Optic atrophy 3 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Optic atrophy 3 protein (OPA3), putative

Species:

Leishmania major

UniProt:

Q4QH44_LEIMA

TriTrypDb:

LmjF.11.0360 , LMJLV39_110009000 , LMJSD75_110009100

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH44

Function

Biological processes
Term	Name	Level	Count
GO:0019216	regulation of lipid metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.280
CLV_NRD_NRD_1	295	297	PF00675	0.502
CLV_NRD_NRD_1	321	323	PF00675	0.736
CLV_PCSK_KEX2_1	295	297	PF00082	0.502
CLV_PCSK_KEX2_1	32	34	PF00082	0.389
CLV_PCSK_KEX2_1	321	323	PF00082	0.588
CLV_PCSK_KEX2_1	392	394	PF00082	0.621
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.389
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.643
CLV_PCSK_PC7_1	28	34	PF00082	0.389
CLV_PCSK_PC7_1	291	297	PF00082	0.502
CLV_PCSK_SKI1_1	15	19	PF00082	0.411
CLV_PCSK_SKI1_1	151	155	PF00082	0.411
CLV_PCSK_SKI1_1	32	36	PF00082	0.411
CLV_PCSK_SKI1_1	8	12	PF00082	0.411
DEG_APCC_DBOX_1	150	158	PF00400	0.411
DEG_SPOP_SBC_1	107	111	PF00917	0.436
DOC_CYCLIN_RxL_1	148	156	PF00134	0.411
DOC_MAPK_gen_1	366	376	PF00069	0.695
DOC_MAPK_MEF2A_6	171	179	PF00069	0.280
DOC_PP4_FxxP_1	206	209	PF00568	0.411
DOC_USP7_MATH_1	116	120	PF00917	0.377
DOC_USP7_MATH_1	128	132	PF00917	0.457
DOC_USP7_MATH_1	194	198	PF00917	0.411
DOC_USP7_MATH_1	260	264	PF00917	0.369
DOC_USP7_MATH_1	80	84	PF00917	0.299
DOC_USP7_MATH_1	98	102	PF00917	0.520
DOC_WW_Pin1_4	139	144	PF00397	0.499
DOC_WW_Pin1_4	275	280	PF00397	0.645
LIG_14-3-3_CanoR_1	149	154	PF00244	0.411
LIG_14-3-3_CanoR_1	203	207	PF00244	0.443
LIG_14-3-3_CanoR_1	274	279	PF00244	0.632
LIG_14-3-3_CanoR_1	295	300	PF00244	0.656
LIG_14-3-3_CanoR_1	321	330	PF00244	0.582
LIG_14-3-3_CanoR_1	33	38	PF00244	0.407
LIG_14-3-3_CanoR_1	45	49	PF00244	0.399
LIG_Actin_WH2_2	277	293	PF00022	0.754
LIG_APCC_ABBA_1	207	212	PF00400	0.411
LIG_BRCT_BRCA1_1	172	176	PF00533	0.411
LIG_Clathr_ClatBox_1	235	239	PF01394	0.353
LIG_DLG_GKlike_1	149	157	PF00625	0.411
LIG_FHA_1	16	22	PF00498	0.389
LIG_FHA_1	172	178	PF00498	0.411
LIG_FHA_1	232	238	PF00498	0.411
LIG_FHA_1	302	308	PF00498	0.647
LIG_FHA_1	330	336	PF00498	0.706
LIG_FHA_1	34	40	PF00498	0.411
LIG_FHA_1	371	377	PF00498	0.650
LIG_FHA_2	180	186	PF00498	0.411
LIG_FHA_2	56	62	PF00498	0.411
LIG_LIR_Apic_2	205	209	PF02991	0.411
LIG_LIR_Gen_1	173	183	PF02991	0.436
LIG_LIR_Gen_1	197	207	PF02991	0.411
LIG_LIR_LC3C_4	234	238	PF02991	0.411
LIG_LIR_Nem_3	173	179	PF02991	0.436
LIG_LIR_Nem_3	197	202	PF02991	0.411
LIG_LIR_Nem_3	297	303	PF02991	0.637
LIG_NRBOX	231	237	PF00104	0.411
LIG_Pex14_2	202	206	PF04695	0.411
LIG_Pex14_2	7	11	PF04695	0.411
LIG_SH2_CRK	229	233	PF00017	0.411
LIG_SH2_CRK	357	361	PF00017	0.804
LIG_SH2_SRC	357	360	PF00017	0.768
LIG_SH2_STAT3	159	162	PF00017	0.411
LIG_SH2_STAT5	229	232	PF00017	0.411
LIG_SH2_STAT5	37	40	PF00017	0.436
