Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QH36_LEIMA

TriTrypDb:

LmjF.11.0440 , LMJLV39_110009800 , LMJSD75_110010000

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

Q4QH36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH36

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0019900	kinase binding	4	2
GO:0019901	protein kinase binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.631
CLV_C14_Caspase3-7	537	541	PF00656	0.631
CLV_NRD_NRD_1	180	182	PF00675	0.451
CLV_NRD_NRD_1	340	342	PF00675	0.630
CLV_NRD_NRD_1	438	440	PF00675	0.465
CLV_NRD_NRD_1	445	447	PF00675	0.482
CLV_NRD_NRD_1	495	497	PF00675	0.685
CLV_NRD_NRD_1	501	503	PF00675	0.593
CLV_NRD_NRD_1	567	569	PF00675	0.646
CLV_NRD_NRD_1	7	9	PF00675	0.477
CLV_PCSK_KEX2_1	182	184	PF00082	0.443
CLV_PCSK_KEX2_1	340	342	PF00082	0.630
CLV_PCSK_KEX2_1	438	440	PF00082	0.469
CLV_PCSK_KEX2_1	445	447	PF00082	0.482
CLV_PCSK_KEX2_1	501	503	PF00082	0.605
CLV_PCSK_KEX2_1	567	569	PF00082	0.521
CLV_PCSK_KEX2_1	6	8	PF00082	0.422
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.443
CLV_PCSK_PC7_1	434	440	PF00082	0.460
CLV_PCSK_SKI1_1	182	186	PF00082	0.444
CLV_PCSK_SKI1_1	340	344	PF00082	0.598
CLV_Separin_Metazoa	417	421	PF03568	0.492
DEG_APCC_DBOX_1	444	452	PF00400	0.513
DEG_Nend_UBRbox_3	1	3	PF02207	0.401
DEG_SPOP_SBC_1	210	214	PF00917	0.619
DEG_SPOP_SBC_1	221	225	PF00917	0.645
DEG_SPOP_SBC_1	315	319	PF00917	0.668
DEG_SPOP_SBC_1	555	559	PF00917	0.627
DOC_CYCLIN_RxL_1	179	186	PF00134	0.444
DOC_CYCLIN_RxL_1	26	40	PF00134	0.388
DOC_MAPK_gen_1	127	137	PF00069	0.430
DOC_MAPK_gen_1	181	190	PF00069	0.483
DOC_MAPK_gen_1	438	444	PF00069	0.458
DOC_MAPK_gen_1	445	455	PF00069	0.450
DOC_MAPK_gen_1	510	518	PF00069	0.568
DOC_MAPK_HePTP_8	180	192	PF00069	0.436
DOC_MAPK_MEF2A_6	183	192	PF00069	0.478
DOC_MAPK_MEF2A_6	446	455	PF00069	0.540
DOC_MAPK_MEF2A_6	510	518	PF00069	0.568
DOC_PP2B_LxvP_1	190	193	PF13499	0.439
DOC_USP7_MATH_1	221	225	PF00917	0.624
DOC_USP7_MATH_1	235	239	PF00917	0.614
DOC_USP7_MATH_1	306	310	PF00917	0.668
DOC_USP7_MATH_1	373	377	PF00917	0.724
DOC_USP7_MATH_1	471	475	PF00917	0.544
DOC_USP7_MATH_1	525	529	PF00917	0.671
DOC_USP7_MATH_1	539	543	PF00917	0.562
DOC_USP7_MATH_1	554	558	PF00917	0.650
DOC_USP7_MATH_1	94	98	PF00917	0.325
DOC_WW_Pin1_4	287	292	PF00397	0.653
DOC_WW_Pin1_4	349	354	PF00397	0.632
DOC_WW_Pin1_4	358	363	PF00397	0.615
DOC_WW_Pin1_4	367	372	PF00397	0.506
DOC_WW_Pin1_4	391	396	PF00397	0.670
DOC_WW_Pin1_4	510	515	PF00397	0.607
DOC_WW_Pin1_4	535	540	PF00397	0.685
LIG_14-3-3_CanoR_1	141	147	PF00244	0.412
LIG_14-3-3_CanoR_1	183	192	PF00244	0.496
LIG_14-3-3_CanoR_1	211	216	PF00244	0.629
LIG_14-3-3_CanoR_1	253	262	PF00244	0.709
LIG_14-3-3_CanoR_1	266	272	PF00244	0.524
LIG_14-3-3_CanoR_1	300	308	PF00244	0.647
