Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QH51_LEIMA

TriTrypDb:

LmjF.11.0290 , LMJLV39_110008300 , LMJSD75_110008400

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.529
CLV_NRD_NRD_1	225	227	PF00675	0.703
CLV_NRD_NRD_1	309	311	PF00675	0.630
CLV_NRD_NRD_1	344	346	PF00675	0.642
CLV_NRD_NRD_1	38	40	PF00675	0.566
CLV_NRD_NRD_1	430	432	PF00675	0.591
CLV_NRD_NRD_1	67	69	PF00675	0.691
CLV_PCSK_FUR_1	223	227	PF00082	0.630
CLV_PCSK_FUR_1	352	356	PF00082	0.653
CLV_PCSK_FUR_1	36	40	PF00082	0.622
CLV_PCSK_KEX2_1	225	227	PF00082	0.698
CLV_PCSK_KEX2_1	309	311	PF00082	0.630
CLV_PCSK_KEX2_1	344	346	PF00082	0.667
CLV_PCSK_KEX2_1	354	356	PF00082	0.626
CLV_PCSK_KEX2_1	36	38	PF00082	0.606
CLV_PCSK_KEX2_1	430	432	PF00082	0.591
CLV_PCSK_KEX2_1	48	50	PF00082	0.654
CLV_PCSK_KEX2_1	67	69	PF00082	0.574
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.704
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.573
CLV_PCSK_PC7_1	340	346	PF00082	0.639
CLV_PCSK_PC7_1	426	432	PF00082	0.600
CLV_PCSK_SKI1_1	27	31	PF00082	0.489
CLV_PCSK_SKI1_1	309	313	PF00082	0.650
CLV_PCSK_SKI1_1	345	349	PF00082	0.668
CLV_PCSK_SKI1_1	444	448	PF00082	0.557
CLV_Separin_Metazoa	441	445	PF03568	0.543
DEG_APCC_DBOX_1	344	352	PF00400	0.552
DEG_Nend_Nbox_1	1	3	PF02207	0.481
DEG_SCF_FBW7_1	101	106	PF00400	0.651
DEG_SPOP_SBC_1	396	400	PF00917	0.480
DOC_ANK_TNKS_1	354	361	PF00023	0.681
DOC_CKS1_1	237	242	PF01111	0.696
DOC_CYCLIN_RxL_1	306	315	PF00134	0.694
DOC_MAPK_MEF2A_6	3	12	PF00069	0.485
DOC_PP2B_LxvP_1	95	98	PF13499	0.701
DOC_PP4_FxxP_1	237	240	PF00568	0.702
DOC_PP4_FxxP_1	347	350	PF00568	0.623
DOC_USP7_MATH_1	134	138	PF00917	0.800
DOC_USP7_MATH_1	146	150	PF00917	0.611
DOC_USP7_MATH_1	164	168	PF00917	0.632
DOC_USP7_MATH_1	212	216	PF00917	0.665
DOC_USP7_MATH_1	29	33	PF00917	0.476
DOC_USP7_MATH_1	437	441	PF00917	0.642
DOC_USP7_MATH_1	53	57	PF00917	0.553
DOC_WW_Pin1_4	130	135	PF00397	0.722
DOC_WW_Pin1_4	142	147	PF00397	0.627
DOC_WW_Pin1_4	181	186	PF00397	0.635
DOC_WW_Pin1_4	236	241	PF00397	0.632
DOC_WW_Pin1_4	292	297	PF00397	0.820
DOC_WW_Pin1_4	99	104	PF00397	0.604
LIG_14-3-3_CanoR_1	214	221	PF00244	0.727
LIG_14-3-3_CanoR_1	444	449	PF00244	0.621
LIG_14-3-3_CanoR_1	92	98	PF00244	0.604
LIG_Clathr_ClatBox_1	311	315	PF01394	0.678
LIG_FHA_1	100	106	PF00498	0.670
LIG_FHA_1	145	151	PF00498	0.570
LIG_FHA_1	226	232	PF00498	0.674
LIG_FHA_1	237	243	PF00498	0.754
LIG_FHA_1	397	403	PF00498	0.577
LIG_FHA_1	71	77	PF00498	0.649
LIG_FHA_2	398	404	PF00498	0.514
LIG_FHA_2	436	442	PF00498	0.534
LIG_FHA_2	85	91	PF00498	0.726
LIG_Integrin_RGD_1	355	357	PF01839	0.565
LIG_LIR_Apic_2	336	341	PF02991	0.667
LIG_LIR_Gen_1	381	391	PF02991	0.697
LIG_LIR_Nem_3	381	386	PF02991	0.703
LIG_MYND_1	346	350	PF01753	0.670
LIG_SH2_CRK	338	342	PF00017	0.668
LIG_SH2_CRK	383	387	PF00017	0.577
LIG_SH2_NCK_1	338	342	PF00017	0.619
LIG_SH2_STAP1	383	387	PF00017	0.577
LIG_SH2_STAT5	252	255	PF00017	0.522
LIG_SH3_1	414	420	PF00018	0.581
LIG_SH3_3	125	131	PF00018	0.787
LIG_SH3_3	140	146	PF00018	0.533
LIG_SH3_3	290	296	PF00018	0.713
LIG_SH3_3	343	349	PF00018	0.681
LIG_SH3_3	414	420	PF00018	0.627