LIG_SH3_1	357	363	PF00018	0.698
LIG_SH3_3	14	20	PF00018	0.411
LIG_SH3_3	155	161	PF00018	0.411
LIG_SH3_3	341	347	PF00018	0.666
LIG_SH3_3	357	363	PF00018	0.697
LIG_SUMO_SIM_anti_2	234	239	PF11976	0.411
LIG_SUMO_SIM_par_1	233	239	PF11976	0.411
LIG_TRAF2_1	280	283	PF00917	0.605
LIG_TRAF2_1	331	334	PF00917	0.658
LIG_TYR_ITIM	227	232	PF00017	0.411
LIG_WW_3	358	362	PF00397	0.699
MOD_CDK_SPK_2	144	149	PF00069	0.389
MOD_CDK_SPxxK_3	144	151	PF00069	0.389
MOD_CK1_1	110	116	PF00069	0.511
MOD_CK1_1	132	138	PF00069	0.432
MOD_CK1_1	139	145	PF00069	0.462
MOD_CK1_1	244	250	PF00069	0.411
MOD_CK1_1	315	321	PF00069	0.692
MOD_CK1_1	324	330	PF00069	0.642
MOD_CK1_1	96	102	PF00069	0.395
MOD_CK2_1	179	185	PF00069	0.411
MOD_CK2_1	55	61	PF00069	0.411
MOD_CK2_1	96	102	PF00069	0.455
MOD_Cter_Amidation	293	296	PF01082	0.499
MOD_Cter_Amidation	319	322	PF01082	0.742
MOD_GlcNHglycan	110	113	PF01048	0.468
MOD_GlcNHglycan	118	121	PF01048	0.319
MOD_GlcNHglycan	138	141	PF01048	0.211
MOD_GlcNHglycan	196	199	PF01048	0.513
MOD_GlcNHglycan	246	249	PF01048	0.513
MOD_GlcNHglycan	340	343	PF01048	0.692
MOD_GlcNHglycan	50	53	PF01048	0.411
MOD_GlcNHglycan	82	85	PF01048	0.311
MOD_GlcNHglycan	98	101	PF01048	0.202
MOD_GSK3_1	103	110	PF00069	0.370
MOD_GSK3_1	112	119	PF00069	0.464
MOD_GSK3_1	128	135	PF00069	0.381
MOD_GSK3_1	149	156	PF00069	0.411
MOD_GSK3_1	167	174	PF00069	0.411
MOD_GSK3_1	227	234	PF00069	0.411
MOD_GSK3_1	24	31	PF00069	0.513
MOD_GSK3_1	290	297	PF00069	0.702
MOD_GSK3_1	321	328	PF00069	0.798
MOD_GSK3_1	44	51	PF00069	0.183
MOD_GSK3_1	69	76	PF00069	0.313
MOD_GSK3_1	92	99	PF00069	0.354
MOD_N-GLC_1	350	355	PF02516	0.688
MOD_NEK2_1	153	158	PF00069	0.411
MOD_NEK2_1	177	182	PF00069	0.499
MOD_NEK2_1	202	207	PF00069	0.378
MOD_NEK2_1	290	295	PF00069	0.751
MOD_NEK2_1	338	343	PF00069	0.650
MOD_NEK2_1	48	53	PF00069	0.411
MOD_PKA_1	295	301	PF00069	0.490
MOD_PKA_1	321	327	PF00069	0.743
MOD_PKA_2	170	176	PF00069	0.280
MOD_PKA_2	202	208	PF00069	0.400
MOD_PKA_2	244	250	PF00069	0.411
MOD_PKA_2	290	296	PF00069	0.740
MOD_PKA_2	315	321	PF00069	0.706
MOD_PKA_2	44	50	PF00069	0.393
MOD_Plk_1	129	135	PF00069	0.397
MOD_Plk_1	171	177	PF00069	0.411
MOD_Plk_1	370	376	PF00069	0.627
MOD_Plk_4	153	159	PF00069	0.400
MOD_Plk_4	171	177	PF00069	0.411
MOD_Plk_4	202	208	PF00069	0.400
MOD_Plk_4	227	233	PF00069	0.411
MOD_Plk_4	295	301	PF00069	0.591
MOD_Plk_4	370	376	PF00069	0.570
MOD_ProDKin_1	139	145	PF00069	0.499
MOD_ProDKin_1	275	281	PF00069	0.651
MOD_SUMO_rev_2	259	265	PF00179	0.389
TRG_DiLeu_BaEn_4	333	339	PF01217	0.693
TRG_ENDOCYTIC_2	229	232	PF00928	0.411
TRG_ER_diArg_1	148	151	PF00400	0.411
TRG_NES_CRM1_1	378	391	PF08389	0.600
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X1	Leptomonas seymouri	55%	92%
A0A3Q8I8X5	Leishmania donovani	91%	99%
A4H6F3	Leishmania braziliensis	73%	98%
A4HUU7	Leishmania infantum	91%	99%
E9ANI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%