Exocyst complex component Sec8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH64_LEIMA

TriTrypDb:

LmjF.11.0160 , LMJLV39_110006600 , LMJSD75_110006500

Length:

1022

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000145	exocyst	3	2
GO:0032991	protein-containing complex	1	2
GO:0099023	vesicle tethering complex	2	2

Expansion

Sequence features

Q4QH64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH64

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006887	exocytosis	4	2
GO:0006892	post-Golgi vesicle-mediated transport	6	2
GO:0006893	Golgi to plasma membrane transport	5	2
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016043	cellular component organization	3	12
GO:0016192	vesicle-mediated transport	4	2
GO:0032940	secretion by cell	3	2
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046903	secretion	4	2
GO:0046907	intracellular transport	3	12
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090522	vesicle tethering involved in exocytosis	3	12
GO:0098876	vesicle-mediated transport to the plasma membrane	4	2
GO:0099022	vesicle tethering	4	12
GO:0140029	exocytic process	2	12
GO:0140352	export from cell	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.689
CLV_C14_Caspase3-7	170	174	PF00656	0.798
CLV_C14_Caspase3-7	175	179	PF00656	0.745
CLV_C14_Caspase3-7	225	229	PF00656	0.500
CLV_C14_Caspase3-7	286	290	PF00656	0.524
CLV_C14_Caspase3-7	323	327	PF00656	0.562
CLV_NRD_NRD_1	11	13	PF00675	0.616
CLV_NRD_NRD_1	203	205	PF00675	0.752
CLV_NRD_NRD_1	852	854	PF00675	0.522
CLV_NRD_NRD_1	855	857	PF00675	0.566
CLV_NRD_NRD_1	943	945	PF00675	0.491
CLV_PCSK_KEX2_1	11	13	PF00082	0.616
CLV_PCSK_KEX2_1	852	854	PF00082	0.539
CLV_PCSK_KEX2_1	943	945	PF00082	0.469
CLV_PCSK_SKI1_1	118	122	PF00082	0.622
CLV_PCSK_SKI1_1	25	29	PF00082	0.574
CLV_PCSK_SKI1_1	312	316	PF00082	0.520
CLV_PCSK_SKI1_1	60	64	PF00082	0.495
CLV_PCSK_SKI1_1	735	739	PF00082	0.472
CLV_PCSK_SKI1_1	758	762	PF00082	0.454
CLV_PCSK_SKI1_1	811	815	PF00082	0.524
DEG_APCC_DBOX_1	324	332	PF00400	0.545
DEG_APCC_DBOX_1	431	439	PF00400	0.308
DEG_APCC_KENBOX_2	257	261	PF00400	0.562
DEG_Nend_UBRbox_2	1	3	PF02207	0.674
DOC_CDC14_PxL_1	871	879	PF14671	0.408
DOC_CYCLIN_RxL_1	20	32	PF00134	0.590
DOC_CYCLIN_RxL_1	811	822	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	507	513	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	687	693	PF00134	0.516
