Putative chromatin binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulator of chromatin condensation, putative

Species:

Leishmania major

UniProt:

Q4QH38_LEIMA

TriTrypDb:

LmjF.11.0420 , LMJLV39_110009600 , LMJSD75_110009800

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QH38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	501	505	PF00656	0.584
CLV_C14_Caspase3-7	705	709	PF00656	0.461
CLV_NRD_NRD_1	364	366	PF00675	0.489
CLV_NRD_NRD_1	465	467	PF00675	0.609
CLV_NRD_NRD_1	717	719	PF00675	0.574
CLV_PCSK_FUR_1	715	719	PF00082	0.486
CLV_PCSK_KEX2_1	364	366	PF00082	0.445
CLV_PCSK_KEX2_1	464	466	PF00082	0.635
CLV_PCSK_KEX2_1	717	719	PF00082	0.580
CLV_PCSK_SKI1_1	496	500	PF00082	0.579
CLV_PCSK_SKI1_1	687	691	PF00082	0.492
CLV_PCSK_SKI1_1	697	701	PF00082	0.494
DEG_MDM2_SWIB_1	590	597	PF02201	0.528
DEG_SPOP_SBC_1	650	654	PF00917	0.510
DEG_SPOP_SBC_1	769	773	PF00917	0.726
DOC_CDC14_PxL_1	287	295	PF14671	0.409
DOC_CYCLIN_yCln2_LP_2	397	403	PF00134	0.420
DOC_MAPK_RevD_3	450	465	PF00069	0.397
DOC_USP7_MATH_1	158	162	PF00917	0.428
DOC_USP7_MATH_1	219	223	PF00917	0.632
DOC_USP7_MATH_1	227	231	PF00917	0.482
DOC_USP7_MATH_1	267	271	PF00917	0.592
DOC_USP7_MATH_1	278	282	PF00917	0.702
DOC_USP7_MATH_1	325	329	PF00917	0.651
DOC_USP7_MATH_1	367	371	PF00917	0.456
DOC_USP7_MATH_1	432	436	PF00917	0.617
DOC_USP7_MATH_1	490	494	PF00917	0.525
DOC_USP7_MATH_1	503	507	PF00917	0.688
DOC_USP7_MATH_1	56	60	PF00917	0.487
DOC_USP7_MATH_1	641	645	PF00917	0.760
DOC_USP7_MATH_1	651	655	PF00917	0.390
DOC_USP7_MATH_1	748	752	PF00917	0.446
DOC_USP7_MATH_1	763	767	PF00917	0.489
DOC_USP7_MATH_1	770	774	PF00917	0.718
DOC_USP7_UBL2_3	352	356	PF12436	0.680
DOC_WW_Pin1_4	215	220	PF00397	0.570
DOC_WW_Pin1_4	268	273	PF00397	0.603
DOC_WW_Pin1_4	274	279	PF00397	0.573
DOC_WW_Pin1_4	537	542	PF00397	0.570
DOC_WW_Pin1_4	558	563	PF00397	0.649
DOC_WW_Pin1_4	564	569	PF00397	0.593
DOC_WW_Pin1_4	629	634	PF00397	0.683
LIG_14-3-3_CanoR_1	327	331	PF00244	0.568
LIG_14-3-3_CanoR_1	343	353	PF00244	0.436
LIG_14-3-3_CanoR_1	404	411	PF00244	0.489
LIG_14-3-3_CanoR_1	592	598	PF00244	0.425
LIG_14-3-3_CanoR_1	629	633	PF00244	0.560
LIG_14-3-3_CanoR_1	647	651	PF00244	0.420
LIG_14-3-3_CanoR_1	697	706	PF00244	0.467
LIG_14-3-3_CanoR_1	749	753	PF00244	0.320
LIG_BRCT_BRCA1_1	369	373	PF00533	0.383
LIG_BRCT_BRCA1_1	595	599	PF00533	0.415
LIG_BRCT_BRCA1_1	653	657	PF00533	0.420
LIG_FHA_1	164	170	PF00498	0.412
LIG_FHA_1	183	189	PF00498	0.319
LIG_FHA_1	309	315	PF00498	0.572
LIG_FHA_1	538	544	PF00498	0.450
LIG_FHA_1	72	78	PF00498	0.314
LIG_FHA_1	727	733	PF00498	0.474
LIG_FHA_2	122	128	PF00498	0.466
LIG_FHA_2	199	205	PF00498	0.580
LIG_FHA_2	390	396	PF00498	0.616
LIG_FHA_2	405	411	PF00498	0.526
LIG_FHA_2	421	427	PF00498	0.483
LIG_FHA_2	58	64	PF00498	0.395
LIG_FHA_2	703	709	PF00498	0.593
