Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH65_LEIMA

TriTrypDb:

LmjF.11.0150 , LMJLV39_110006500 , LMJSD75_110006400

Length:

885

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.741
CLV_C14_Caspase3-7	526	530	PF00656	0.743
CLV_NRD_NRD_1	185	187	PF00675	0.739
CLV_NRD_NRD_1	251	253	PF00675	0.593
CLV_NRD_NRD_1	28	30	PF00675	0.677
CLV_NRD_NRD_1	287	289	PF00675	0.619
CLV_NRD_NRD_1	45	47	PF00675	0.566
CLV_NRD_NRD_1	506	508	PF00675	0.708
CLV_NRD_NRD_1	515	517	PF00675	0.648
CLV_NRD_NRD_1	60	62	PF00675	0.575
CLV_NRD_NRD_1	854	856	PF00675	0.600
CLV_NRD_NRD_1	86	88	PF00675	0.713
CLV_NRD_NRD_1	96	98	PF00675	0.617
CLV_PCSK_FUR_1	513	517	PF00082	0.691
CLV_PCSK_KEX2_1	242	244	PF00082	0.557
CLV_PCSK_KEX2_1	251	253	PF00082	0.501
CLV_PCSK_KEX2_1	287	289	PF00082	0.619
CLV_PCSK_KEX2_1	45	47	PF00082	0.720
CLV_PCSK_KEX2_1	505	507	PF00082	0.706
CLV_PCSK_KEX2_1	513	515	PF00082	0.658
CLV_PCSK_KEX2_1	543	545	PF00082	0.736
CLV_PCSK_KEX2_1	60	62	PF00082	0.575
CLV_PCSK_KEX2_1	680	682	PF00082	0.568
CLV_PCSK_KEX2_1	854	856	PF00082	0.650
CLV_PCSK_KEX2_1	86	88	PF00082	0.713
CLV_PCSK_KEX2_1	96	98	PF00082	0.617
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.557
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.687
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.568
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.713
CLV_PCSK_SKI1_1	222	226	PF00082	0.537
CLV_PCSK_SKI1_1	490	494	PF00082	0.725
CLV_PCSK_SKI1_1	506	510	PF00082	0.545
CLV_PCSK_SKI1_1	648	652	PF00082	0.604
CLV_PCSK_SKI1_1	855	859	PF00082	0.638
DEG_Nend_UBRbox_2	1	3	PF02207	0.682
DEG_SCF_FBW7_1	416	423	PF00400	0.683
DEG_SPOP_SBC_1	119	123	PF00917	0.684
DEG_SPOP_SBC_1	129	133	PF00917	0.609
DEG_SPOP_SBC_1	155	159	PF00917	0.806
DEG_SPOP_SBC_1	685	689	PF00917	0.562
DEG_SPOP_SBC_1	877	881	PF00917	0.553
DOC_CKS1_1	331	336	PF01111	0.672
DOC_CKS1_1	417	422	PF01111	0.829
DOC_CKS1_1	706	711	PF01111	0.652
DOC_CYCLIN_yCln2_LP_2	571	574	PF00134	0.706
DOC_MAPK_gen_1	505	512	PF00069	0.677
DOC_MAPK_gen_1	722	731	PF00069	0.721
DOC_MAPK_MEF2A_6	505	512	PF00069	0.665
DOC_PP1_RVXF_1	584	591	PF00149	0.666
DOC_PP1_RVXF_1	852	859	PF00149	0.663
DOC_PP2B_LxvP_1	571	574	PF13499	0.706
DOC_PP2B_LxvP_1	761	764	PF13499	0.684
DOC_PP4_FxxP_1	590	593	PF00568	0.704
DOC_PP4_FxxP_1	780	783	PF00568	0.679
DOC_PP4_FxxP_1	858	861	PF00568	0.663
DOC_PP4_MxPP_1	791	794	PF00568	0.696
DOC_SPAK_OSR1_1	258	262	PF12202	0.577
DOC_USP7_MATH_1	11	15	PF00917	0.607
DOC_USP7_MATH_1	147	151	PF00917	0.735
