GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GRIP domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QH73_LEIMA

TriTrypDb:

LmjF.11.0070 , LMJLV39_110005600 , LMJLV39_110005700 , LMJSD75_110005600

Length:

1334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.505
CLV_C14_Caspase3-7	8	12	PF00656	0.471
CLV_NRD_NRD_1	1013	1015	PF00675	0.423
CLV_NRD_NRD_1	1168	1170	PF00675	0.689
CLV_NRD_NRD_1	352	354	PF00675	0.519
CLV_PCSK_KEX2_1	1142	1144	PF00082	0.743
CLV_PCSK_KEX2_1	1254	1256	PF00082	0.577
CLV_PCSK_KEX2_1	352	354	PF00082	0.519
CLV_PCSK_PC1ET2_1	1142	1144	PF00082	0.743
CLV_PCSK_PC1ET2_1	1254	1256	PF00082	0.695
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.519
CLV_PCSK_SKI1_1	1000	1004	PF00082	0.620
CLV_PCSK_SKI1_1	3	7	PF00082	0.681
CLV_PCSK_SKI1_1	356	360	PF00082	0.572
CLV_PCSK_SKI1_1	457	461	PF00082	0.505
CLV_PCSK_SKI1_1	46	50	PF00082	0.480
CLV_PCSK_SKI1_1	62	66	PF00082	0.654
CLV_PCSK_SKI1_1	825	829	PF00082	0.568
CLV_Separin_Metazoa	1112	1116	PF03568	0.655
DEG_APCC_KENBOX_2	1247	1251	PF00400	0.684
DEG_COP1_1	283	293	PF00400	0.592
DEG_Nend_UBRbox_2	1	3	PF02207	0.665
DEG_SPOP_SBC_1	310	314	PF00917	0.742
DOC_CKS1_1	338	343	PF01111	0.661
DOC_MAPK_gen_1	1237	1247	PF00069	0.444
DOC_MAPK_gen_1	356	365	PF00069	0.664
DOC_MAPK_gen_1	44	51	PF00069	0.649
DOC_MAPK_MEF2A_6	1105	1113	PF00069	0.446
DOC_MAPK_MEF2A_6	1275	1284	PF00069	0.616
DOC_PP4_MxPP_1	317	320	PF00568	0.645
DOC_USP7_MATH_1	1025	1029	PF00917	0.497
DOC_USP7_MATH_1	1094	1098	PF00917	0.557
DOC_USP7_MATH_1	1205	1209	PF00917	0.649
DOC_USP7_MATH_1	310	314	PF00917	0.753
DOC_USP7_MATH_1	449	453	PF00917	0.457
DOC_USP7_MATH_1	817	821	PF00917	0.469
DOC_USP7_UBL2_3	444	448	PF12436	0.536
DOC_USP7_UBL2_3	58	62	PF12436	0.682
DOC_USP7_UBL2_3	812	816	PF12436	0.589
DOC_USP7_UBL2_3	996	1000	PF12436	0.615
DOC_WW_Pin1_4	1043	1048	PF00397	0.615
DOC_WW_Pin1_4	1194	1199	PF00397	0.802
DOC_WW_Pin1_4	284	289	PF00397	0.779
DOC_WW_Pin1_4	318	323	PF00397	0.839
DOC_WW_Pin1_4	337	342	PF00397	0.493
DOC_WW_Pin1_4	91	96	PF00397	0.718
LIG_14-3-3_CanoR_1	1026	1034	PF00244	0.411
LIG_14-3-3_CanoR_1	1143	1151	PF00244	0.746
LIG_Actin_WH2_2	1102	1119	PF00022	0.655
LIG_deltaCOP1_diTrp_1	1071	1078	PF00928	0.558
LIG_FHA_1	1087	1093	PF00498	0.613
LIG_FHA_1	1156	1162	PF00498	0.694
LIG_FHA_1	139	145	PF00498	0.446
LIG_FHA_1	92	98	PF00498	0.578
LIG_FHA_2	1144	1150	PF00498	0.745
LIG_FHA_2	1309	1315	PF00498	0.539
LIG_FHA_2	134	140	PF00498	0.594
LIG_FHA_2	235	241	PF00498	0.605
LIG_FHA_2	259	265	PF00498	0.528
LIG_FHA_2	26	32	PF00498	0.665
LIG_FHA_2	338	344	PF00498	0.576
LIG_FHA_2	369	375	PF00498	0.572
LIG_FHA_2	54	60	PF00498	0.645
LIG_FHA_2	63	69	PF00498	0.561
LIG_GBD_Chelix_1	32	40	PF00786	0.679
LIG_HCF-1_HBM_1	325	328	PF13415	0.730
LIG_LIR_Gen_1	181	189	PF02991	0.487
LIG_LIR_Nem_3	1077	1081	PF02991	0.583