LIG_Integrin_RGD_1	299	301	PF01839	0.481
LIG_LIR_Gen_1	190	199	PF02991	0.384
LIG_LIR_Gen_1	310	319	PF02991	0.505
LIG_LIR_Gen_1	370	379	PF02991	0.497
LIG_LIR_Gen_1	497	505	PF02991	0.563
LIG_LIR_Gen_1	591	602	PF02991	0.496
LIG_LIR_Gen_1	733	744	PF02991	0.378
LIG_LIR_Nem_3	190	194	PF02991	0.382
LIG_LIR_Nem_3	301	305	PF02991	0.351
LIG_LIR_Nem_3	310	315	PF02991	0.467
LIG_LIR_Nem_3	370	376	PF02991	0.497
LIG_LIR_Nem_3	497	502	PF02991	0.509
LIG_LIR_Nem_3	591	597	PF02991	0.397
LIG_LIR_Nem_3	733	739	PF02991	0.387
LIG_LYPXL_yS_3	290	293	PF13949	0.416
LIG_MLH1_MIPbox_1	369	373	PF16413	0.445
LIG_PCNA_yPIPBox_3	609	618	PF02747	0.440
LIG_Pex14_1	479	483	PF04695	0.355
LIG_Pex14_2	368	372	PF04695	0.510
LIG_Pex14_2	51	55	PF04695	0.448
LIG_Pex14_2	590	594	PF04695	0.447
LIG_SH2_CRK	18	22	PF00017	0.341
LIG_SH2_CRK	241	245	PF00017	0.504
LIG_SH2_CRK	72	76	PF00017	0.406
LIG_SH2_NCK_1	18	22	PF00017	0.341
LIG_SH2_NCK_1	736	740	PF00017	0.369
LIG_SH2_STAP1	18	22	PF00017	0.341
LIG_SH2_STAP1	736	740	PF00017	0.391
LIG_SH2_STAT5	170	173	PF00017	0.434
LIG_SH2_STAT5	18	21	PF00017	0.346
LIG_SH2_STAT5	189	192	PF00017	0.487
LIG_SH2_STAT5	414	417	PF00017	0.378
LIG_SH2_STAT5	483	486	PF00017	0.444
LIG_SH2_STAT5	621	624	PF00017	0.371
LIG_SH3_3	10	16	PF00018	0.408
LIG_SH3_3	123	129	PF00018	0.535
LIG_SH3_3	266	272	PF00018	0.507
LIG_SH3_3	285	291	PF00018	0.322
LIG_SH3_3	384	390	PF00018	0.490
LIG_SH3_3	538	544	PF00018	0.586
LIG_SH3_3	566	572	PF00018	0.530
LIG_SH3_3	680	686	PF00018	0.439
LIG_SUMO_SIM_anti_2	43	50	PF11976	0.383
LIG_SUMO_SIM_par_1	73	78	PF11976	0.406
LIG_TRAF2_1	527	530	PF00917	0.435
LIG_TYR_ITIM	239	244	PF00017	0.420
LIG_TYR_ITIM	288	293	PF00017	0.412
LIG_WRC_WIRS_1	52	57	PF05994	0.488
LIG_WRC_WIRS_1	725	730	PF05994	0.480
MOD_CK1_1	121	127	PF00069	0.480
MOD_CK1_1	248	254	PF00069	0.325
MOD_CK1_1	271	277	PF00069	0.618
MOD_CK1_1	281	287	PF00069	0.448
MOD_CK1_1	40	46	PF00069	0.391
MOD_CK1_1	459	465	PF00069	0.439
MOD_CK1_1	558	564	PF00069	0.794
MOD_CK1_1	57	63	PF00069	0.323
MOD_CK1_1	631	637	PF00069	0.733
MOD_CK1_1	727	733	PF00069	0.552
MOD_CK1_1	99	105	PF00069	0.634
MOD_CK2_1	389	395	PF00069	0.545
MOD_CK2_1	404	410	PF00069	0.540
MOD_CK2_1	442	448	PF00069	0.661
MOD_CK2_1	482	488	PF00069	0.550
MOD_CK2_1	57	63	PF00069	0.386
MOD_CK2_1	727	733	PF00069	0.542
MOD_DYRK1A_RPxSP_1	215	219	PF00069	0.581
MOD_DYRK1A_RPxSP_1	629	633	PF00069	0.560
MOD_GlcNHglycan	145	150	PF01048	0.522
MOD_GlcNHglycan	221	224	PF01048	0.546
MOD_GlcNHglycan	225	228	PF01048	0.637
MOD_GlcNHglycan	369	372	PF01048	0.503
MOD_GlcNHglycan	383	387	PF01048	0.421
MOD_GlcNHglycan	39	42	PF01048	0.408
MOD_GlcNHglycan	434	437	PF01048	0.686
MOD_GlcNHglycan	440	443	PF01048	0.651
MOD_GlcNHglycan	458	461	PF01048	0.257
MOD_GlcNHglycan	545	548	PF01048	0.704
MOD_GlcNHglycan	554	560	PF01048	0.762