DOC_USP7_MATH_1	155	159	PF00917	0.753
DOC_USP7_MATH_1	34	38	PF00917	0.647
DOC_USP7_MATH_1	382	386	PF00917	0.708
DOC_USP7_MATH_1	420	424	PF00917	0.693
DOC_USP7_MATH_1	434	438	PF00917	0.608
DOC_USP7_MATH_1	486	490	PF00917	0.725
DOC_USP7_MATH_1	553	557	PF00917	0.738
DOC_USP7_MATH_1	707	711	PF00917	0.670
DOC_USP7_MATH_1	743	747	PF00917	0.604
DOC_USP7_MATH_1	768	772	PF00917	0.557
DOC_USP7_MATH_1	77	81	PF00917	0.728
DOC_USP7_UBL2_3	841	845	PF12436	0.503
DOC_USP7_UBL2_3	86	90	PF12436	0.718
DOC_USP7_UBL2_3	94	98	PF12436	0.631
DOC_WW_Pin1_4	276	281	PF00397	0.657
DOC_WW_Pin1_4	330	335	PF00397	0.703
DOC_WW_Pin1_4	362	367	PF00397	0.804
DOC_WW_Pin1_4	371	376	PF00397	0.732
DOC_WW_Pin1_4	412	417	PF00397	0.787
DOC_WW_Pin1_4	51	56	PF00397	0.680
DOC_WW_Pin1_4	536	541	PF00397	0.699
DOC_WW_Pin1_4	547	552	PF00397	0.652
DOC_WW_Pin1_4	574	579	PF00397	0.798
DOC_WW_Pin1_4	625	630	PF00397	0.643
DOC_WW_Pin1_4	635	640	PF00397	0.644
DOC_WW_Pin1_4	654	659	PF00397	0.470
DOC_WW_Pin1_4	705	710	PF00397	0.690
DOC_WW_Pin1_4	750	755	PF00397	0.682
LIG_14-3-3_CanoR_1	102	107	PF00244	0.764
LIG_14-3-3_CanoR_1	186	192	PF00244	0.617
LIG_14-3-3_CanoR_1	251	256	PF00244	0.633
LIG_14-3-3_CanoR_1	287	291	PF00244	0.635
LIG_14-3-3_CanoR_1	391	400	PF00244	0.667
LIG_14-3-3_CanoR_1	427	434	PF00244	0.579
LIG_14-3-3_CanoR_1	496	500	PF00244	0.674
LIG_14-3-3_CanoR_1	60	64	PF00244	0.666
LIG_14-3-3_CanoR_1	725	730	PF00244	0.716
LIG_14-3-3_CanoR_1	787	794	PF00244	0.546
LIG_14-3-3_CanoR_1	812	819	PF00244	0.454
LIG_14-3-3_CanoR_1	824	834	PF00244	0.405
LIG_BIR_III_2	353	357	PF00653	0.565
LIG_BRCT_BRCA1_1	102	106	PF00533	0.727
LIG_BRCT_BRCA1_1	827	831	PF00533	0.565
LIG_EVH1_1	572	576	PF00568	0.678
LIG_EVH1_1	780	784	PF00568	0.635
LIG_FHA_1	277	283	PF00498	0.639
LIG_FHA_1	372	378	PF00498	0.747
LIG_FHA_1	659	665	PF00498	0.639
LIG_FHA_2	381	387	PF00498	0.650
LIG_FHA_2	391	397	PF00498	0.650
LIG_FHA_2	417	423	PF00498	0.706
LIG_FHA_2	496	502	PF00498	0.672
LIG_FHA_2	526	532	PF00498	0.695
LIG_FHA_2	745	751	PF00498	0.579
LIG_GSK3_LRP6_1	330	336	PF00069	0.632
LIG_GSK3_LRP6_1	416	421	PF00069	0.655
LIG_GSK3_LRP6_1	574	580	PF00069	0.689
LIG_LIR_Apic_2	289	293	PF02991	0.529
LIG_LIR_Apic_2	37	42	PF02991	0.647
LIG_LIR_Apic_2	653	658	PF02991	0.658
LIG_LIR_Apic_2	779	783	PF02991	0.685
LIG_LIR_Gen_1	498	503	PF02991	0.592
LIG_LIR_Gen_1	825	835	PF02991	0.536
LIG_LIR_LC3C_4	773	778	PF02991	0.646
LIG_LIR_Nem_3	498	502	PF02991	0.597
LIG_LIR_Nem_3	646	650	PF02991	0.614