LIG_LIR_Nem_3	181	186	PF02991	0.512
LIG_PCNA_yPIPBox_3	1254	1268	PF02747	0.680
LIG_REV1ctd_RIR_1	2	11	PF16727	0.683
LIG_SH2_CRK	47	51	PF00017	0.654
LIG_SH2_SRC	151	154	PF00017	0.655
LIG_SH2_STAP1	47	51	PF00017	0.654
LIG_SH2_STAT5	1091	1094	PF00017	0.630
LIG_SH2_STAT5	1267	1270	PF00017	0.658
LIG_SH2_STAT5	1286	1289	PF00017	0.248
LIG_SH2_STAT5	1294	1297	PF00017	0.417
LIG_SH2_STAT5	151	154	PF00017	0.655
LIG_SH3_3	1041	1047	PF00018	0.481
LIG_SH3_3	1325	1331	PF00018	0.728
LIG_SH3_3	285	291	PF00018	0.784
LIG_SH3_3	316	322	PF00018	0.767
LIG_SH3_3	335	341	PF00018	0.488
LIG_SUMO_SIM_anti_2	1110	1115	PF11976	0.444
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.699
LIG_TRAF2_1	15	18	PF00917	0.696
LIG_TRAF2_1	182	185	PF00917	0.697
LIG_TRAF2_1	237	240	PF00917	0.733
LIG_TRAF2_1	322	325	PF00917	0.730
LIG_TRAF2_1	459	462	PF00917	0.586
LIG_TRAF2_1	827	830	PF00917	0.649
LIG_WRC_WIRS_1	1222	1227	PF05994	0.685
MOD_CDK_SPxxK_3	91	98	PF00069	0.715
MOD_CK1_1	1119	1125	PF00069	0.672
MOD_CK1_1	1197	1203	PF00069	0.736
MOD_CK1_1	1228	1234	PF00069	0.599
MOD_CK1_1	241	247	PF00069	0.693
MOD_CK1_1	281	287	PF00069	0.590
MOD_CK1_1	67	73	PF00069	0.688
MOD_CK2_1	1039	1045	PF00069	0.564
MOD_CK2_1	1050	1056	PF00069	0.536
MOD_CK2_1	1143	1149	PF00069	0.677
MOD_CK2_1	128	134	PF00069	0.683
MOD_CK2_1	1308	1314	PF00069	0.539
MOD_CK2_1	179	185	PF00069	0.711
MOD_CK2_1	220	226	PF00069	0.731
MOD_CK2_1	234	240	PF00069	0.529
MOD_CK2_1	25	31	PF00069	0.446
MOD_CK2_1	277	283	PF00069	0.795
MOD_CK2_1	318	324	PF00069	0.752
MOD_CK2_1	337	343	PF00069	0.494
MOD_CK2_1	368	374	PF00069	0.521
MOD_CK2_1	53	59	PF00069	0.637
MOD_CK2_1	536	542	PF00069	0.649
MOD_CK2_1	991	997	PF00069	0.615
MOD_GlcNHglycan	1006	1009	PF01048	0.505
MOD_GlcNHglycan	1096	1099	PF01048	0.646
MOD_GlcNHglycan	1123	1126	PF01048	0.611
MOD_GlcNHglycan	1203	1206	PF01048	0.665
MOD_GlcNHglycan	223	226	PF01048	0.741
MOD_GlcNHglycan	313	316	PF01048	0.746
MOD_GSK3_1	1004	1011	PF00069	0.500
MOD_GSK3_1	1039	1046	PF00069	0.521
MOD_GSK3_1	1156	1163	PF00069	0.606
MOD_GSK3_1	1197	1204	PF00069	0.728
MOD_GSK3_1	1221	1228	PF00069	0.589
MOD_GSK3_1	1232	1239	PF00069	0.477
MOD_GSK3_1	128	135	PF00069	0.685
MOD_GSK3_1	234	241	PF00069	0.739
MOD_GSK3_1	27	34	PF00069	0.552
MOD_GSK3_1	274	281	PF00069	0.643
MOD_GSK3_1	49	56	PF00069	0.593
MOD_N-GLC_1	1008	1013	PF02516	0.415
MOD_N-GLC_1	1201	1206	PF02516	0.679
MOD_N-GLC_1	204	209	PF02516	0.694
MOD_N-GLC_1	227	232	PF02516	0.680
MOD_N-GLC_1	284	289	PF02516	0.805
MOD_N-GLC_2	1039	1041	PF02516	0.385
MOD_NEK2_1	1004	1009	PF00069	0.439
MOD_NEK2_1	1225	1230	PF00069	0.560
MOD_NEK2_1	1236	1241	PF00069	0.551
MOD_NEK2_1	1313	1318	PF00069	0.564
MOD_NEK2_1	238	243	PF00069	0.584
MOD_NEK2_1	49	54	PF00069	0.641
MOD_NEK2_1	5	10	PF00069	0.549
MOD_NEK2_1	536	541	PF00069	0.583
MOD_PIKK_1	1143	1149	PF00454	0.743
