Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH41_LEIMA

TriTrypDb:

LmjF.11.0390 , LMJLV39_110009300 , LMJSD75_110009400

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.541
CLV_C14_Caspase3-7	327	331	PF00656	0.627
CLV_NRD_NRD_1	116	118	PF00675	0.663
CLV_NRD_NRD_1	120	122	PF00675	0.641
CLV_NRD_NRD_1	240	242	PF00675	0.453
CLV_NRD_NRD_1	5	7	PF00675	0.603
CLV_PCSK_KEX2_1	102	104	PF00082	0.647
CLV_PCSK_KEX2_1	115	117	PF00082	0.624
CLV_PCSK_KEX2_1	120	122	PF00082	0.576
CLV_PCSK_KEX2_1	161	163	PF00082	0.468
CLV_PCSK_KEX2_1	240	242	PF00082	0.453
CLV_PCSK_KEX2_1	369	371	PF00082	0.499
CLV_PCSK_KEX2_1	5	7	PF00082	0.752
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.633
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.468
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.441
CLV_PCSK_PC7_1	116	122	PF00082	0.646
CLV_PCSK_SKI1_1	168	172	PF00082	0.483
CLV_PCSK_SKI1_1	225	229	PF00082	0.574
CLV_PCSK_SKI1_1	240	244	PF00082	0.280
CLV_PCSK_SKI1_1	47	51	PF00082	0.621
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DEG_SCF_FBW7_1	1	7	PF00400	0.522
DEG_SPOP_SBC_1	227	231	PF00917	0.578
DEG_SPOP_SBC_1	324	328	PF00917	0.572
DEG_SPOP_SBC_1	35	39	PF00917	0.586
DOC_CKS1_1	1	6	PF01111	0.490
DOC_CKS1_1	277	282	PF01111	0.663
DOC_MAPK_gen_1	240	248	PF00069	0.425
DOC_MAPK_gen_1	305	315	PF00069	0.430
DOC_MAPK_gen_1	369	377	PF00069	0.514
DOC_MAPK_gen_1	447	457	PF00069	0.470
DOC_MAPK_JIP1_4	476	482	PF00069	0.388
DOC_MAPK_MEF2A_6	240	248	PF00069	0.408
DOC_MAPK_MEF2A_6	450	457	PF00069	0.578
DOC_PP2B_LxvP_1	480	483	PF13499	0.361
DOC_SPAK_OSR1_1	241	245	PF12202	0.396
DOC_USP7_MATH_1	104	108	PF00917	0.568
DOC_USP7_MATH_1	135	139	PF00917	0.634
DOC_USP7_MATH_1	16	20	PF00917	0.581
DOC_USP7_MATH_1	324	328	PF00917	0.690
DOC_USP7_MATH_1	350	354	PF00917	0.678
DOC_USP7_MATH_1	4	8	PF00917	0.616
DOC_USP7_UBL2_3	219	223	PF12436	0.483
DOC_USP7_UBL2_3	447	451	PF12436	0.468
DOC_WW_Pin1_4	235	240	PF00397	0.526
DOC_WW_Pin1_4	276	281	PF00397	0.686
DOC_WW_Pin1_4	360	365	PF00397	0.656
DOC_WW_Pin1_4	391	396	PF00397	0.565
DOC_WW_Pin1_4	436	441	PF00397	0.520
LIG_14-3-3_CanoR_1	115	122	PF00244	0.618
LIG_14-3-3_CanoR_1	5	9	PF00244	0.584
LIG_BIR_III_4	21	25	PF00653	0.537
LIG_BIR_III_4	351	355	PF00653	0.630
LIG_BRCT_BRCA1_1	373	377	PF00533	0.485
LIG_BRCT_BRCA1_1	62	66	PF00533	0.586
LIG_Clathr_ClatBox_1	454	458	PF01394	0.464
LIG_FHA_1	178	184	PF00498	0.619
LIG_FHA_1	241	247	PF00498	0.475
LIG_FHA_1	272	278	PF00498	0.685
LIG_FHA_1	317	323	PF00498	0.516
LIG_FHA_1	35	41	PF00498	0.506
LIG_FHA_1	405	411	PF00498	0.659
LIG_FHA_2	127	133	PF00498	0.636
LIG_FHA_2	143	149	PF00498	0.604
LIG_FHA_2	16	22	PF00498	0.578
LIG_FHA_2	256	262	PF00498	0.526
LIG_FHA_2	333	339	PF00498	0.655
LIG_LIR_Apic_2	359	364	PF02991	0.511
LIG_LIR_Gen_1	319	324	PF02991	0.427
LIG_LIR_Nem_3	210	215	PF02991	0.346
LIG_LIR_Nem_3	319	323	PF02991	0.422
LIG_MYND_1	391	395	PF01753	0.595
LIG_PDZ_Class_2	503	508	PF00595	0.433
LIG_SH2_STAT5	2	5	PF00017	0.537
LIG_SH2_STAT5	216	219	PF00017	0.401