LIG_LIR_Nem_3	694	699	PF02991	0.653
LIG_LIR_Nem_3	828	834	PF02991	0.532
LIG_MAD2	326	334	PF02301	0.653
LIG_Pex14_1	31	35	PF04695	0.650
LIG_Pex14_1	827	831	PF04695	0.575
LIG_Pex14_2	823	827	PF04695	0.575
LIG_Pex14_2	831	835	PF04695	0.531
LIG_PROFILIN_1	64	70	PF00235	0.674
LIG_PROFILIN_1	71	77	PF00235	0.604
LIG_Rb_LxCxE_1	646	662	PF01857	0.647
LIG_RPA_C_Fungi	502	514	PF08784	0.672
LIG_SH2_CRK	290	294	PF00017	0.516
LIG_SH2_CRK	39	43	PF00017	0.650
LIG_SH2_CRK	92	96	PF00017	0.574
LIG_SH2_GRB2like	47	50	PF00017	0.719
LIG_SH2_NCK_1	39	43	PF00017	0.650
LIG_SH2_PTP2	655	658	PF00017	0.667
LIG_SH2_SRC	145	148	PF00017	0.678
LIG_SH2_SRC	39	42	PF00017	0.655
LIG_SH2_STAP1	27	31	PF00017	0.629
LIG_SH2_STAT3	23	26	PF00017	0.649
LIG_SH2_STAT5	307	310	PF00017	0.630
LIG_SH2_STAT5	47	50	PF00017	0.647
LIG_SH2_STAT5	655	658	PF00017	0.667
LIG_SH2_STAT5	696	699	PF00017	0.649
LIG_SH3_1	414	420	PF00018	0.732
LIG_SH3_1	61	67	PF00018	0.694
LIG_SH3_2	41	46	PF14604	0.705
LIG_SH3_2	55	60	PF14604	0.579
LIG_SH3_2	74	79	PF14604	0.523
LIG_SH3_3	325	331	PF00018	0.642
LIG_SH3_3	352	358	PF00018	0.720
LIG_SH3_3	38	44	PF00018	0.698
LIG_SH3_3	414	420	PF00018	0.732
LIG_SH3_3	49	55	PF00018	0.632
LIG_SH3_3	570	576	PF00018	0.797
LIG_SH3_3	61	67	PF00018	0.705
LIG_SH3_3	660	666	PF00018	0.644
LIG_SH3_3	68	74	PF00018	0.616
LIG_SH3_3	703	709	PF00018	0.663
LIG_SH3_3	775	781	PF00018	0.632
LIG_SH3_3	864	870	PF00018	0.653
LIG_SH3_4	94	101	PF00018	0.642
LIG_SUMO_SIM_anti_2	345	353	PF11976	0.668
LIG_SUMO_SIM_par_1	271	279	PF11976	0.608
LIG_SUMO_SIM_par_1	345	353	PF11976	0.651
LIG_SUMO_SIM_par_1	765	775	PF11976	0.558
LIG_TRAF2_1	281	284	PF00917	0.609
LIG_WW_3	42	46	PF00397	0.661
MOD_CDC14_SPxK_1	753	756	PF00782	0.650
MOD_CDK_SPK_2	51	56	PF00069	0.645
MOD_CDK_SPxK_1	705	711	PF00069	0.651
MOD_CDK_SPxK_1	750	756	PF00069	0.652
MOD_CDK_SPxxK_3	536	543	PF00069	0.673
MOD_CDK_SPxxK_3	574	581	PF00069	0.571
MOD_CK1_1	105	111	PF00069	0.771
MOD_CK1_1	113	119	PF00069	0.715
MOD_CK1_1	120	126	PF00069	0.690
MOD_CK1_1	127	133	PF00069	0.617
MOD_CK1_1	135	141	PF00069	0.692
MOD_CK1_1	154	160	PF00069	0.806
MOD_CK1_1	161	167	PF00069	0.690
MOD_CK1_1	173	179	PF00069	0.534
MOD_CK1_1	296	302	PF00069	0.772
MOD_CK1_1	360	366	PF00069	0.768
MOD_CK1_1	577	583	PF00069	0.720
MOD_CK1_1	59	65	PF00069	0.639
MOD_CK1_1	710	716	PF00069	0.702
MOD_CK1_1	811	817	PF00069	0.552
MOD_CK1_1	825	831	PF00069	0.434
MOD_CK2_1	145	151	PF00069	0.729
MOD_CK2_1	174	180	PF00069	0.845
MOD_CK2_1	380	386	PF00069	0.677
MOD_CK2_1	390	396	PF00069	0.684
