3-PAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

myotubularin-associated protein, putative

Species:

Leishmania major

UniProt:

Q4QH63_LEIMA

TriTrypDb:

LmjF.11.0170 , LMJLV39_110006700 , LMJSD75_110006600

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.624
CLV_C14_Caspase3-7	249	253	PF00656	0.578
CLV_C14_Caspase3-7	538	542	PF00656	0.667
CLV_C14_Caspase3-7	575	579	PF00656	0.632
CLV_C14_Caspase3-7	605	609	PF00656	0.672
CLV_NRD_NRD_1	28	30	PF00675	0.239
CLV_PCSK_KEX2_1	117	119	PF00082	0.332
CLV_PCSK_KEX2_1	155	157	PF00082	0.522
CLV_PCSK_KEX2_1	28	30	PF00082	0.239
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.285
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.522
CLV_PCSK_SKI1_1	13	17	PF00082	0.434
CLV_PCSK_SKI1_1	133	137	PF00082	0.332
CLV_PCSK_SKI1_1	152	156	PF00082	0.492
CLV_PCSK_SKI1_1	384	388	PF00082	0.510
CLV_PCSK_SKI1_1	420	424	PF00082	0.550
CLV_Separin_Metazoa	381	385	PF03568	0.483
DEG_APCC_DBOX_1	143	151	PF00400	0.497
DEG_APCC_DBOX_1	696	704	PF00400	0.579
DEG_Nend_UBRbox_3	1	3	PF02207	0.484
DEG_SCF_FBW7_1	557	564	PF00400	0.709
DOC_CDC14_PxL_1	188	196	PF14671	0.600
DOC_CKS1_1	506	511	PF01111	0.575
DOC_CKS1_1	558	563	PF01111	0.710
DOC_CYCLIN_RxL_1	664	677	PF00134	0.651
DOC_CYCLIN_yClb5_NLxxxL_5	138	147	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.627
DOC_MAPK_gen_1	131	138	PF00069	0.532
DOC_MAPK_MEF2A_6	36	44	PF00069	0.532
DOC_PP2B_LxvP_1	194	197	PF13499	0.608
DOC_PP2B_LxvP_1	274	277	PF13499	0.608
DOC_PP2B_LxvP_1	470	473	PF13499	0.618
DOC_PP4_FxxP_1	18	21	PF00568	0.532
DOC_USP7_MATH_1	187	191	PF00917	0.637
DOC_USP7_MATH_1	197	201	PF00917	0.616
DOC_USP7_MATH_1	270	274	PF00917	0.665
DOC_USP7_MATH_1	408	412	PF00917	0.527
DOC_USP7_MATH_1	458	462	PF00917	0.593
DOC_USP7_MATH_1	500	504	PF00917	0.675
DOC_USP7_MATH_1	601	605	PF00917	0.691
DOC_USP7_MATH_1	625	629	PF00917	0.669
DOC_USP7_MATH_1	636	640	PF00917	0.606
DOC_WW_Pin1_4	304	309	PF00397	0.679
DOC_WW_Pin1_4	423	428	PF00397	0.639
DOC_WW_Pin1_4	451	456	PF00397	0.630
DOC_WW_Pin1_4	502	507	PF00397	0.702
DOC_WW_Pin1_4	511	516	PF00397	0.575
DOC_WW_Pin1_4	545	550	PF00397	0.664
DOC_WW_Pin1_4	551	556	PF00397	0.682
DOC_WW_Pin1_4	557	562	PF00397	0.630
DOC_WW_Pin1_4	637	642	PF00397	0.637
DOC_WW_Pin1_4	646	651	PF00397	0.682
LIG_14-3-3_CanoR_1	13	22	PF00244	0.532
LIG_14-3-3_CanoR_1	133	139	PF00244	0.466
LIG_14-3-3_CanoR_1	144	148	PF00244	0.476
LIG_14-3-3_CanoR_1	208	213	PF00244	0.635
LIG_14-3-3_CanoR_1	262	270	PF00244	0.695
LIG_14-3-3_CanoR_1	297	301	PF00244	0.529
LIG_14-3-3_CanoR_1	312	320	PF00244	0.631
LIG_14-3-3_CanoR_1	347	353	PF00244	0.476
LIG_14-3-3_CanoR_1	384	391	PF00244	0.512
LIG_14-3-3_CanoR_1	463	471	PF00244	0.675
LIG_14-3-3_CanoR_1	669	674	PF00244	0.704
LIG_Actin_WH2_2	131	146	PF00022	0.625
LIG_Actin_WH2_2	409	425	PF00022	0.417
LIG_APCC_ABBAyCdc20_2	289	295	PF00400	0.519
LIG_BIR_III_2	424	428	PF00653	0.600
