Sec20 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sec20, putative

Species:

Leishmania major

UniProt:

Q4QH50_LEIMA

TriTrypDb:

LmjF.11.0300 , LMJLV39_110008400 , LMJSD75_110008500

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	10
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

Q4QH50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH50

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	10
GO:0016192	vesicle-mediated transport	4	10
GO:0048193	Golgi vesicle transport	5	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10

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Molecular functions
Term	Name	Level	Count
GO:0005484	SNAP receptor activity	3	10
GO:0030674	protein-macromolecule adaptor activity	2	10
GO:0060090	molecular adaptor activity	1	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	193	199	PF00089	0.485
CLV_NRD_NRD_1	93	95	PF00675	0.440
CLV_PCSK_KEX2_1	93	95	PF00082	0.440
CLV_PCSK_PC7_1	89	95	PF00082	0.432
CLV_PCSK_SKI1_1	130	134	PF00082	0.290
CLV_PCSK_SKI1_1	136	140	PF00082	0.290
CLV_PCSK_SKI1_1	182	186	PF00082	0.290
CLV_PCSK_SKI1_1	93	97	PF00082	0.459
DEG_APCC_DBOX_1	88	96	PF00400	0.704
DEG_SPOP_SBC_1	114	118	PF00917	0.723

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V7	Leptomonas seymouri	64%	89%
A0A1X0NV60	Trypanosomatidae	47%	100%
A0A3S5ISC5	Trypanosoma rangeli	42%	100%
A0A3S7WRJ0	Leishmania donovani	95%	84%
A4H9S8	Leishmania braziliensis	82%	72%
A4HUU1	Leishmania infantum	95%	84%
E9ANH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	84%
V5BBG4	Trypanosoma cruzi	44%	100%

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