Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH68_LEIMA

TriTrypDb:

LmjF.11.0120 , LMJLV39_110006200 , LMJSD75_110006100

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.427
CLV_NRD_NRD_1	9	11	PF00675	0.431
CLV_NRD_NRD_1	93	95	PF00675	0.385
CLV_PCSK_KEX2_1	131	133	PF00082	0.439
CLV_PCSK_KEX2_1	9	11	PF00082	0.431
CLV_PCSK_KEX2_1	93	95	PF00082	0.385
CLV_PCSK_SKI1_1	32	36	PF00082	0.441
DEG_Nend_Nbox_1	1	3	PF02207	0.570
DOC_MAPK_gen_1	28	37	PF00069	0.409
DOC_MAPK_gen_1	75	82	PF00069	0.533
DOC_MAPK_gen_1	9	16	PF00069	0.382
DOC_MAPK_gen_1	93	100	PF00069	0.264
DOC_PP4_FxxP_1	60	63	PF00568	0.395
DOC_USP7_MATH_1	123	127	PF00917	0.623
DOC_USP7_MATH_1	161	165	PF00917	0.578
LIG_14-3-3_CanoR_1	32	38	PF00244	0.445
LIG_APCC_ABBA_1	14	19	PF00400	0.381
LIG_BRCT_BRCA1_1	102	106	PF00533	0.379
LIG_BRCT_BRCA1_1	142	146	PF00533	0.409
LIG_BRCT_BRCA1_1	163	167	PF00533	0.364
LIG_BRCT_BRCA1_1	75	79	PF00533	0.388
LIG_FHA_1	62	68	PF00498	0.453
LIG_FHA_2	34	40	PF00498	0.367
LIG_LIR_Apic_2	58	63	PF02991	0.381
LIG_LIR_Gen_1	11	18	PF02991	0.405
LIG_LIR_Gen_1	143	154	PF02991	0.515
LIG_LIR_Gen_1	76	87	PF02991	0.349
LIG_LIR_Nem_3	103	109	PF02991	0.265
LIG_LIR_Nem_3	11	16	PF02991	0.396
LIG_LIR_Nem_3	164	170	PF02991	0.373
LIG_LIR_Nem_3	76	82	PF02991	0.342
LIG_LIR_Nem_3	86	91	PF02991	0.336
LIG_SH2_STAT5	13	16	PF00017	0.353
LIG_SH2_STAT5	170	173	PF00017	0.353
LIG_SH3_3	151	157	PF00018	0.550
LIG_SH3_3	60	66	PF00018	0.487
LIG_SUMO_SIM_anti_2	95	101	PF11976	0.367
LIG_TRAF2_1	18	21	PF00917	0.604
LIG_TRAF2_1	36	39	PF00917	0.278
LIG_TRAF2_1	56	59	PF00917	0.243
MOD_CK1_1	108	114	PF00069	0.367
MOD_CK1_1	126	132	PF00069	0.296
MOD_CK1_1	140	146	PF00069	0.312
MOD_CK2_1	160	166	PF00069	0.422
MOD_CK2_1	33	39	PF00069	0.371
MOD_CK2_1	46	52	PF00069	0.391
MOD_CK2_1	53	59	PF00069	0.258
MOD_GlcNHglycan	125	128	PF01048	0.490
MOD_GlcNHglycan	146	149	PF01048	0.397
MOD_GlcNHglycan	176	179	PF01048	0.548
MOD_GSK3_1	100	107	PF00069	0.420
MOD_GSK3_1	140	147	PF00069	0.560
MOD_GSK3_1	161	168	PF00069	0.429
MOD_GSK3_1	61	68	PF00069	0.445
MOD_GSK3_1	83	90	PF00069	0.394
MOD_LATS_1	51	57	PF00433	0.368
MOD_N-GLC_1	104	109	PF02516	0.383
MOD_NEK2_1	174	179	PF00069	0.418
MOD_NEK2_1	73	78	PF00069	0.431
MOD_PIKK_1	100	106	PF00454	0.432
MOD_PK_1	53	59	PF00069	0.401
MOD_Plk_1	104	110	PF00069	0.380
MOD_Plk_2-3	46	52	PF00069	0.455
MOD_Plk_4	65	71	PF00069	0.482
MOD_Plk_4	83	89	PF00069	0.541
TRG_ENDOCYTIC_2	13	16	PF00928	0.353
TRG_ER_diArg_1	131	133	PF00400	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM1	Leptomonas seymouri	70%	98%
A0A3Q8I8Z4	Leishmania donovani	96%	97%
A4H9U6	Leishmania braziliensis	87%	97%
A4HUS4	Leishmania infantum	96%	97%
E9ANF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	97%