MOD_PIKK_1	1228	1234	PF00454	0.599
MOD_PIKK_1	138	144	PF00454	0.529
MOD_PIKK_1	151	157	PF00454	0.602
MOD_PIKK_1	229	235	PF00454	0.636
MOD_PIKK_1	449	455	PF00454	0.520
MOD_PIKK_1	536	542	PF00454	0.614
MOD_PIKK_1	74	80	PF00454	0.681
MOD_PIKK_1	817	823	PF00454	0.533
MOD_PKA_1	1142	1148	PF00069	0.742
MOD_PKA_1	6	12	PF00069	0.691
MOD_PKA_2	1004	1010	PF00069	0.585
MOD_PKA_2	1025	1031	PF00069	0.402
MOD_PKA_2	1142	1148	PF00069	0.742
MOD_PKA_2	1149	1155	PF00069	0.642
MOD_PKA_2	1228	1234	PF00069	0.599
MOD_PKA_2	277	283	PF00069	0.795
MOD_Plk_1	1008	1014	PF00069	0.416
MOD_Plk_1	1119	1125	PF00069	0.672
MOD_Plk_1	1201	1207	PF00069	0.675
MOD_Plk_1	133	139	PF00069	0.694
MOD_Plk_1	204	210	PF00069	0.657
MOD_Plk_1	227	233	PF00069	0.681
MOD_Plk_1	263	269	PF00069	0.761
MOD_Plk_1	278	284	PF00069	0.572
MOD_Plk_1	67	73	PF00069	0.604
MOD_Plk_2-3	1149	1155	PF00069	0.749
MOD_Plk_2-3	161	167	PF00069	0.645
MOD_Plk_2-3	199	205	PF00069	0.716
MOD_Plk_2-3	234	240	PF00069	0.743
MOD_Plk_4	1205	1211	PF00069	0.646
MOD_Plk_4	1221	1227	PF00069	0.434
MOD_Plk_4	1308	1314	PF00069	0.539
MOD_Plk_4	212	218	PF00069	0.697
MOD_ProDKin_1	1043	1049	PF00069	0.618
MOD_ProDKin_1	1194	1200	PF00069	0.792
MOD_ProDKin_1	284	290	PF00069	0.780
MOD_ProDKin_1	318	324	PF00069	0.835
MOD_ProDKin_1	337	343	PF00069	0.496
MOD_ProDKin_1	91	97	PF00069	0.717
MOD_SUMO_for_1	1253	1256	PF00179	0.696
MOD_SUMO_for_1	15	18	PF00179	0.696
MOD_SUMO_rev_2	1138	1144	PF00179	0.732
MOD_SUMO_rev_2	182	191	PF00179	0.615
MOD_SUMO_rev_2	37	45	PF00179	0.649
MOD_SUMO_rev_2	425	431	PF00179	0.556
MOD_SUMO_rev_2	793	799	PF00179	0.568
MOD_SUMO_rev_2	977	983	PF00179	0.525
TRG_DiLeu_BaEn_1	17	22	PF01217	0.701
TRG_DiLeu_BaEn_1	437	442	PF01217	0.435
TRG_DiLeu_BaEn_1	805	810	PF01217	0.445
TRG_DiLeu_BaEn_4	17	23	PF01217	0.699
TRG_DiLeu_BaEn_4	509	515	PF01217	0.700
TRG_DiLeu_BaEn_4	555	561	PF01217	0.811
TRG_DiLeu_BaEn_4	601	607	PF01217	0.647
TRG_DiLeu_BaEn_4	647	653	PF01217	0.823
TRG_DiLeu_BaEn_4	693	699	PF01217	0.817
TRG_DiLeu_BaEn_4	739	745	PF01217	0.747
TRG_DiLeu_BaEn_4	831	837	PF01217	0.686
TRG_DiLeu_BaEn_4	877	883	PF01217	0.745
TRG_DiLeu_BaEn_4	923	929	PF01217	0.777
TRG_ENDOCYTIC_2	47	50	PF00928	0.656
TRG_ER_diArg_1	1161	1164	PF00400	0.685
TRG_ER_diArg_1	69	72	PF00400	0.686
TRG_NES_CRM1_1	142	153	PF08389	0.651
TRG_NES_CRM1_1	265	279	PF08389	0.763
TRG_NES_CRM1_1	432	445	PF08389	0.438
TRG_NES_CRM1_1	800	813	PF08389	0.448
TRG_NLS_MonoExtC_3	351	356	PF00514	0.515
TRG_NLS_MonoExtN_4	352	357	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	1288	1292	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.736
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.705

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6H7	Leishmania donovani	87%	89%
A4HUR9	Leishmania infantum	69%	100%
E9ANF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	85%