Putative DNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative DNA ligase

Gene product:

DNA ligase, putative

Species:

Leishmania major

UniProt:

Q4QH35_LEIMA

TriTrypDb:

LmjF.11.0450 , LMJLV39_110009900 , LMJSD75_110010100

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QH35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QH35

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003909	DNA ligase activity	4	8
GO:0003910	DNA ligase (ATP) activity	5	8
GO:0016874	ligase activity	2	11
GO:0016886	ligase activity, forming phosphoric ester bonds	3	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.560
CLV_C14_Caspase3-7	180	184	PF00656	0.642
CLV_C14_Caspase3-7	596	600	PF00656	0.530
CLV_NRD_NRD_1	167	169	PF00675	0.749
CLV_NRD_NRD_1	352	354	PF00675	0.708
CLV_NRD_NRD_1	444	446	PF00675	0.767
CLV_NRD_NRD_1	462	464	PF00675	0.415
CLV_NRD_NRD_1	497	499	PF00675	0.539
CLV_NRD_NRD_1	526	528	PF00675	0.561
CLV_PCSK_KEX2_1	169	171	PF00082	0.764
CLV_PCSK_KEX2_1	444	446	PF00082	0.754
CLV_PCSK_KEX2_1	462	464	PF00082	0.408
CLV_PCSK_KEX2_1	497	499	PF00082	0.539
CLV_PCSK_KEX2_1	526	528	PF00082	0.540
CLV_PCSK_KEX2_1	588	590	PF00082	0.712
CLV_PCSK_KEX2_1	689	691	PF00082	0.755
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.600
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.745
CLV_PCSK_PC1ET2_1	689	691	PF00082	0.743
CLV_PCSK_SKI1_1	174	178	PF00082	0.624
CLV_PCSK_SKI1_1	322	326	PF00082	0.285
CLV_PCSK_SKI1_1	467	471	PF00082	0.531
CLV_PCSK_SKI1_1	527	531	PF00082	0.545
CLV_PCSK_SKI1_1	538	542	PF00082	0.556
CLV_PCSK_SKI1_1	544	548	PF00082	0.498
CLV_PCSK_SKI1_1	557	561	PF00082	0.305
CLV_PCSK_SKI1_1	658	662	PF00082	0.449
DOC_CDC14_PxL_1	216	224	PF14671	0.430
DOC_CKS1_1	606	611	PF01111	0.652
DOC_CKS1_1	683	688	PF01111	0.528
DOC_CYCLIN_RxL_1	551	564	PF00134	0.490
DOC_MAPK_DCC_7	217	227	PF00069	0.344
DOC_MAPK_gen_1	462	472	PF00069	0.580
DOC_MAPK_gen_1	565	575	PF00069	0.515
DOC_MAPK_MEF2A_6	465	474	PF00069	0.617
DOC_MAPK_NFAT4_5	467	475	PF00069	0.615
DOC_PP2B_LxvP_1	240	243	PF13499	0.570
DOC_PP2B_LxvP_1	31	34	PF13499	0.552
DOC_PP2B_LxvP_1	430	433	PF13499	0.635
DOC_PP4_FxxP_1	228	231	PF00568	0.502
DOC_PP4_FxxP_1	61	64	PF00568	0.360
DOC_USP7_MATH_1	162	166	PF00917	0.547
DOC_USP7_MATH_1	176	180	PF00917	0.732
DOC_USP7_MATH_1	335	339	PF00917	0.429
DOC_USP7_MATH_1	34	38	PF00917	0.747
DOC_USP7_MATH_1	536	540	PF00917	0.609
DOC_USP7_MATH_1	703	707	PF00917	0.605
DOC_USP7_UBL2_3	262	266	PF12436	0.580
DOC_USP7_UBL2_3	420	424	PF12436	0.606
