MORN repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat, putative

Species:

Leishmania major

UniProt:

Q4QH71_LEIMA

TriTrypDb:

LmjF.11.0090 , LMJLV39_110005900 , LMJSD75_110005800

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.594
CLV_C14_Caspase3-7	510	514	PF00656	0.502
CLV_MEL_PAP_1	274	280	PF00089	0.543
CLV_NRD_NRD_1	123	125	PF00675	0.270
CLV_NRD_NRD_1	521	523	PF00675	0.663
CLV_PCSK_KEX2_1	123	125	PF00082	0.326
CLV_PCSK_KEX2_1	392	394	PF00082	0.654
CLV_PCSK_KEX2_1	521	523	PF00082	0.663
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.590
CLV_PCSK_SKI1_1	130	134	PF00082	0.306
CLV_PCSK_SKI1_1	228	232	PF00082	0.560
CLV_PCSK_SKI1_1	302	306	PF00082	0.641
CLV_PCSK_SKI1_1	521	525	PF00082	0.656
CLV_Separin_Metazoa	289	293	PF03568	0.522
DEG_APCC_DBOX_1	411	419	PF00400	0.598
DEG_COP1_1	187	197	PF00400	0.590
DEG_Nend_UBRbox_1	1	4	PF02207	0.270
DOC_CKS1_1	101	106	PF01111	0.381
DOC_CYCLIN_RxL_1	222	235	PF00134	0.629
DOC_PP1_RVXF_1	433	439	PF00149	0.613
DOC_SPAK_OSR1_1	277	281	PF12202	0.419
DOC_USP7_MATH_1	11	15	PF00917	0.352
DOC_USP7_MATH_1	136	140	PF00917	0.292
DOC_USP7_MATH_1	348	352	PF00917	0.568
DOC_USP7_MATH_1	77	81	PF00917	0.403
DOC_USP7_UBL2_3	228	232	PF12436	0.568
DOC_USP7_UBL2_3	69	73	PF12436	0.342
DOC_WW_Pin1_4	186	191	PF00397	0.676
DOC_WW_Pin1_4	195	200	PF00397	0.700
DOC_WW_Pin1_4	44	49	PF00397	0.342
DOC_WW_Pin1_4	96	101	PF00397	0.504
LIG_14-3-3_CanoR_1	222	228	PF00244	0.522
LIG_14-3-3_CanoR_1	258	268	PF00244	0.613
LIG_14-3-3_CanoR_1	302	308	PF00244	0.564
LIG_14-3-3_CanoR_1	32	39	PF00244	0.258
LIG_14-3-3_CanoR_1	332	338	PF00244	0.464
LIG_14-3-3_CanoR_1	367	375	PF00244	0.627
LIG_14-3-3_CanoR_1	406	412	PF00244	0.648
LIG_14-3-3_CanoR_1	446	451	PF00244	0.654
LIG_BRCT_BRCA1_1	59	63	PF00533	0.433
LIG_FAT_LD_1	512	520	PF03623	0.479
LIG_FHA_1	155	161	PF00498	0.352
LIG_FHA_1	213	219	PF00498	0.617
LIG_FHA_1	260	266	PF00498	0.635
LIG_FHA_1	308	314	PF00498	0.526
LIG_FHA_1	33	39	PF00498	0.406
LIG_FHA_1	369	375	PF00498	0.589
LIG_FHA_1	379	385	PF00498	0.563
LIG_FHA_1	97	103	PF00498	0.636
LIG_FHA_2	183	189	PF00498	0.737
LIG_FHA_2	206	212	PF00498	0.669
LIG_FHA_2	244	250	PF00498	0.582
LIG_FHA_2	453	459	PF00498	0.733
LIG_FHA_2	497	503	PF00498	0.580
LIG_FHA_2	508	514	PF00498	0.546
LIG_LIR_Apic_2	105	110	PF02991	0.446
LIG_LIR_Gen_1	487	498	PF02991	0.503
LIG_LIR_Gen_1	83	93	PF02991	0.543
LIG_LIR_Nem_3	229	234	PF02991	0.553
LIG_LIR_Nem_3	320	326	PF02991	0.609
LIG_LIR_Nem_3	487	493	PF02991	0.515
LIG_NRBOX	201	207	PF00104	0.665
LIG_PCNA_yPIPBox_3	222	231	PF02747	0.519
LIG_SH2_CRK	107	111	PF00017	0.560
LIG_SH2_NCK_1	107	111	PF00017	0.496
LIG_SH2_SRC	135	138	PF00017	0.285
LIG_SH2_STAT5	118	121	PF00017	0.314
LIG_SH3_3	238	244	PF00018	0.674
LIG_SUMO_SIM_anti_2	310	316	PF11976	0.436
LIG_TRAF2_1	170	173	PF00917	0.568
LIG_TRAF2_1	176	179	PF00917	0.586
LIG_TRAF2_1	185	188	PF00917	0.520
MOD_CK1_1	189	195	PF00069	0.722
MOD_CK1_1	235	241	PF00069	0.651
MOD_CK1_1	276	282	PF00069	0.639
MOD_CK1_1	359	365	PF00069	0.708
