYTIC_2	187	190	PF00928	0.348
TRG_ENDOCYTIC_2	265	268	PF00928	0.452
TRG_ENDOCYTIC_2	330	333	PF00928	0.507
TRG_ENDOCYTIC_2	358	361	PF00928	0.357
TRG_ENDOCYTIC_2	379	382	PF00928	0.367
TRG_ENDOCYTIC_2	383	386	PF00928	0.369
TRG_ENDOCYTIC_2	418	421	PF00928	0.358
TRG_ENDOCYTIC_2	447	450	PF00928	0.362
TRG_ENDOCYTIC_2	50	53	PF00928	0.492
TRG_ENDOCYTIC_2	503	506	PF00928	0.494
TRG_ENDOCYTIC_2	89	92	PF00928	0.361
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	45%	94%
A0A0N1HY49	Leptomonas seymouri	46%	98%
A0A0N1HZ06	Leptomonas seymouri	38%	100%
A0A0N1IHL1	Leptomonas seymouri	40%	92%
A0A0N1PAY4	Leptomonas seymouri	42%	75%
A0A0N1PB77	Leptomonas seymouri	40%	100%
A0A0N1PBZ2	Leptomonas seymouri	45%	98%
A0A0N1PCC1	Leptomonas seymouri	43%	99%
A0A0S4INN8	Bodo saltans	31%	100%
A0A381MBI0	Leishmania infantum	95%	100%
A0A3Q8I8X7	Leishmania donovani	94%	100%
A0A3Q8IAZ0	Leishmania donovani	44%	94%
A0A3Q8IH50	Leishmania donovani	46%	91%
A0A3Q8IVN0	Leishmania donovani	39%	100%
A0A3R7M4J1	Trypanosoma rangeli	42%	100%
A0A3S5H5P4	Leishmania donovani	45%	97%
A0A3S5H5V2	Leishmania donovani	45%	100%
A0A3S5H6F6	Leishmania donovani	43%	94%
A0A3S5H763	Leishmania donovani	47%	98%
A0A3S7WR10	Leishmania donovani	41%	88%
A0A3S7WR14	Leishmania donovani	46%	96%
A0A3S7WR15	Leishmania donovani	43%	78%
A0A3S7WR24	Leishmania donovani	44%	94%
A4H4T8	Leishmania braziliensis	44%	100%
A4H5Y4	Leishmania braziliensis	84%	100%
A4H617	Leishmania braziliensis	45%	95%
A4H618	Leishmania braziliensis	45%	96%
A4H619	Leishmania braziliensis	46%	95%
A4H620	Leishmania braziliensis	49%	93%
A4H6C3	Leishmania braziliensis	84%	100%
A4HNH7	Leishmania braziliensis	38%	100%
A4HSS2	Leishmania infantum	45%	97%
A4HUE4	Leishmania infantum	41%	88%
A4HUE5	Leishmania infantum	42%	95%
A4HUE6	Leishmania infantum	46%	96%
A4HUE7	Leishmania infantum	44%	94%
A4HUE8	Leishmania infantum	44%	94%
A4HUF4	Leishmania infantum	43%	94%
A4HUF5	Leishmania infantum	48%	100%
A4HYA9	Leishmania infantum	47%	98%
A4IC33	Leishmania infantum	39%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	95%
E9AG72	Leishmania infantum	45%	100%
E9AI40	Leishmania braziliensis	46%	97%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	97%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	88%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	93%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	98%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q4QDC4	Leishmania major	45%	100%
Q4QHH7	Leishmania major	46%	92%
Q4QHH8	Leishmania major	44%	90%
Q4QHH9	Leishmania major	44%	93%
Q4QHI0	Leishmania major	44%	95%
Q4QHI1	Leishmania major	46%	100%
Q4QHI2	Leishmania major	43%	99%
Q4QIU9	Leishmania major	46%	100%
Q4QJ48	Leishmania major	46%	97%
Q7KIP2	Leishmania major	39%	100%