Putative 14-3-3 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

14-3-3 protein 2, putative

Species:

Leishmania major

UniProt:

Q4QH45_LEIMA

TriTrypDb:

LmjF.11.0350 , LMJLV39_110008900 , LMJSD75_110009000

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0020016	ciliary pocket	2	2
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QH45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH45

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0007165	signal transduction	2	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0010564	regulation of cell cycle process	5	2
GO:0016192	vesicle-mediated transport	4	2
GO:0032465	regulation of cytokinesis	5	2
GO:0033036	macromolecule localization	2	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051302	regulation of cell division	4	2
GO:0051641	cellular localization	2	2
GO:0051726	regulation of cell cycle	4	2
GO:0065007	biological regulation	1	2
GO:0070727	cellular macromolecule localization	3	2
GO:1902412	regulation of mitotic cytokinesis	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	63	65	PF00675	0.360
CLV_PCSK_KEX2_1	10	12	PF00082	0.466
CLV_PCSK_KEX2_1	35	37	PF00082	0.360
CLV_PCSK_KEX2_1	63	65	PF00082	0.360
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.471
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.360
CLV_PCSK_SKI1_1	199	203	PF00082	0.360
CLV_PCSK_SKI1_1	36	40	PF00082	0.360
CLV_PCSK_SKI1_1	49	53	PF00082	0.176
CLV_Separin_Metazoa	186	190	PF03568	0.480
DOC_CYCLIN_RxL_1	146	154	PF00134	0.468
DOC_MAPK_MEF2A_6	167	176	PF00069	0.360
DOC_MAPK_NFAT4_5	173	181	PF00069	0.360
DOC_PIKK_1	244	252	PF02985	0.694
DOC_PP4_FxxP_1	5	8	PF00568	0.501
DOC_USP7_UBL2_3	35	39	PF12436	0.360
DOC_USP7_UBL2_3	6	10	PF12436	0.559
DOC_WW_Pin1_4	167	172	PF00397	0.360
DOC_WW_Pin1_4	187	192	PF00397	0.176
LIG_14-3-3_CanoR_1	43	52	PF00244	0.422
LIG_14-3-3_CanoR_1	68	74	PF00244	0.511
LIG_FHA_1	15	21	PF00498	0.445
LIG_FHA_1	161	167	PF00498	0.389
LIG_FHA_1	82	88	PF00498	0.480
LIG_FHA_2	245	251	PF00498	0.694
LIG_LIR_Apic_2	111	116	PF02991	0.445
LIG_LIR_Apic_2	2	8	PF02991	0.560
LIG_LIR_Nem_3	133	137	PF02991	0.360
LIG_LIR_Nem_3	181	187	PF02991	0.360
LIG_LIR_Nem_3	53	59	PF02991	0.360
LIG_LIR_Nem_3	86	91	PF02991	0.480
LIG_SH2_CRK	56	60	PF00017	0.360
LIG_SH2_SRC	113	116	PF00017	0.445
LIG_SH2_SRC	58	61	PF00017	0.480
LIG_SH2_STAP1	16	20	PF00017	0.411
LIG_SH2_STAT5	113	116	PF00017	0.445
LIG_SH2_STAT5	137	140	PF00017	0.388
LIG_SH2_STAT5	16	19	PF00017	0.559
LIG_SH2_STAT5	58	61	PF00017	0.480
LIG_SH3_2	168	173	PF14604	0.365
LIG_SH3_3	165	171	PF00018	0.363
LIG_SUMO_SIM_anti_2	104	111	PF11976	0.361
LIG_SUMO_SIM_par_1	104	111	PF11976	0.361
LIG_TRAF2_1	201	204	PF00917	0.360
LIG_TRAF2_1	248	251	PF00917	0.704
LIG_TRAF2_1	45	48	PF00917	0.375
LIG_TYR_ITIM	125	130	PF00017	0.480
LIG_TYR_ITIM	182	187	PF00017	0.360
LIG_UBA3_1	106	112	PF00899	0.360
LIG_UBA3_1	30	39	PF00899	0.360
MOD_CDC14_SPxK_1	170	173	PF00782	0.360
MOD_CDC14_SPxK_1	190	193	PF00782	0.176
MOD_CDK_SPxK_1	167	173	PF00069	0.360
MOD_CDK_SPxK_1	187	193	PF00069	0.176
MOD_CK1_1	160	166	PF00069	0.480
MOD_CK1_1	69	75	PF00069	0.450
MOD_CK2_1	204	210	PF00069	0.468
MOD_CK2_1	235	241	PF00069	0.615
MOD_CK2_1	244	250	PF00069	0.663
MOD_CK2_1	42	48	PF00069	0.374
MOD_GlcNHglycan	142	145	PF01048	0.507
MOD_GlcNHglycan	219	222	PF01048	0.480
MOD_GlcNHglycan	52	55	PF01048	0.476
MOD_GlcNHglycan	60	63	PF01048	0.450