LIG_14-3-3_CanoR_1	364	370	PF00244	0.671
LIG_14-3-3_CanoR_1	380	389	PF00244	0.630
LIG_14-3-3_CanoR_1	429	437	PF00244	0.531
LIG_14-3-3_CanoR_1	8	14	PF00244	0.436
LIG_Actin_WH2_2	139	156	PF00022	0.360
LIG_BRCT_BRCA1_1	168	172	PF00533	0.417
LIG_Clathr_ClatBox_1	134	138	PF01394	0.471
LIG_FHA_1	116	122	PF00498	0.426
LIG_FHA_1	221	227	PF00498	0.643
LIG_FHA_1	266	272	PF00498	0.712
LIG_FHA_1	324	330	PF00498	0.605
LIG_FHA_1	382	388	PF00498	0.631
LIG_FHA_2	120	126	PF00498	0.505
LIG_FHA_2	71	77	PF00498	0.401
LIG_Integrin_isoDGR_2	378	380	PF01839	0.636
LIG_LIR_Gen_1	104	111	PF02991	0.327
LIG_LIR_Gen_1	122	131	PF02991	0.378
LIG_LIR_Gen_1	35	44	PF02991	0.292
LIG_LIR_Nem_3	104	108	PF02991	0.327
LIG_LIR_Nem_3	122	126	PF02991	0.498
LIG_LIR_Nem_3	35	41	PF02991	0.281
LIG_NRBOX	24	30	PF00104	0.414
LIG_RPA_C_Fungi	452	464	PF08784	0.484
LIG_SH2_CRK	38	42	PF00017	0.310
LIG_SH2_CRK	398	402	PF00017	0.614
LIG_SH2_SRC	123	126	PF00017	0.347
LIG_SH2_STAT5	123	126	PF00017	0.395
LIG_SH2_STAT5	310	313	PF00017	0.629
LIG_SH2_STAT5	42	45	PF00017	0.425
LIG_SH3_3	285	291	PF00018	0.628
LIG_SH3_3	399	405	PF00018	0.699
LIG_SUMO_SIM_anti_2	51	57	PF11976	0.304
LIG_SUMO_SIM_par_1	517	522	PF11976	0.607
LIG_SUMO_SIM_par_1	70	76	PF11976	0.410
LIG_TYR_ITIM	121	126	PF00017	0.377
LIG_TYR_ITIM	36	41	PF00017	0.287
LIG_WRC_WIRS_1	10	15	PF05994	0.402
MOD_CDC14_SPxK_1	361	364	PF00782	0.597
MOD_CDK_SPK_2	287	292	PF00069	0.638
MOD_CDK_SPxK_1	358	364	PF00069	0.602
MOD_CDK_SPxxK_3	510	517	PF00069	0.678
MOD_CK1_1	166	172	PF00069	0.374
MOD_CK1_1	209	215	PF00069	0.628
MOD_CK1_1	225	231	PF00069	0.612
MOD_CK1_1	274	280	PF00069	0.793
MOD_CK1_1	309	315	PF00069	0.641
MOD_CK1_1	322	328	PF00069	0.639
MOD_CK1_1	332	338	PF00069	0.589
MOD_CK1_1	357	363	PF00069	0.640
MOD_CK1_1	37	43	PF00069	0.384
MOD_CK1_1	382	388	PF00069	0.597
MOD_CK1_1	413	419	PF00069	0.586
MOD_CK1_1	474	480	PF00069	0.589
MOD_CK1_1	524	530	PF00069	0.608
MOD_CK1_1	559	565	PF00069	0.689
MOD_CK1_1	97	103	PF00069	0.325
MOD_CK2_1	191	197	PF00069	0.562
MOD_CK2_1	233	239	PF00069	0.677
MOD_CK2_1	70	76	PF00069	0.417
MOD_GlcNHglycan	168	171	PF01048	0.459
MOD_GlcNHglycan	173	176	PF01048	0.439
MOD_GlcNHglycan	247	250	PF01048	0.810
MOD_GlcNHglycan	255	258	PF01048	0.758
MOD_GlcNHglycan	273	277	PF01048	0.634
MOD_GlcNHglycan	304	307	PF01048	0.728
MOD_GlcNHglycan	311	314	PF01048	0.722
MOD_GlcNHglycan	321	324	PF01048	0.744
MOD_GlcNHglycan	354	357	PF01048	0.613
MOD_GlcNHglycan	490	494	PF01048	0.698
MOD_GlcNHglycan	522	526	PF01048	0.597
MOD_GlcNHglycan	547	550	PF01048	0.831
MOD_GlcNHglycan	552	555	PF01048	0.633
MOD_GSK3_1	115	122	PF00069	0.430
MOD_GSK3_1	201	208	PF00069	0.577
MOD_GSK3_1	216	223	PF00069	0.621
MOD_GSK3_1	225	232	PF00069	0.610
MOD_GSK3_1	245	252	PF00069	0.584
MOD_GSK3_1	261	268	PF00069	0.682
