Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH54_LEIMA

TriTrypDb:

LmjF.11.0260 , LMJLV39_110007700 , LMJSD75_110007600

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH54

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0005996	monosaccharide metabolic process	3	11
GO:0006006	glucose metabolic process	5	11
GO:0006094	gluconeogenesis	6	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0016051	carbohydrate biosynthetic process	4	11
GO:0019318	hexose metabolic process	4	11
GO:0019319	hexose biosynthetic process	5	11
GO:0044238	primary metabolic process	2	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046364	monosaccharide biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004611	phosphoenolpyruvate carboxykinase activity	5	11
GO:0005488	binding	1	11
GO:0016829	lyase activity	2	11
GO:0016830	carbon-carbon lyase activity	3	11
GO:0016831	carboxy-lyase activity	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0036094	small molecule binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.511
CLV_C14_Caspase3-7	537	541	PF00656	0.526
CLV_NRD_NRD_1	161	163	PF00675	0.414
CLV_NRD_NRD_1	296	298	PF00675	0.450
CLV_NRD_NRD_1	478	480	PF00675	0.517
CLV_NRD_NRD_1	64	66	PF00675	0.587
CLV_PCSK_KEX2_1	176	178	PF00082	0.602
CLV_PCSK_KEX2_1	217	219	PF00082	0.475
CLV_PCSK_KEX2_1	283	285	PF00082	0.570
CLV_PCSK_KEX2_1	296	298	PF00082	0.474
CLV_PCSK_KEX2_1	478	480	PF00082	0.516
CLV_PCSK_KEX2_1	64	66	PF00082	0.587
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.616
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.403
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.563
CLV_PCSK_PC7_1	474	480	PF00082	0.478
CLV_PCSK_SKI1_1	206	210	PF00082	0.454
CLV_PCSK_SKI1_1	217	221	PF00082	0.454
CLV_PCSK_SKI1_1	251	255	PF00082	0.369
CLV_PCSK_SKI1_1	391	395	PF00082	0.497
CLV_PCSK_SKI1_1	552	556	PF00082	0.402
CLV_PCSK_SKI1_1	571	575	PF00082	0.283
CLV_PCSK_SKI1_1	585	589	PF00082	0.370
CLV_PCSK_SKI1_1	66	70	PF00082	0.605
DOC_MAPK_gen_1	162	172	PF00069	0.408
DOC_MAPK_gen_1	296	302	PF00069	0.387
DOC_MAPK_gen_1	388	397	PF00069	0.515
DOC_MAPK_HePTP_8	385	397	PF00069	0.467
DOC_MAPK_MEF2A_6	388	397	PF00069	0.512
DOC_PP1_RVXF_1	183	189	PF00149	0.508
DOC_PP2B_LxvP_1	378	381	PF13499	0.467
DOC_PP4_FxxP_1	310	313	PF00568	0.469
DOC_PP4_FxxP_1	319	322	PF00568	0.537
DOC_PP4_FxxP_1	486	489	PF00568	0.663
DOC_PP4_FxxP_1	507	510	PF00568	0.556
DOC_USP7_MATH_1	114	118	PF00917	0.569
DOC_USP7_MATH_1	14	18	PF00917	0.621
DOC_USP7_MATH_1	381	385	PF00917	0.425
DOC_USP7_MATH_1	520	524	PF00917	0.561
DOC_USP7_MATH_1	544	548	PF00917	0.513
DOC_USP7_MATH_1	572	576	PF00917	0.466
DOC_USP7_MATH_1	580	584	PF00917	0.586
DOC_WW_Pin1_4	245	250	PF00397	0.403
DOC_WW_Pin1_4	253	258	PF00397	0.372
