NADH-cytochrome b5 reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-cytochrome b5 reductase-like protein

Species:

Leishmania major

UniProt:

Q4QH53_LEIMA

TriTrypDb:

LmjF.11.0270 , LMJLV39_110007800 , LMJSD75_110007700

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QH53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH53

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	10
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050660	flavin adenine dinucleotide binding	4	2
GO:0071949	FAD binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	298	304	PF00089	0.536
CLV_NRD_NRD_1	232	234	PF00675	0.676
CLV_NRD_NRD_1	38	40	PF00675	0.615
CLV_PCSK_KEX2_1	232	234	PF00082	0.673
CLV_PCSK_KEX2_1	38	40	PF00082	0.575
CLV_PCSK_KEX2_1	43	45	PF00082	0.553
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.586
CLV_PCSK_PC7_1	39	45	PF00082	0.575
CLV_PCSK_SKI1_1	29	33	PF00082	0.454
CLV_PCSK_SKI1_1	71	75	PF00082	0.454
DEG_Nend_Nbox_1	1	3	PF02207	0.702
DEG_SPOP_SBC_1	165	169	PF00917	0.377
DOC_CKS1_1	105	110	PF01111	0.254
DOC_CYCLIN_yCln2_LP_2	258	264	PF00134	0.353
DOC_MAPK_gen_1	216	223	PF00069	0.335
DOC_PP2B_LxvP_1	258	261	PF13499	0.307
DOC_PP4_FxxP_1	72	75	PF00568	0.254
DOC_USP7_MATH_1	85	89	PF00917	0.254
DOC_USP7_UBL2_3	59	63	PF12436	0.379
DOC_WW_Pin1_4	104	109	PF00397	0.256
LIG_14-3-3_CanoR_1	129	137	PF00244	0.312
LIG_14-3-3_CanoR_1	220	226	PF00244	0.354
LIG_14-3-3_CanoR_1	301	306	PF00244	0.376
LIG_AP2alpha_1	205	209	PF02296	0.392
LIG_BRCT_BRCA1_1	337	341	PF00533	0.466
LIG_BRCT_BRCA1_1	64	68	PF00533	0.335
LIG_eIF4E_1	25	31	PF01652	0.442
LIG_eIF4E_1	282	288	PF01652	0.383
LIG_FHA_1	188	194	PF00498	0.365
LIG_FHA_1	337	343	PF00498	0.421
LIG_FHA_2	156	162	PF00498	0.332
LIG_FHA_2	53	59	PF00498	0.319
LIG_GBD_Chelix_1	173	181	PF00786	0.541
LIG_LIR_Apic_2	103	108	PF02991	0.254
LIG_LIR_Gen_1	114	122	PF02991	0.351
LIG_LIR_Gen_1	224	229	PF02991	0.371
LIG_LIR_Nem_3	103	109	PF02991	0.285
LIG_LIR_Nem_3	114	120	PF02991	0.285
LIG_LIR_Nem_3	158	162	PF02991	0.342
LIG_LIR_Nem_3	207	213	PF02991	0.348
LIG_LIR_Nem_3	224	228	PF02991	0.328
LIG_LIR_Nem_3	24	28	PF02991	0.332
LIG_LIR_Nem_3	303	308	PF02991	0.448
LIG_LIR_Nem_3	77	83	PF02991	0.257
LIG_Pex14_1	148	152	PF04695	0.305
LIG_Pex14_1	311	315	PF04695	0.326
LIG_Pex14_2	17	21	PF04695	0.187
LIG_Pex14_2	205	209	PF04695	0.324
LIG_Pex14_2	68	72	PF04695	0.307
LIG_PTB_Apo_2	304	311	PF02174	0.372
LIG_PTB_Phospho_1	304	310	PF10480	0.379
LIG_REV1ctd_RIR_1	207	215	PF16727	0.411
LIG_SH2_CRK	106	110	PF00017	0.307
LIG_SH2_CRK	225	229	PF00017	0.401
LIG_SH2_CRK	28	32	PF00017	0.420
LIG_SH2_NCK_1	106	110	PF00017	0.307
LIG_SH2_NCK_1	83	87	PF00017	0.254
LIG_SH2_SRC	136	139	PF00017	0.335
LIG_SH2_SRC	78	81	PF00017	0.268
LIG_SH2_SRC	83	86	PF00017	0.239
LIG_SH2_STAT3	282	285	PF00017	0.399
LIG_SH2_STAT5	106	109	PF00017	0.285
LIG_SH2_STAT5	136	139	PF00017	0.297
LIG_SH2_STAT5	144	147	PF00017	0.243
LIG_SH2_STAT5	195	198	PF00017	0.302
LIG_SH2_STAT5	245	248	PF00017	0.425
LIG_SH2_STAT5	327	330	PF00017	0.394
LIG_SH2_STAT5	9	12	PF00017	0.404
LIG_SH3_1	150	156	PF00018	0.391
LIG_SH3_3	150	156	PF00018	0.391
LIG_SH3_3	28	34	PF00018	0.529
LIG_SH3_3	47	53	PF00018	0.188
LIG_SUMO_SIM_anti_2	11	17	PF11976	0.187
LIG_SUMO_SIM_anti_2	187	195	PF11976	0.353
LIG_SUMO_SIM_par_1	52	58	PF11976	0.301
LIG_SxIP_EBH_1	196	206	PF03271	0.383
LIG_TYR_ITIM	223	228	PF00017	0.383
LIG_UBA3_1	177	185	PF00899	0.319
LIG_WRC_WIRS_1	302	307	PF05994	0.432
LIG_WW_1	279	282	PF00397	0.271
MOD_CK1_1	100	106	PF00069	0.307
MOD_CK1_1	169	175	PF00069	0.302
MOD_CK2_1	155	161	PF00069	0.338
MOD_CK2_1	52	58	PF00069	0.331
MOD_Cter_Amidation	230	233	PF01082	0.667
MOD_GlcNHglycan	130	133	PF01048	0.507
