Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QH46_LEIMA

TriTrypDb:

LmjF.11.0340 , LMJLV39_110008800 , LMJSD75_110008900

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.615
CLV_NRD_NRD_1	13	15	PF00675	0.729
CLV_NRD_NRD_1	17	19	PF00675	0.688
CLV_NRD_NRD_1	335	337	PF00675	0.571
CLV_NRD_NRD_1	385	387	PF00675	0.701
CLV_NRD_NRD_1	394	396	PF00675	0.632
CLV_NRD_NRD_1	4	6	PF00675	0.756
CLV_PCSK_KEX2_1	13	15	PF00082	0.681
CLV_PCSK_KEX2_1	335	337	PF00082	0.571
CLV_PCSK_KEX2_1	385	387	PF00082	0.682
CLV_PCSK_KEX2_1	392	394	PF00082	0.584
CLV_PCSK_KEX2_1	4	6	PF00082	0.743
CLV_PCSK_KEX2_1	457	459	PF00082	0.738
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.640
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.715
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.738
CLV_PCSK_SKI1_1	430	434	PF00082	0.640
DEG_SIAH_1	472	480	PF03145	0.692
DEG_SPOP_SBC_1	233	237	PF00917	0.754
DOC_CKS1_1	130	135	PF01111	0.736
DOC_PP2B_LxvP_1	381	384	PF13499	0.698
DOC_USP7_MATH_1	111	115	PF00917	0.776
DOC_USP7_MATH_1	279	283	PF00917	0.746
DOC_USP7_MATH_1	292	296	PF00917	0.666
DOC_USP7_MATH_1	360	364	PF00917	0.651
DOC_USP7_MATH_1	436	440	PF00917	0.586
DOC_USP7_MATH_1	462	466	PF00917	0.592
DOC_USP7_MATH_2	96	102	PF00917	0.615
DOC_USP7_UBL2_3	6	10	PF12436	0.777
DOC_WW_Pin1_4	12	17	PF00397	0.601
DOC_WW_Pin1_4	129	134	PF00397	0.741
DOC_WW_Pin1_4	163	168	PF00397	0.744
DOC_WW_Pin1_4	215	220	PF00397	0.716
DOC_WW_Pin1_4	221	226	PF00397	0.679
DOC_WW_Pin1_4	234	239	PF00397	0.534
DOC_WW_Pin1_4	274	279	PF00397	0.709
DOC_WW_Pin1_4	352	357	PF00397	0.711
DOC_WW_Pin1_4	370	375	PF00397	0.608
DOC_WW_Pin1_4	394	399	PF00397	0.804
DOC_WW_Pin1_4	434	439	PF00397	0.658
DOC_WW_Pin1_4	475	480	PF00397	0.657
DOC_WW_Pin1_4	79	84	PF00397	0.680
LIG_14-3-3_CanoR_1	138	142	PF00244	0.760
LIG_14-3-3_CanoR_1	326	334	PF00244	0.569
LIG_14-3-3_CanoR_1	350	355	PF00244	0.622
LIG_14-3-3_CanoR_1	61	70	PF00244	0.656
LIG_Actin_WH2_2	191	207	PF00022	0.687
LIG_Actin_WH2_2	306	323	PF00022	0.737
LIG_BIR_III_2	435	439	PF00653	0.618
LIG_BIR_III_4	251	255	PF00653	0.654
LIG_Clathr_ClatBox_1	264	268	PF01394	0.786
LIG_FHA_1	120	126	PF00498	0.752
LIG_FHA_1	241	247	PF00498	0.757
LIG_FHA_1	353	359	PF00498	0.744
LIG_FHA_1	376	382	PF00498	0.622
LIG_FHA_1	476	482	PF00498	0.654
LIG_FHA_2	130	136	PF00498	0.643
LIG_GBD_Chelix_1	180	188	PF00786	0.683
LIG_HP1_1	479	483	PF01393	0.749
LIG_LIR_Apic_2	297	303	PF02991	0.743
LIG_LIR_Apic_2	442	447	PF02991	0.668
LIG_LIR_Gen_1	308	316	PF02991	0.670
LIG_LIR_Gen_1	349	358	PF02991	0.698
LIG_LIR_Nem_3	176	182	PF02991	0.679
LIG_LIR_Nem_3	197	202	PF02991	0.730
LIG_LIR_Nem_3	297	302	PF02991	0.746
LIG_LIR_Nem_3	308	313	PF02991	0.571
LIG_LIR_Nem_3	349	354	PF02991	0.689
LIG_SH2_CRK	127	131	PF00017	0.753
LIG_SH2_CRK	444	448	PF00017	0.700
LIG_SH2_NCK_1	127	131	PF00017	0.753
LIG_SH2_STAT5	179	182	PF00017	0.671
LIG_SH2_STAT5	448	451	PF00017	0.739
LIG_SH3_1	127	133	PF00018	0.748
LIG_SH3_1	371	377	PF00018	0.611
LIG_SH3_3	127	133	PF00018	0.799
LIG_SH3_3	154	160	PF00018	0.706
LIG_SH3_3	322	328	PF00018	0.692
LIG_SH3_3	371	377	PF00018	0.643
LIG_SH3_3	435	441	PF00018	0.600
LIG_SH3_4	103	110	PF00018	0.614
LIG_SUMO_SIM_anti_2	308	315	PF11976	0.476
LIG_SUMO_SIM_anti_2	478	484	PF11976	0.655
LIG_SUMO_SIM_par_1	262	268	PF11976	0.717