DOC_WW_Pin1_4	285	290	PF00397	0.555
DOC_WW_Pin1_4	309	314	PF00397	0.487
DOC_WW_Pin1_4	407	412	PF00397	0.416
LIG_14-3-3_CanoR_1	140	144	PF00244	0.497
LIG_14-3-3_CanoR_1	177	183	PF00244	0.605
LIG_14-3-3_CanoR_1	284	290	PF00244	0.574
LIG_14-3-3_CanoR_1	333	339	PF00244	0.468
LIG_14-3-3_CanoR_1	391	396	PF00244	0.434
LIG_14-3-3_CanoR_1	456	462	PF00244	0.507
LIG_14-3-3_CanoR_1	478	488	PF00244	0.685
LIG_14-3-3_CanoR_1	581	588	PF00244	0.324
LIG_14-3-3_CanoR_1	6	16	PF00244	0.629
LIG_APCC_ABBAyCdc20_2	552	558	PF00400	0.380
LIG_BRCT_BRCA1_1	306	310	PF00533	0.422
LIG_DCNL_PONY_1	1	4	PF03556	0.670
LIG_deltaCOP1_diTrp_1	291	295	PF00928	0.501
LIG_eIF4E_1	501	507	PF01652	0.642
LIG_eIF4E_1	95	101	PF01652	0.582
LIG_FHA_1	140	146	PF00498	0.496
LIG_FHA_1	165	171	PF00498	0.533
LIG_FHA_1	359	365	PF00498	0.336
LIG_FHA_1	392	398	PF00498	0.369
LIG_FHA_1	445	451	PF00498	0.510
LIG_FHA_1	491	497	PF00498	0.600
LIG_FHA_1	510	516	PF00498	0.686
LIG_FHA_2	102	108	PF00498	0.569
LIG_FHA_2	396	402	PF00498	0.489
LIG_FHA_2	546	552	PF00498	0.563
LIG_LIR_Apic_2	292	298	PF02991	0.492
LIG_LIR_Apic_2	307	313	PF02991	0.445
LIG_LIR_Apic_2	317	322	PF02991	0.505
LIG_LIR_Apic_2	337	343	PF02991	0.233
LIG_LIR_Apic_2	483	489	PF02991	0.672
LIG_LIR_Gen_1	121	130	PF02991	0.525
LIG_LIR_Gen_1	270	279	PF02991	0.552
LIG_LIR_Gen_1	374	385	PF02991	0.434
LIG_LIR_Gen_1	427	437	PF02991	0.392
LIG_LIR_Nem_3	121	126	PF02991	0.534
LIG_LIR_Nem_3	17	22	PF02991	0.589
LIG_LIR_Nem_3	248	253	PF02991	0.389
LIG_LIR_Nem_3	270	274	PF02991	0.579
LIG_LIR_Nem_3	374	380	PF02991	0.429
LIG_LIR_Nem_3	427	433	PF02991	0.363
LIG_MAD2	314	322	PF02301	0.511
LIG_PDZ_Class_1	589	594	PF00595	0.492
LIG_Pex14_1	139	143	PF04695	0.500
LIG_Pex14_1	488	492	PF04695	0.637
LIG_RPA_C_Fungi	1	13	PF08784	0.570
LIG_SH2_CRK	250	254	PF00017	0.369
LIG_SH2_CRK	30	34	PF00017	0.615
LIG_SH2_CRK	303	307	PF00017	0.333
LIG_SH2_CRK	340	344	PF00017	0.389
LIG_SH2_CRK	95	99	PF00017	0.567
LIG_SH2_GRB2like	129	132	PF00017	0.525
LIG_SH2_GRB2like	30	33	PF00017	0.579
LIG_SH2_NCK_1	129	133	PF00017	0.515
LIG_SH2_NCK_1	30	34	PF00017	0.615
LIG_SH2_SRC	129	132	PF00017	0.525
LIG_SH2_SRC	30	33	PF00017	0.614
LIG_SH2_STAP1	492	496	PF00017	0.479
LIG_SH2_STAP1	556	560	PF00017	0.509
LIG_SH2_STAT5	141	144	PF00017	0.486
LIG_SH2_STAT5	234	237	PF00017	0.353
LIG_SH2_STAT5	261	264	PF00017	0.352
LIG_SH2_STAT5	273	276	PF00017	0.469
LIG_SH2_STAT5	377	380	PF00017	0.533
LIG_SH2_STAT5	492	495	PF00017	0.494
LIG_SH2_STAT5	86	89	PF00017	0.419
LIG_SH3_3	430	436	PF00018	0.395
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.640
LIG_SUMO_SIM_anti_2	392	398	PF11976	0.461
LIG_SUMO_SIM_anti_2	529	534	PF11976	0.356
LIG_SUMO_SIM_par_1	392	398	PF11976	0.403
LIG_SUMO_SIM_par_1	531	537	PF11976	0.383