MOD_GlcNHglycan	168	171	PF01048	0.511
MOD_GlcNHglycan	235	238	PF01048	0.693
MOD_GlcNHglycan	318	321	PF01048	0.552
MOD_GlcNHglycan	92	95	PF01048	0.485
MOD_GSK3_1	100	107	PF00069	0.259
MOD_GSK3_1	165	172	PF00069	0.290
MOD_GSK3_1	274	281	PF00069	0.466
MOD_NEK2_1	205	210	PF00069	0.367
MOD_NEK2_1	21	26	PF00069	0.375
MOD_NEK2_1	325	330	PF00069	0.309
MOD_NEK2_1	335	340	PF00069	0.330
MOD_NEK2_2	85	90	PF00069	0.268
MOD_PIKK_1	274	280	PF00454	0.508
MOD_PIKK_1	327	333	PF00454	0.310
MOD_PKA_1	233	239	PF00069	0.471
MOD_PKA_2	128	134	PF00069	0.335
MOD_PKA_2	221	227	PF00069	0.338
MOD_PKA_2	300	306	PF00069	0.370
MOD_PKA_2	316	322	PF00069	0.337
MOD_Plk_1	186	192	PF00069	0.246
MOD_Plk_1	97	103	PF00069	0.335
MOD_Plk_4	189	195	PF00069	0.343
MOD_Plk_4	205	211	PF00069	0.363
MOD_Plk_4	290	296	PF00069	0.308
MOD_ProDKin_1	104	110	PF00069	0.256
TRG_ENDOCYTIC_2	106	109	PF00928	0.307
TRG_ENDOCYTIC_2	225	228	PF00928	0.319
TRG_ENDOCYTIC_2	28	31	PF00928	0.306
TRG_ENDOCYTIC_2	318	321	PF00928	0.313
TRG_ENDOCYTIC_2	83	86	PF00928	0.254
TRG_ER_diArg_1	133	136	PF00400	0.285
TRG_ER_diArg_1	220	223	PF00400	0.318
TRG_ER_diArg_1	38	40	PF00400	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L4	Leptomonas seymouri	26%	100%
A0A0N0P705	Leptomonas seymouri	25%	100%
A0A0N1I0P2	Leptomonas seymouri	78%	80%
A0A0N1I279	Leptomonas seymouri	24%	100%
A0A0N1ILC4	Leptomonas seymouri	25%	100%
A0A0N1PBS9	Leptomonas seymouri	24%	100%
A0A0S4IMP5	Bodo saltans	22%	95%
A0A0S4ITW4	Bodo saltans	48%	84%
A0A0S4JV75	Bodo saltans	24%	97%
A0A1X0NRH2	Trypanosomatidae	25%	100%
A0A1X0NT99	Trypanosomatidae	25%	100%
A0A1X0NTX4	Trypanosomatidae	24%	100%
A0A1X0NV22	Trypanosomatidae	24%	100%
A0A1X0NWV9	Trypanosomatidae	52%	87%
A0A1X0P541	Trypanosomatidae	24%	100%
A0A3Q8I8J2	Leishmania donovani	25%	100%
A0A3Q8I905	Leishmania donovani	94%	100%
A0A3Q8IBE7	Leishmania donovani	25%	100%
A0A3Q8ILI9	Leishmania donovani	25%	100%
A0A3R7JSY9	Trypanosoma rangeli	26%	100%
A0A3R7JZZ7	Trypanosoma rangeli	24%	100%
A0A3R7MD20	Trypanosoma rangeli	24%	100%
A0A3S5H6T5	Leishmania donovani	25%	100%
A0A3S5H7H5	Leishmania donovani	23%	100%
A0A3S7X5Q8	Leishmania donovani	24%	100%
A0A422NMZ5	Trypanosoma rangeli	22%	100%
A1C7E9	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	24%	100%
A1DHW1	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	100%
A2Q898	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	22%	100%
A2QCV4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	100%
A3GF86	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	28%	100%
A3LT66	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	26%	100%
A4H794	Leishmania braziliensis	24%	100%
A4H7X5	Leishmania braziliensis	24%	100%
A4HCD2	Leishmania braziliensis	23%	100%
A4HCD3	Leishmania braziliensis	24%	100%
A4HKM5	Leishmania braziliensis	25%	100%
A4HUT9	Leishmania infantum	94%	100%
A4HVN4	Leishmania infantum	25%	100%
A4HWA2	Leishmania infantum	25%	100%
A4HZV4	Leishmania infantum	25%	100%
A4HZV5	Leishmania infantum	25%	100%
A4I862	Leishmania infantum	24%	100%
A4QR21	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	100%
A4R935	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	100%
A5DQ25	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	100%
A5DQE4	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	100%
A5E5C5	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	25%	100%
A5E7U2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	27%	100%
A6R1T7	Ajellomyces capsulatus (strain NAm1 / WU24)	21%	100%
A6R2K7	Ajellomyces capsulatus (strain NAm1 / WU24)	26%	100%
A6SI59	Botryotinia fuckeliana (strain B05.10)	24%	100%
A6ZVM6	Saccharomyces cerevisiae (strain YJM789)	24%	100%