LIG_BRCT_BRCA1_1	671	675	PF00533	0.655
LIG_Clathr_ClatBox_1	599	603	PF01394	0.695
LIG_DLG_GKlike_1	669	677	PF00625	0.653
LIG_EVH1_2	277	281	PF00568	0.608
LIG_EVH1_2	515	519	PF00568	0.621
LIG_FHA_1	138	144	PF00498	0.512
LIG_FHA_1	17	23	PF00498	0.501
LIG_FHA_1	343	349	PF00498	0.590
LIG_FHA_1	359	365	PF00498	0.386
LIG_FHA_1	506	512	PF00498	0.573
LIG_FHA_1	66	72	PF00498	0.439
LIG_FHA_1	668	674	PF00498	0.664
LIG_FHA_2	220	226	PF00498	0.565
LIG_FHA_2	312	318	PF00498	0.655
LIG_FHA_2	533	539	PF00498	0.548
LIG_FHA_2	573	579	PF00498	0.580
LIG_FHA_2	675	681	PF00498	0.638
LIG_GBD_Chelix_1	171	179	PF00786	0.493
LIG_GBD_Chelix_1	73	81	PF00786	0.285
LIG_LIR_Apic_2	16	21	PF02991	0.532
LIG_LIR_Gen_1	116	127	PF02991	0.532
LIG_LIR_Gen_1	628	638	PF02991	0.561
LIG_LIR_Nem_3	116	122	PF02991	0.532
LIG_LIR_Nem_3	283	287	PF02991	0.599
LIG_LIR_Nem_3	354	360	PF02991	0.513
LIG_LIR_Nem_3	628	634	PF02991	0.646
LIG_MAD2	633	641	PF02301	0.569
LIG_MYND_1	192	196	PF01753	0.631
LIG_NRBOX	699	705	PF00104	0.580
LIG_NRP_CendR_1	714	717	PF00754	0.658
LIG_Pex14_2	519	523	PF04695	0.633
LIG_SH2_CRK	631	635	PF00017	0.569
LIG_SH2_SRC	290	293	PF00017	0.515
LIG_SH2_STAP1	371	375	PF00017	0.544
LIG_SH2_STAP1	631	635	PF00017	0.569
LIG_SH2_STAT5	14	17	PF00017	0.532
LIG_SH2_STAT5	290	293	PF00017	0.559
LIG_SH3_2	643	648	PF14604	0.713
LIG_SH3_3	181	187	PF00018	0.496
LIG_SH3_3	189	195	PF00018	0.611
LIG_SH3_3	264	270	PF00018	0.681
LIG_SH3_3	27	33	PF00018	0.532
LIG_SH3_3	273	279	PF00018	0.612
LIG_SH3_3	330	336	PF00018	0.671
LIG_SH3_3	37	43	PF00018	0.466
LIG_SH3_3	431	437	PF00018	0.653
LIG_SH3_3	449	455	PF00018	0.525
LIG_SH3_3	503	509	PF00018	0.694
LIG_SH3_3	635	641	PF00018	0.666
LIG_SH3_3	653	659	PF00018	0.580
LIG_SH3_4	494	501	PF00018	0.646
LIG_SUMO_SIM_anti_2	596	601	PF11976	0.697
LIG_SUMO_SIM_par_1	134	140	PF11976	0.532
LIG_TRAF2_1	322	325	PF00917	0.556
LIG_WRC_WIRS_1	353	358	PF05994	0.560
LIG_WRC_WIRS_1	520	525	PF05994	0.671
LIG_WW_1	642	645	PF00397	0.699
LIG_WW_3	195	199	PF00397	0.637
MOD_CDK_SPxxK_3	425	432	PF00069	0.638
MOD_CK1_1	137	143	PF00069	0.489
MOD_CK1_1	211	217	PF00069	0.651
MOD_CK1_1	240	246	PF00069	0.674
MOD_CK1_1	253	259	PF00069	0.559
MOD_CK1_1	441	447	PF00069	0.632
MOD_CK1_1	50	56	PF00069	0.523
MOD_CK1_1	505	511	PF00069	0.642
MOD_CK1_1	582	588	PF00069	0.664
MOD_CK1_1	604	610	PF00069	0.700
MOD_CK1_1	611	617	PF00069	0.651
MOD_CK1_1	676	682	PF00069	0.640
MOD_CK1_1	686	692	PF00069	0.532
MOD_CK1_1	84	90	PF00069	0.532
MOD_CK2_1	311	317	PF00069	0.652
MOD_CK2_1	319	325	PF00069	0.587
MOD_CK2_1	532	538	PF00069	0.547
MOD_GlcNHglycan	107	110	PF01048	0.408
MOD_GlcNHglycan	189	192	PF01048	0.738
MOD_GlcNHglycan	210	213	PF01048	0.628
MOD_GlcNHglycan	255	258	PF01048	0.678
MOD_GlcNHglycan	464	467	PF01048	0.673
MOD_GlcNHglycan	49	52	PF01048	0.332
MOD_GlcNHglycan	502	505	PF01048	0.721
MOD_GlcNHglycan	525	528	PF01048	0.616
