PUA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytoplasmic translation machinery associated protein, putative

Species:

Leishmania major

UniProt:

Q4QH62_LEIMA

TriTrypDb:

LmjF.11.0180 , LMJLV39_110006800 , LMJSD75_110006700

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QH62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH62

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	9	13	PF00082	0.241
DOC_MAPK_gen_1	51	57	PF00069	0.453
DOC_USP7_MATH_1	20	24	PF00917	0.502
DOC_USP7_MATH_1	50	54	PF00917	0.466
DOC_USP7_UBL2_3	165	169	PF12436	0.513
DOC_USP7_UBL2_3	91	95	PF12436	0.453
LIG_APCC_ABBA_1	141	146	PF00400	0.441
LIG_BRCT_BRCA1_1	52	56	PF00533	0.546
LIG_LIR_Apic_2	181	187	PF02991	0.474
LIG_LIR_Gen_1	42	50	PF02991	0.452
LIG_LIR_Nem_3	36	41	PF02991	0.445
LIG_LIR_Nem_3	42	48	PF02991	0.442
LIG_LIR_Nem_3	6	11	PF02991	0.405
LIG_LYPXL_yS_3	38	41	PF13949	0.453
LIG_LYPXL_yS_3	96	99	PF13949	0.481
LIG_PDZ_Class_2	191	196	PF00595	0.606
LIG_SH2_SRC	112	115	PF00017	0.519
LIG_SH2_SRC	144	147	PF00017	0.482
LIG_SH2_SRC	86	89	PF00017	0.436
LIG_SH2_STAT5	112	115	PF00017	0.450
LIG_SH2_STAT5	144	147	PF00017	0.472
LIG_SH2_STAT5	86	89	PF00017	0.436
LIG_SH3_3	82	88	PF00018	0.453
MOD_CK2_1	157	163	PF00069	0.461
MOD_CK2_1	20	26	PF00069	0.461
MOD_CK2_1	69	75	PF00069	0.472
MOD_GlcNHglycan	114	117	PF01048	0.241
MOD_GlcNHglycan	125	128	PF01048	0.241
MOD_GlcNHglycan	189	192	PF01048	0.443
MOD_GlcNHglycan	3	6	PF01048	0.420
MOD_GSK3_1	153	160	PF00069	0.457
MOD_GSK3_1	65	72	PF00069	0.502
MOD_NEK2_1	1	6	PF00069	0.493
MOD_NEK2_1	189	194	PF00069	0.420
MOD_NEK2_1	69	74	PF00069	0.479
MOD_NEK2_1	98	103	PF00069	0.323
MOD_PIKK_1	69	75	PF00454	0.502
MOD_PKA_1	9	15	PF00069	0.441
MOD_Plk_4	153	159	PF00069	0.469
MOD_Plk_4	3	9	PF00069	0.545
MOD_SUMO_rev_2	21	30	PF00179	0.503
TRG_ENDOCYTIC_2	38	41	PF00928	0.443
TRG_ENDOCYTIC_2	96	99	PF00928	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P0	Leptomonas seymouri	82%	100%
A0A0S4JUH4	Bodo saltans	72%	94%
A0A1X0NV76	Trypanosomatidae	72%	100%
A0A3B3IRV3	Homo sapiens	44%	100%
A0A3S5H6H9	Leishmania donovani	97%	100%
A0A3S5ISC7	Trypanosoma rangeli	74%	100%
A4H9U0	Leishmania braziliensis	89%	100%
A4HUT0	Leishmania infantum	97%	100%
D0A7N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	97%
E9ANG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P87313	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
P89886	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
Q2KIE4	Bos taurus	44%	100%
Q4G009	Rattus norvegicus	44%	100%
Q58827	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	35%	100%
Q5PPY1	Xenopus laevis	45%	100%
Q5ZI42	Gallus gallus	44%	100%
Q6DER1	Xenopus tropicalis	45%	100%
Q6NRJ7	Xenopus laevis	45%	100%
Q75AA8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	100%
Q7ZV34	Danio rerio	44%	100%
Q86KL4	Dictyostelium discoideum	43%	100%
Q9CQ21	Mus musculus	44%	100%
Q9DB27	Mus musculus	44%	100%
Q9ULC4	Homo sapiens	44%	100%
Q9W445	Drosophila melanogaster	46%	100%
V5BWL1	Trypanosoma cruzi	71%	100%