Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH43_LEIMA

TriTrypDb:

LmjF.11.0370 , LMJLV39_110009100 , LMJSD75_110009200

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QH43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	508	512	PF00656	0.688
CLV_NRD_NRD_1	105	107	PF00675	0.401
CLV_NRD_NRD_1	16	18	PF00675	0.361
CLV_NRD_NRD_1	457	459	PF00675	0.481
CLV_NRD_NRD_1	506	508	PF00675	0.522
CLV_NRD_NRD_1	563	565	PF00675	0.463
CLV_NRD_NRD_1	588	590	PF00675	0.554
CLV_NRD_NRD_1	591	593	PF00675	0.459
CLV_PCSK_FUR_1	589	593	PF00082	0.515
CLV_PCSK_KEX2_1	104	106	PF00082	0.410
CLV_PCSK_KEX2_1	325	327	PF00082	0.410
CLV_PCSK_KEX2_1	362	364	PF00082	0.442
CLV_PCSK_KEX2_1	506	508	PF00082	0.558
CLV_PCSK_KEX2_1	562	564	PF00082	0.443
CLV_PCSK_KEX2_1	588	590	PF00082	0.554
CLV_PCSK_KEX2_1	591	593	PF00082	0.459
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.442
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.410
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.442
CLV_PCSK_SKI1_1	292	296	PF00082	0.435
CLV_PCSK_SKI1_1	362	366	PF00082	0.394
CLV_PCSK_SKI1_1	459	463	PF00082	0.396
CLV_PCSK_SKI1_1	592	596	PF00082	0.377
DEG_APCC_DBOX_1	22	30	PF00400	0.599
DEG_APCC_DBOX_1	55	63	PF00400	0.553
DEG_APCC_DBOX_1	87	95	PF00400	0.640
DOC_CKS1_1	432	437	PF01111	0.596
DOC_CYCLIN_RxL_1	250	263	PF00134	0.630
DOC_CYCLIN_RxL_1	560	570	PF00134	0.651
DOC_MAPK_gen_1	17	28	PF00069	0.657
DOC_MAPK_gen_1	362	368	PF00069	0.667
DOC_MAPK_gen_1	88	97	PF00069	0.646
DOC_MAPK_MEF2A_6	90	99	PF00069	0.642
DOC_MAPK_NFAT4_5	92	100	PF00069	0.637
DOC_PP2B_LxvP_1	565	568	PF13499	0.669
DOC_USP7_MATH_1	189	193	PF00917	0.723
DOC_USP7_MATH_1	276	280	PF00917	0.532
DOC_USP7_MATH_1	301	305	PF00917	0.673
DOC_USP7_MATH_1	351	355	PF00917	0.562
DOC_USP7_MATH_1	401	405	PF00917	0.727
DOC_USP7_MATH_1	410	414	PF00917	0.798
DOC_USP7_MATH_1	425	429	PF00917	0.800
DOC_USP7_MATH_1	494	498	PF00917	0.734
DOC_WW_Pin1_4	406	411	PF00397	0.692
DOC_WW_Pin1_4	431	436	PF00397	0.660
DOC_WW_Pin1_4	534	539	PF00397	0.670
LIG_14-3-3_CanoR_1	332	338	PF00244	0.656
LIG_14-3-3_CanoR_1	363	367	PF00244	0.629
LIG_Actin_WH2_2	250	267	PF00022	0.628
LIG_BRCT_BRCA1_1	353	357	PF00533	0.579
LIG_BRCT_BRCA1_1	511	515	PF00533	0.743
LIG_FHA_1	164	170	PF00498	0.766
LIG_FHA_1	233	239	PF00498	0.595
LIG_FHA_1	249	255	PF00498	0.625
LIG_FHA_1	363	369	PF00498	0.575
LIG_FHA_1	534	540	PF00498	0.688