LIG_TRAF2_1	275	278	PF00917	0.457
LIG_TRAF2_1	60	63	PF00917	0.564
LIG_TRAF2_1	80	83	PF00917	0.517
LIG_TRFH_1	148	152	PF08558	0.394
LIG_TYR_ITIM	28	33	PF00017	0.651
LIG_TYR_ITSM	246	253	PF00017	0.397
LIG_WRC_WIRS_1	268	273	PF05994	0.538
MOD_CDK_SPK_2	309	314	PF00069	0.487
MOD_CDK_SPxK_1	245	251	PF00069	0.405
MOD_CK1_1	121	127	PF00069	0.551
MOD_CK1_1	384	390	PF00069	0.400
MOD_CK1_1	460	466	PF00069	0.502
MOD_CK2_1	395	401	PF00069	0.423
MOD_Cter_Amidation	160	163	PF01082	0.407
MOD_Cter_Amidation	174	177	PF01082	0.484
MOD_Cter_Amidation	215	218	PF01082	0.405
MOD_Cter_Amidation	476	479	PF01082	0.515
MOD_GlcNHglycan	135	138	PF01048	0.516
MOD_GlcNHglycan	210	214	PF01048	0.494
MOD_GSK3_1	114	121	PF00069	0.565
MOD_GSK3_1	239	246	PF00069	0.360
MOD_GSK3_1	251	258	PF00069	0.362
MOD_GSK3_1	334	341	PF00069	0.453
MOD_GSK3_1	391	398	PF00069	0.496
MOD_GSK3_1	490	497	PF00069	0.446
MOD_N-GLC_1	114	119	PF02516	0.569
MOD_N-GLC_1	121	126	PF02516	0.534
MOD_N-GLC_1	490	495	PF02516	0.550
MOD_NEK2_1	2	7	PF00069	0.637
MOD_NEK2_1	327	332	PF00069	0.468
MOD_NEK2_1	357	362	PF00069	0.323
MOD_NEK2_1	413	418	PF00069	0.452
MOD_NEK2_2	572	577	PF00069	0.452
MOD_NEK2_2	86	91	PF00069	0.443
MOD_PIKK_1	121	127	PF00454	0.551
MOD_PIKK_1	283	289	PF00454	0.593
MOD_PKA_1	176	182	PF00069	0.527
MOD_PKA_1	283	289	PF00069	0.567
MOD_PKA_2	139	145	PF00069	0.488
MOD_PKA_2	176	182	PF00069	0.527
MOD_PKA_2	2	8	PF00069	0.619
MOD_PKA_2	283	289	PF00069	0.567
MOD_PKA_2	520	526	PF00069	0.480
MOD_PKA_2	580	586	PF00069	0.335
MOD_Plk_1	114	120	PF00069	0.566
MOD_Plk_1	121	127	PF00069	0.532
MOD_Plk_1	209	215	PF00069	0.473
MOD_Plk_1	277	283	PF00069	0.614
MOD_Plk_1	358	364	PF00069	0.361
MOD_Plk_4	277	283	PF00069	0.639
MOD_Plk_4	381	387	PF00069	0.375
MOD_Plk_4	391	397	PF00069	0.397
MOD_Plk_4	96	102	PF00069	0.522
MOD_ProDKin_1	245	251	PF00069	0.401
MOD_ProDKin_1	253	259	PF00069	0.367
MOD_ProDKin_1	285	291	PF00069	0.553
MOD_ProDKin_1	309	315	PF00069	0.498
MOD_ProDKin_1	407	413	PF00069	0.411
TRG_DiLeu_BaEn_4	82	88	PF01217	0.478
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.620
TRG_ENDOCYTIC_2	250	253	PF00928	0.389
TRG_ENDOCYTIC_2	30	33	PF00928	0.579
TRG_ENDOCYTIC_2	377	380	PF00928	0.467
TRG_ENDOCYTIC_2	95	98	PF00928	0.564
TRG_ER_diArg_1	155	158	PF00400	0.457
TRG_ER_diArg_1	295	297	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F9	Leptomonas seymouri	82%	99%
A0A0S4IUG4	Bodo saltans	53%	100%
A0A1X0NVG4	Trypanosomatidae	63%	97%
A0A3S5H6I1	Leishmania donovani	97%	100%
A4H9T2	Leishmania braziliensis	91%	99%
A4HUT8	Leishmania infantum	98%	100%
D0A7M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	98%
E9ANH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BB32	Trypanosoma cruzi	65%	100%