DOC_MAPK_gen_1	312	320	PF00069	0.488
DOC_MAPK_gen_1	551	559	PF00069	0.518
DOC_MAPK_HePTP_8	755	767	PF00069	0.414
DOC_MAPK_MEF2A_6	20	28	PF00069	0.622
DOC_MAPK_MEF2A_6	432	439	PF00069	0.307
DOC_MAPK_MEF2A_6	670	678	PF00069	0.430
DOC_MAPK_MEF2A_6	758	767	PF00069	0.427
DOC_MAPK_MEF2A_6	932	940	PF00069	0.462
DOC_MAPK_NFAT4_5	432	440	PF00069	0.303
DOC_MAPK_NFAT4_5	758	766	PF00069	0.430
DOC_PP1_RVXF_1	23	29	PF00149	0.595
DOC_PP2B_LxvP_1	370	373	PF13499	0.530
DOC_PP2B_LxvP_1	676	679	PF13499	0.407
DOC_PP2B_LxvP_1	687	690	PF13499	0.388
DOC_USP7_MATH_1	1011	1015	PF00917	0.733
DOC_USP7_MATH_1	222	226	PF00917	0.495
DOC_USP7_MATH_1	314	318	PF00917	0.531
DOC_USP7_MATH_1	440	444	PF00917	0.518
DOC_USP7_MATH_1	580	584	PF00917	0.496
DOC_USP7_MATH_1	681	685	PF00917	0.494
DOC_USP7_MATH_1	838	842	PF00917	0.567
DOC_USP7_MATH_1	862	866	PF00917	0.491
DOC_USP7_MATH_2	518	524	PF00917	0.520
DOC_USP7_UBL2_3	118	122	PF12436	0.545
DOC_USP7_UBL2_3	811	815	PF12436	0.443
DOC_USP7_UBL2_3	996	1000	PF12436	0.628
DOC_WW_Pin1_4	213	218	PF00397	0.673
DOC_WW_Pin1_4	514	519	PF00397	0.537
DOC_WW_Pin1_4	544	549	PF00397	0.543
DOC_WW_Pin1_4	92	97	PF00397	0.746
LIG_14-3-3_CanoR_1	1012	1016	PF00244	0.736
LIG_14-3-3_CanoR_1	109	114	PF00244	0.402
LIG_14-3-3_CanoR_1	25	35	PF00244	0.566
LIG_14-3-3_CanoR_1	432	436	PF00244	0.496
LIG_14-3-3_CanoR_1	670	675	PF00244	0.479
LIG_14-3-3_CanoR_1	71	76	PF00244	0.479
LIG_14-3-3_CanoR_1	823	832	PF00244	0.516
LIG_14-3-3_CanoR_1	932	937	PF00244	0.531
LIG_Actin_WH2_2	106	124	PF00022	0.547
LIG_APCC_ABBA_1	459	464	PF00400	0.633
LIG_APCC_ABBA_1	482	487	PF00400	0.524
LIG_BIR_III_2	3	7	PF00653	0.683
LIG_BRCT_BRCA1_1	58	62	PF00533	0.584
LIG_BRCT_BRCA1_1	644	648	PF00533	0.523
LIG_CaM_IQ_9	999	1014	PF13499	0.733
LIG_Clathr_ClatBox_1	752	756	PF01394	0.553
LIG_deltaCOP1_diTrp_1	444	452	PF00928	0.502
LIG_DLG_GKlike_1	670	678	PF00625	0.483
LIG_FHA_1	110	116	PF00498	0.549
LIG_FHA_1	138	144	PF00498	0.543
LIG_FHA_1	222	228	PF00498	0.559
LIG_FHA_1	299	305	PF00498	0.578
LIG_FHA_1	313	319	PF00498	0.571
LIG_FHA_1	52	58	PF00498	0.503
LIG_FHA_1	715	721	PF00498	0.635
LIG_FHA_1	812	818	PF00498	0.433
LIG_FHA_1	933	939	PF00498	0.459
LIG_FHA_2	361	367	PF00498	0.505
LIG_FHA_2	5	11	PF00498	0.648
LIG_FHA_2	620	626	PF00498	0.516
LIG_FHA_2	670	676	PF00498	0.503