MOD_GlcNHglycan	56	59	PF01048	0.484
MOD_GlcNHglycan	578	581	PF01048	0.423
MOD_GlcNHglycan	637	640	PF01048	0.640
MOD_GlcNHglycan	7	10	PF01048	0.550
MOD_GlcNHglycan	729	732	PF01048	0.609
MOD_GlcNHglycan	765	768	PF01048	0.624
MOD_GSK3_1	158	165	PF00069	0.298
MOD_GSK3_1	207	214	PF00069	0.737
MOD_GSK3_1	215	222	PF00069	0.573
MOD_GSK3_1	223	230	PF00069	0.555
MOD_GSK3_1	267	274	PF00069	0.531
MOD_GSK3_1	432	439	PF00069	0.687
MOD_GSK3_1	5	12	PF00069	0.603
MOD_GSK3_1	535	542	PF00069	0.558
MOD_GSK3_1	586	593	PF00069	0.428
MOD_GSK3_1	631	638	PF00069	0.706
MOD_GSK3_1	641	648	PF00069	0.789
MOD_GSK3_1	71	78	PF00069	0.435
MOD_GSK3_1	96	103	PF00069	0.611
MOD_N-GLC_1	158	163	PF02516	0.225
MOD_N-GLC_1	281	286	PF02516	0.501
MOD_N-GLC_2	175	177	PF02516	0.469
MOD_NEK2_1	162	167	PF00069	0.369
MOD_NEK2_1	326	331	PF00069	0.527
MOD_NEK2_1	382	387	PF00069	0.579
MOD_NEK2_1	590	595	PF00069	0.397
MOD_NEK2_1	611	616	PF00069	0.425
MOD_NEK2_1	75	80	PF00069	0.355
MOD_NEK2_2	150	155	PF00069	0.338
MOD_NEK2_2	748	753	PF00069	0.454
MOD_PIKK_1	271	277	PF00454	0.696
MOD_PK_1	539	545	PF00069	0.464
MOD_PKA_2	207	213	PF00069	0.699
MOD_PKA_2	242	248	PF00069	0.411
MOD_PKA_2	326	332	PF00069	0.635
MOD_PKA_2	436	442	PF00069	0.700
MOD_PKA_2	535	541	PF00069	0.551
MOD_PKA_2	628	634	PF00069	0.557
MOD_PKA_2	646	652	PF00069	0.417
MOD_PKA_2	748	754	PF00069	0.322
MOD_PKA_2	96	102	PF00069	0.495
MOD_Plk_1	158	164	PF00069	0.428
MOD_Plk_1	382	388	PF00069	0.464
MOD_Plk_1	528	534	PF00069	0.390
MOD_Plk_1	586	592	PF00069	0.429
MOD_Plk_1	645	651	PF00069	0.546
MOD_Plk_4	158	164	PF00069	0.431
MOD_Plk_4	227	233	PF00069	0.439
MOD_Plk_4	251	257	PF00069	0.309
MOD_Plk_4	289	295	PF00069	0.401
MOD_Plk_4	528	534	PF00069	0.393
MOD_Plk_4	71	77	PF00069	0.378
MOD_Plk_4	748	754	PF00069	0.322
MOD_ProDKin_1	215	221	PF00069	0.553
MOD_ProDKin_1	268	274	PF00069	0.605
MOD_ProDKin_1	537	543	PF00069	0.572
MOD_ProDKin_1	558	564	PF00069	0.650
MOD_ProDKin_1	629	635	PF00069	0.690
MOD_SUMO_rev_2	554	559	PF00179	0.564
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.387
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.517
TRG_ENDOCYTIC_2	18	21	PF00928	0.346
TRG_ENDOCYTIC_2	241	244	PF00928	0.501
TRG_ENDOCYTIC_2	290	293	PF00928	0.381
TRG_ENDOCYTIC_2	72	75	PF00928	0.273
TRG_ENDOCYTIC_2	736	739	PF00928	0.512
TRG_ER_diArg_1	364	366	PF00400	0.498
TRG_ER_diArg_1	463	466	PF00400	0.640
TRG_ER_diArg_1	715	718	PF00400	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q9	Leptomonas seymouri	44%	100%
A0A1X0NV79	Trypanosomatidae	28%	100%
A0A3Q8IHE4	Leishmania donovani	90%	100%
A0A3S5ISC4	Trypanosoma rangeli	30%	100%
A4H6F8	Leishmania braziliensis	76%	100%
A4HUV3	Leishmania infantum	90%	100%
D0A7K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ANI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BB49	Trypanosoma cruzi	30%	100%