PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell cycle sequence binding phosphoprotein (RBP45), putative

Species:

Leishmania major

UniProt:

Q4QH66_LEIMA

TriTrypDb:

LmjF.11.0140 , LMJLV39_110006400 , LMJSD75_110006300

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.441
CLV_NRD_NRD_1	122	124	PF00675	0.636
CLV_NRD_NRD_1	150	152	PF00675	0.480
CLV_NRD_NRD_1	254	256	PF00675	0.303
CLV_PCSK_FUR_1	120	124	PF00082	0.708
CLV_PCSK_KEX2_1	120	122	PF00082	0.607
CLV_PCSK_KEX2_1	150	152	PF00082	0.471
CLV_PCSK_KEX2_1	254	256	PF00082	0.429
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.389
CLV_PCSK_SKI1_1	152	156	PF00082	0.444
CLV_PCSK_SKI1_1	255	259	PF00082	0.274
DEG_SPOP_SBC_1	288	292	PF00917	0.451
DOC_CKS1_1	132	137	PF01111	0.595
DOC_CKS1_1	63	68	PF01111	0.555
DOC_MAPK_gen_1	204	214	PF00069	0.320
DOC_PP1_RVXF_1	253	260	PF00149	0.265
DOC_PP1_RVXF_1	264	270	PF00149	0.263
DOC_USP7_MATH_1	288	292	PF00917	0.500
DOC_USP7_UBL2_3	200	204	PF12436	0.522
DOC_WW_Pin1_4	131	136	PF00397	0.593
DOC_WW_Pin1_4	156	161	PF00397	0.426
DOC_WW_Pin1_4	62	67	PF00397	0.579
DOC_WW_Pin1_4	77	82	PF00397	0.622
LIG_14-3-3_CanoR_1	207	212	PF00244	0.290
LIG_14-3-3_CanoR_1	254	260	PF00244	0.297
LIG_FHA_1	2	8	PF00498	0.657
LIG_FHA_1	224	230	PF00498	0.427
LIG_FHA_1	35	41	PF00498	0.595
LIG_FHA_2	132	138	PF00498	0.717
LIG_FHA_2	220	226	PF00498	0.296
LIG_LIR_Apic_2	159	165	PF02991	0.409
LIG_LIR_Gen_1	258	269	PF02991	0.455
LIG_LIR_Nem_3	268	272	PF02991	0.265
LIG_LIR_Nem_3	275	280	PF02991	0.266
LIG_SH2_NCK_1	157	161	PF00017	0.550
LIG_SH2_PTP2	162	165	PF00017	0.414
LIG_SH2_STAP1	95	99	PF00017	0.539
LIG_SH2_STAT5	162	165	PF00017	0.414
LIG_SH2_STAT5	71	74	PF00017	0.729
LIG_SH3_3	108	114	PF00018	0.674
LIG_SH3_3	126	132	PF00018	0.695
LIG_SH3_3	48	54	PF00018	0.542
LIG_SUMO_SIM_par_1	210	215	PF11976	0.389
LIG_TRAF2_1	114	117	PF00917	0.643
LIG_TYR_ITIM	93	98	PF00017	0.562
LIG_WRC_WIRS_1	277	282	PF05994	0.285
LIG_WW_3	65	69	PF00397	0.708
MOD_CDK_SPxK_1	62	68	PF00069	0.568
MOD_CK2_1	131	137	PF00069	0.734
MOD_CK2_1	207	213	PF00069	0.285
MOD_CK2_1	219	225	PF00069	0.266
MOD_GlcNHglycan	15	18	PF01048	0.576
MOD_GlcNHglycan	238	241	PF01048	0.431
MOD_GlcNHglycan	56	59	PF01048	0.738
MOD_GlcNHglycan	77	80	PF01048	0.753
MOD_GSK3_1	219	226	PF00069	0.468
MOD_GSK3_1	82	89	PF00069	0.627
MOD_N-GLC_1	2	7	PF02516	0.676
MOD_N-GLC_1	75	80	PF02516	0.743
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	212	217	PF00069	0.298
MOD_NEK2_1	276	281	PF00069	0.285
MOD_NEK2_1	29	34	PF00069	0.575
MOD_NEK2_2	260	265	PF00069	0.340
MOD_PIKK_1	212	218	PF00454	0.291
MOD_PK_1	207	213	PF00069	0.432
MOD_PKA_1	255	261	PF00069	0.274
MOD_Plk_1	2	8	PF00069	0.670
MOD_Plk_1	212	218	PF00069	0.306
MOD_Plk_4	2	8	PF00069	0.632
MOD_Plk_4	207	213	PF00069	0.355
MOD_Plk_4	255	261	PF00069	0.293
MOD_ProDKin_1	131	137	PF00069	0.592
MOD_ProDKin_1	156	162	PF00069	0.427
MOD_ProDKin_1	62	68	PF00069	0.584
MOD_ProDKin_1	77	83	PF00069	0.624
TRG_DiLeu_BaEn_1	177	182	PF01217	0.366
TRG_ENDOCYTIC_2	261	264	PF00928	0.404
TRG_ENDOCYTIC_2	277	280	PF00928	0.176
TRG_ENDOCYTIC_2	95	98	PF00928	0.542
TRG_ER_diArg_1	120	123	PF00400	0.608
TRG_ER_diArg_1	151	154	PF00400	0.392
TRG_ER_diArg_1	280	283	PF00400	0.283
TRG_NES_CRM1_1	39	50	PF08389	0.548
TRG_NLS_MonoCore_2	149	154	PF00514	0.396
TRG_NLS_MonoExtN_4	150	155	PF00514	0.404
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D9	Leptomonas seymouri	35%	100%
A0A0N1PAZ1	Leptomonas seymouri	84%	100%
A0A0S4JV55	Bodo saltans	50%	87%
A0A1X0NUF7	Trypanosomatidae	30%	78%
A0A1X0NWX9	Trypanosomatidae	57%	97%
A0A3Q8I8Y8	Leishmania donovani	97%	100%
A0A3S5ISC8	Trypanosoma rangeli	53%	97%
A4H9U4	Leishmania braziliensis	92%	77%
A4HUS6	Leishmania infantum	97%	100%
D0A7N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	93%
E9ANG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BB20	Trypanosoma cruzi	56%	97%
V5DLK4	Trypanosoma cruzi	51%	66%