RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH72_LEIMA

TriTrypDb:

LmjF.11.0080 , LMJLV39_110005800 , LMJSD75_110005700

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH72

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.542
CLV_NRD_NRD_1	180	182	PF00675	0.515
CLV_NRD_NRD_1	32	34	PF00675	0.633
CLV_NRD_NRD_1	76	78	PF00675	0.687
CLV_PCSK_KEX2_1	3	5	PF00082	0.592
CLV_PCSK_KEX2_1	30	32	PF00082	0.634
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.608
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.656
CLV_PCSK_PC7_1	27	33	PF00082	0.648
CLV_PCSK_SKI1_1	103	107	PF00082	0.267
CLV_PCSK_SKI1_1	153	157	PF00082	0.574
CLV_PCSK_SKI1_1	203	207	PF00082	0.554
CLV_PCSK_SKI1_1	78	82	PF00082	0.642
DOC_PP4_FxxP_1	92	95	PF00568	0.606
DOC_USP7_UBL2_3	173	177	PF12436	0.639
DOC_USP7_UBL2_3	216	220	PF12436	0.747
DOC_USP7_UBL2_3	74	78	PF12436	0.638
LIG_14-3-3_CanoR_1	176	180	PF00244	0.578
LIG_FHA_1	49	55	PF00498	0.657
LIG_FHA_2	102	108	PF00498	0.501
LIG_LIR_Gen_1	127	134	PF02991	0.485
LIG_LIR_Nem_3	104	109	PF02991	0.487
LIG_LIR_Nem_3	127	132	PF02991	0.485
LIG_PCNA_yPIPBox_3	81	93	PF02747	0.494
LIG_Pex14_2	201	205	PF04695	0.496
LIG_WRC_WIRS_1	131	136	PF05994	0.476
MOD_CK1_1	63	69	PF00069	0.700
MOD_CK2_1	101	107	PF00069	0.517
MOD_Cter_Amidation	1	4	PF01082	0.714
MOD_GlcNHglycan	209	212	PF01048	0.679
MOD_GSK3_1	165	172	PF00069	0.656
MOD_GSK3_1	48	55	PF00069	0.652
MOD_GSK3_1	56	63	PF00069	0.627
MOD_N-GLC_1	124	129	PF02516	0.287
MOD_NEK2_1	124	129	PF00069	0.504
MOD_NEK2_1	147	152	PF00069	0.501
MOD_NEK2_1	156	161	PF00069	0.539
MOD_NEK2_1	165	170	PF00069	0.518
MOD_NEK2_2	101	106	PF00069	0.517
MOD_NEK2_2	130	135	PF00069	0.476
MOD_NEK2_2	157	162	PF00069	0.665
MOD_PIKK_1	124	130	PF00454	0.512
MOD_PKA_1	73	79	PF00069	0.726
MOD_PKA_1	81	87	PF00069	0.698
MOD_PKA_2	175	181	PF00069	0.574
MOD_PKA_2	76	82	PF00069	0.713
MOD_Plk_1	124	130	PF00069	0.487
MOD_SUMO_for_1	111	114	PF00179	0.501
MOD_SUMO_for_1	72	75	PF00179	0.652
MOD_SUMO_rev_2	107	113	PF00179	0.487
TRG_DiLeu_BaEn_1	188	193	PF01217	0.608
TRG_DiLeu_BaEn_4	194	200	PF01217	0.587
TRG_ER_diArg_1	31	33	PF00400	0.643
TRG_NLS_MonoCore_2	29	34	PF00514	0.698
TRG_NLS_MonoExtC_3	180	186	PF00514	0.523
TRG_NLS_MonoExtN_4	27	34	PF00514	0.667
TRG_NLS_MonoExtN_4	78	85	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P3	Leptomonas seymouri	76%	100%
A0A0S4JVA8	Bodo saltans	53%	100%
A0A1X0NV88	Trypanosomatidae	60%	100%
A0A3R7KAH2	Trypanosoma rangeli	55%	100%
A0A3S7WRD9	Leishmania donovani	92%	100%
A4H9V0	Leishmania braziliensis	82%	100%
A4HUS0	Leishmania infantum	92%	100%
D0A7P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ANF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BRH6	Trypanosoma cruzi	53%	82%