MOD_CK1_1	410	416	PF00069	0.567
MOD_CK1_1	44	50	PF00069	0.342
MOD_CK1_1	80	86	PF00069	0.452
MOD_CK1_1	96	102	PF00069	0.400
MOD_CK2_1	11	17	PF00069	0.319
MOD_CK2_1	136	142	PF00069	0.317
MOD_CK2_1	167	173	PF00069	0.489
MOD_CK2_1	182	188	PF00069	0.694
MOD_CK2_1	452	458	PF00069	0.680
MOD_CK2_1	486	492	PF00069	0.488
MOD_CK2_1	496	502	PF00069	0.445
MOD_GlcNHglycan	150	153	PF01048	0.404
MOD_GlcNHglycan	157	160	PF01048	0.425
MOD_GlcNHglycan	237	240	PF01048	0.693
MOD_GlcNHglycan	350	353	PF01048	0.621
MOD_GlcNHglycan	361	364	PF01048	0.712
MOD_GlcNHglycan	428	431	PF01048	0.432
MOD_GlcNHglycan	468	471	PF01048	0.710
MOD_GlcNHglycan	58	62	PF01048	0.509
MOD_GlcNHglycan	78	82	PF01048	0.150
MOD_GSK3_1	182	189	PF00069	0.683
MOD_GSK3_1	222	229	PF00069	0.575
MOD_GSK3_1	303	310	PF00069	0.596
MOD_GSK3_1	359	366	PF00069	0.684
MOD_GSK3_1	374	381	PF00069	0.684
MOD_GSK3_1	442	449	PF00069	0.714
MOD_GSK3_1	77	84	PF00069	0.406
MOD_GSK3_1	96	103	PF00069	0.531
MOD_N-GLC_1	166	171	PF02516	0.623
MOD_N-GLC_1	223	228	PF02516	0.514
MOD_N-GLC_2	28	30	PF02516	0.342
MOD_NEK2_1	212	217	PF00069	0.601
MOD_NEK2_1	259	264	PF00069	0.593
MOD_NEK2_1	307	312	PF00069	0.497
MOD_NEK2_1	31	36	PF00069	0.342
MOD_NEK2_1	354	359	PF00069	0.552
MOD_NEK2_1	418	423	PF00069	0.567
MOD_NEK2_1	466	471	PF00069	0.539
MOD_NEK2_1	493	498	PF00069	0.579
MOD_NEK2_1	93	98	PF00069	0.648
MOD_NEK2_2	11	16	PF00069	0.346
MOD_NEK2_2	136	141	PF00069	0.363
MOD_NEK2_2	223	228	PF00069	0.554
MOD_NEK2_2	407	412	PF00069	0.584
MOD_PIKK_1	102	108	PF00454	0.474
MOD_PIKK_1	259	265	PF00454	0.542
MOD_PIKK_1	4	10	PF00454	0.342
MOD_PKA_2	257	263	PF00069	0.647
MOD_PKA_2	276	282	PF00069	0.523
MOD_PKA_2	31	37	PF00069	0.380
MOD_PKA_2	359	365	PF00069	0.565
MOD_PKB_1	505	513	PF00069	0.514
MOD_Plk_1	223	229	PF00069	0.604
MOD_Plk_1	486	492	PF00069	0.557
MOD_Plk_2-3	397	403	PF00069	0.588
MOD_Plk_4	11	17	PF00069	0.293
MOD_Plk_4	189	195	PF00069	0.736
MOD_Plk_4	226	232	PF00069	0.580
MOD_Plk_4	309	315	PF00069	0.504
MOD_Plk_4	369	375	PF00069	0.598
MOD_Plk_4	486	492	PF00069	0.519
MOD_Plk_4	493	499	PF00069	0.428
MOD_Plk_4	81	87	PF00069	0.263
MOD_ProDKin_1	186	192	PF00069	0.676
MOD_ProDKin_1	195	201	PF00069	0.697
MOD_ProDKin_1	44	50	PF00069	0.342
MOD_ProDKin_1	96	102	PF00069	0.496
MOD_SUMO_rev_2	66	74	PF00179	0.425
TRG_ENDOCYTIC_2	323	326	PF00928	0.463
TRG_ENDOCYTIC_2	395	398	PF00928	0.592
TRG_ENDOCYTIC_2	64	67	PF00928	0.343
TRG_ENDOCYTIC_2	85	88	PF00928	0.491
TRG_ER_diArg_1	122	124	PF00400	0.270
TRG_ER_diArg_1	521	523	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	521	526	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV83	Leptomonas seymouri	52%	78%
A0A1X0NVA0	Trypanosomatidae	32%	78%
A0A3Q8IHC4	Leishmania donovani	96%	100%
A0A3R7LGF2	Trypanosoma rangeli	31%	81%
A4H9U9	Leishmania braziliensis	84%	79%
A4HUS1	Leishmania infantum	96%	100%
D0A7P2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	81%
E9ANF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BB15	Trypanosoma cruzi	38%	81%