Endoplasmic reticulum vesicle transporter-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative

Species:

Leishmania major

UniProt:

Q4QH78_LEIMA

TriTrypDb:

LmjF.11.0020 , LMJLV39_110005100 , LMJSD75_110005100

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	11
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	2
GO:0030135	coated vesicle	7	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QH78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.409
CLV_NRD_NRD_1	211	213	PF00675	0.518
CLV_NRD_NRD_1	231	233	PF00675	0.509
CLV_NRD_NRD_1	277	279	PF00675	0.523
CLV_NRD_NRD_1	298	300	PF00675	0.560
CLV_PCSK_KEX2_1	211	213	PF00082	0.478
CLV_PCSK_KEX2_1	298	300	PF00082	0.475
CLV_PCSK_SKI1_1	283	287	PF00082	0.551
CLV_PCSK_SKI1_1	299	303	PF00082	0.369
DOC_MAPK_gen_1	200	208	PF00069	0.265
DOC_MAPK_gen_1	298	305	PF00069	0.298
DOC_MAPK_MEF2A_6	200	208	PF00069	0.339
DOC_MAPK_MEF2A_6	298	305	PF00069	0.349
DOC_PP4_FxxP_1	2	5	PF00568	0.435
DOC_USP7_MATH_1	148	152	PF00917	0.334
DOC_USP7_MATH_1	285	289	PF00917	0.335
DOC_USP7_UBL2_3	109	113	PF12436	0.451
DOC_USP7_UBL2_3	257	261	PF12436	0.341
DOC_USP7_UBL2_3	279	283	PF12436	0.353
LIG_14-3-3_CanoR_1	329	339	PF00244	0.278
LIG_APCC_ABBA_1	161	166	PF00400	0.339
LIG_APCC_ABBA_1	60	65	PF00400	0.357
LIG_Clathr_ClatBox_1	313	317	PF01394	0.357
LIG_deltaCOP1_diTrp_1	358	363	PF00928	0.617
LIG_EVH1_2	134	138	PF00568	0.375
LIG_FHA_1	119	125	PF00498	0.378
LIG_FHA_1	172	178	PF00498	0.284
LIG_FHA_1	22	28	PF00498	0.268
LIG_FHA_1	264	270	PF00498	0.317
LIG_FHA_1	298	304	PF00498	0.298
LIG_FHA_1	90	96	PF00498	0.348
LIG_FHA_2	260	266	PF00498	0.339
LIG_FHA_2	98	104	PF00498	0.321
LIG_GBD_Chelix_1	342	350	PF00786	0.321
LIG_LIR_Nem_3	136	141	PF02991	0.380
LIG_LIR_Nem_3	14	19	PF02991	0.399
LIG_LIR_Nem_3	213	219	PF02991	0.347
LIG_Pex14_1	359	363	PF04695	0.593
LIG_Pex14_2	64	68	PF04695	0.357
LIG_SH2_SRC	290	293	PF00017	0.264
LIG_SH2_STAP1	290	294	PF00017	0.265
LIG_SH2_STAP1	46	50	PF00017	0.300
LIG_SH2_STAT3	176	179	PF00017	0.315
LIG_SH2_STAT3	292	295	PF00017	0.264
LIG_SH2_STAT5	176	179	PF00017	0.339
LIG_SH2_STAT5	268	271	PF00017	0.252
LIG_SH2_STAT5	39	42	PF00017	0.235
LIG_SH2_STAT5	91	94	PF00017	0.447
LIG_SH3_3	63	69	PF00018	0.274
LIG_SH3_5	5	9	PF00018	0.446
LIG_SUMO_SIM_anti_2	23	29	PF11976	0.258
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.279
LIG_SUMO_SIM_par_1	18	24	PF11976	0.296
LIG_SUMO_SIM_par_1	29	35	PF11976	0.296
MOD_CK1_1	21	27	PF00069	0.296
MOD_CK1_1	259	265	PF00069	0.323
MOD_CK1_1	297	303	PF00069	0.355
MOD_CK2_1	259	265	PF00069	0.339
MOD_CK2_1	285	291	PF00069	0.317
MOD_Cter_Amidation	126	129	PF01082	0.642
MOD_GlcNHglycan	135	138	PF01048	0.579
MOD_GlcNHglycan	146	149	PF01048	0.636
