Inorganic diphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acidocalcisomal pyrophosphatase

Species:

Leishmania major

UniProt:

Q4QH59_LEIMA

TriTrypDb:

LmjF.11.0210 , LMJLV39_110007100 , LMJSD75_110007000

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	16
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4QH59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH59

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0044237	cellular metabolic process	2	16

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	16
GO:0003824	catalytic activity	1	16
GO:0004427	inorganic diphosphate phosphatase activity	6	16
GO:0005488	binding	1	16
GO:0016462	pyrophosphatase activity	5	16
GO:0016787	hydrolase activity	2	16
GO:0016817	hydrolase activity, acting on acid anhydrides	3	16
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0005509	calcium ion binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.468
CLV_MEL_PAP_1	223	229	PF00089	0.371
CLV_NRD_NRD_1	11	13	PF00675	0.723
CLV_NRD_NRD_1	225	227	PF00675	0.491
CLV_NRD_NRD_1	434	436	PF00675	0.353
CLV_PCSK_KEX2_1	106	108	PF00082	0.470
CLV_PCSK_KEX2_1	224	226	PF00082	0.509
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.397
CLV_PCSK_SKI1_1	371	375	PF00082	0.190
CLV_PCSK_SKI1_1	407	411	PF00082	0.250
CLV_PCSK_SKI1_1	435	439	PF00082	0.543
DOC_CKS1_1	205	210	PF01111	0.329
DOC_MAPK_DCC_7	335	344	PF00069	0.542
DOC_MAPK_gen_1	12	19	PF00069	0.727
DOC_MAPK_gen_1	128	136	PF00069	0.513
DOC_MAPK_gen_1	415	423	PF00069	0.434
DOC_MAPK_MEF2A_6	128	136	PF00069	0.395
DOC_PP4_FxxP_1	188	191	PF00568	0.410
DOC_USP7_UBL2_3	213	217	PF12436	0.461
DOC_USP7_UBL2_3	279	283	PF12436	0.426
DOC_USP7_UBL2_3	436	440	PF12436	0.422
DOC_WW_Pin1_4	204	209	PF00397	0.335
DOC_WW_Pin1_4	225	230	PF00397	0.322
DOC_WW_Pin1_4	41	46	PF00397	0.554
LIG_14-3-3_CanoR_1	111	118	PF00244	0.339
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_BRCT_BRCA1_1	109	113	PF00533	0.426
LIG_BRCT_BRCA1_1	184	188	PF00533	0.416
LIG_deltaCOP1_diTrp_1	162	168	PF00928	0.330
LIG_deltaCOP1_diTrp_1	294	302	PF00928	0.468
LIG_FHA_1	158	164	PF00498	0.494
LIG_FHA_1	178	184	PF00498	0.614
LIG_FHA_1	307	313	PF00498	0.428
LIG_FHA_1	44	50	PF00498	0.645
LIG_FHA_1	82	88	PF00498	0.635
LIG_FHA_1	99	105	PF00498	0.547
LIG_FHA_2	168	174	PF00498	0.542
LIG_FHA_2	241	247	PF00498	0.417
LIG_FHA_2	71	77	PF00498	0.624
LIG_LIR_Apic_2	185	191	PF02991	0.409
LIG_LIR_Apic_2	4	10	PF02991	0.712
LIG_LIR_Gen_1	110	121	PF02991	0.435
LIG_LIR_Gen_1	146	155	PF02991	0.520
LIG_LIR_Gen_1	179	188	PF02991	0.497
LIG_LIR_Gen_1	228	237	PF02991	0.325
LIG_LIR_Nem_3	110	116	PF02991	0.425
LIG_LIR_Nem_3	146	152	PF02991	0.492
LIG_LIR_Nem_3	160	164	PF02991	0.253
LIG_LIR_Nem_3	179	184	PF02991	0.508
LIG_LIR_Nem_3	228	233	PF02991	0.326
LIG_LIR_Nem_3	273	278	PF02991	0.428
LIG_LIR_Nem_3	32	36	PF02991	0.594
LIG_LIR_Nem_3	357	361	PF02991	0.421
LIG_LIR_Nem_3	392	397	PF02991	0.446
LIG_PCNA_yPIPBox_3	359	373	PF02747	0.434
LIG_PDZ_Class_3	438	443	PF00595	0.490
LIG_Pex14_1	167	171	PF04695	0.388
LIG_Pex14_1	393	397	PF04695	0.440