MOD_GlcNHglycan	610	613	PF01048	0.652
MOD_GlcNHglycan	665	668	PF01048	0.672
MOD_GSK3_1	211	218	PF00069	0.638
MOD_GSK3_1	219	226	PF00069	0.638
MOD_GSK3_1	242	249	PF00069	0.641
MOD_GSK3_1	296	303	PF00069	0.626
MOD_GSK3_1	342	349	PF00069	0.641
MOD_GSK3_1	358	365	PF00069	0.392
MOD_GSK3_1	437	444	PF00069	0.599
MOD_GSK3_1	458	465	PF00069	0.618
MOD_GSK3_1	490	497	PF00069	0.616
MOD_GSK3_1	507	514	PF00069	0.580
MOD_GSK3_1	515	522	PF00069	0.593
MOD_GSK3_1	541	548	PF00069	0.688
MOD_GSK3_1	557	564	PF00069	0.552
MOD_GSK3_1	602	609	PF00069	0.698
MOD_GSK3_1	610	617	PF00069	0.637
MOD_GSK3_1	663	670	PF00069	0.688
MOD_GSK3_1	679	686	PF00069	0.512
MOD_LATS_1	26	32	PF00433	0.532
MOD_N-GLC_1	1	6	PF02516	0.460
MOD_N-GLC_1	490	495	PF02516	0.710
MOD_N-GLC_1	646	651	PF02516	0.663
MOD_N-GLC_1	65	70	PF02516	0.239
MOD_N-GLC_1	667	672	PF02516	0.659
MOD_NEK2_1	1	6	PF00069	0.679
MOD_NEK2_1	143	148	PF00069	0.508
MOD_NEK2_1	150	155	PF00069	0.456
MOD_NEK2_1	457	462	PF00069	0.661
MOD_NEK2_1	519	524	PF00069	0.665
MOD_NEK2_1	525	530	PF00069	0.610
MOD_NEK2_1	602	607	PF00069	0.695
MOD_NEK2_1	673	678	PF00069	0.648
MOD_NEK2_1	693	698	PF00069	0.440
MOD_NEK2_1	81	86	PF00069	0.545
MOD_NEK2_2	458	463	PF00069	0.593
MOD_NEK2_2	55	60	PF00069	0.532
MOD_PIKK_1	197	203	PF00454	0.641
MOD_PIKK_1	342	348	PF00454	0.520
MOD_PIKK_1	384	390	PF00454	0.536
MOD_PIKK_1	494	500	PF00454	0.644
MOD_PIKK_1	611	617	PF00454	0.670
MOD_PIKK_1	687	693	PF00454	0.626
MOD_PIKK_1	84	90	PF00454	0.532
MOD_PK_1	28	34	PF00069	0.532
MOD_PKA_1	28	34	PF00069	0.464
MOD_PKA_2	143	149	PF00069	0.517
MOD_PKA_2	197	203	PF00069	0.684
MOD_PKA_2	215	221	PF00069	0.524
MOD_PKA_2	237	243	PF00069	0.646
MOD_PKA_2	28	34	PF00069	0.439
MOD_PKA_2	296	302	PF00069	0.625
MOD_PKA_2	311	317	PF00069	0.556
MOD_PKA_2	346	352	PF00069	0.532
MOD_PKA_2	462	468	PF00069	0.671
MOD_PKA_2	693	699	PF00069	0.567
MOD_Plk_1	1	7	PF00069	0.457
MOD_Plk_1	150	156	PF00069	0.532
MOD_Plk_1	224	230	PF00069	0.565
MOD_Plk_1	246	252	PF00069	0.661
MOD_Plk_1	55	61	PF00069	0.501
MOD_Plk_1	667	673	PF00069	0.658
MOD_Plk_4	1	7	PF00069	0.667
MOD_Plk_4	219	225	PF00069	0.647
MOD_Plk_4	296	302	PF00069	0.494
MOD_Plk_4	352	358	PF00069	0.560
MOD_Plk_4	515	521	PF00069	0.658
MOD_ProDKin_1	304	310	PF00069	0.682
MOD_ProDKin_1	423	429	PF00069	0.642
MOD_ProDKin_1	451	457	PF00069	0.633
MOD_ProDKin_1	502	508	PF00069	0.700
MOD_ProDKin_1	511	517	PF00069	0.577
MOD_ProDKin_1	545	551	PF00069	0.660
MOD_ProDKin_1	557	563	PF00069	0.631
MOD_ProDKin_1	637	643	PF00069	0.639
MOD_ProDKin_1	646	652	PF00069	0.682
MOD_SUMO_for_1	173	176	PF00179	0.512
TRG_ENDOCYTIC_2	119	122	PF00928	0.532
TRG_ENDOCYTIC_2	631	634	PF00928	0.655
TRG_ER_diArg_1	27	29	PF00400	0.439
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRG7	Leishmania donovani	89%	100%
A4H9U1	Leishmania braziliensis	66%	100%
A4HUS9	Leishmania infantum	89%	100%
E9ANG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%