MOD_CK2_1	495	501	PF00069	0.677
MOD_CK2_1	529	535	PF00069	0.718
MOD_CK2_1	640	646	PF00069	0.576
MOD_CK2_1	744	750	PF00069	0.602
MOD_CK2_1	796	802	PF00069	0.671
MOD_Cter_Amidation	839	842	PF01082	0.579
MOD_DYRK1A_RPxSP_1	547	551	PF00069	0.664
MOD_GlcNHglycan	102	105	PF01048	0.763
MOD_GlcNHglycan	141	144	PF01048	0.694
MOD_GlcNHglycan	153	156	PF01048	0.806
MOD_GlcNHglycan	295	298	PF01048	0.695
MOD_GlcNHglycan	362	365	PF01048	0.797
MOD_GlcNHglycan	393	396	PF01048	0.744
MOD_GlcNHglycan	422	425	PF01048	0.688
MOD_GlcNHglycan	452	455	PF01048	0.603
MOD_GlcNHglycan	471	474	PF01048	0.595
MOD_GlcNHglycan	531	534	PF01048	0.670
MOD_GlcNHglycan	61	64	PF01048	0.770
MOD_GlcNHglycan	669	672	PF01048	0.593
MOD_GlcNHglycan	682	685	PF01048	0.660
MOD_GlcNHglycan	760	764	PF01048	0.610
MOD_GlcNHglycan	816	819	PF01048	0.570
MOD_GlcNHglycan	827	830	PF01048	0.430
MOD_GlcNHglycan	864	867	PF01048	0.667
MOD_GSK3_1	100	107	PF00069	0.815
MOD_GSK3_1	109	116	PF00069	0.678
MOD_GSK3_1	117	124	PF00069	0.572
MOD_GSK3_1	125	132	PF00069	0.614
MOD_GSK3_1	133	140	PF00069	0.655
MOD_GSK3_1	141	148	PF00069	0.550
MOD_GSK3_1	151	158	PF00069	0.846
MOD_GSK3_1	159	166	PF00069	0.702
MOD_GSK3_1	167	174	PF00069	0.572
MOD_GSK3_1	293	300	PF00069	0.689
MOD_GSK3_1	303	310	PF00069	0.533
MOD_GSK3_1	356	363	PF00069	0.752
MOD_GSK3_1	412	419	PF00069	0.750
MOD_GSK3_1	516	523	PF00069	0.731
MOD_GSK3_1	525	532	PF00069	0.644
MOD_GSK3_1	646	653	PF00069	0.693
MOD_GSK3_1	654	661	PF00069	0.611
MOD_GSK3_1	680	687	PF00069	0.680
MOD_GSK3_1	721	728	PF00069	0.661
MOD_GSK3_1	825	832	PF00069	0.512
MOD_N-GLC_1	109	114	PF02516	0.583
MOD_N-GLC_1	725	730	PF02516	0.581
MOD_NEK2_1	106	111	PF00069	0.654
MOD_NEK2_1	275	280	PF00069	0.616
MOD_NEK2_1	286	291	PF00069	0.514
MOD_NEK2_1	390	395	PF00069	0.765
MOD_NEK2_1	401	406	PF00069	0.712
MOD_NEK2_1	450	455	PF00069	0.583
MOD_OFUCOSY	808	815	PF10250	0.559
MOD_OFUCOSY	820	826	PF10250	0.488
MOD_OGLYCOS	815	820	PF02709	0.524
MOD_PIKK_1	185	191	PF00454	0.556
MOD_PIKK_1	251	257	PF00454	0.594
MOD_PIKK_1	357	363	PF00454	0.760
MOD_PIKK_1	553	559	PF00454	0.862
MOD_PIKK_1	595	601	PF00454	0.708
MOD_PIKK_1	79	85	PF00454	0.776
MOD_PK_1	561	567	PF00069	0.657
MOD_PK_1	725	731	PF00069	0.676
MOD_PKA_1	251	257	PF00069	0.564
MOD_PKA_1	514	520	PF00069	0.668
MOD_PKA_1	680	686	PF00069	0.594
MOD_PKA_2	117	123	PF00069	0.854
MOD_PKA_2	151	157	PF00069	0.838
MOD_PKA_2	174	180	PF00069	0.700
MOD_PKA_2	185	191	PF00069	0.577
MOD_PKA_2	250	256	PF00069	0.600