DOC_USP7_UBL2_3	561	565	PF12436	0.484
DOC_USP7_UBL2_3	613	617	PF12436	0.664
DOC_WW_Pin1_4	24	29	PF00397	0.754
DOC_WW_Pin1_4	267	272	PF00397	0.422
DOC_WW_Pin1_4	301	306	PF00397	0.581
DOC_WW_Pin1_4	323	328	PF00397	0.498
DOC_WW_Pin1_4	353	358	PF00397	0.759
DOC_WW_Pin1_4	481	486	PF00397	0.729
DOC_WW_Pin1_4	60	65	PF00397	0.381
DOC_WW_Pin1_4	602	607	PF00397	0.683
DOC_WW_Pin1_4	682	687	PF00397	0.726
DOC_WW_Pin1_4	701	706	PF00397	0.661
DOC_WW_Pin1_4	73	78	PF00397	0.465
LIG_14-3-3_CanoR_1	203	208	PF00244	0.627
LIG_14-3-3_CanoR_1	282	291	PF00244	0.497
LIG_14-3-3_CanoR_1	309	314	PF00244	0.486
LIG_14-3-3_CanoR_1	538	546	PF00244	0.606
LIG_14-3-3_CanoR_1	589	595	PF00244	0.577
LIG_14-3-3_CanoR_1	70	75	PF00244	0.432
LIG_Actin_WH2_2	423	438	PF00022	0.649
LIG_APCC_ABBA_1	397	402	PF00400	0.447
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BIR_III_4	181	185	PF00653	0.572
LIG_BRCT_BRCA1_1	203	207	PF00533	0.433
LIG_BRCT_BRCA1_1	628	632	PF00533	0.419
LIG_Clathr_ClatBox_1	119	123	PF01394	0.450
LIG_FHA_1	188	194	PF00498	0.390
LIG_FHA_1	284	290	PF00498	0.423
LIG_FHA_1	3	9	PF00498	0.623
LIG_FHA_1	344	350	PF00498	0.751
LIG_FHA_1	474	480	PF00498	0.631
LIG_FHA_1	567	573	PF00498	0.621
LIG_FHA_2	147	153	PF00498	0.578
LIG_FHA_2	510	516	PF00498	0.653
LIG_FHA_2	545	551	PF00498	0.578
LIG_FHA_2	720	726	PF00498	0.546
LIG_Integrin_RGD_1	492	494	PF01839	0.555
LIG_LIR_Apic_2	110	115	PF02991	0.406
LIG_LIR_Apic_2	73	77	PF02991	0.566
LIG_LIR_Gen_1	190	199	PF02991	0.375
LIG_LIR_Gen_1	712	723	PF02991	0.407
LIG_LIR_Nem_3	107	112	PF02991	0.381
LIG_LIR_Nem_3	190	195	PF02991	0.399
LIG_LIR_Nem_3	550	556	PF02991	0.457
LIG_LIR_Nem_3	629	635	PF02991	0.484
LIG_LIR_Nem_3	712	718	PF02991	0.425
LIG_LYPXL_yS_3	553	556	PF13949	0.475
LIG_MYND_1	554	558	PF01753	0.557
LIG_NRBOX	315	321	PF00104	0.351
LIG_NRBOX	660	666	PF00104	0.432
LIG_PCNA_PIPBox_1	657	666	PF02747	0.426
LIG_Pex14_2	188	192	PF04695	0.538
LIG_SH2_CRK	112	116	PF00017	0.529
LIG_SH2_CRK	383	387	PF00017	0.446
LIG_SH2_CRK	715	719	PF00017	0.377
LIG_SH2_NCK_1	40	44	PF00017	0.546
LIG_SH2_PTP2	74	77	PF00017	0.549
LIG_SH2_SRC	218	221	PF00017	0.426
LIG_SH2_SRC	400	403	PF00017	0.485
LIG_SH2_STAT3	145	148	PF00017	0.482
LIG_SH2_STAT3	633	636	PF00017	0.368
LIG_SH2_STAT5	145	148	PF00017	0.371
LIG_SH2_STAT5	218	221	PF00017	0.390
LIG_SH2_STAT5	315	318	PF00017	0.410
LIG_SH2_STAT5	400	403	PF00017	0.444
LIG_SH2_STAT5	74	77	PF00017	0.541
LIG_SH3_1	217	223	PF00018	0.377
LIG_SH3_1	497	503	PF00018	0.541
LIG_SH3_3	217	223	PF00018	0.487