MOD_GlcNHglycan	188	191	PF01048	0.523
MOD_GlcNHglycan	253	256	PF01048	0.497
MOD_GlcNHglycan	291	295	PF01048	0.499
MOD_GSK3_1	144	151	PF00069	0.420
MOD_GSK3_1	251	258	PF00069	0.332
MOD_GSK3_1	259	266	PF00069	0.292
MOD_GSK3_1	273	280	PF00069	0.189
MOD_GSK3_1	286	293	PF00069	0.257
MOD_GSK3_1	44	51	PF00069	0.232
MOD_N-GLC_1	89	94	PF02516	0.545
MOD_NEK2_1	20	25	PF00069	0.448
MOD_NEK2_1	225	230	PF00069	0.264
MOD_NEK2_1	89	94	PF00069	0.378
MOD_NEK2_2	108	113	PF00069	0.448
MOD_PKA_2	186	192	PF00069	0.269
MOD_PKA_2	210	216	PF00069	0.338
MOD_PKA_2	242	248	PF00069	0.258
MOD_PKA_2	251	257	PF00069	0.262
MOD_PKA_2	277	283	PF00069	0.312
MOD_PKA_2	297	303	PF00069	0.122
MOD_PKA_2	74	80	PF00069	0.329
MOD_Plk_1	11	17	PF00069	0.498
MOD_Plk_1	225	231	PF00069	0.240
MOD_Plk_1	237	243	PF00069	0.223
MOD_Plk_1	48	54	PF00069	0.258
MOD_Plk_2-3	118	124	PF00069	0.468
MOD_Plk_4	156	162	PF00069	0.297
MOD_Plk_4	202	208	PF00069	0.332
MOD_Plk_4	23	29	PF00069	0.311
MOD_SUMO_rev_2	196	202	PF00179	0.339
TRG_DiLeu_BaEn_1	265	270	PF01217	0.357
TRG_ENDOCYTIC_2	164	167	PF00928	0.357
TRG_ER_diArg_1	210	212	PF00400	0.329
TRG_ER_diArg_1	40	43	PF00400	0.330
TRG_NLS_MonoExtN_4	125	132	PF00514	0.423
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S9	Leptomonas seymouri	58%	92%
A0A0N0P4A5	Leptomonas seymouri	24%	89%
A0A0S4JE72	Bodo saltans	26%	91%
A0A0S4JXT2	Bodo saltans	36%	86%
A0A1X0NIB7	Trypanosomatidae	24%	93%
A0A1X0NVX1	Trypanosomatidae	44%	93%
A0A3Q8IGE1	Leishmania donovani	24%	78%
A0A3R7KGP9	Trypanosoma rangeli	25%	77%
A0A3R7MPC0	Trypanosoma rangeli	42%	93%
A0A3S5H6H6	Leishmania donovani	94%	99%
A4H9V6	Leishmania braziliensis	76%	100%
A4HJ02	Leishmania braziliensis	21%	100%
A4HJR2	Leishmania braziliensis	23%	67%
A4HL28	Leishmania braziliensis	23%	100%
A4HUR4	Leishmania infantum	94%	99%
A4I779	Leishmania infantum	24%	78%
C9ZMG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	90%
C9ZWM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	90%
D0A7P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	93%
E9ANE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
E9B273	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	90%
Q09895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	94%
Q4Q5Y6	Leishmania major	24%	100%
Q4R5C3	Macaca fascicularis	23%	97%
Q4R8X1	Macaca fascicularis	28%	96%
Q54DW2	Dictyostelium discoideum	24%	95%
Q5EAE0	Bos taurus	27%	95%
Q5R8G3	Pongo abelii	28%	95%
Q66KH2	Xenopus laevis	26%	94%
Q6NVS2	Xenopus tropicalis	27%	95%
Q7T2D4	Danio rerio	24%	97%
Q803I2	Danio rerio	27%	95%
Q96RQ1	Homo sapiens	23%	97%
Q9CQE7	Mus musculus	28%	95%
Q9CR89	Mus musculus	23%	97%
Q9Y282	Homo sapiens	28%	95%
V5AS26	Trypanosoma cruzi	25%	90%
V5BGJ7	Trypanosoma cruzi	41%	93%