Gamma carbonic dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bacterial transferase hexapeptide (six repeats), putative

Species:

Leishmania major

UniProt:

Q4QH77_LEIMA

TriTrypDb:

LmjF.11.0030 , LMJLV39_110005200 , LMJSD75_110005200

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH77

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.553
CLV_C14_Caspase3-7	288	292	PF00656	0.587
CLV_C14_Caspase3-7	81	85	PF00656	0.466
CLV_NRD_NRD_1	101	103	PF00675	0.252
CLV_NRD_NRD_1	277	279	PF00675	0.620
CLV_NRD_NRD_1	283	285	PF00675	0.605
CLV_PCSK_KEX2_1	28	30	PF00082	0.481
CLV_PCSK_KEX2_1	283	285	PF00082	0.729
CLV_PCSK_KEX2_1	78	80	PF00082	0.440
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.512
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.452
CLV_PCSK_SKI1_1	220	224	PF00082	0.444
CLV_PCSK_SKI1_1	250	254	PF00082	0.621
CLV_PCSK_SKI1_1	38	42	PF00082	0.444
CLV_PCSK_SKI1_1	45	49	PF00082	0.407
CLV_PCSK_SKI1_1	71	75	PF00082	0.429
CLV_Separin_Metazoa	272	276	PF03568	0.591
DEG_Nend_Nbox_1	1	3	PF02207	0.619
DEG_ODPH_VHL_1	88	100	PF01847	0.452
DOC_CDC14_PxL_1	66	74	PF14671	0.453
DOC_MAPK_gen_1	220	230	PF00069	0.395
DOC_MAPK_gen_1	261	270	PF00069	0.551
DOC_MAPK_gen_1	28	36	PF00069	0.474
DOC_MAPK_MEF2A_6	223	230	PF00069	0.395
DOC_MAPK_MEF2A_6	28	36	PF00069	0.484
DOC_MAPK_NFAT4_5	29	37	PF00069	0.513
DOC_PP4_FxxP_1	87	90	PF00568	0.452
DOC_USP7_MATH_1	158	162	PF00917	0.351
DOC_USP7_MATH_1	222	226	PF00917	0.499
DOC_USP7_UBL2_3	74	78	PF12436	0.518
DOC_WW_Pin1_4	282	287	PF00397	0.604
LIG_14-3-3_CanoR_1	29	35	PF00244	0.428
LIG_BH_BH3_1	42	58	PF00452	0.480
LIG_BRCT_BRCA1_1	158	162	PF00533	0.351
LIG_Clathr_ClatBox_1	227	231	PF01394	0.399
LIG_deltaCOP1_diTrp_1	234	240	PF00928	0.441
LIG_eIF4E_1	67	73	PF01652	0.450
LIG_FHA_1	181	187	PF00498	0.272
LIG_FHA_1	2	8	PF00498	0.553
LIG_FHA_1	46	52	PF00498	0.526
LIG_FHA_1	93	99	PF00498	0.504
LIG_FHA_2	142	148	PF00498	0.389
LIG_FHA_2	209	215	PF00498	0.430
LIG_FHA_2	237	243	PF00498	0.454
LIG_FHA_2	283	289	PF00498	0.613
LIG_FHA_2	79	85	PF00498	0.378
LIG_LIR_Apic_2	64	70	PF02991	0.479
LIG_LIR_Apic_2	84	90	PF02991	0.320
LIG_LIR_Gen_1	237	245	PF02991	0.453
LIG_LIR_Gen_1	30	36	PF02991	0.483
LIG_LIR_Nem_3	237	243	PF02991	0.456
LIG_LIR_Nem_3	251	256	PF02991	0.470
LIG_LIR_Nem_3	30	34	PF02991	0.489
LIG_Pex14_2	2	6	PF04695	0.646
LIG_SH2_CRK	108	112	PF00017	0.452
LIG_SH2_CRK	67	71	PF00017	0.468
LIG_SH2_SRC	256	259	PF00017	0.597
LIG_SH2_STAT5	105	108	PF00017	0.452
LIG_SH2_STAT5	269	272	PF00017	0.559
LIG_SH2_STAT5	31	34	PF00017	0.473
LIG_SH3_2	273	278	PF14604	0.603