LIG_SH3_3	236	242	PF00018	0.725
LIG_SH3_3	359	365	PF00018	0.769
LIG_SH3_3	497	503	PF00018	0.673
LIG_SH3_3	53	59	PF00018	0.549
LIG_SH3_3	570	576	PF00018	0.464
LIG_SH3_3	603	609	PF00018	0.577
LIG_SH3_3	97	103	PF00018	0.669
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.526
LIG_SUMO_SIM_anti_2	515	520	PF11976	0.567
LIG_SUMO_SIM_par_1	4	10	PF11976	0.530
LIG_SUMO_SIM_par_1	470	476	PF11976	0.489
LIG_SUMO_SIM_par_1	706	712	PF11976	0.495
LIG_SxIP_EBH_1	374	387	PF03271	0.512
LIG_TYR_ITIM	381	386	PF00017	0.395
LIG_UBA3_1	316	325	PF00899	0.274
LIG_UBA3_1	555	561	PF00899	0.416
LIG_WRC_WIRS_1	185	190	PF05994	0.386
MOD_CDC14_SPxK_1	704	707	PF00782	0.544
MOD_CDK_SPK_2	24	29	PF00069	0.600
MOD_CDK_SPK_2	60	65	PF00069	0.370
MOD_CDK_SPK_2	605	610	PF00069	0.650
MOD_CDK_SPxK_1	701	707	PF00069	0.557
MOD_CDK_SPxxK_3	323	330	PF00069	0.396
MOD_CDK_SPxxK_3	682	689	PF00069	0.529
MOD_CK1_1	187	193	PF00069	0.429
MOD_CK1_1	211	217	PF00069	0.410
MOD_CK1_1	252	258	PF00069	0.618
MOD_CK1_1	35	41	PF00069	0.607
MOD_CK1_1	473	479	PF00069	0.597
MOD_CK1_1	590	596	PF00069	0.691
MOD_CK1_1	721	727	PF00069	0.524
MOD_CK1_1	73	79	PF00069	0.450
MOD_CK1_1	90	96	PF00069	0.762
MOD_CK2_1	509	515	PF00069	0.634
MOD_CK2_1	688	694	PF00069	0.543
MOD_CK2_1	719	725	PF00069	0.449
MOD_Cter_Amidation	166	169	PF01082	0.549
MOD_Cter_Amidation	460	463	PF01082	0.653
MOD_Cter_Amidation	524	527	PF01082	0.633
MOD_Cter_Amidation	611	614	PF01082	0.613
MOD_GlcNHglycan	195	198	PF01048	0.344
MOD_GlcNHglycan	251	254	PF01048	0.583
MOD_GlcNHglycan	34	37	PF01048	0.731
MOD_GlcNHglycan	366	369	PF01048	0.738
MOD_GlcNHglycan	458	462	PF01048	0.767
MOD_GlcNHglycan	531	534	PF01048	0.592
MOD_GlcNHglycan	628	631	PF01048	0.419
MOD_GlcNHglycan	665	668	PF01048	0.628
MOD_GlcNHglycan	679	682	PF01048	0.670
MOD_GlcNHglycan	84	87	PF01048	0.722
MOD_GSK3_1	172	179	PF00069	0.770
MOD_GSK3_1	34	41	PF00069	0.741
MOD_GSK3_1	385	392	PF00069	0.462
MOD_GSK3_1	571	578	PF00069	0.504
MOD_GSK3_1	703	710	PF00069	0.588
MOD_GSK3_1	714	721	PF00069	0.348
MOD_GSK3_1	78	85	PF00069	0.614
MOD_GSK3_1	88	95	PF00069	0.619
MOD_LATS_1	448	454	PF00433	0.641
MOD_N-GLC_1	162	167	PF02516	0.520
MOD_N-GLC_1	283	288	PF02516	0.548
MOD_N-GLC_1	301	306	PF02516	0.408
MOD_N-GLC_1	38	43	PF02516	0.561
MOD_N-GLC_1	645	650	PF02516	0.448
MOD_NEK2_1	1	6	PF00069	0.527
MOD_NEK2_1	151	156	PF00069	0.638
MOD_NEK2_1	18	23	PF00069	0.490
MOD_NEK2_1	193	198	PF00069	0.348
MOD_NEK2_1	202	207	PF00069	0.413
MOD_NEK2_1	389	394	PF00069	0.536
MOD_NEK2_1	449	454	PF00069	0.790