LIG_SH3_3	75	81	PF00018	0.583
LIG_TRFH_1	312	316	PF08558	0.675
LIG_UBA3_1	253	261	PF00899	0.467
LIG_WRC_WIRS_1	172	177	PF05994	0.591
LIG_WRC_WIRS_1	445	450	PF05994	0.566
MOD_CDC14_SPxK_1	145	148	PF00782	0.680
MOD_CDK_SPK_2	236	241	PF00069	0.655
MOD_CDK_SPxK_1	142	148	PF00069	0.677
MOD_CK1_1	133	139	PF00069	0.756
MOD_CK1_1	173	179	PF00069	0.613
MOD_CK1_1	194	200	PF00069	0.659
MOD_CK1_1	207	213	PF00069	0.613
MOD_CK1_1	215	221	PF00069	0.718
MOD_CK1_1	259	265	PF00069	0.612
MOD_CK1_1	62	68	PF00069	0.679
MOD_CK1_1	99	105	PF00069	0.808
MOD_CK2_1	150	156	PF00069	0.559
MOD_CK2_1	207	213	PF00069	0.676
MOD_CK2_1	259	265	PF00069	0.610
MOD_CK2_1	322	328	PF00069	0.774
MOD_CK2_1	397	403	PF00069	0.601
MOD_CK2_1	435	441	PF00069	0.535
MOD_CK2_1	53	59	PF00069	0.576
MOD_GlcNHglycan	110	113	PF01048	0.691
MOD_GlcNHglycan	117	120	PF01048	0.600
MOD_GlcNHglycan	136	139	PF01048	0.750
MOD_GlcNHglycan	140	143	PF01048	0.749
MOD_GlcNHglycan	153	156	PF01048	0.565
MOD_GlcNHglycan	185	188	PF01048	0.586
MOD_GlcNHglycan	193	196	PF01048	0.775
MOD_GlcNHglycan	258	261	PF01048	0.514
MOD_GlcNHglycan	324	327	PF01048	0.691
MOD_GlcNHglycan	330	333	PF01048	0.711
MOD_GlcNHglycan	359	363	PF01048	0.679
MOD_GlcNHglycan	432	436	PF01048	0.548
MOD_GSK3_1	130	137	PF00069	0.761
MOD_GSK3_1	138	145	PF00069	0.662
MOD_GSK3_1	146	153	PF00069	0.574
MOD_GSK3_1	203	210	PF00069	0.616
MOD_GSK3_1	212	219	PF00069	0.646
MOD_GSK3_1	225	232	PF00069	0.652
MOD_GSK3_1	255	262	PF00069	0.615
MOD_GSK3_1	431	438	PF00069	0.698
MOD_GSK3_1	53	60	PF00069	0.627
MOD_GSK3_1	70	77	PF00069	0.664
MOD_GSK3_1	84	91	PF00069	0.580
MOD_GSK3_1	93	100	PF00069	0.658
MOD_NEK2_1	203	208	PF00069	0.637
MOD_NEK2_1	30	35	PF00069	0.505
MOD_NEK2_1	395	400	PF00069	0.529
MOD_NEK2_1	57	62	PF00069	0.634
MOD_NEK2_1	93	98	PF00069	0.633
MOD_PIKK_1	10	16	PF00454	0.454
MOD_PIKK_1	30	36	PF00454	0.465
MOD_PIKK_1	79	85	PF00454	0.686
MOD_PKA_1	225	231	PF00069	0.623
MOD_PKA_2	213	219	PF00069	0.754
MOD_PKA_2	225	231	PF00069	0.694
MOD_PKA_2	425	431	PF00069	0.665
MOD_PKA_2	93	99	PF00069	0.607
MOD_PKB_1	223	231	PF00069	0.628
MOD_Plk_1	170	176	PF00069	0.678
MOD_Plk_1	88	94	PF00069	0.578
MOD_Plk_2-3	171	177	PF00069	0.639
MOD_Plk_4	164	170	PF00069	0.683
MOD_Plk_4	204	210	PF00069	0.605
MOD_Plk_4	248	254	PF00069	0.563
MOD_Plk_4	397	403	PF00069	0.577
MOD_ProDKin_1	130	136	PF00069	0.722
MOD_ProDKin_1	142	148	PF00069	0.629
MOD_ProDKin_1	181	187	PF00069	0.638
MOD_ProDKin_1	236	242	PF00069	0.626
MOD_ProDKin_1	292	298	PF00069	0.820
MOD_ProDKin_1	99	105	PF00069	0.604
MOD_SUMO_rev_2	458	463	PF00179	0.672
TRG_DiLeu_BaEn_2	373	379	PF01217	0.541
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.530
TRG_ENDOCYTIC_2	383	386	PF00928	0.590
TRG_ER_diArg_1	223	226	PF00400	0.722
TRG_ER_diArg_1	309	311	PF00400	0.630
TRG_ER_diArg_1	344	346	PF00400	0.642
TRG_ER_diArg_1	36	39	PF00400	0.699
TRG_ER_diArg_1	92	95	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV85	Leptomonas seymouri	26%	100%
A0A3S7WRI4	Leishmania donovani	88%	100%
A4H9S9	Leishmania braziliensis	58%	93%
A4HUU0	Leishmania infantum	88%	100%
E9ANH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	97%