RECA_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rad51, putative

Species:

Leishmania major

UniProt:

Q4QH57_LEIMA

TriTrypDb:

LmjF.11.0230 , LMJLV39_110007400 , LMJSD75_110007300

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH57

Function

Biological processes
Term	Name	Level	Count
GO:0000730	DNA recombinase assembly	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006310	DNA recombination	5	2
GO:0006312	mitotic recombination	6	2
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0042148	strand invasion	5	2
GO:0043170	macromolecule metabolic process	3	7
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0065003	protein-containing complex assembly	5	2
GO:0065004	protein-DNA complex assembly	6	2
GO:0071704	organic substance metabolic process	2	7
GO:0071824	protein-DNA complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	7
GO:0090735	DNA repair complex assembly	6	2
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0006281	DNA repair	5	5
GO:0006950	response to stress	2	5
GO:0006974	DNA damage response	4	5
GO:0033554	cellular response to stress	3	5
GO:0050896	response to stimulus	1	5
GO:0051716	cellular response to stimulus	2	5

Molecular functions
Term	Name	Level	Count
GO:0000150	DNA strand exchange activity	4	2
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003690	double-stranded DNA binding	5	2
GO:0003697	single-stranded DNA binding	5	2
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140299	small molecule sensor activity	1	7
GO:0140612	DNA damage sensor activity	2	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:0140664	ATP-dependent DNA damage sensor activity	3	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.747
CLV_C14_Caspase3-7	222	226	PF00656	0.538
CLV_C14_Caspase3-7	231	235	PF00656	0.426
CLV_C14_Caspase3-7	242	246	PF00656	0.479
CLV_C14_Caspase3-7	4	8	PF00656	0.706
CLV_C14_Caspase3-7	477	481	PF00656	0.548
CLV_NRD_NRD_1	164	166	PF00675	0.346
CLV_NRD_NRD_1	20	22	PF00675	0.708
CLV_NRD_NRD_1	280	282	PF00675	0.334
CLV_PCSK_KEX2_1	164	166	PF00082	0.346
CLV_PCSK_KEX2_1	20	22	PF00082	0.708
CLV_PCSK_KEX2_1	280	282	PF00082	0.363
CLV_PCSK_KEX2_1	305	307	PF00082	0.346
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.346
CLV_PCSK_SKI1_1	26	30	PF00082	0.472
CLV_PCSK_SKI1_1	390	394	PF00082	0.466
CLV_PCSK_SKI1_1	428	432	PF00082	0.662
DEG_APCC_DBOX_1	433	441	PF00400	0.601
DEG_COP1_1	508	518	PF00400	0.633
DEG_ODPH_VHL_1	492	504	PF01847	0.787
DEG_SCF_FBW7_2	30	35	PF00400	0.638
DEG_SPOP_SBC_1	140	144	PF00917	0.563
DOC_CKS1_1	29	34	PF01111	0.648
DOC_CKS1_1	456	461	PF01111	0.537
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.500
DOC_MAPK_gen_1	432	439	PF00069	0.619
DOC_MAPK_MEF2A_6	468	476	PF00069	0.475
DOC_PP1_RVXF_1	388	394	PF00149	0.520