LIG_FHA_1	568	574	PF00498	0.669
LIG_FHA_1	581	587	PF00498	0.515
LIG_FHA_1	64	70	PF00498	0.661
LIG_FHA_1	7	13	PF00498	0.653
LIG_FHA_2	145	151	PF00498	0.583
LIG_FHA_2	177	183	PF00498	0.806
LIG_FHA_2	338	344	PF00498	0.620
LIG_FHA_2	66	72	PF00498	0.521
LIG_LIR_Gen_1	147	156	PF02991	0.681
LIG_LIR_Gen_1	349	357	PF02991	0.554
LIG_LIR_Nem_3	147	152	PF02991	0.585
LIG_LIR_Nem_3	349	355	PF02991	0.551
LIG_LIR_Nem_3	609	614	PF02991	0.587
LIG_NRBOX	151	157	PF00104	0.670
LIG_Pex14_1	382	386	PF04695	0.556
LIG_RPA_C_Fungi	453	465	PF08784	0.484
LIG_SH2_CRK	387	391	PF00017	0.555
LIG_SH2_NCK_1	387	391	PF00017	0.627
LIG_SH2_STAP1	149	153	PF00017	0.581
LIG_SH2_STAP1	299	303	PF00017	0.565
LIG_SH3_3	429	435	PF00018	0.641
LIG_SH3_3	497	503	PF00018	0.643
LIG_TRAF2_1	340	343	PF00917	0.465
LIG_WRC_WIRS_1	608	613	PF05994	0.538
MOD_CDC14_SPxK_1	409	412	PF00782	0.619
MOD_CDK_SPxK_1	406	412	PF00069	0.621
MOD_CK1_1	304	310	PF00069	0.496
MOD_CK1_1	358	364	PF00069	0.563
MOD_CK1_1	479	485	PF00069	0.486
MOD_CK1_1	513	519	PF00069	0.639
MOD_CK2_1	176	182	PF00069	0.783
MOD_CK2_1	201	207	PF00069	0.723
MOD_CK2_1	337	343	PF00069	0.450
MOD_CK2_1	415	421	PF00069	0.725
MOD_CK2_1	519	525	PF00069	0.571
MOD_CK2_1	65	71	PF00069	0.545
MOD_Cter_Amidation	504	507	PF01082	0.716
MOD_GlcNHglycan	182	185	PF01048	0.774
MOD_GlcNHglycan	191	194	PF01048	0.751
MOD_GlcNHglycan	195	198	PF01048	0.735
MOD_GlcNHglycan	303	306	PF01048	0.603
MOD_GlcNHglycan	412	415	PF01048	0.792
MOD_GlcNHglycan	421	424	PF01048	0.717
MOD_GlcNHglycan	427	430	PF01048	0.779
MOD_GlcNHglycan	489	492	PF01048	0.554
MOD_GlcNHglycan	578	581	PF01048	0.614
MOD_GSK3_1	140	147	PF00069	0.391
MOD_GSK3_1	176	183	PF00069	0.690
MOD_GSK3_1	189	196	PF00069	0.609
MOD_GSK3_1	351	358	PF00069	0.446
MOD_GSK3_1	386	393	PF00069	0.566
MOD_GSK3_1	406	413	PF00069	0.467
MOD_GSK3_1	415	422	PF00069	0.620
MOD_GSK3_1	472	479	PF00069	0.573
MOD_GSK3_1	509	516	PF00069	0.608
MOD_GSK3_1	534	541	PF00069	0.614
MOD_GSK3_1	542	549	PF00069	0.575
MOD_GSK3_1	576	583	PF00069	0.656
MOD_GSK3_1	72	79	PF00069	0.618
MOD_N-GLC_1	176	181	PF02516	0.694
MOD_N-GLC_1	201	206	PF02516	0.714
MOD_NEK2_1	140	145	PF00069	0.452
MOD_NEK2_1	239	244	PF00069	0.542
MOD_NEK2_1	331	336	PF00069	0.623
MOD_NEK2_1	485	490	PF00069	0.534
MOD_NEK2_1	533	538	PF00069	0.619
MOD_NEK2_1	539	544	PF00069	0.607
MOD_NEK2_1	551	556	PF00069	0.489
MOD_NEK2_1	595	600	PF00069	0.349