MOD_GSK3_1	140	147	PF00069	0.480
MOD_GSK3_1	157	164	PF00069	0.373
MOD_N-GLC_1	178	183	PF02516	0.433
MOD_NEK2_1	14	19	PF00069	0.511
MOD_NEK2_1	162	167	PF00069	0.421
MOD_NEK2_1	178	183	PF00069	0.275
MOD_PIKK_1	144	150	PF00454	0.458
MOD_PKA_1	157	163	PF00069	0.480
MOD_PKA_2	42	48	PF00069	0.507
MOD_Plk_1	178	184	PF00069	0.433
MOD_Plk_2-3	204	210	PF00069	0.396
MOD_Plk_4	83	89	PF00069	0.387
MOD_ProDKin_1	167	173	PF00069	0.360
MOD_ProDKin_1	187	193	PF00069	0.176
MOD_SUMO_rev_2	119	125	PF00179	0.338
TRG_DiLeu_BaEn_1	47	52	PF01217	0.360
TRG_DiLeu_BaEn_4	47	53	PF01217	0.360
TRG_ENDOCYTIC_2	127	130	PF00928	0.368
TRG_ENDOCYTIC_2	184	187	PF00928	0.347
TRG_ENDOCYTIC_2	56	59	PF00928	0.360
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P443	Leptomonas seymouri	96%	100%
A0A0N1IJ96	Leptomonas seymouri	52%	98%
A0A0S4IUJ3	Bodo saltans	70%	91%
A0A0S4JJB7	Bodo saltans	56%	97%
A0A1X0NVF8	Trypanosomatidae	74%	100%
A0A1X0P3Q3	Trypanosomatidae	53%	96%
A0A3R7KVM5	Trypanosoma rangeli	72%	100%
A0A3S7WRH0	Leishmania donovani	99%	100%
A0A3S7XB66	Leishmania donovani	52%	98%
A0A422NKL2	Trypanosoma rangeli	53%	97%
A4H6F2	Leishmania braziliensis	94%	100%
A4HPI7	Leishmania braziliensis	51%	98%
A4HUU6	Leishmania infantum	100%	100%
A4IDA9	Leishmania infantum	52%	98%
A4K2U9	Pongo abelii	51%	100%
B8NLM9	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	56%	100%
C0H4V6	Plasmodium falciparum (isolate 3D7)	46%	97%
D0A7L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
D0A8F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	97%
E2RU97	Giardia intestinalis (strain ATCC 50803 / WB clone C6)	51%	100%
E9ANI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AT99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	98%
O42766	Candida albicans (strain SC5314 / ATCC MYA-2876)	54%	96%
O49995	Nicotiana tabacum	51%	99%
O49996	Nicotiana tabacum	51%	100%
O49997	Nicotiana tabacum	52%	93%
O49998	Nicotiana tabacum	51%	98%
O65352	Helianthus annuus	51%	98%
O70456	Mus musculus	47%	100%
O77642	Ovis aries	47%	100%
O96436	Eimeria tenella	46%	91%
P27348	Homo sapiens	51%	100%
P29305	Hordeum vulgare	52%	97%
P29307	Oenothera elata subsp. hookeri	51%	97%
P29308	Spinacia oleracea	53%	100%
P29309	Xenopus laevis	51%	100%
P29310	Drosophila melanogaster	53%	100%
P29311	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	56%	95%
P29361	Ovis aries	49%	100%
P31946	Homo sapiens	51%	100%
P31947	Homo sapiens	46%	100%
P34730	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	55%	93%
P35213	Rattus norvegicus	51%	100%
P41932	Caenorhabditis elegans	50%	100%
P42643	Arabidopsis thaliana	54%	95%
P42644	Arabidopsis thaliana	53%	99%
P42645	Arabidopsis thaliana	52%	94%
P42648	Entamoeba histolytica	51%	100%
P42649	Entamoeba histolytica	48%	100%
P42650	Entamoeba histolytica	49%	100%
P42652	Solanum lycopersicum	51%	97%
P42653	Vicia faba	53%	97%
P42654	Vicia faba	51%	97%
P42656	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	57%	94%
P42657	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	56%	94%
P46077	Arabidopsis thaliana	52%	95%
P46266	Pisum sativum	52%	97%
P48347	Arabidopsis thaliana	50%	100%
P48348	Arabidopsis thaliana	54%	100%
P48349	Arabidopsis thaliana	54%	100%
P49106	Zea mays	52%	97%
P52908	Chlamydomonas reinhardtii	54%	98%
P54632	Dictyostelium discoideum	53%	100%
P61981	Homo sapiens	46%	100%
P61982	Mus musculus	46%	100%
P61983	Rattus norvegicus	46%	100%
