Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH60_LEIMA

TriTrypDb:

LmjF.11.0200 , LMJLV39_110007000 , LMJSD75_110006900

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.624
CLV_NRD_NRD_1	158	160	PF00675	0.417
CLV_NRD_NRD_1	164	166	PF00675	0.409
CLV_NRD_NRD_1	90	92	PF00675	0.469
CLV_PCSK_KEX2_1	158	160	PF00082	0.415
CLV_PCSK_KEX2_1	164	166	PF00082	0.406
CLV_PCSK_KEX2_1	90	92	PF00082	0.524
CLV_PCSK_SKI1_1	150	154	PF00082	0.582
CLV_PCSK_SKI1_1	90	94	PF00082	0.440
CLV_Separin_Metazoa	77	81	PF03568	0.462
DOC_MAPK_gen_1	142	151	PF00069	0.467
DOC_MAPK_HePTP_8	141	153	PF00069	0.469
DOC_MAPK_MEF2A_6	144	153	PF00069	0.473
DOC_USP7_MATH_1	37	41	PF00917	0.598
DOC_USP7_MATH_1	47	51	PF00917	0.755
DOC_USP7_MATH_1	59	63	PF00917	0.637
DOC_USP7_MATH_1	9	13	PF00917	0.642
DOC_WW_Pin1_4	107	112	PF00397	0.639
DOC_WW_Pin1_4	13	18	PF00397	0.651
LIG_Actin_WH2_2	38	54	PF00022	0.505
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_CaM_IQ_9	134	149	PF13499	0.405
LIG_FHA_1	13	19	PF00498	0.665
LIG_FHA_1	53	59	PF00498	0.612
LIG_FHA_1	73	79	PF00498	0.434
LIG_FHA_2	126	132	PF00498	0.517
LIG_LIR_Nem_3	87	92	PF02991	0.600
LIG_PDZ_Class_2	179	184	PF00595	0.525
LIG_SH2_CRK	89	93	PF00017	0.518
LIG_SH2_STAT3	100	103	PF00017	0.560
LIG_SH3_3	16	22	PF00018	0.524
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.467
LIG_SUMO_SIM_par_1	28	33	PF11976	0.490
LIG_TRAF2_1	84	87	PF00917	0.449
MOD_CK1_1	12	18	PF00069	0.650
MOD_CK1_1	125	131	PF00069	0.401
MOD_CK1_1	2	8	PF00069	0.628
MOD_CK1_1	40	46	PF00069	0.571
MOD_CK2_1	125	131	PF00069	0.479
MOD_CK2_1	51	57	PF00069	0.662
MOD_GlcNHglycan	103	106	PF01048	0.544
MOD_GlcNHglycan	111	114	PF01048	0.609
MOD_GlcNHglycan	12	15	PF01048	0.710
MOD_GlcNHglycan	175	178	PF01048	0.432
MOD_GlcNHglycan	7	10	PF01048	0.681
MOD_GSK3_1	109	116	PF00069	0.608
MOD_GSK3_1	13	20	PF00069	0.547
MOD_GSK3_1	36	43	PF00069	0.712
MOD_GSK3_1	47	54	PF00069	0.590
MOD_GSK3_1	5	12	PF00069	0.606
MOD_GSK3_1	68	75	PF00069	0.597
MOD_NEK2_1	175	180	PF00069	0.475
MOD_NEK2_1	51	56	PF00069	0.695
MOD_NEK2_2	47	52	PF00069	0.525
MOD_PIKK_1	99	105	PF00454	0.599
MOD_Plk_1	2	8	PF00069	0.724
MOD_Plk_4	122	128	PF00069	0.489
MOD_Plk_4	2	8	PF00069	0.525
MOD_ProDKin_1	107	113	PF00069	0.639
MOD_ProDKin_1	13	19	PF00069	0.648
MOD_SUMO_for_1	169	172	PF00179	0.480
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.430
TRG_ENDOCYTIC_2	89	92	PF00928	0.518
TRG_ER_diArg_1	157	159	PF00400	0.432
TRG_ER_diArg_1	89	91	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P1	Leptomonas seymouri	44%	100%
A0A3R7M7U3	Trypanosoma rangeli	32%	100%
A0A3S7WRH9	Leishmania donovani	89%	100%
A4H9T8	Leishmania braziliensis	75%	80%
A4HUT2	Leishmania infantum	89%	100%
E9ANG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%