LIG_FHA_2	741	747	PF00498	0.421
LIG_FHA_2	83	89	PF00498	0.578
LIG_HCF-1_HBM_1	269	272	PF13415	0.641
LIG_LIR_Gen_1	218	227	PF02991	0.512
LIG_LIR_Gen_1	233	242	PF02991	0.488
LIG_LIR_Gen_1	50	57	PF02991	0.425
LIG_LIR_Gen_1	520	530	PF02991	0.483
LIG_LIR_Gen_1	688	698	PF02991	0.403
LIG_LIR_Gen_1	707	714	PF02991	0.516
LIG_LIR_Gen_1	868	877	PF02991	0.298
LIG_LIR_Nem_3	218	223	PF02991	0.516
LIG_LIR_Nem_3	228	234	PF02991	0.512
LIG_LIR_Nem_3	269	275	PF02991	0.526
LIG_LIR_Nem_3	49	55	PF02991	0.404
LIG_LIR_Nem_3	520	525	PF02991	0.504
LIG_LIR_Nem_3	59	65	PF02991	0.408
LIG_LIR_Nem_3	688	694	PF02991	0.441
LIG_LIR_Nem_3	707	713	PF02991	0.535
LIG_LIR_Nem_3	738	744	PF02991	0.396
LIG_LYPXL_yS_3	272	275	PF13949	0.617
LIG_MAD2	25	33	PF02301	0.577
LIG_MAD2	408	416	PF02301	0.514
LIG_NRBOX	574	580	PF00104	0.523
LIG_PCNA_yPIPBox_3	811	825	PF02747	0.435
LIG_Pex14_1	788	792	PF04695	0.526
LIG_REV1ctd_RIR_1	810	819	PF16727	0.512
LIG_RPA_C_Fungi	66	78	PF08784	0.565
LIG_SH2_CRK	14	18	PF00017	0.559
LIG_SH2_CRK	234	238	PF00017	0.525
LIG_SH2_CRK	691	695	PF00017	0.462
LIG_SH2_CRK	710	714	PF00017	0.439
LIG_SH2_PTP2	220	223	PF00017	0.581
LIG_SH2_SRC	377	380	PF00017	0.478
LIG_SH2_SRC	913	916	PF00017	0.607
LIG_SH2_STAP1	53	57	PF00017	0.462
LIG_SH2_STAP1	65	69	PF00017	0.445
LIG_SH2_STAP1	659	663	PF00017	0.452
LIG_SH2_STAP1	691	695	PF00017	0.346
LIG_SH2_STAP1	710	714	PF00017	0.401
LIG_SH2_STAT3	398	401	PF00017	0.501
LIG_SH2_STAT3	930	933	PF00017	0.550
LIG_SH2_STAT5	132	135	PF00017	0.553
LIG_SH2_STAT5	158	161	PF00017	0.702
LIG_SH2_STAT5	220	223	PF00017	0.487
LIG_SH2_STAT5	234	237	PF00017	0.497
LIG_SH2_STAT5	382	385	PF00017	0.400
LIG_SH2_STAT5	489	492	PF00017	0.454
LIG_SH2_STAT5	494	497	PF00017	0.423
LIG_SH2_STAT5	528	531	PF00017	0.367
LIG_SH2_STAT5	53	56	PF00017	0.354
LIG_SH2_STAT5	682	685	PF00017	0.510
LIG_SH2_STAT5	736	739	PF00017	0.351
LIG_SH2_STAT5	766	769	PF00017	0.379
LIG_SH2_STAT5	869	872	PF00017	0.415
LIG_SH3_3	383	389	PF00018	0.475
LIG_Sin3_3	300	307	PF02671	0.527
LIG_Sin3_3	757	764	PF02671	0.507
LIG_SUMO_SIM_anti_2	29	38	PF11976	0.582
LIG_SUMO_SIM_par_1	111	117	PF11976	0.593
LIG_SUMO_SIM_par_1	773	778	PF11976	0.435
LIG_TRAF2_1	926	929	PF00917	0.508
LIG_TRAF2_1	965	968	PF00917	0.573
LIG_TYR_ITIM	689	694	PF00017	0.466
LIG_TYR_ITIM	734	739	PF00017	0.398
LIG_UBA3_1	249	258	PF00899	0.577