A6ZZH2	Saccharomyces cerevisiae (strain YJM789)	23%	100%
A7EKT5	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	24%	100%
A7THS1	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	22%	100%
A7TM72	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	26%	100%
A7TNL7	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	24%	100%
C9ZNT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
C9ZSH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
D0A5S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
D0A6L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A7L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	89%
D0AAC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AD50	Leishmania major	23%	100%
E9AHE4	Leishmania infantum	23%	100%
E9ANH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9APD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AQ02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AVR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AVR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AYX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B313	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
O74557	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P0CP14	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	25%	100%
P0CP15	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	25%	100%
P36060	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P83291	Arabidopsis thaliana	28%	100%
Q0CRD8	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	21%	100%
Q0CY37	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	100%
Q0U9W5	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	25%	100%
Q0UEY4	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	23%	100%
Q1DWN4	Coccidioides immitis (strain RS)	26%	100%
Q1DXN1	Coccidioides immitis (strain RS)	22%	100%
Q2UFN3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
Q2UKB8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	22%	100%
Q3KNK3	Mus musculus	25%	100%
Q4P7Y8	Ustilago maydis (strain 521 / FGSC 9021)	24%	99%
Q4PGW7	Ustilago maydis (strain 521 / FGSC 9021)	24%	100%
Q4Q541	Leishmania major	23%	100%
Q4QBR9	Leishmania major	24%	100%
Q4QBS0	Leishmania major	23%	100%
Q4QFH9	Leishmania major	24%	97%
Q4QG48	Leishmania major	26%	100%
Q4WJW8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	20%	100%
Q4X0B5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54NC1	Dictyostelium discoideum	26%	100%
Q59M70	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	100%
Q59P03	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q5AZB4	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
Q6AY12	Rattus norvegicus	24%	100%
Q6BCY4	Homo sapiens	23%	100%
Q6BQ54	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	100%
Q6BUX2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	100%
Q6C9G8	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	100%
Q6CA86	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	100%
Q6CID0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	100%
Q6CS27	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
Q6FUX5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	100%
Q75AL4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	100%
Q75C62	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	100%
Q7RXL1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
Q7SFY2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	100%
Q9DB73	Mus musculus	24%	100%
Q9UHQ9	Homo sapiens	24%	100%
V5AU35	Trypanosoma cruzi	23%	100%
V5B8B1	Trypanosoma cruzi	25%	100%
V5BVT5	Trypanosoma cruzi	24%	100%
V5DSW9	Trypanosoma cruzi	58%	92%