DOC_PP1_RVXF_1	430	436	PF00149	0.644
DOC_PP2B_LxvP_1	146	149	PF13499	0.619
DOC_PP2B_LxvP_1	444	447	PF13499	0.518
DOC_PP2B_LxvP_1	454	457	PF13499	0.566
DOC_PP4_FxxP_1	29	32	PF00568	0.449
DOC_USP7_MATH_1	10	14	PF00917	0.699
DOC_USP7_MATH_1	140	144	PF00917	0.556
DOC_USP7_MATH_1	211	215	PF00917	0.609
DOC_USP7_MATH_1	355	359	PF00917	0.715
DOC_USP7_MATH_1	375	379	PF00917	0.459
DOC_USP7_MATH_1	413	417	PF00917	0.697
DOC_WW_Pin1_4	109	114	PF00397	0.623
DOC_WW_Pin1_4	259	264	PF00397	0.619
DOC_WW_Pin1_4	28	33	PF00397	0.556
DOC_WW_Pin1_4	411	416	PF00397	0.731
DOC_WW_Pin1_4	439	444	PF00397	0.551
DOC_WW_Pin1_4	455	460	PF00397	0.483
DOC_WW_Pin1_4	482	487	PF00397	0.523
DOC_WW_Pin1_4	56	61	PF00397	0.621
DOC_WW_Pin1_4	91	96	PF00397	0.732
LIG_14-3-3_CanoR_1	165	175	PF00244	0.546
LIG_14-3-3_CanoR_1	280	284	PF00244	0.530
LIG_14-3-3_CanoR_1	331	341	PF00244	0.682
LIG_14-3-3_CanoR_1	39	45	PF00244	0.539
LIG_14-3-3_CanoR_1	51	61	PF00244	0.574
LIG_14-3-3_CanoR_1	97	105	PF00244	0.710
LIG_Actin_WH2_2	148	166	PF00022	0.546
LIG_Actin_WH2_2	389	405	PF00022	0.501
LIG_AP2alpha_2	508	510	PF02296	0.746
LIG_BIR_III_2	7	11	PF00653	0.753
LIG_BIR_III_4	123	127	PF00653	0.739
LIG_BRCT_BRCA1_1	415	419	PF00533	0.710
LIG_CaM_IQ_9	298	314	PF13499	0.530
LIG_Clathr_ClatBox_1	269	273	PF01394	0.543
LIG_Clathr_ClatBox_1	504	508	PF01394	0.765
LIG_FHA_1	264	270	PF00498	0.543
LIG_FHA_1	4	10	PF00498	0.714
LIG_FHA_1	63	69	PF00498	0.697
LIG_FHA_2	197	203	PF00498	0.536
LIG_FHA_2	217	223	PF00498	0.383
LIG_FHA_2	494	500	PF00498	0.793
LIG_FHA_2	83	89	PF00498	0.849
LIG_FHA_2	98	104	PF00498	0.469
LIG_LIR_Gen_1	511	520	PF02991	0.644
LIG_LIR_Nem_3	511	515	PF02991	0.656
LIG_LIR_Nem_3	517	521	PF02991	0.671
LIG_NRBOX	246	252	PF00104	0.546
LIG_PDZ_Class_2	516	521	PF00595	0.694
LIG_SH2_NCK_1	512	516	PF00017	0.640
LIG_SH2_SRC	342	345	PF00017	0.593
LIG_SH2_STAP1	66	70	PF00017	0.570
LIG_SH2_STAT5	512	515	PF00017	0.610
LIG_SH2_STAT5	66	69	PF00017	0.656
LIG_SH3_1	110	116	PF00018	0.597
LIG_SH3_1	412	418	PF00018	0.737
LIG_SH3_3	108	114	PF00018	0.495
LIG_SH3_3	367	373	PF00018	0.793
LIG_SH3_3	412	418	PF00018	0.737
LIG_SH3_3	453	459	PF00018	0.572
LIG_SH3_3	488	494	PF00018	0.720
LIG_SH3_3	92	98	PF00018	0.798
LIG_SUMO_SIM_anti_2	499	506	PF11976	0.747
LIG_SUMO_SIM_par_1	268	274	PF11976	0.546
LIG_SUMO_SIM_par_1	314	319	PF11976	0.546
LIG_SUMO_SIM_par_1	503	508	PF11976	0.770
LIG_TRAF2_1	220	223	PF00917	0.617
LIG_WRC_WIRS_1	515	520	PF05994	0.613
MOD_CDC14_SPxK_1	414	417	PF00782	0.700
MOD_CDC14_SPxK_1	94	97	PF00782	0.722
MOD_CDK_SPxK_1	411	417	PF00069	0.692
MOD_CDK_SPxK_1	91	97	PF00069	0.734
MOD_CK1_1	154	160	PF00069	0.496
MOD_CK1_1	262	268	PF00069	0.412
MOD_CK1_1	332	338	PF00069	0.729
MOD_CK1_1	358	364	PF00069	0.679
MOD_CK1_1	378	384	PF00069	0.498