LIG_UBA3_1	824	830	PF00899	0.528
LIG_UBA3_1	870	876	PF00899	0.448
LIG_UBA3_1	987	996	PF00899	0.666
MOD_CDC14_SPxK_1	216	219	PF00782	0.448
MOD_CDK_SPxK_1	213	219	PF00069	0.469
MOD_CDK_SPxxK_3	544	551	PF00069	0.530
MOD_CK1_1	111	117	PF00069	0.540
MOD_CK1_1	168	174	PF00069	0.693
MOD_CK1_1	298	304	PF00069	0.536
MOD_CK1_1	321	327	PF00069	0.548
MOD_CK1_1	583	589	PF00069	0.492
MOD_CK1_1	677	683	PF00069	0.531
MOD_CK1_1	904	910	PF00069	0.506
MOD_CK2_1	169	175	PF00069	0.708
MOD_CK2_1	281	287	PF00069	0.559
MOD_CK2_1	360	366	PF00069	0.498
MOD_CK2_1	514	520	PF00069	0.505
MOD_CK2_1	549	555	PF00069	0.412
MOD_CK2_1	669	675	PF00069	0.503
MOD_CK2_1	740	746	PF00069	0.386
MOD_CK2_1	775	781	PF00069	0.348
MOD_CK2_1	862	868	PF00069	0.496
MOD_CK2_1	95	101	PF00069	0.806
MOD_Cter_Amidation	202	205	PF01082	0.700
MOD_GlcNHglycan	118	121	PF01048	0.524
MOD_GlcNHglycan	135	138	PF01048	0.416
MOD_GlcNHglycan	167	170	PF01048	0.711
MOD_GlcNHglycan	184	187	PF01048	0.651
MOD_GlcNHglycan	189	192	PF01048	0.716
MOD_GlcNHglycan	295	300	PF01048	0.521
MOD_GlcNHglycan	305	308	PF01048	0.472
MOD_GlcNHglycan	563	566	PF01048	0.517
MOD_GlcNHglycan	679	682	PF01048	0.429
MOD_GlcNHglycan	683	686	PF01048	0.438
MOD_GlcNHglycan	691	694	PF01048	0.360
MOD_GlcNHglycan	825	828	PF01048	0.519
MOD_GlcNHglycan	952	955	PF01048	0.551
MOD_GSK3_1	133	140	PF00069	0.555
MOD_GSK3_1	165	172	PF00069	0.718
MOD_GSK3_1	180	187	PF00069	0.690
MOD_GSK3_1	314	321	PF00069	0.564
MOD_GSK3_1	47	54	PF00069	0.528
MOD_GSK3_1	670	677	PF00069	0.475
MOD_GSK3_1	681	688	PF00069	0.405
MOD_GSK3_1	704	711	PF00069	0.405
MOD_GSK3_1	712	719	PF00069	0.464
MOD_GSK3_1	740	747	PF00069	0.425
MOD_GSK3_1	76	83	PF00069	0.499
MOD_GSK3_1	876	883	PF00069	0.416
MOD_GSK3_1	885	892	PF00069	0.362
MOD_GSK3_1	900	907	PF00069	0.447
MOD_GSK3_1	95	102	PF00069	0.776
MOD_N-GLC_1	514	519	PF02516	0.539
MOD_NEK2_1	133	138	PF00069	0.535
MOD_NEK2_1	303	308	PF00069	0.473
MOD_NEK2_1	318	323	PF00069	0.398
MOD_NEK2_1	46	51	PF00069	0.477
MOD_NEK2_1	559	564	PF00069	0.471
MOD_NEK2_1	56	61	PF00069	0.482
MOD_NEK2_1	627	632	PF00069	0.464
MOD_NEK2_1	644	649	PF00069	0.315
MOD_NEK2_1	674	679	PF00069	0.477
MOD_NEK2_1	73	78	PF00069	0.310
MOD_NEK2_1	740	745	PF00069	0.371
MOD_NEK2_1	813	818	PF00069	0.415
MOD_NEK2_1	881	886	PF00069	0.420
MOD_NEK2_1	900	905	PF00069	0.517
MOD_NEK2_2	1011	1016	PF00069	0.657