LIG_TRFH_1	257	261	PF08558	0.678
LIG_TRFH_1	299	303	PF08558	0.706
LIG_UBA3_1	301	307	PF00899	0.496
LIG_WW_3	323	327	PF00397	0.697
MOD_CDK_SPK_2	396	401	PF00069	0.808
MOD_CDK_SPxK_1	12	18	PF00069	0.602
MOD_CDK_SPxxK_3	12	19	PF00069	0.600
MOD_CDK_SPxxK_3	352	359	PF00069	0.680
MOD_CDK_SPxxK_3	394	401	PF00069	0.747
MOD_CK1_1	120	126	PF00069	0.774
MOD_CK1_1	140	146	PF00069	0.487
MOD_CK1_1	189	195	PF00069	0.716
MOD_CK1_1	203	209	PF00069	0.505
MOD_CK1_1	224	230	PF00069	0.721
MOD_CK1_1	234	240	PF00069	0.717
MOD_CK1_1	263	269	PF00069	0.789
MOD_CK1_1	280	286	PF00069	0.567
MOD_CK1_1	375	381	PF00069	0.703
MOD_CK1_1	439	445	PF00069	0.565
MOD_CK1_1	460	466	PF00069	0.591
MOD_CK1_1	54	60	PF00069	0.757
MOD_CK2_1	360	366	PF00069	0.633
MOD_CK2_1	79	85	PF00069	0.684
MOD_GlcNHglycan	113	116	PF01048	0.817
MOD_GlcNHglycan	121	125	PF01048	0.660
MOD_GlcNHglycan	127	130	PF01048	0.566
MOD_GlcNHglycan	143	146	PF01048	0.609
MOD_GlcNHglycan	171	176	PF01048	0.594
MOD_GlcNHglycan	205	208	PF01048	0.641
MOD_GlcNHglycan	294	297	PF01048	0.706
MOD_GlcNHglycan	362	365	PF01048	0.688
MOD_GlcNHglycan	459	462	PF01048	0.749
MOD_GlcNHglycan	53	56	PF01048	0.621
MOD_GlcNHglycan	89	92	PF01048	0.760
MOD_GSK3_1	125	132	PF00069	0.745
MOD_GSK3_1	137	144	PF00069	0.596
MOD_GSK3_1	182	189	PF00069	0.693
MOD_GSK3_1	190	197	PF00069	0.591
MOD_GSK3_1	259	266	PF00069	0.752
MOD_GSK3_1	346	353	PF00069	0.578
MOD_GSK3_1	354	361	PF00069	0.667
MOD_GSK3_1	420	427	PF00069	0.747
MOD_GSK3_1	50	57	PF00069	0.816
MOD_GSK3_1	66	73	PF00069	0.556
MOD_N-GLC_1	189	194	PF02516	0.716
MOD_N-GLC_1	70	75	PF02516	0.690
MOD_NEK2_1	125	130	PF00069	0.808
MOD_NEK2_1	151	156	PF00069	0.693
MOD_NEK2_1	306	311	PF00069	0.657
MOD_NEK2_1	358	363	PF00069	0.624
MOD_NEK2_1	420	425	PF00069	0.587
MOD_NEK2_2	200	205	PF00069	0.676
MOD_OFUCOSY	158	165	PF10250	0.668
MOD_PK_1	350	356	PF00069	0.608
MOD_PKA_1	457	463	PF00069	0.682
MOD_PKA_1	6	12	PF00069	0.594
MOD_PKA_2	137	143	PF00069	0.760
MOD_PKA_2	384	390	PF00069	0.666
MOD_PKA_2	457	463	PF00069	0.682
MOD_PKA_2	6	12	PF00069	0.601
MOD_Plk_1	189	195	PF00069	0.651
MOD_Plk_4	146	152	PF00069	0.749
MOD_Plk_4	194	200	PF00069	0.708
MOD_Plk_4	260	266	PF00069	0.754
MOD_Plk_4	301	307	PF00069	0.735
MOD_Plk_4	407	413	PF00069	0.672
MOD_ProDKin_1	12	18	PF00069	0.602
MOD_ProDKin_1	129	135	PF00069	0.739
MOD_ProDKin_1	163	169	PF00069	0.745
MOD_ProDKin_1	215	221	PF00069	0.716
MOD_ProDKin_1	234	240	PF00069	0.531
MOD_ProDKin_1	274	280	PF00069	0.709
MOD_ProDKin_1	352	358	PF00069	0.711
MOD_ProDKin_1	370	376	PF00069	0.604
MOD_ProDKin_1	394	400	PF00069	0.801
MOD_ProDKin_1	434	440	PF00069	0.655
MOD_ProDKin_1	475	481	PF00069	0.654
MOD_ProDKin_1	79	85	PF00069	0.684
TRG_ENDOCYTIC_2	299	302	PF00928	0.713
TRG_ER_diArg_1	334	336	PF00400	0.585
TRG_ER_diArg_1	384	386	PF00400	0.664
TRG_ER_diArg_1	393	395	PF00400	0.577
TRG_ER_diArg_1	428	431	PF00400	0.703
TRG_NLS_MonoCore_2	3	8	PF00514	0.716
TRG_NLS_MonoCore_2	391	396	PF00514	0.621
TRG_NLS_MonoExtC_3	9	14	PF00514	0.713
TRG_NLS_MonoExtN_4	390	396	PF00514	0.661
TRG_NLS_MonoExtN_4	4	9	PF00514	0.768

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8Z9	Leishmania donovani	80%	100%
A4H6F1	Leishmania braziliensis	65%	100%
A4HUU5	Leishmania infantum	80%	100%
E9ANI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%