RECA_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rad51, putative

Species:

Leishmania major

UniProt:

Q4QH57_LEIMA

TriTrypDb:

LmjF.11.0230 , LMJLV39_110007400 , LMJSD75_110007300

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH57

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000730	DNA recombinase assembly	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	5
GO:0006310	DNA recombination	5	2
GO:0006312	mitotic recombination	6	2
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	5
GO:0006974	DNA damage response	4	5

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Molecular functions
Term	Name	Level	Count
GO:0000150	DNA strand exchange activity	4	2
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003690	double-stranded DNA binding	5	2
GO:0003697	single-stranded DNA binding	5	2
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.747
CLV_C14_Caspase3-7	222	226	PF00656	0.538
CLV_C14_Caspase3-7	231	235	PF00656	0.426
CLV_C14_Caspase3-7	242	246	PF00656	0.479
CLV_C14_Caspase3-7	4	8	PF00656	0.706
CLV_C14_Caspase3-7	477	481	PF00656	0.548
CLV_NRD_NRD_1	164	166	PF00675	0.346
CLV_NRD_NRD_1	20	22	PF00675	0.708
CLV_NRD_NRD_1	280	282	PF00675	0.334
CLV_PCSK_KEX2_1	164	166	PF00082	0.346

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF4	Leptomonas seymouri	39%	100%
A0A3Q8IB69	Leishmania donovani	90%	100%
A4H9T5	Leishmania braziliensis	68%	91%
A4HUT5	Leishmania infantum	89%	100%
E9ANG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%

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