LIG_Pex14_2	161	165	PF04695	0.315
LIG_Pex14_2	302	306	PF04695	0.485
LIG_PTAP_UEV_1	50	55	PF05743	0.515
LIG_SH2_CRK	253	257	PF00017	0.232
LIG_SH2_CRK	7	11	PF00017	0.720
LIG_SH2_SRC	123	126	PF00017	0.453
LIG_SH2_STAP1	419	423	PF00017	0.490
LIG_SH2_STAT3	192	195	PF00017	0.358
LIG_SH2_STAT5	123	126	PF00017	0.328
LIG_SH2_STAT5	135	138	PF00017	0.361
LIG_SH2_STAT5	215	218	PF00017	0.339
LIG_SH2_STAT5	236	239	PF00017	0.367
LIG_SH3_2	274	279	PF14604	0.476
LIG_SH3_3	234	240	PF00018	0.527
LIG_SH3_3	271	277	PF00018	0.464
LIG_SH3_3	362	368	PF00018	0.544
LIG_SH3_3	48	54	PF00018	0.679
LIG_TRAF2_1	73	76	PF00917	0.702
LIG_TYR_ITIM	121	126	PF00017	0.387
LIG_UBA3_1	148	153	PF00899	0.556
MOD_CDK_SPxxK_3	204	211	PF00069	0.322
MOD_CK1_1	182	188	PF00069	0.454
MOD_CK1_1	2	8	PF00069	0.595
MOD_CK1_1	35	41	PF00069	0.567
MOD_CK2_1	240	246	PF00069	0.405
MOD_CK2_1	70	76	PF00069	0.600
MOD_CMANNOS	165	168	PF00535	0.327
MOD_GlcNHglycan	113	116	PF01048	0.330
MOD_GlcNHglycan	184	187	PF01048	0.487
MOD_GlcNHglycan	317	320	PF01048	0.291
MOD_GlcNHglycan	51	54	PF01048	0.593
MOD_GSK3_1	107	114	PF00069	0.445
MOD_GSK3_1	138	145	PF00069	0.543
MOD_GSK3_1	167	174	PF00069	0.444
MOD_GSK3_1	182	189	PF00069	0.507
MOD_GSK3_1	302	309	PF00069	0.441
MOD_GSK3_1	54	61	PF00069	0.504
MOD_GSK3_1	66	73	PF00069	0.511
MOD_LATS_1	105	111	PF00433	0.410
MOD_N-GLC_1	138	143	PF02516	0.487
MOD_NEK2_1	100	105	PF00069	0.460
MOD_NEK2_1	116	121	PF00069	0.290
MOD_NEK2_1	19	24	PF00069	0.690
MOD_NEK2_1	65	70	PF00069	0.624
MOD_PIKK_1	116	122	PF00454	0.266
MOD_PIKK_1	138	144	PF00454	0.556
MOD_PIKK_1	98	104	PF00454	0.471
MOD_Plk_1	116	122	PF00069	0.416
MOD_Plk_1	186	192	PF00069	0.454
MOD_Plk_1	2	8	PF00069	0.525
MOD_Plk_1	415	421	PF00069	0.457
MOD_Plk_1	424	430	PF00069	0.418
MOD_Plk_2-3	76	82	PF00069	0.774
MOD_ProDKin_1	204	210	PF00069	0.326
MOD_ProDKin_1	225	231	PF00069	0.324
MOD_ProDKin_1	41	47	PF00069	0.552
MOD_SUMO_for_1	199	202	PF00179	0.522
MOD_SUMO_for_1	265	268	PF00179	0.440
MOD_SUMO_rev_2	145	155	PF00179	0.498
MOD_SUMO_rev_2	22	32	PF00179	0.536
MOD_SUMO_rev_2	352	361	PF00179	0.440
MOD_SUMO_rev_2	44	52	PF00179	0.656
TRG_ENDOCYTIC_2	123	126	PF00928	0.391
TRG_ENDOCYTIC_2	253	256	PF00928	0.264
TRG_ENDOCYTIC_2	299	302	PF00928	0.440
TRG_ER_diArg_1	223	226	PF00400	0.515
TRG_ER_diLys_1	438	443	PF00400	0.537
TRG_NES_CRM1_1	355	367	PF08389	0.542
TRG_NLS_MonoExtC_3	434	439	PF00514	0.411
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.235

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDG0	Leptomonas seymouri	81%	99%
A0A0S4JW75	Bodo saltans	62%	100%
A0A1X0NVA1	Trypanosomatidae	67%	100%
A0A1X0NVH4	Trypanosomatidae	72%	100%
A0A1X0NWW9	Trypanosomatidae	67%	100%
A0A3R7KMZ3	Trypanosoma rangeli	64%	100%
A0A3S7WRH5	Leishmania donovani	98%	100%
A4H3Q3	Leishmania braziliensis	39%	100%
A4H9T7	Leishmania braziliensis	93%	100%
A4HUT3	Leishmania infantum	98%	100%
D0A7N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
D0A7N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9ANG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BB26	Trypanosoma cruzi	62%	100%