MOD_GSK3_1	274	281	PF00069	0.561
MOD_GSK3_1	302	309	PF00069	0.665
MOD_GSK3_1	315	322	PF00069	0.578
MOD_GSK3_1	352	359	PF00069	0.745
MOD_GSK3_1	379	386	PF00069	0.634
MOD_GSK3_1	521	528	PF00069	0.607
MOD_GSK3_1	535	542	PF00069	0.746
MOD_GSK3_1	550	557	PF00069	0.619
MOD_GSK3_1	578	585	PF00069	0.644
MOD_GSK3_1	97	104	PF00069	0.313
MOD_N-GLC_1	101	106	PF02516	0.344
MOD_N-GLC_1	115	120	PF02516	0.502
MOD_N-GLC_1	266	271	PF02516	0.604
MOD_NEK2_1	101	106	PF00069	0.346
MOD_NEK2_1	229	234	PF00069	0.585
MOD_NEK2_1	265	270	PF00069	0.649
MOD_NEK2_1	278	283	PF00069	0.559
MOD_NEK2_1	34	39	PF00069	0.345
MOD_NEK2_1	374	379	PF00069	0.628
MOD_NEK2_1	383	388	PF00069	0.745
MOD_NEK2_1	451	456	PF00069	0.413
MOD_NEK2_1	556	561	PF00069	0.686
MOD_NEK2_1	573	578	PF00069	0.562
MOD_NEK2_1	77	82	PF00069	0.386
MOD_NEK2_2	471	476	PF00069	0.548
MOD_PIKK_1	183	189	PF00454	0.519
MOD_PIKK_1	528	534	PF00454	0.648
MOD_PK_1	512	518	PF00069	0.636
MOD_PKA_2	210	216	PF00069	0.627
MOD_PKA_2	265	271	PF00069	0.653
MOD_PKA_2	299	305	PF00069	0.649
MOD_PKA_2	306	312	PF00069	0.592
MOD_PKA_2	347	353	PF00069	0.655
MOD_PKA_2	379	385	PF00069	0.671
MOD_PKA_2	428	434	PF00069	0.531
MOD_PKB_1	181	189	PF00069	0.496
MOD_PKB_1	510	518	PF00069	0.547
MOD_Plk_1	101	107	PF00069	0.343
MOD_Plk_1	221	227	PF00069	0.623
MOD_Plk_1	229	235	PF00069	0.606
MOD_Plk_1	266	272	PF00069	0.717
MOD_Plk_1	34	40	PF00069	0.299
MOD_Plk_1	362	368	PF00069	0.783
MOD_Plk_4	119	125	PF00069	0.384
MOD_Plk_4	130	136	PF00069	0.371
MOD_Plk_4	163	169	PF00069	0.497
MOD_Plk_4	258	264	PF00069	0.651
MOD_Plk_4	306	312	PF00069	0.646
MOD_Plk_4	37	43	PF00069	0.365
MOD_Plk_4	383	389	PF00069	0.654
MOD_Plk_4	51	57	PF00069	0.355
MOD_ProDKin_1	287	293	PF00069	0.653
MOD_ProDKin_1	349	355	PF00069	0.632
MOD_ProDKin_1	358	364	PF00069	0.619
MOD_ProDKin_1	367	373	PF00069	0.501
MOD_ProDKin_1	391	397	PF00069	0.672
MOD_ProDKin_1	510	516	PF00069	0.608
MOD_ProDKin_1	535	541	PF00069	0.687
TRG_DiLeu_BaEn_1	23	28	PF01217	0.425
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.380
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.433
TRG_ENDOCYTIC_2	123	126	PF00928	0.368
TRG_ENDOCYTIC_2	38	41	PF00928	0.300
TRG_ENDOCYTIC_2	398	401	PF00928	0.612
TRG_ER_diArg_1	180	183	PF00400	0.455
TRG_ER_diArg_1	339	341	PF00400	0.620
TRG_ER_diArg_1	437	439	PF00400	0.476
TRG_ER_diArg_1	444	446	PF00400	0.490
TRG_ER_diArg_1	5	8	PF00400	0.388
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	341	346	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	517	522	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI0	Leptomonas seymouri	52%	93%
A0A3Q8I916	Leishmania donovani	93%	100%
A4H6G0	Leishmania braziliensis	69%	97%
A4HUV5	Leishmania infantum	92%	100%
E9ANJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%