LIG_SH3_3	270	276	PF00018	0.588
LIG_SUMO_SIM_par_1	225	231	PF11976	0.414
LIG_SUMO_SIM_par_1	48	55	PF11976	0.491
LIG_TRAF2_1	239	242	PF00917	0.462
LIG_TRAF2_2	18	23	PF00917	0.530
LIG_TYR_ITIM	106	111	PF00017	0.452
LIG_WW_3	272	276	PF00397	0.591
MOD_CK1_1	174	180	PF00069	0.473
MOD_CK2_1	141	147	PF00069	0.388
MOD_CK2_1	170	176	PF00069	0.472
MOD_CK2_1	208	214	PF00069	0.430
MOD_CK2_1	236	242	PF00069	0.452
MOD_CK2_1	256	262	PF00069	0.275
MOD_CK2_1	282	288	PF00069	0.599
MOD_Cter_Amidation	100	103	PF01082	0.252
MOD_Cter_Amidation	281	284	PF01082	0.691
MOD_Cter_Amidation	76	79	PF01082	0.479
MOD_GlcNHglycan	11	14	PF01048	0.593
MOD_GlcNHglycan	153	156	PF01048	0.407
MOD_GlcNHglycan	165	168	PF01048	0.358
MOD_GlcNHglycan	176	179	PF01048	0.333
MOD_GlcNHglycan	194	197	PF01048	0.267
MOD_GlcNHglycan	75	78	PF01048	0.464
MOD_GlcNHglycan	90	93	PF01048	0.187
MOD_GSK3_1	132	139	PF00069	0.373
MOD_GSK3_1	170	177	PF00069	0.431
MOD_GSK3_1	232	239	PF00069	0.409
MOD_GSK3_1	88	95	PF00069	0.447
MOD_N-GLC_1	136	141	PF02516	0.447
MOD_N-GLC_1	208	213	PF02516	0.324
MOD_NEK2_1	1	6	PF00069	0.597
MOD_NEK2_1	122	127	PF00069	0.372
MOD_NEK2_1	170	175	PF00069	0.457
MOD_NEK2_1	180	185	PF00069	0.467
MOD_NEK2_1	299	304	PF00069	0.590
MOD_NEK2_1	73	78	PF00069	0.479
MOD_PK_1	171	177	PF00069	0.486
MOD_PKA_1	78	84	PF00069	0.417
MOD_PKA_2	78	84	PF00069	0.316
MOD_Plk_1	136	142	PF00069	0.490
MOD_Plk_1	236	242	PF00069	0.471
MOD_Plk_4	158	164	PF00069	0.343
MOD_Plk_4	176	182	PF00069	0.362
MOD_Plk_4	222	228	PF00069	0.479
MOD_Plk_4	78	84	PF00069	0.328
MOD_ProDKin_1	282	288	PF00069	0.599
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.409
TRG_ENDOCYTIC_2	108	111	PF00928	0.452
TRG_ENDOCYTIC_2	31	34	PF00928	0.512
TRG_ER_diArg_1	2	5	PF00400	0.565
TRG_NLS_MonoExtN_4	275	282	PF00514	0.727

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A3	Leptomonas seymouri	82%	100%
A0A0N1ICC0	Leptomonas seymouri	26%	100%
A0A0S4JVD5	Bodo saltans	64%	96%
A0A1X0NVC1	Trypanosomatidae	71%	100%
A0A3S7WQ41	Leishmania donovani	26%	100%
A0A3S7WRH8	Leishmania donovani	97%	100%
A4H585	Leishmania braziliensis	24%	100%
A4H9V5	Leishmania braziliensis	91%	100%
A4HTG9	Leishmania infantum	26%	100%
A4HUR5	Leishmania infantum	97%	100%
C9ZPP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A7P7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AM97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ANE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QIF1	Leishmania major	26%	100%
Q54JC2	Dictyostelium discoideum	30%	100%
Q9C6B3	Arabidopsis thaliana	33%	100%
V5BBY5	Trypanosoma cruzi	74%	100%