MOD_PKA_2	286	292	PF00069	0.631
MOD_PKA_2	390	396	PF00069	0.673
MOD_PKA_2	495	501	PF00069	0.677
MOD_PKA_2	514	520	PF00069	0.555
MOD_PKA_2	59	65	PF00069	0.669
MOD_PKA_2	619	625	PF00069	0.712
MOD_PKA_2	680	686	PF00069	0.570
MOD_PKA_2	710	716	PF00069	0.738
MOD_PKA_2	721	727	PF00069	0.752
MOD_PKA_2	786	792	PF00069	0.543
MOD_PKA_2	811	817	PF00069	0.455
MOD_PKB_1	100	108	PF00069	0.724
MOD_PKB_1	425	433	PF00069	0.582
MOD_PKB_1	514	522	PF00069	0.714
MOD_Plk_1	401	407	PF00069	0.697
MOD_Plk_1	658	664	PF00069	0.635
MOD_Plk_1	725	731	PF00069	0.580
MOD_Plk_2-3	396	402	PF00069	0.708
MOD_Plk_2-3	796	802	PF00069	0.671
MOD_Plk_4	303	309	PF00069	0.581
MOD_Plk_4	396	402	PF00069	0.708
MOD_Plk_4	646	652	PF00069	0.620
MOD_Plk_4	659	665	PF00069	0.554
MOD_ProDKin_1	276	282	PF00069	0.658
MOD_ProDKin_1	330	336	PF00069	0.707
MOD_ProDKin_1	362	368	PF00069	0.804
MOD_ProDKin_1	371	377	PF00069	0.733
MOD_ProDKin_1	412	418	PF00069	0.786
MOD_ProDKin_1	51	57	PF00069	0.681
MOD_ProDKin_1	536	542	PF00069	0.699
MOD_ProDKin_1	547	553	PF00069	0.654
MOD_ProDKin_1	574	580	PF00069	0.801
MOD_ProDKin_1	625	631	PF00069	0.640
MOD_ProDKin_1	635	641	PF00069	0.641
MOD_ProDKin_1	654	660	PF00069	0.471
MOD_ProDKin_1	705	711	PF00069	0.695
MOD_ProDKin_1	750	756	PF00069	0.686
MOD_SUMO_rev_2	643	650	PF00179	0.616
TRG_DiLeu_BaEn_1	396	401	PF01217	0.711
TRG_DiLeu_BaEn_1	646	651	PF01217	0.567
TRG_DiLeu_BaEn_3	345	351	PF01217	0.615
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.494
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.433
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.679
TRG_ENDOCYTIC_2	499	502	PF00928	0.600
TRG_ER_diArg_1	19	22	PF00400	0.656
TRG_ER_diArg_1	199	202	PF00400	0.524
TRG_ER_diArg_1	286	288	PF00400	0.610
TRG_ER_diArg_1	44	46	PF00400	0.718
TRG_ER_diArg_1	505	507	PF00400	0.706
TRG_ER_diArg_1	512	515	PF00400	0.664
TRG_ER_diArg_1	854	856	PF00400	0.650
TRG_ER_diArg_1	95	97	PF00400	0.710
TRG_NLS_Bipartite_1	86	101	PF00514	0.694
TRG_NLS_MonoCore_2	841	846	PF00514	0.528
TRG_NLS_MonoExtC_3	840	845	PF00514	0.498
TRG_NLS_MonoExtC_3	85	90	PF00514	0.719
TRG_NLS_MonoExtN_4	841	846	PF00514	0.506
TRG_NLS_MonoExtN_4	86	91	PF00514	0.720
TRG_NLS_MonoExtN_4	94	101	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	854	859	PF00026	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8W5	Leishmania donovani	89%	100%
A4H9U3	Leishmania braziliensis	63%	100%
A4HUS7	Leishmania infantum	89%	100%
E9ANG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%