MOD_NEK2_2	360	365	PF00069	0.411
MOD_NEK2_2	431	436	PF00069	0.442
MOD_PIKK_1	347	353	PF00454	0.546
MOD_PIKK_1	704	710	PF00454	0.465
MOD_PIKK_1	980	986	PF00454	0.619
MOD_PK_1	71	77	PF00069	0.506
MOD_PK_1	876	882	PF00069	0.534
MOD_PKA_1	312	318	PF00069	0.571
MOD_PKA_2	1011	1017	PF00069	0.744
MOD_PKA_2	108	114	PF00069	0.411
MOD_PKA_2	203	209	PF00069	0.633
MOD_PKA_2	321	327	PF00069	0.541
MOD_PKA_2	431	437	PF00069	0.489
MOD_PKA_2	669	675	PF00069	0.503
MOD_Plk_1	232	238	PF00069	0.520
MOD_Plk_1	674	680	PF00069	0.484
MOD_Plk_1	715	721	PF00069	0.519
MOD_Plk_4	1011	1017	PF00069	0.712
MOD_Plk_4	222	228	PF00069	0.561
MOD_Plk_4	314	320	PF00069	0.502
MOD_Plk_4	51	57	PF00069	0.491
MOD_Plk_4	594	600	PF00069	0.456
MOD_Plk_4	627	633	PF00069	0.444
MOD_Plk_4	709	715	PF00069	0.463
MOD_Plk_4	716	722	PF00069	0.538
MOD_Plk_4	735	741	PF00069	0.376
MOD_Plk_4	768	774	PF00069	0.447
MOD_Plk_4	840	846	PF00069	0.538
MOD_Plk_4	876	882	PF00069	0.400
MOD_ProDKin_1	213	219	PF00069	0.668
MOD_ProDKin_1	514	520	PF00069	0.536
MOD_ProDKin_1	544	550	PF00069	0.535
MOD_ProDKin_1	92	98	PF00069	0.746
MOD_SUMO_rev_2	111	120	PF00179	0.592
TRG_DiLeu_BaEn_1	245	250	PF01217	0.537
TRG_DiLeu_BaEn_4	245	251	PF01217	0.560
TRG_DiLeu_BaLyEn_6	820	825	PF01217	0.461
TRG_ENDOCYTIC_2	14	17	PF00928	0.554
TRG_ENDOCYTIC_2	220	223	PF00928	0.496
TRG_ENDOCYTIC_2	234	237	PF00928	0.522
TRG_ENDOCYTIC_2	272	275	PF00928	0.497
TRG_ENDOCYTIC_2	53	56	PF00928	0.387
TRG_ENDOCYTIC_2	659	662	PF00928	0.514
TRG_ENDOCYTIC_2	691	694	PF00928	0.369
TRG_ENDOCYTIC_2	710	713	PF00928	0.418
TRG_ENDOCYTIC_2	736	739	PF00928	0.374
TRG_ENDOCYTIC_2	869	872	PF00928	0.294
TRG_ER_diArg_1	11	13	PF00400	0.616
TRG_ER_diArg_1	550	553	PF00400	0.514
TRG_ER_diArg_1	943	945	PF00400	0.473
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.799
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	943	947	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3J5	Leptomonas seymouri	74%	100%
A0A0S4JSF8	Bodo saltans	32%	91%
A0A1X0NVP2	Trypanosomatidae	42%	98%
A0A3S7WRE4	Leishmania donovani	96%	100%
A0A422NYQ9	Trypanosoma rangeli	45%	98%
A4H9U2	Leishmania braziliensis	87%	98%
A4HUS8	Leishmania infantum	96%	100%
D0A7N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ANG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
V5BW65	Trypanosoma cruzi	44%	98%