Sec20 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sec20, putative

Species:

Leishmania major

UniProt:

Q4QH50_LEIMA

TriTrypDb:

LmjF.11.0300 , LMJLV39_110008400 , LMJSD75_110008500

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	10
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QH50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH50

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	10
GO:0016192	vesicle-mediated transport	4	10
GO:0048193	Golgi vesicle transport	5	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10

Molecular functions
Term	Name	Level	Count
GO:0005484	SNAP receptor activity	3	10
GO:0030674	protein-macromolecule adaptor activity	2	10
GO:0060090	molecular adaptor activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	193	199	PF00089	0.485
CLV_NRD_NRD_1	93	95	PF00675	0.440
CLV_PCSK_KEX2_1	93	95	PF00082	0.440
CLV_PCSK_PC7_1	89	95	PF00082	0.432
CLV_PCSK_SKI1_1	130	134	PF00082	0.290
CLV_PCSK_SKI1_1	136	140	PF00082	0.290
CLV_PCSK_SKI1_1	182	186	PF00082	0.290
CLV_PCSK_SKI1_1	93	97	PF00082	0.459
DEG_APCC_DBOX_1	88	96	PF00400	0.704
DEG_SPOP_SBC_1	114	118	PF00917	0.723
DOC_CYCLIN_RxL_1	127	137	PF00134	0.488
DOC_CYCLIN_RxL_1	178	189	PF00134	0.490
DOC_MAPK_gen_1	10	20	PF00069	0.707
DOC_MAPK_gen_1	179	187	PF00069	0.509
DOC_MAPK_gen_1	76	85	PF00069	0.718
DOC_MAPK_MEF2A_6	136	143	PF00069	0.465
DOC_MAPK_MEF2A_6	190	197	PF00069	0.502
DOC_MAPK_NFAT4_5	190	198	PF00069	0.514
DOC_USP7_MATH_1	128	132	PF00917	0.501
DOC_USP7_MATH_1	154	158	PF00917	0.508
DOC_USP7_MATH_1	5	9	PF00917	0.738
DOC_USP7_MATH_1	65	69	PF00917	0.821
DOC_WW_Pin1_4	56	61	PF00397	0.734
DOC_WW_Pin1_4	63	68	PF00397	0.742
LIG_14-3-3_CanoR_1	120	129	PF00244	0.687
LIG_14-3-3_CanoR_1	136	142	PF00244	0.585
LIG_14-3-3_CanoR_1	179	185	PF00244	0.500
LIG_14-3-3_CanoR_1	196	204	PF00244	0.285
LIG_Actin_WH2_2	180	198	PF00022	0.490
LIG_Actin_WH2_2	78	95	PF00022	0.705
LIG_FHA_1	219	225	PF00498	0.491
LIG_FHA_1	9	15	PF00498	0.742
LIG_FHA_2	108	114	PF00498	0.775
LIG_FHA_2	32	38	PF00498	0.618
LIG_FHA_2	73	79	PF00498	0.758
LIG_LIR_Gen_1	220	229	PF02991	0.527
LIG_LIR_Nem_3	220	226	PF02991	0.494
LIG_NRBOX	128	134	PF00104	0.490
LIG_PDZ_Class_3	224	229	PF00595	0.476
LIG_SH2_PTP2	223	226	PF00017	0.487
LIG_SH2_STAT5	208	211	PF00017	0.344
LIG_SH2_STAT5	223	226	PF00017	0.424
LIG_SUMO_SIM_par_1	137	142	PF11976	0.543
LIG_SUMO_SIM_par_1	183	189	PF11976	0.474
LIG_TRAF2_1	75	78	PF00917	0.757
LIG_TRFH_1	215	219	PF08558	0.489
MOD_CDK_SPxxK_3	56	63	PF00069	0.753
MOD_CK1_1	118	124	PF00069	0.719
MOD_CK1_1	137	143	PF00069	0.531
MOD_CK1_1	156	162	PF00069	0.401
MOD_CK1_1	54	60	PF00069	0.761
MOD_CK1_1	8	14	PF00069	0.693
MOD_CK2_1	169	175	PF00069	0.563
MOD_CK2_1	31	37	PF00069	0.631
MOD_CK2_1	72	78	PF00069	0.734
MOD_GlcNHglycan	117	120	PF01048	0.532
MOD_GlcNHglycan	197	200	PF01048	0.444
MOD_GlcNHglycan	53	56	PF01048	0.585
MOD_GSK3_1	114	121	PF00069	0.716
MOD_GSK3_1	128	135	PF00069	0.427
MOD_GSK3_1	59	66	PF00069	0.784
MOD_N-GLC_1	107	112	PF02516	0.516
MOD_N-GLC_1	8	13	PF02516	0.557
MOD_NEK2_1	132	137	PF00069	0.490
MOD_NEK2_1	163	168	PF00069	0.508
MOD_NEK2_1	180	185	PF00069	0.496
MOD_NEK2_1	195	200	PF00069	0.235
MOD_PIKK_1	8	14	PF00454	0.693
MOD_PKA_2	195	201	PF00069	0.344
MOD_Plk_2-3	107	113	PF00069	0.706
MOD_Plk_4	218	224	PF00069	0.462
MOD_ProDKin_1	56	62	PF00069	0.735
MOD_ProDKin_1	63	69	PF00069	0.740
MOD_SUMO_rev_2	137	146	PF00179	0.561
TRG_ENDOCYTIC_2	223	226	PF00928	0.487
TRG_ENDOCYTIC_2	82	85	PF00928	0.697
TRG_ER_diArg_1	92	94	PF00400	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V7	Leptomonas seymouri	64%	89%
A0A1X0NV60	Trypanosomatidae	47%	100%
A0A3S5ISC5	Trypanosoma rangeli	42%	100%
A0A3S7WRJ0	Leishmania donovani	95%	84%
A4H9S8	Leishmania braziliensis	82%	72%
A4HUU1	Leishmania infantum	95%	84%
E9ANH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	84%
V5BBG4	Trypanosoma cruzi	44%	100%