LIG_SH2_STAT5	301	304	PF00017	0.405
LIG_SH2_STAT5	42	45	PF00017	0.537
LIG_SH2_STAT5	48	51	PF00017	0.510
LIG_SH2_STAT5	55	58	PF00017	0.508
LIG_SH3_3	151	157	PF00018	0.605
LIG_SH3_3	243	249	PF00018	0.515
LIG_SH3_3	279	285	PF00018	0.665
LIG_SH3_3	460	466	PF00018	0.539
LIG_Sin3_3	163	170	PF02671	0.523
LIG_SUMO_SIM_anti_2	478	483	PF11976	0.394
LIG_SUMO_SIM_par_1	151	158	PF11976	0.596
LIG_SUMO_SIM_par_1	204	210	PF11976	0.388
LIG_SUMO_SIM_par_1	453	460	PF11976	0.449
MOD_CDK_SPK_2	235	240	PF00069	0.548
MOD_CDK_SPxK_1	235	241	PF00069	0.504
MOD_CDK_SPxxK_3	391	398	PF00069	0.525
MOD_CK1_1	134	140	PF00069	0.628
MOD_CK1_1	229	235	PF00069	0.600
MOD_CK1_1	276	282	PF00069	0.647
MOD_CK1_1	456	462	PF00069	0.468
MOD_CK1_1	7	13	PF00069	0.683
MOD_CK1_1	74	80	PF00069	0.623
MOD_CK2_1	126	132	PF00069	0.637
MOD_CK2_1	142	148	PF00069	0.618
MOD_CK2_1	152	158	PF00069	0.573
MOD_CK2_1	255	261	PF00069	0.557
MOD_CK2_1	330	336	PF00069	0.634
MOD_CK2_1	360	366	PF00069	0.474
MOD_CK2_1	456	462	PF00069	0.468
MOD_GlcNHglycan	106	109	PF01048	0.676
MOD_GlcNHglycan	112	115	PF01048	0.729
MOD_GlcNHglycan	132	136	PF01048	0.707
MOD_GlcNHglycan	18	21	PF01048	0.527
MOD_GlcNHglycan	255	258	PF01048	0.639
MOD_GlcNHglycan	263	266	PF01048	0.638
MOD_GlcNHglycan	351	355	PF01048	0.653
MOD_GlcNHglycan	425	429	PF01048	0.685
MOD_GlcNHglycan	9	12	PF01048	0.711
MOD_GSK3_1	131	138	PF00069	0.686
MOD_GSK3_1	226	233	PF00069	0.598
MOD_GSK3_1	255	262	PF00069	0.549
MOD_GSK3_1	356	363	PF00069	0.607
MOD_GSK3_1	53	60	PF00069	0.566
MOD_N-GLC_1	138	143	PF02516	0.639
MOD_NEK2_1	228	233	PF00069	0.615
MOD_NEK2_1	36	41	PF00069	0.565
MOD_NEK2_1	446	451	PF00069	0.456
MOD_NEK2_1	495	500	PF00069	0.414
MOD_NEK2_2	61	66	PF00069	0.579
MOD_PIKK_1	120	126	PF00454	0.643
MOD_PIKK_1	325	331	PF00454	0.673
MOD_PIKK_1	87	93	PF00454	0.578
MOD_PKA_1	102	108	PF00069	0.635
MOD_PKA_1	115	121	PF00069	0.589
MOD_PKA_1	240	246	PF00069	0.422
MOD_PKA_2	102	108	PF00069	0.652
MOD_PKA_2	115	121	PF00069	0.606
MOD_PKA_2	240	246	PF00069	0.402
MOD_PKA_2	4	10	PF00069	0.713
MOD_Plk_1	71	77	PF00069	0.637
MOD_Plk_2-3	330	336	PF00069	0.652
MOD_Plk_4	357	363	PF00069	0.557
MOD_Plk_4	482	488	PF00069	0.382
MOD_Plk_4	61	67	PF00069	0.605
MOD_Plk_4	71	77	PF00069	0.554
MOD_ProDKin_1	235	241	PF00069	0.516
MOD_ProDKin_1	276	282	PF00069	0.678
MOD_ProDKin_1	360	366	PF00069	0.649
MOD_ProDKin_1	391	397	PF00069	0.564
MOD_ProDKin_1	436	442	PF00069	0.510
MOD_SUMO_for_1	475	478	PF00179	0.437
MOD_SUMO_rev_2	373	383	PF00179	0.532
TRG_DiLeu_BaEn_2	372	378	PF01217	0.475
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.580
TRG_DiLeu_BaLyEn_6	450	455	PF01217	0.579
TRG_ER_diArg_1	115	117	PF00400	0.651
TRG_ER_diArg_1	120	122	PF00400	0.657
TRG_ER_diArg_1	239	241	PF00400	0.517
TRG_ER_diArg_1	4	6	PF00400	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH30	Leptomonas seymouri	34%	100%
A0A3Q8I7W7	Leishmania donovani	89%	100%
A4H6K7	Leishmania braziliensis	63%	90%
A4HUV0	Leishmania infantum	89%	100%
E9ANI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%