MOD_NEK2_1	470	475	PF00069	0.616
MOD_NEK2_1	52	57	PF00069	0.514
MOD_NEK2_1	645	650	PF00069	0.432
MOD_NEK2_1	714	719	PF00069	0.376
MOD_NEK2_2	104	109	PF00069	0.536
MOD_NEK2_2	679	684	PF00069	0.603
MOD_PIKK_1	304	310	PF00454	0.390
MOD_PIKK_1	390	396	PF00454	0.567
MOD_PK_1	730	736	PF00069	0.502
MOD_PKA_1	588	594	PF00069	0.487
MOD_PKA_1	613	619	PF00069	0.689
MOD_PKA_2	202	208	PF00069	0.604
MOD_PKA_2	435	441	PF00069	0.596
MOD_PKA_2	449	455	PF00069	0.708
MOD_PKA_2	588	594	PF00069	0.672
MOD_PKB_1	201	209	PF00069	0.525
MOD_Plk_1	134	140	PF00069	0.560
MOD_Plk_1	645	651	PF00069	0.436
MOD_Plk_4	134	140	PF00069	0.481
MOD_Plk_4	211	217	PF00069	0.403
MOD_Plk_4	27	33	PF00069	0.620
MOD_Plk_4	656	662	PF00069	0.448
MOD_ProDKin_1	24	30	PF00069	0.754
MOD_ProDKin_1	267	273	PF00069	0.414
MOD_ProDKin_1	301	307	PF00069	0.573
MOD_ProDKin_1	323	329	PF00069	0.496
MOD_ProDKin_1	353	359	PF00069	0.756
MOD_ProDKin_1	481	487	PF00069	0.727
MOD_ProDKin_1	60	66	PF00069	0.378
MOD_ProDKin_1	602	608	PF00069	0.685
MOD_ProDKin_1	682	688	PF00069	0.725
MOD_ProDKin_1	701	707	PF00069	0.659
MOD_ProDKin_1	73	79	PF00069	0.479
MOD_SUMO_rev_2	255	264	PF00179	0.460
TRG_DiLeu_BaEn_1	124	129	PF01217	0.313
TRG_DiLeu_BaEn_4	124	130	PF01217	0.315
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.533
TRG_DiLeu_BaLyEn_6	555	560	PF01217	0.410
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.503
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.438
TRG_DiLeu_LyEn_5	124	129	PF01217	0.392
TRG_ENDOCYTIC_2	117	120	PF00928	0.474
TRG_ENDOCYTIC_2	383	386	PF00928	0.461
TRG_ENDOCYTIC_2	553	556	PF00928	0.399
TRG_ENDOCYTIC_2	715	718	PF00928	0.371
TRG_ER_diArg_1	444	447	PF00400	0.777
TRG_ER_diArg_1	462	465	PF00400	0.441
TRG_ER_diArg_1	496	498	PF00400	0.544
TRG_ER_diArg_1	567	570	PF00400	0.564
TRG_NLS_MonoCore_2	167	172	PF00514	0.527
TRG_NLS_MonoExtC_3	167	172	PF00514	0.620
TRG_NLS_MonoExtC_3	612	617	PF00514	0.544
TRG_NLS_MonoExtN_4	168	173	PF00514	0.599
TRG_NLS_MonoExtN_4	610	617	PF00514	0.564
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	557	562	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN9	Leptomonas seymouri	52%	97%
A0A1X0NVK9	Trypanosomatidae	35%	100%
A0A3R7NRR1	Trypanosoma rangeli	35%	100%
A0A3S7WRI1	Leishmania donovani	90%	100%
A4H6G1	Leishmania braziliensis	74%	97%
A4HUV6	Leishmania infantum	91%	100%
D0A7J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ANJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BB55	Trypanosoma cruzi	34%	100%