MOD_CK1_1	408	414	PF00069	0.635
MOD_CK1_1	467	473	PF00069	0.542
MOD_CK1_1	485	491	PF00069	0.635
MOD_CK1_1	503	509	PF00069	0.446
MOD_CK2_1	216	222	PF00069	0.437
MOD_CK2_1	493	499	PF00069	0.790
MOD_CK2_1	82	88	PF00069	0.848
MOD_DYRK1A_RPxSP_1	455	459	PF00069	0.510
MOD_GlcNHglycan	119	122	PF01048	0.816
MOD_GlcNHglycan	156	159	PF01048	0.280
MOD_GlcNHglycan	207	210	PF01048	0.465
MOD_GlcNHglycan	213	216	PF01048	0.497
MOD_GlcNHglycan	258	262	PF01048	0.509
MOD_GlcNHglycan	357	360	PF01048	0.683
MOD_GlcNHglycan	364	367	PF01048	0.654
MOD_GlcNHglycan	407	410	PF01048	0.773
MOD_GlcNHglycan	469	472	PF01048	0.648
MOD_GlcNHglycan	487	490	PF01048	0.679
MOD_GlcNHglycan	71	74	PF01048	0.726
MOD_GSK3_1	126	133	PF00069	0.717
MOD_GSK3_1	147	154	PF00069	0.488
MOD_GSK3_1	174	181	PF00069	0.433
MOD_GSK3_1	207	214	PF00069	0.418
MOD_GSK3_1	224	231	PF00069	0.353
MOD_GSK3_1	259	266	PF00069	0.419
MOD_GSK3_1	296	303	PF00069	0.411
MOD_GSK3_1	330	337	PF00069	0.721
MOD_GSK3_1	358	365	PF00069	0.624
MOD_GSK3_1	375	382	PF00069	0.513
MOD_GSK3_1	460	467	PF00069	0.616
MOD_GSK3_1	510	517	PF00069	0.586
MOD_GSK3_1	52	59	PF00069	0.580
MOD_GSK3_1	62	69	PF00069	0.686
MOD_GSK3_1	79	86	PF00069	0.693
MOD_LATS_1	125	131	PF00433	0.603
MOD_NEK2_1	1	6	PF00069	0.770
MOD_NEK2_1	104	109	PF00069	0.659
MOD_NEK2_1	117	122	PF00069	0.786
MOD_NEK2_1	196	201	PF00069	0.334
MOD_NEK2_1	279	284	PF00069	0.430
MOD_NEK2_1	297	302	PF00069	0.510
MOD_NEK2_1	316	321	PF00069	0.411
MOD_NEK2_1	329	334	PF00069	0.695
MOD_PIKK_1	316	322	PF00454	0.352
MOD_PIKK_1	49	55	PF00454	0.653
MOD_PIKK_1	493	499	PF00454	0.790
MOD_PKA_2	126	132	PF00069	0.794
MOD_PKA_2	279	285	PF00069	0.389
MOD_PKA_2	330	336	PF00069	0.675
MOD_PKA_2	467	473	PF00069	0.616
MOD_Plk_1	83	89	PF00069	0.849
MOD_Plk_2-3	228	234	PF00069	0.397
MOD_Plk_2-3	379	385	PF00069	0.646
MOD_Plk_4	500	506	PF00069	0.738
MOD_Plk_4	514	520	PF00069	0.493
MOD_ProDKin_1	109	115	PF00069	0.626
MOD_ProDKin_1	259	265	PF00069	0.513
MOD_ProDKin_1	28	34	PF00069	0.563
MOD_ProDKin_1	411	417	PF00069	0.736
MOD_ProDKin_1	439	445	PF00069	0.553
MOD_ProDKin_1	455	461	PF00069	0.493
MOD_ProDKin_1	482	488	PF00069	0.525
MOD_ProDKin_1	56	62	PF00069	0.627
MOD_ProDKin_1	91	97	PF00069	0.730
MOD_SUMO_for_1	11	14	PF00179	0.724
TRG_DiLeu_BaEn_1	500	505	PF01217	0.749
TRG_DiLeu_BaEn_2	513	519	PF01217	0.592
TRG_ENDOCYTIC_2	512	515	PF00928	0.647
TRG_ER_diArg_1	163	165	PF00400	0.411
TRG_ER_diArg_1	20	22	PF00400	0.708
TRG_ER_diArg_1	279	281	PF00400	0.436
TRG_ER_diArg_1	431	434	PF00400	0.669
TRG_ER_diArg_1	452	455	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF4	Leptomonas seymouri	39%	100%
A0A3Q8IB69	Leishmania donovani	90%	100%
A4H9T5	Leishmania braziliensis	68%	91%
A4HUT5	Leishmania infantum	89%	100%
E9ANG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%