MOD_NEK2_1	606	611	PF00069	0.307
MOD_NEK2_1	84	89	PF00069	0.478
MOD_NEK2_2	510	515	PF00069	0.492
MOD_PIKK_1	112	118	PF00454	0.592
MOD_PIKK_1	232	238	PF00454	0.511
MOD_PIKK_1	248	254	PF00454	0.519
MOD_PIKK_1	304	310	PF00454	0.536
MOD_PIKK_1	331	337	PF00454	0.621
MOD_PIKK_1	390	396	PF00454	0.575
MOD_PIKK_1	401	407	PF00454	0.591
MOD_PIKK_1	476	482	PF00454	0.401
MOD_PIKK_1	7	13	PF00454	0.491
MOD_PKA_1	362	368	PF00069	0.465
MOD_PKA_1	63	69	PF00069	0.383
MOD_PKA_2	140	146	PF00069	0.528
MOD_PKA_2	283	289	PF00069	0.568
MOD_PKA_2	331	337	PF00069	0.541
MOD_PKA_2	362	368	PF00069	0.544
MOD_Plk_1	112	118	PF00069	0.527
MOD_Plk_1	248	254	PF00069	0.511
MOD_Plk_1	276	282	PF00069	0.501
MOD_Plk_1	342	348	PF00069	0.494
MOD_Plk_1	49	55	PF00069	0.442
MOD_Plk_1	510	516	PF00069	0.492
MOD_Plk_2-3	343	349	PF00069	0.514
MOD_Plk_2-3	415	421	PF00069	0.725
MOD_Plk_4	151	157	PF00069	0.533
MOD_Plk_4	266	272	PF00069	0.459
MOD_Plk_4	351	357	PF00069	0.509
MOD_Plk_4	479	485	PF00069	0.481
MOD_Plk_4	510	516	PF00069	0.548
MOD_Plk_4	542	548	PF00069	0.501
MOD_ProDKin_1	406	412	PF00069	0.635
MOD_ProDKin_1	431	437	PF00069	0.578
MOD_ProDKin_1	534	540	PF00069	0.592
MOD_SUMO_rev_2	25	34	PF00179	0.419
MOD_SUMO_rev_2	261	267	PF00179	0.547
MOD_SUMO_rev_2	354	364	PF00179	0.512
MOD_SUMO_rev_2	377	384	PF00179	0.550
MOD_SUMO_rev_2	71	76	PF00179	0.551
TRG_DiLeu_BaEn_1	151	156	PF01217	0.463
TRG_DiLeu_BaEn_1	24	29	PF01217	0.479
TRG_DiLeu_BaEn_1	249	254	PF01217	0.491
TRG_DiLeu_BaEn_4	24	30	PF01217	0.548
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.677
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.378
TRG_DiLeu_LyEn_5	24	29	PF01217	0.479
TRG_ENDOCYTIC_2	149	152	PF00928	0.451
TRG_ENDOCYTIC_2	387	390	PF00928	0.532
TRG_ER_diArg_1	562	564	PF00400	0.526
TRG_ER_diArg_1	587	589	PF00400	0.669
TRG_ER_diArg_1	590	592	PF00400	0.669
TRG_NLS_MonoExtC_3	16	21	PF00514	0.442
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	556	561	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHW2	Leptomonas seymouri	57%	96%
A0A0S4ITZ6	Bodo saltans	25%	100%
A0A1X0NWL4	Trypanosomatidae	36%	100%
A0A3R7KMY4	Trypanosoma rangeli	34%	100%
A0A3S5H6I2	Leishmania donovani	91%	99%
A4H6F4	Leishmania braziliensis	76%	100%
A4HUU8	Leishmania infantum	91%	100%
D0A7K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ANI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BB44	Trypanosoma cruzi	34%	100%