P62258	Homo sapiens	55%	99%
P62259	Mus musculus	55%	99%
P62260	Rattus norvegicus	55%	99%
P62261	Bos taurus	55%	99%
P62262	Ovis aries	55%	99%
P63101	Mus musculus	50%	100%
P63102	Rattus norvegicus	50%	100%
P63103	Bos taurus	50%	100%
P63104	Homo sapiens	50%	100%
P68250	Bos taurus	51%	100%
P68251	Ovis aries	41%	100%
P68252	Bos taurus	46%	100%
P68254	Mus musculus	50%	100%
P68255	Rattus norvegicus	50%	100%
P68509	Bos taurus	49%	100%
P68510	Mus musculus	49%	100%
P68511	Rattus norvegicus	49%	100%
P92177	Drosophila melanogaster	54%	97%
P93206	Solanum lycopersicum	49%	100%
P93207	Solanum lycopersicum	51%	100%
P93208	Solanum lycopersicum	52%	100%
P93209	Solanum lycopersicum	50%	97%
P93210	Solanum lycopersicum	51%	99%
P93211	Solanum lycopersicum	52%	98%
P93212	Solanum lycopersicum	52%	100%
P93213	Solanum lycopersicum	48%	97%
P93214	Solanum lycopersicum	49%	97%
P93259	Mesembryanthemum crystallinum	54%	96%
P93342	Nicotiana tabacum	51%	99%
P93343	Nicotiana tabacum	52%	97%
P93784	Solanum tuberosum	52%	98%
Q01525	Arabidopsis thaliana	52%	98%
Q01526	Zea mays	52%	97%
Q04917	Homo sapiens	49%	100%
Q06967	Oryza sativa subsp. japonica	52%	97%
Q0VC36	Bos taurus	47%	100%
Q1HR36	Aedes aegypti	54%	100%
Q20655	Caenorhabditis elegans	51%	100%
Q24902	Echinococcus multilocularis	46%	100%
Q25538	Neospora caninum	49%	95%
Q26537	Schistosoma mansoni	51%	100%
Q26540	Schistosoma mansoni	46%	100%
Q2F637	Bombyx mori	53%	100%
Q2R1D5	Oryza sativa subsp. japonica	35%	100%
Q2R2W2	Oryza sativa subsp. japonica	53%	95%
Q39757	Fucus vesiculosus	50%	100%
Q3SZI4	Bos taurus	51%	100%
Q41246	Nicotiana tabacum	50%	100%
Q41418	Solanum tuberosum	51%	98%
Q43470	Hordeum vulgare	54%	97%
Q43643	Solanum tuberosum	51%	100%
Q4Q198	Leishmania major	52%	100%
Q4R572	Macaca fascicularis	51%	100%
Q52M98	Xenopus laevis	50%	100%
Q5F3W6	Gallus gallus	46%	100%
Q5PRD0	Danio rerio	49%	100%
Q5QNB8	Oryza sativa subsp. japonica	50%	98%
Q5R651	Pongo abelii	50%	100%
Q5RC20	Pongo abelii	46%	100%
Q5RFJ2	Pongo abelii	51%	100%
Q5XGC8	Xenopus tropicalis	51%	100%
Q5XHK2	Xenopus laevis	50%	100%
Q5ZKC9	Gallus gallus	50%	100%
Q5ZLQ6	Gallus gallus	51%	100%
Q5ZMD1	Gallus gallus	51%	100%
Q5ZMT0	Gallus gallus	55%	99%
Q6EUP4	Oryza sativa subsp. japonica	53%	97%
Q6NRY9	Xenopus laevis	46%	100%
Q6P4Z5	Xenopus tropicalis	50%	100%
Q6PC29	Danio rerio	46%	100%
Q6PCG0	Xenopus laevis	46%	100%
Q6Q6X0	Oryctolagus cuniculus	50%	100%
Q6UFZ2	Oncorhynchus mykiss	46%	100%
Q6UFZ3	Oncorhynchus mykiss	47%	100%
Q6UFZ8	Oncorhynchus mykiss	47%	100%
Q6UFZ9	Oncorhynchus mykiss	48%	100%
Q6ZKC0	Oryza sativa subsp. japonica	52%	99%
Q7T356	Danio rerio	49%	100%
Q7XTE8	Oryza sativa subsp. japonica	53%	97%
Q84J55	Oryza sativa subsp. japonica	51%	96%
Q8AVQ3	Xenopus laevis	51%	100%
Q8MM75	Echinococcus multilocularis	49%	100%
Q8MUA4	Echinococcus granulosus	48%	100%
Q8SW28	Encephalitozoon cuniculi (strain GB-M1)	41%	98%
Q91896	Xenopus laevis	50%	100%
Q96299	Arabidopsis thaliana	50%	96%
Q96300	Arabidopsis thaliana	52%	95%
Q96450	Glycine max	51%	98%
Q96451	Glycine max	51%	100%
Q96452	Glycine max	51%	98%
Q96453	Glycine max	51%	97%
Q99002	Trichoderma harzianum	56%	97%
Q9C5W6	Arabidopsis thaliana	51%	94%
Q9CQV8	Mus musculus	51%	100%
Q9S9Z8	Arabidopsis thaliana	52%	100%
Q9SP07	Lilium longiflorum	52%	98%
Q9U408	Echinococcus granulosus	46%	100%
V5B9L7	Trypanosoma cruzi	52%	97%
V5C116	Trypanosoma cruzi	73%	100%